SUUR joins separate subsets of PcG, HP1 and B-type lamin targets in Drosophila.

abstract：:In many epithelial cells, epidermal growth factor (EGF) augments the epithelial-mesenchymal transition (EMT) that occurs when cells are treated with transforming growth factor β (TGFβ). We demonstrate that this augmentation requires activation of SH2 domain-containing phosphatase-2 (SHP2; also known as PTPN11), a prot...

journal_title：Journal of cell science

authors： Buonato JM,Lan IS,Lazzara MJ

更新日期：2015-11-01 00:00:00

abstract：:Morphological, enzymic and antigenic data are presented regarding a human bone-marrow stromal cell line maintained for 10 months and subcultured weekly. The main characteristics are a fibroblastoid morphology, diffuse growth in collagen gels, no colony formation in soft gel media, contact inhibition of growth and conv...

journal_title：Journal of cell science

authors： Lanotte M,Allen TD,Dexter TM

更新日期：1981-08-01 00:00:00

abstract：:Atherosclerosis depends on risk factors such as hyperlipidemia, smoking, hypertension and diabetes. Although these risk factors are relatively constant throughout the arterial circulation, atherosclerotic plaques occur at specific sites where flow patterns are disturbed, with lower overall magnitude and complex change...

journal_title：Journal of cell science

authors： Conway DE,Schwartz MA

更新日期：2013-11-15 00:00:00

abstract：:The relationshio between Con A-receptor mobility and Con A-induced agglutination of Novikoff hepatoma and normal rat liver cells was investigated. Novikoff cells, incubated with fluorescein-labelled Con A at 3 degrees C displayed uniform, ring-like surface fluorescence. Increasing the temperature of the cells to 37 de...

journal_title：Journal of cell science

authors： Mastromarino P,Neri G,Serra A,Walborg EF Jr

更新日期：1980-04-01 00:00:00

abstract：:To investigate the mechanism of chromatin assembly at human centromeres, we isolated cultured human cell lines in which a transfected alpha-satellite (alphoid) YAC was integrated ectopically into the terminal region of host chromosome 16, where it was stably maintained. Centromere activity of the alphoid YAC was suppr...

journal_title：Journal of cell science

authors： Nakano M,Okamoto Y,Ohzeki J,Masumoto H

更新日期：2003-10-01 00:00:00

abstract：:Accurate chromosome segregation requires the spindle assembly checkpoint to be active at the onset of mitosis, before being silenced following chromosome alignment. p31(comet) is a checkpoint antagonist in that its inhibition delays mitotic exit, whereas its overexpression overrides the checkpoint. How exactly p31(com...

journal_title：Journal of cell science

authors： Westhorpe FG,Tighe A,Lara-Gonzalez P,Taylor SS

更新日期：2011-11-15 00:00:00

abstract：:Compartmentalization of surface membrane antigens into discrete regions or domains is a characteristic feature of differentiated cells. In mammalian spermatozoa at least 5 surface domains are known, implying the presence of barriers or boundaries within the plasma membrane. Using the technique of fluorescence recovery...

journal_title：Journal of cell science

authors： Ladha S,James PS,Clark DC,Howes EA,Jones R

更新日期：1997-05-01 00:00:00

abstract：:Deleted in liver cancer 1 (DLC1) is a multi-modular Rho-GTPase-activating protein (RhoGAP) and a tumor suppressor. Besides its RhoGAP domain, functions of other domains in DLC1 remain largely unknown. By protein precipitation and mass spectrometry, we identified eukaryotic elongation factor 1A1 (EF1A1) as a novel part...

journal_title：Journal of cell science

authors： Zhong D,Zhang J,Yang S,Soh UJ,Buschdorf JP,Zhou YT,Yang D,Low BC

更新日期：2009-02-01 00:00:00

abstract：:Elementary Ca(2+) signals, such as "Ca(2+) puffs", which arise from the activation of inositol 1,4,5-trisphosphate receptors, are building blocks for local and global Ca(2+) signalling. We characterized Ca(2+) puffs in six cell types that expressed differing ratios of the three inositol 1,4,5-trisphosphate receptor is...

journal_title：Journal of cell science

authors： Tovey SC,de Smet P,Lipp P,Thomas D,Young KW,Missiaen L,De Smedt H,Parys JB,Berridge MJ,Thuring J,Holmes A,Bootman MD

更新日期：2001-11-01 00:00:00

abstract：:The plasma membrane Ca2+-ATPase-2 (PMCA2) is expressed in stereocilia of hair cells of the inner ear, whereas PMCA1 is expressed in the basolateral plasma membrane of hair cells. Both extrude excess Ca2+ from the cytosol. They are predicted to contain ten membrane-spanning segments, two large cytoplasmic loops as well...

