Abstract:
:Left ventricular (LV) remodeling is the most common term used to describe the functional, structural, myocellular, and interstitial changes that occur in response to myocardial injury and/or chronic changes in myocardial loading conditions. Progression of LV remodeling over time in response to neurohormonal activation, increased wall stress, and inflammatory signaling pathways is associated with an increased risk of major morbidity and mortality. LV reverse remodeling describes the process by which an injured LV with a dilated spherical phenotype may return toward a normalization of ventricular structure and function, either spontaneously or in response to therapeutic interventions. LV reverse remodeling can occur in response to interventions that mitigate the source of myocardial injury, or that reduce or eliminate the neurohormonal and/or hemodynamic factors that contribute to the progression of the LV remodeling process. In this article, we review selected studies that demonstrate the LV reverse remodeling process in response to pharmacological, pacemaker device, and mechanical circulatory support device interventions. Future therapies targeting the physiological, neurohormonal, and/or molecular signaling pathways to effect reverse remodeling may further improve clinical outcomes in heart failure patients.
journal_name
Cardiol Revjournal_title
Cardiology in reviewauthors
Saraon T,Katz SDdoi
10.1097/CRD.0000000000000068subject
Has Abstractpub_date
2015-07-01 00:00:00pages
173-81issue
4eissn
1061-5377issn
1538-4683journal_volume
23pub_type
杂志文章,评审abstract::Underlying causes, risk factors, and precipitating causes of heart failure (HF) should be treated. Drugs known to precipitate or aggravate HF such as nonsteroidal antiinflammatory drugs should be stopped. Patients with HF and a low left ventricular ejection fraction (systolic heart failure) or normal ejection fraction...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/01.crd.0000175289.87583.e5
更新日期:2006-05-01 00:00:00
abstract::Endothelin is a potent vasoconstrictor substance that also can exert proliferative, inflammatory, and fibrotic changes in blood vessels and other organs. It acts on tissues in a paracrine and autocrine fashion, with local production and regulation occurring in both endothelial and nonendothelial cells. Endothelin stim...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e3181aa8f4a
更新日期:2009-07-01 00:00:00
abstract::Patients presenting to the Emergency Department with chest pain are common and often present diagnostic difficulties. Because of the limitations of the initial evaluation, the majority of patients are admitted, although many are later found to have noncardiac causes for their symptoms. Recognition of these limitations...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/00045415-200109000-00006
更新日期:2001-09-01 00:00:00
abstract::The effect of an ongoing educational program on the use of cardiovascular drugs in patients with coronary artery disease without contraindications to these drugs seen in an academic cardiology clinic was assessed in 100 patients seen during the 6-month period prior to the educational program and in 200 patients seen 9...
journal_title:Cardiology in review
pub_type: 杂志文章
doi:10.1097/01.crd.0000131191.57664.e7
更新日期:2005-03-01 00:00:00
abstract::Cardiovascular disease is the leading cause of death in the United States, accounting for approximately 60% of total mortality in 2002. There is evidence that race and ethnicity is a risk factor for atherothrombotic events. Blacks have a greater risk of complications from coronary heart disease and unstable angina, wi...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e31815685fa
更新日期:2008-03-01 00:00:00
abstract::Myocardial infarction (MI) complicated by cardiogenic shock (MI-CS) is a major cause of cardiovascular morbidity and mortality. Predictors of outcomes in MI-CS include clinical, laboratory, radiologic variables, and management strategies. This article reviews the existing literature on short- and long-term predictors ...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0000000000000190
更新日期:2018-09-01 00:00:00
abstract::Management of patients with coronary artery disease is a major challenge for physicians, patients, and the healthcare system. Chest pain experienced by patients with coronary disease can be of noncardiac origin, and symptoms frequently related to gastroesophageal etiologies. The distal esophagus and the heart share a ...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/01.crd.0000148844.13702.ce
更新日期:2005-07-01 00:00:00
abstract::An estimated 400,000 coronary artery bypass graft operations are performed annually in the United States. Saphenous vein grafts are the most commonly used conduits; however, graft failure is common. In contrast, left internal mammary artery grafts have more favorable long-term patency rates. Guidelines recommend aggre...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0000000000000261
更新日期:2020-01-01 00:00:00
