Endothelin as a clinical target in the treatment of systemic hypertension.

abstract：:Cardiovascular disease is the leading cause of death in women in most developed countries of the world. Even though cardiovascular deaths of men in the United States have been declining, until recently the number of cardiovascular deaths in US women was on the rise, with 1 in 3 women dying from heart disease. Over the...

journal_title：Cardiology in review

authors： Dullum MK,Dullum MK

更新日期：2008-01-01 00:00:00

abstract：:A decision-tree analysis was used to estimate the average cost per patient using the direct thrombin inhibitor argatroban for early treatment (<48 hours after thrombocytopenia onset) compared with delayed treatment (> or =48 hours after thrombocytopenia onset) of immune-mediated heparin-induced thrombocytopenia (HIT) ...

journal_title：Cardiology in review

authors： Arnold RJ,Kim R,Tang B

更新日期：2006-01-01 00:00:00

abstract：:The obesity epidemic has reached unprecedented proportions in Western society. Evidence continues to accumulate that obesity is associated with significant morbidity and mortality and in particular that it is an independent risk factor for cardiovascular disease (CVD). The association of obesity with CVD and its risk ...

journal_title：Cardiology in review

authors： Melanson KJ,McInnis KJ,Rippe JM,Blackburn G,Wilson PF

更新日期：2001-07-01 00:00:00

abstract：:Vitamin K antagonists (VKAs) such as warfarin have traditionally been the major therapeutic option for anticoagulation in clinical practice. VKAs are effective and extensively recommended for the prevention of venous and arterial thromboembolism in cardiovascular disease. Despite its effectiveness, warfarin is limited...

journal_title：Cardiology in review

authors： Maan A,Padmanabhan R,Shaikh AY,Mansour M,Ruskin JN,Heist EK

更新日期：2012-09-01 00:00:00

abstract：:Relaxin, a naturally-occurring hormone in the insulin family, was discovered to have a physiologic role in pregnancy. Named initially for its relaxing effect on the pubic ligament, relaxin receptors have since been found to be widely distributed in many organs in both males and females. Acting through multiple pathway...

journal_title：Cardiology in review

authors： Grossman J,Frishman WH

更新日期：2010-11-01 00:00:00

abstract：:Established coronary artery disease has a prevalence of 7% in adult Americans, accounting for 16 million people. As morbidity and mortality rates have risen, research efforts to identify the pathophysiologic mechanisms of systolic dysfunction have risen in parallel. The current goal is to develop new therapeutic strat...

journal_title：Cardiology in review

authors： Romero J,Lupercio F,Haramati LB,Garcia MJ,Lucariello RJ

更新日期：2014-09-01 00:00:00

abstract：:Heart failure continues to be a leading cause of morbidity and mortality throughout the United States. The pathophysiology of heart failure involves the activation of complex neurohormonal pathways, many of which mediate not only hypertrophy and fibrosis within ventricular myocardium and interstitium, but also activat...

journal_title：Cardiology in review

authors： Carazo M,Berger JS,Reyentovich A,Katz SD

更新日期：2016-09-01 00:00:00

abstract：:Atrial fibrillation (AF) is a common cardiac arrhythmia with significant morbidity and public health cost. Because of limitations of efficacy and safety of conventional antiarrhythmic agents, alternative therapies for AF are needed. The potential antiarrhythmic properties of lipid-altering therapy, including the 3-hyd...

journal_title：Cardiology in review

authors： Bachmann JM,Majmudar M,Tompkins C,Blumenthal RS,Marine JE

更新日期：2008-07-01 00:00:00

abstract：:Mechanical valve thrombosis is a life-threatening event. Pregnancy is associated with a hypercoagulable state that further emphasizes the importance of adequate anticoagulation. This is associated with a therapeutic dilemma. Continued anticoagulation with warfarin throughout the first trimester can result in fetopathi...

journal_title：Cardiology in review

authors： Behrendt P,Schwartzkopff B,Perings S,Gerhardt A,Zotz RB,Strauer BE

更新日期：2002-11-01 00:00:00

abstract：:Left ventricular (LV) remodeling is the most common term used to describe the functional, structural, myocellular, and interstitial changes that occur in response to myocardial injury and/or chronic changes in myocardial loading conditions. Progression of LV remodeling over time in response to neurohormonal activation...