journal_title：Journal of cell science

authors： Grati M,Aggarwal N,Strehler EE,Wenthold RJ

更新日期：2006-07-15 00:00:00

abstract：:The murine macrophage-like cell line P388D1 ingests immunoglobulin-coated sheep red cells (IgG-SRC) poorly, but after 3 days incubation in the presence of 1.5% dimethyl sulphoxide (DMSO), it becomes highly phagocytic. We used this model to correlate triggering of phagocytosis with some surface properties of P388D1 cel...

journal_title：Journal of cell science

authors： Capo C,Mishal Z,Balloy V,Benoliel AM,Bongrand P

更新日期：1983-11-01 00:00:00

abstract：:CENP-C, one of the few known intrinsic proteins of the human centromere, is thought to play structural as well as regulatory roles crucial to proper chromosome segregation and mitotic progression. To further define the functions of CENP-C throughout the cell cycle we have used the yeast interaction trap to identify pr...

journal_title：Journal of cell science

authors： Pluta AF,Earnshaw WC,Goldberg IG

更新日期：1998-07-30 00:00:00

abstract：:The cell nucleus is highly organized. Many nuclear functions are localized in discrete domains, suggesting that compartmentalization is an important aspect of the regulation and coordination of nuclear functions. We investigated the subnuclear distribution of the glucocorticoid receptor, a hormone-dependent transcript...

journal_title：Journal of cell science

authors： van Steensel B,Brink M,van der Meulen K,van Binnendijk EP,Wansink DG,de Jong L,de Kloet ER,van Driel R

更新日期：1995-09-01 00:00:00

abstract：:Two isoforms of laminin were extracted from human placenta by neutral buffer containing EDTA, copurified through several steps and finally separated by Mono Q anion exchange chromatography. One variant consisted of disulphide-linked 340, 230 and 190 kDa subunits, which were identified by immunoblotting as Am, B1e and ...

journal_title：Journal of cell science

authors： Brown JC,Wiedemann H,Timpl R

更新日期：1994-01-01 00:00:00

abstract：:To examine the relative roles of chromosomes, spindle poles and microtubules in the formation of the metaphase spindle and metakinesis, I have experimentally placed an extra centrosome-free pronucleus close to a forming bipolar spindle in a living cell. The chromosomes from the extra nucleus induce the formation of an...

journal_title：Journal of cell science

authors： Leslie RJ

更新日期：1992-09-01 00:00:00

abstract：:Plasmid DNA or artificial mRNA injected intramuscularly into skeletal muscle via a 27 g needle expressed transgenes at relatively efficient levels in skeletal myofibers and cardiac cells. In the present study, several approaches were used to determine the mechanism of cellular uptake. After exposure of naked plasmid D...

journal_title：Journal of cell science

authors： Wolff JA,Dowty ME,Jiao S,Repetto G,Berg RK,Ludtke JJ,Williams P,Slautterback DB

更新日期：1992-12-01 00:00:00

abstract：:In hepatocytes, PLIN2 is the major protein coating lipid droplets (LDs), an organelle the hepatitis C virus (HCV) hijacks for virion morphogenesis. We investigated the consequences of PLIN2 deficiency on LDs and on HCV infection. Knockdown of PLIN2 did not affect LD homeostasis, likely due to compensation by PLIN3, bu...

journal_title：Journal of cell science

authors： Lassen S,Grüttner C,Nguyen-Dinh V,Herker E

更新日期：2019-01-09 00:00:00

abstract：:When Swiss 3T3 cells are treated with colcemid for 60 min (0.5-2 micrograms/ml), although the cytoplasmic network of microtubules is considerably reduced, a significant but variable number of microtubules remain. These residual microtubules appear to converge on a single, usually ciliated, organizing centre. In contra...

journal_title：Journal of cell science

authors： Brooks RF,Richmond FN

更新日期：1983-05-01 00:00:00

abstract：:Cells that have been pre-exposed to thermal stress can acquire a transient resistance against the killing effect of a subsequent thermal stress. The cause for this phenomenon, called thermotolerance, seems to be an enhanced resistance of proteins against thermal denaturation and aggregation. This resistance can be exp...

journal_title：Journal of cell science

authors： Kampinga HH

更新日期：1993-01-01 00:00:00

abstract：:Focal adhesion kinase is a recently characterized tyrosine kinase that is concentrated at focal contacts in cultured cells. It is thought to play an important role in the regulation of the integrin-based signal transduction mechanism involved in the assembly of this membrane specialization. In this study, we examined ...

