Role of cell surface receptor mobility in concanavalin A-induced agglutination of Novikoff hepatoma and normal rat liver cells.

abstract：:Interstitial stem cells in Hydra are rapidly proliferating multipotent stem cells which continuously give rise to precursors for nerve and nematocyte differentiation. Growth of the stem cell population is controlled by the cell cycle time of the stem cells and the self-renewal probability, Ps (the fraction of stem cel...

journal_title：Journal of cell science

authors： Sproull F,David CN

更新日期：1979-08-01 00:00:00

abstract：:We have found that Ehrlich ascites tumour (EAT) cells, deprived of any carbon source, and suspended at a density of 2 X 10(5) cells/cm3, begin to die only after 12 h of starvation, though it is known that under these conditions they lose over 80% of their ATP within 30 min. Moreover, we have found that the viability o...

journal_title：Journal of cell science

authors： Zaporowska-Siwiak E,Michalik M,Kajstura J,Korohoda W

更新日期：1985-08-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is known to be a crucial regulator of neuronal survival and synaptic plasticity in the mammalian brain. Furthermore, BDNF positively influences differentiation of embryonic neural precursors, as well as that of neural stem cells from adult neurogenic niches. To study the impact...

journal_title：Journal of cell science

authors： Leschik J,Eckenstaler R,Nieweg K,Lichtenecker P,Brigadski T,Gottmann K,Lessmann V,Lutz B

更新日期：2013-11-01 00:00:00

abstract：:In our previous experiments with linear strips of adhesive substrate, we found that elongated cultured fibroblasts preserve their length regardless of cell width and the number of cytoplasmic processes. This constancy of length was called 'length control'. In contrast to fibroblasts, single cultured epitheliocytes hav...

journal_title：Journal of cell science

authors： Kharitonova MA,Vasiliev JM

更新日期：2004-04-15 00:00:00

abstract：:Chloroquine resistance in the human malaria parasite, Plasmodium falciparum, arises from decreased accumulation of the drug in the ;digestive vacuole' of the parasite, an acidic compartment in which chloroquine exerts its primary toxic effect. It has been proposed that changes in the pH of the digestive vacuole might ...

journal_title：Journal of cell science

authors： Hayward R,Saliba KJ,Kirk K

更新日期：2006-03-15 00:00:00

abstract：:Treatment of cells arrested in the cell cycle at the G1/S-phase boundary with 5 mM caffeine induces premature mitosis, resulting in chromosomal fragmentation and detachment of centromere-kinetochore fragments, which are subsequently attached to the mitotic spindle and segregated in anaphase. Taking advantage of this i...

journal_title：Journal of cell science

authors： Ouspenski II,Brinkley BR

更新日期：1993-06-01 00:00:00

abstract：:Recent biochemical and molecular approaches have begun to establish the protein interactions that lead to desmosome assembly. To determine whether these associations occur in native desmosomes we have performed ultrastructural localisation of specific domains of the major desmosomal components and have used the result...

journal_title：Journal of cell science

authors： North AJ,Bardsley WG,Hyam J,Bornslaeger EA,Cordingley HC,Trinnaman B,Hatzfeld M,Green KJ,Magee AI,Garrod DR

更新日期：1999-12-01 00:00:00

abstract：:The Arabidopsis AINTEGUMENTA (ANT) gene, which encodes an APETALA2 (AP2)-like transcription factor, controls plant organ cell number and organ size throughout shoot development. ANT is thus a key factor in the development of plant shoots. Here, we have found that ANT plays an essential role in conferring salt toleranc...

journal_title：Journal of cell science

authors： Meng LS,Wang YB,Yao SQ,Liu A

更新日期：2015-08-01 00:00:00

abstract：:Ran is an abundant GTPase of the Ras superfamily that is highly conserved in eukaryotes. In interphase cells, Ran is mainly nuclear and thought to be predominantly GTP-bound, but it is also present in the cytoplasm, probably GDP-bound. This asymmetric distribution plays an important role in directing nucleocytoplasmic...

journal_title：Journal of cell science

authors： Zhang C,Hughes M,Clarke PR

更新日期：1999-07-01 00:00:00

abstract：:Endothelial integrity relies on a mechanical crosstalk between intercellular and cell-matrix interactions. This crosstalk is compromised in hemorrhagic vascular lesions of patients carrying loss-of-function mutations in cerebral cavernous malformation (CCM) genes. RhoA/ROCK-dependent cytoskeletal remodeling is central...

journal_title：Journal of cell science

authors： Lisowska J,Rödel CJ,Manet S,Miroshnikova YA,Boyault C,Planus E,De Mets R,Lee HH,Destaing O,Mertani H,Boulday G,Tournier-Lasserve E,Balland M,Abdelilah-Seyfried S,Albiges-Rizo C,Faurobert E