journal_title：Cardiology in review

authors： Saraon T,Katz SD

更新日期：2015-07-01 00:00:00

abstract：:The effect of an ongoing educational program on the use of cardiovascular drugs in patients with coronary artery disease without contraindications to these drugs seen in an academic cardiology clinic was assessed in 100 patients seen during the 6-month period prior to the educational program and in 200 patients seen 9...

journal_title：Cardiology in review

authors： Nayak D,Aronow WS

更新日期：2005-03-01 00:00:00

abstract：:Differences in the overall mortality for acute infarction in women vs men have been appreciated for some time. Some of these differences are based on the age at the time of presentation of women compared with men. Excess mortality in women is most clear at the younger end of the age spectrum. More careful examination ...

journal_title：Cardiology in review

authors： Feldman T,Silver R

更新日期：2000-07-01 00:00:00

abstract：:Computed tomography is an established tool in the assessment of cardiac anatomy and function. As demonstrated by single photon emission computed tomography, positron emission tomography, and magnetic resonance, the noninvasive evaluation of coronary hemodynamics is an important step in guiding clinical management. Nev...

journal_title：Cardiology in review

authors： Lempel M,Frishman WH

更新日期：2019-07-01 00:00:00

abstract：:Magnesium, the fourth most abundant cation in the human body, is involved in several essential physiological, biochemical, and cellular processes regulating cardiovascular function. It plays a critical role in modulating vascular smooth muscle tone, endothelial cell function, and myocardial excitability and is thus ce...

journal_title：Cardiology in review

authors： Kolte D,Vijayaraghavan K,Khera S,Sica DA,Frishman WH

更新日期：2014-07-01 00:00:00

abstract：:As direct oral anticoagulants (DOACs) have demonstrated favorable efficacy and safety outcomes compared with vitamin K antagonists for the treatment and prevention of venous thromboembolism and the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, their role in the management...

journal_title：Cardiology in review

authors： Finks SW,Dobesh PP,Trujillo TC,Crossley GH

更新日期：2018-09-01 00:00:00

abstract：:The literature on the relationship between work-related psychosocial factors and the development of ischemic heart disease (IHD) was systematically reviewed: 33 articles presented 51 analyses of studies involving male participants, 18 analyses involving female participants, and 8 analyses with both genders. Twenty of ...

journal_title：Cardiology in review

authors： Eller NH,Netterstrøm B,Gyntelberg F,Kristensen TS,Nielsen F,Steptoe A,Theorell T

更新日期：2009-03-01 00:00:00

abstract：:The increased life expectancy of women living in industrialized countries is associated with an increase in diseases dependent or facilitated by a state of estrogen deficiency, such as cardiovascular and cerebrovascular diseases. Several studies have shown that estrogen replacement therapy reduces the occurrence of co...

journal_title：Cardiology in review

authors： Rosano GM,Fini M

更新日期：2002-01-01 00:00:00

abstract：:The complex mechanism of platelet activation creates an optimal target for pharmacological treatment in patients with acute coronary syndromes. Current antiplatelet medications that are used in addition to aspirin include the thienopyridines, clopidogrel and prasugrel, but there are several limitations to the use of t...

journal_title：Cardiology in review

authors： Nawarskas JJ,Clark SM

更新日期：2011-03-01 00:00:00

abstract：:Inflammatory cardiomyopathy is a broad term encompassing any disease leading to myocardial inflammation with associated cardiac dysfunction. While endomyocardial biopsy remains the gold standard for diagnosis, non-invasive imaging techniques, such as cardiac magnetic resonance imaging and positron emission tomography,...

journal_title：Cardiology in review

authors： Li B,Lento PA,Pan S

更新日期：2020-11-02 00:00:00

abstract：:Valvular endocarditis after percutaneous coronary intervention is unusual. We report a new case of mitral valve endocarditis after stent implantation to a saphenous vein graft. ...