journal_title：Journal of cell science

authors： Baker LP,Daggett DF,Peng HB

更新日期：1994-06-01 00:00:00

abstract：:A scanning electron-microscope study has established that there are major modifications in the surface membranes of malignant cells transformed from the pronephric kidney of the frog. Tumours were induced in vivo after exposure of embryos Lucké Herpes virus. A pronephric cell line from normal embryos and 3 tumour cell...

journal_title：Journal of cell science

authors： Tweedell KS,Williams DC

更新日期：1976-11-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have emerged as important regulators of cancer progression. Abnormal sialylation leads to renal cell carcinoma (RCC) malignancy. However, the mechanism by which the lncRNA maternally expressed gene 3 (MEG3) mediates RCC progression by regulating ST3Gal1 transcription and EGFR sialylation ...

journal_title：Journal of cell science

authors： Gong A,Zhao X,Pan Y,Qi Y,Li S,Huang Y,Guo Y,Qi X,Zheng W,Jia L

更新日期：2020-08-25 00:00:00

abstract：:In the fission yeast Schizosaccharomyces pombe, the protein kinase Chk1 has an essential role in transducing a delay signal to the cell cycle machinery in the presence of DNA damage. Fission yeast cells lacking the chk1 gene do not delay progression of the cell cycle in response to damage and are thus sensitive to DNA...

journal_title：Journal of cell science

authors： Capasso H,Palermo C,Wan S,Rao H,John UP,O'Connell MJ,Walworth NC

更新日期：2002-12-01 00:00:00

abstract：:A universal feature of mitosis is that all chromosomes become aligned at the spindle equator--the halfway point between the two spindle poles--prior to anaphase onset. This migratory event is called congression, and is powered by centromere-bound protein machines called kinetochores. This Commentary aims to document r...

journal_title：Journal of cell science

authors： Auckland P,McAinsh AD

更新日期：2015-09-15 00:00:00

abstract：:Mammalian Delta9 stearoyl-CoA desaturase 1 (SCD1) is a key enzyme in the biosynthesis of mono-unsaturated fatty acids in the endoplasmic reticulum (ER). It is a short-lived multispanning ER membrane protein, reported to be degraded by the ubiquitin-proteasome-independent pathway. We have examined SCD1 protein degradat...

journal_title：Journal of cell science

authors： Kato H,Sakaki K,Mihara K

更新日期：2006-06-01 00:00:00

abstract：:Exocytosis and membrane recycling at the cytoproct (cell anus) of Tetrahymena pyriformis were studied using thin-section electron microscopy. Single cells were fixed at specific times relative to the elimination of the vacuole's contents--before elimination, at elimination, 3--5 s and 10--15 s following elimination. T...

journal_title：Journal of cell science

authors： Allen RD,Wolf RW

更新日期：1979-02-01 00:00:00

abstract：:Axonemal dyneins are multisubunit molecular motors that provide the driving force for flagellar motility. Dynein light chain 1 (LC1) has been well studied in Chlamydomonas reinhardtii and is unique among all dynein components as the only protein known to bind directly to the catalytic motor domain of the dynein heavy ...

journal_title：Journal of cell science

authors： Baron DM,Kabututu ZP,Hill KL

更新日期：2007-05-01 00:00:00

abstract：:Cells depend on a highly ordered organisation of their content and must develop strategies to maintain the anisotropic distribution of organelles during periods of nutrient shortage. One of these strategies is to solidify the cytoplasm, which was observed in bacteria and yeast cells with acutely interrupted energy pro...

journal_title：Journal of cell science

authors： Heimlicher MB,Bächler M,Liu M,Ibeneche-Nnewihe C,Florin EL,Hoenger A,Brunner D

更新日期：2019-11-08 00:00:00

abstract：:Assembly of contractile apparatuses in striated muscle requires precisely regulated reorganization of the actin cytoskeletal proteins into sarcomeric organization. Regulation of actin filament dynamics is one of the essential processes of myofibril assembly, but the mechanism of actin regulation in striated muscle is ...

journal_title：Journal of cell science

authors： Nomura K,Ono K,Ono S

更新日期：2012-09-01 00:00:00

abstract：:The surface of the ciliate Dileptus contains locomotor and sensory domains. Each domain contains cilia of its own kind, arranged in a characteristic pattern. Transformation of a portion of the locomotor area into the sensory domain has been studied. Locomotor ciliary units in the transforming area undergo resorption o...

journal_title：Journal of cell science

authors： Golinska K

更新日期：1983-07-01 00:00:00