Myocarditis: basic and clinical aspects.

Abstract:

:Myocarditis represents a heterogeneous final common pathway for myocardial inflammation of diverse etiologies and accounts for up to one-third of cases of dilated cardiomyopathy. The pathophysiology of viral myocarditis can be disaggregated into the effects of direct viral mediated injury, triggered acute and chronic autoimmune responses, and subsequent adverse remodeling. Recent research highlights the pathogenic role of persistent viral genome expression, Fas-ligand, tumor necrosis factor-alpha receptor 1, and antimyosin autoantibodies in the evolution of chronic systolic and diastolic heart failure. Recent refinements in endomyocardial biopsy evaluation, cardiac magnetic resonance imaging, and cytokine assays augment existing diagnostic modalities. Novel specific immunosuppressive targets aimed at interrupting myocyte injury and apoptosis, including interferon-beta seem promising to date in small clinical studies performed on selected patients.

journal_name

Cardiol Rev

journal_title

Cardiology in review

authors

Ellis CR,Di Salvo T

doi

10.1097/CRD.0b013e31806450c4

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

170-7

issue

4

eissn

1061-5377

issn

1538-4683

pii

00045415-200707000-00002

journal_volume

15

pub_type

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