journal_title：Cardiology in review

authors： Palmer ND,Ramsdale DR

更新日期：2005-05-01 00:00:00

abstract：:Radiation-induced heart disease (RIHD) is becoming an increasing concern for patients and clinicians alike as the use of radiation therapy for the treatment of certain malignancies increases, and patient mortality secondary to neoplasms of the thorax, in particular Hodgkin's lymphoma and breast cancer, decreases. The ...

journal_title：Cardiology in review

authors： Filopei J,Frishman W

更新日期：2012-07-01 00:00:00

abstract：:Short QT syndrome is a rare inherited autosomal dominant cardiac channelopathy associated with malignant ventricular and atrial arrhythmias. A shortened corrected QT interval is a marker for risk of malignant arrhythmias, which are secondary to increased transmural dispersion of repolarization. The underlying gain of ...

journal_title：Cardiology in review

authors： Khera S,Jacobson JT

更新日期：2016-07-01 00:00:00

abstract：:Acute pericarditis (AP) is basically a clinical diagnosis. Although specific electrocardiographic (ECG) manifestations may indeed point to its diagnosis, sole reliance on such findings in isolation of the clinical setting, however, is often the common pitfall that could lead to a misguided diagnosis. We briefly review...

journal_title：Cardiology in review

authors： Ariyarajah V,Spodick DH

更新日期：2007-01-01 00:00:00

abstract：:This article provides a brief overview of several recently developed, emerging technologies and discusses their potential uses on clinical grounds. These new technologies include three-dimensional imaging, objective automated evaluation of ventricular function with acoustic quantification, assessment of regional ventr...

journal_title：Cardiology in review

authors： Mor-Avi V,Lang RM

更新日期：2001-05-01 00:00:00

abstract：:Antiplatelet therapy reduces the risks for cardiovascular morbidity and mortality in patients with atherosclerotic disease, and it is also beneficial in managing peripheral arterial disease (PAD). These agents work through various therapeutic pathways to achieve antithrombotic effects. Although single- or two-drug reg...

journal_title：Cardiology in review

authors： Lam S,Tran T

更新日期：2015-09-01 00:00:00

abstract：:Arsenic is a ubiquitously dispersed metalloid that has been implicated as the cause of various adverse health effects. Human exposure to arsenic primarily occurs through contaminated drinking water and dietary intake of rice and grains, posing a great public health risk to millions of people worldwide. High levels of ...

journal_title：Cardiology in review

authors： Kononenko M,Frishman WH

更新日期：2020-09-15 00:00:00

abstract：:Cardiovascular disease is the leading cause of death in the United States, accounting for approximately 60% of total mortality in 2002. There is evidence that race and ethnicity is a risk factor for atherothrombotic events. Blacks have a greater risk of complications from coronary heart disease and unstable angina, wi...

journal_title：Cardiology in review

authors： Saunders E,Ofili E

更新日期：2008-03-01 00:00:00

abstract：:Acute decompensated heart failure (ADHF) is a common syndrome with diverse etiologies and precipitating factors, which is associated with significant morbidity and mortality. Tremendous resources are used in treating this syndrome, with few prospectively designed clinical trials to guide therapy. Patients suffering fr...

journal_title：Cardiology in review

authors： Sanchez CE,Richards DR

更新日期：2011-05-01 00:00:00

abstract：:Myocardial infarction (MI) complicated by cardiogenic shock (MI-CS) is a major cause of cardiovascular morbidity and mortality. Predictors of outcomes in MI-CS include clinical, laboratory, radiologic variables, and management strategies. This article reviews the existing literature on short- and long-term predictors ...

journal_title：Cardiology in review

authors： Acharya D

更新日期：2018-09-01 00:00:00

abstract：:Numerous investigators have attempted to target the natriuretic peptide system in the treatment of heart failure since it was first described over 30 years ago. The history of neprilysin inhibition as a treatment for heart failure has been characterized by numerous setbacks. Recently, the PARADIGM-HF trial has shown f...

journal_title：Cardiology in review

authors： Bartell N,Frishman WH

更新日期：2017-11-01 00:00:00