更新日期：2018-08-13 00:00:00

abstract：:We have identified a novel autoantibody specificity in scleroderma that we term anti-chromo. These antibodies recognize several chromosomal antigens with apparent molecular mass of between 23 and 25 kDa, as determined by immunoblots. Anti-chromo autoantibodies occur in 10-15% of sera from patients with anti-centromere...

journal_title：Journal of cell science

authors： Saunders WS,Chue C,Goebl M,Craig C,Clark RF,Powers JA,Eissenberg JC,Elgin SC,Rothfield NF,Earnshaw WC

更新日期：1993-02-01 00:00:00

abstract：:In many epithelial cells, epidermal growth factor (EGF) augments the epithelial-mesenchymal transition (EMT) that occurs when cells are treated with transforming growth factor β (TGFβ). We demonstrate that this augmentation requires activation of SH2 domain-containing phosphatase-2 (SHP2; also known as PTPN11), a prot...

journal_title：Journal of cell science

authors： Buonato JM,Lan IS,Lazzara MJ

更新日期：2015-11-01 00:00:00

abstract：:Endothelial cell-based angiogenesis requires activation of survival signals that generate resistance to external apoptotic stimuli, such as tumor necrosis factor-alpha (TNF-alpha), during pathobiologic settings. Mechanisms by which this is achieved are not fully defined. Here, we use a model in which the multifunction...

journal_title：Journal of cell science

authors： Kang-Decker N,Cao S,Chatterjee S,Yao J,Egan LJ,Semela D,Mukhopadhyay D,Shah V

更新日期：2007-02-01 00:00:00

abstract：:Endocytosis and recycling of membrane proteins are key processes for nutrient uptake, receptor signaling and synaptic transmission. Different steps in these fission and fusion cycles have been proposed to be regulated by physiological changes in plasma membrane (PM) phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)...

journal_title：Journal of cell science

authors： Abe N,Inoue T,Galvez T,Klein L,Meyer T

更新日期：2008-05-01 00:00:00

abstract：:Several properties of cadherin-4 and cadherin-5 were characterized by using the cDNA transfection approach. The proteins of both cadherins had a relative molecular mass of about 130 kDa and were present at the cell periphery, especially at cell-cell contact sites. These cadherins were easily digested with trypsin, and...

journal_title：Journal of cell science

authors： Tanihara H,Kido M,Obata S,Heimark RL,Davidson M,St John T,Suzuki S

更新日期：1994-06-01 00:00:00

abstract：:Xenopus egg extracts, which support nuclear assembly and DNA replication, were functionally depleted of lamin LIII by inoculating them with monoclonal anti-lamin antibodies. Phase-contrast microscopy and electron-microscopy studies indicated that lamin-depleted extracts supported efficient chromatin decondensation, an...

journal_title：Journal of cell science

authors： Meier J,Campbell KH,Ford CC,Stick R,Hutchison CJ

更新日期：1991-03-01 00:00:00

abstract：:Tumour necrosis factor receptors (TNF-Rs) and their ligands, tumour necrosis factors, are highly conserved proteins described in all metazoan phyla. They function as inducers of extrinsic apoptotic signalling and facilitate inflammation, differentiation and cell survival. TNF-Rs use distinct adaptor molecules to activ...

journal_title：Journal of cell science

authors： Steichele M,Sauermann LS,König AC,Hauck S,Böttger A

更新日期：2021-01-25 00:00:00

abstract：:The GGGGCC (G4C2) repeat expansion mutation in the C9ORF72 gene is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Transcription of the repeat and formation of nuclear RNA foci, which sequester specific RNA-binding proteins, is one of the possible pathological me...

journal_title：Journal of cell science

authors： Bajc Česnik A,Darovic S,Prpar Mihevc S,Štalekar M,Malnar M,Motaln H,Lee YB,Mazej J,Pohleven J,Grosch M,Modic M,Fonovič M,Turk B,Drukker M,Shaw CE,Rogelj B

更新日期：2019-03-07 00:00:00

abstract：:Reorganization of the actin cytoskeleton is essential to numerous cellular processes including cell locomotion and cytokinesis. This actin remodeling is regulated in part by Rho family GTPases. Previous studies implicated Trio, a Dbl-homology guanine nucleotide exchange factor with two exchange factor domains, in regu...

journal_title：Journal of cell science

authors： Seipel K,O'Brien SP,Iannotti E,Medley QG,Streuli M

更新日期：2001-01-01 00:00:00

abstract：:Intermediate filament (IF) dynamics during organelle transport and their role in organelle movement were studied using Xenopus laevis melanophores. In these cells, pigment granules (melanosomes) move along microtubules and microfilaments, toward and away from the cell periphery in response to alpha-melanocyte stimulat...

journal_title：Journal of cell science

authors： Chang L,Barlan K,Chou YH,Grin B,Lakonishok M,Serpinskaya AS,Shumaker DK,Herrmann H,Gelfand VI,Goldman RD

更新日期：2009-08-15 00:00:00

abstract：:The position of the nucleus is regulated in different developmental stages and cellular events. During polarization, the nucleus moves away from the future leading edge and this movement is required for proper cell migration. Nuclear movement requires the LINC complex components nesprin-2G and SUN2, which form transme...

journal_title：Journal of cell science

authors： Borrego-Pinto J,Jegou T,Osorio DS,Auradé F,Gorjánácz M,Koch B,Mattaj IW,Gomes ER

更新日期：2012-03-01 00:00:00

abstract：:BMP2 stimulates bone formation and signals preferably through BMP receptor (BMPR) 1A, whereas GDF5 is a cartilage inducer and signals preferably through BMPR1B. Consequently, BMPR1A and BMPR1B are believed to be involved in bone and cartilage formation, respectively. However, their function is not yet fully clarified....

journal_title：Journal of cell science

authors： Mang T,Kleinschmidt-Doerr K,Ploeger F,Schoenemann A,Lindemann S,Gigout A

更新日期：2020-08-21 00:00:00

abstract：:Cystogenesis is a morphological consequence of numerous genetic diseases of the epithelium. In the kidney, the pathogenic mechanisms underlying the program of altered cell and tubule morphology are obscured by secondary effects of cyst expansion. Here, we developed a new 3D tubuloid system to isolate the rapid changes...

journal_title：Journal of cell science

authors： Dixon EE,Maxim DS,Halperin Kuhns VL,Lane-Harris AC,Outeda P,Ewald AJ,Watnick TJ,Welling PA,Woodward OM

更新日期：2020-07-16 00:00:00

abstract：:Developing oral organelles of dividing Tetrahymena corlissi appear to be positioned by mechanisms which assess distances as a proportion of the organism's overall dimensions. In some respects, the cortex of this protozoan obeys the 'French flag' rule formulated by Wolpert for describing regulation of spatial proportio...

journal_title：Journal of cell science

authors： Lynn DH,Tucker JB

更新日期：1976-06-01 00:00:00

abstract：:When human cells enter S-phase, overlapping differential inhibitory mechanisms downregulate the replication licensing factors ORC1, CDC6 and Cdt1. Such regulation prevents re-replication so that deregulation of any individual factor alone would not be expected to induce overt re-replication. However, this has been cha...

journal_title：Journal of cell science

authors： Sugimoto N,Yoshida K,Tatsumi Y,Yugawa T,Narisawa-Saito M,Waga S,Kiyono T,Fujita M

更新日期：2009-04-15 00:00:00

abstract：:Fibrin deposits in tumor beds are an intriguing phenomenon. It has been suggested that fibrin plays a role as a provisional matrix in which the tumor grows and induces development of a vascular network. On the other hand fibrin possibly protects the tumor nodule from host defense mechanisms. We therefore investigate w...

journal_title：Journal of cell science

authors： Lichtenbeld HH,Muller AD,van Dam-Mieras MC,Blijham GH

更新日期：1993-10-01 00:00:00

abstract：:Activator of G-protein signaling 3 (AGS3, also known as GPSM1) regulates the trans-Golgi network. The AGS3 GoLoco motif binds to Gαi and thereby regulates the transport of proteins to the plasma membrane. Compaction of early embryos is based on the accumulation of E-cadherin (Cdh1) at cell-contacted membranes. However...

journal_title：Journal of cell science

authors： Nie ZW,Niu YJ,Zhou W,Zhou DJ,Kim JY,Cui XS

更新日期：2020-12-07 00:00:00

abstract：:Besides regulating glucose levels, insulin has been reported to participate actively in many other functions, including modulating inflammatory reactions. In this study we investigated how topical insulin application would affect the diabetic wound healing process. We found that the excessive expression of insulin-deg...

journal_title：Journal of cell science

authors： Yang P,Wang X,Wang D,Shi Y,Zhang M,Yu T,Liu D,Gao M,Zhang X,Liu Y

更新日期：2020-10-12 00:00:00

abstract：:The widespread ability of eukaryotic cells to produce thin cytoplasmic sheets or lamellae 100-200 nm thick can give rise to uncertainties in the interpretation of interference reflection microscopy (IRM) images when cell-substratum topography is the key interest. If allowed to spread upon a poly-L-lysine-coated surfac...

journal_title：Journal of cell science

authors： Todd I,Mellor JS,Gingell D

更新日期：1988-01-01 00:00:00

abstract：:Two isoforms of laminin were extracted from human placenta by neutral buffer containing EDTA, copurified through several steps and finally separated by Mono Q anion exchange chromatography. One variant consisted of disulphide-linked 340, 230 and 190 kDa subunits, which were identified by immunoblotting as Am, B1e and ...

journal_title：Journal of cell science

authors： Brown JC,Wiedemann H,Timpl R

更新日期：1994-01-01 00:00:00