abstract::The ever-increasing complexity of medical device therapy and installation of public electronic security systems demands vigilance in discerning interactions that may be harmful to patients during typical activities of daily living. Premature pacemaker stimulation, isolated skipped beats, or reversion to backup asynchr...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/00045415-200101000-00004
更新日期:2001-01-01 00:00:00
abstract::Stress radionuclide myocardial perfusion imaging is a commonly used modality to evaluate patients with known or suspected coronary artery disease. The dual isotope rest thallium-201/stress technetium-99m sestamibi gated single-photon emission computed tomography protocol has gained increasing popularity for these appl...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/00045415-199903000-00011
更新日期:1999-03-01 00:00:00
abstract::The obesity epidemic has reached unprecedented proportions in Western society. Evidence continues to accumulate that obesity is associated with significant morbidity and mortality and in particular that it is an independent risk factor for cardiovascular disease (CVD). The association of obesity with CVD and its risk ...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/00045415-200107000-00005
更新日期:2001-07-01 00:00:00
abstract::Cardiac computed tomographic angiography (CCTA) has evolved at an unprecedented pace over the past decade, during which time it has proven to be an accurate and effective tool for imaging of the heart in a growing list of clinical applications. However, the rapid growth in the use of CT imaging in general has prompted...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e31821daa8f
更新日期:2011-07-01 00:00:00
abstract::In this article, we critically evaluate the evidence relating to the effects of the Mediterranean diet (MD) on the risk of cardiovascular disease (CVD). Strong evidence indicating that the MD prevents CVD has come from prospective cohort studies. However, there is only weak supporting evidence from randomized controll...
journal_title:Cardiology in review
pub_type: 杂志文章,meta分析,评审
doi:10.1097/CRD.0000000000000222
更新日期:2019-05-01 00:00:00
abstract::Eisenmenger syndrome is characterized by elevated pulmonary vascular resistance and right-to-left shunting of blood through a systemic to pulmonary circulation connection. Treatment requires either lung transplantation with intracardiac repair or heart-lung transplantation. There are inadequate data regarding treatmen...
journal_title:Cardiology in review
pub_type: 杂志文章
doi:10.1097/01.crd.0000181618.29506.1e
更新日期:2005-11-01 00:00:00
abstract::The presence of pulmonary arterial hypertension (PAH) in pregnancy is rare and signifies a high-risk pregnancy. Although the majority of mothers have knowledge of their condition before pregnancy, approximately one-third of patients are diagnosed during pregnancy. Termination of pregnancy should be discussed, and is o...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e318275cf01
更新日期:2013-07-01 00:00:00
abstract::Automatic implantable cardioverter-defibrillators (AICDs) were implanted in 378 men and 95 women, mean age 69 +/- 12 years. At 3.6-year follow up, survival was 76% in patients who had an AICD because of cardiac arrest as a result of ventricular fibrillation or ventricular tachycardia not resulting from a transient or ...
journal_title:Cardiology in review
pub_type: 杂志文章
doi:10.1097/01.crd.0000128728.49766.3f
更新日期:2005-01-01 00:00:00
abstract::There is growing evidence that inflammatory processes may be involved in the development of atherosclerosis and its complications. Viral and bacterial pathogens have been implicated as possible causative factors in the pathogenesis of coronary artery disease and postangioplasty restenosis. Antibiotic trials have been ...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/00045415-200207000-00004
更新日期:2002-07-01 00:00:00
abstract::Hypertension remains a major cause of cardiovascular morbidity and mortality in the United States. Disturbing trends have been reported recently and include declining rates of successful blood pressure control and increasing rates of stroke, congestive heart failure, and hypertension-associated end-stage renal disease...
journal_title:Cardiology in review
pub_type: 杂志文章
doi:10.1097/00045415-199809000-00009
更新日期:1998-10-01 00:00:00
abstract::This article provides a brief overview of several recently developed, emerging technologies and discusses their potential uses on clinical grounds. These new technologies include three-dimensional imaging, objective automated evaluation of ventricular function with acoustic quantification, assessment of regional ventr...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/00045415-200105000-00008
更新日期:2001-05-01 00:00:00
abstract::Primary pulmonary hypertension and cor pulmonale represent forms of precapillary pulmonary hypertension due to intrinsic lung disease. In the case of primary pulmonary hypertension, this is due to disease of the pulmonary vasculature while cor pulmonale is related to diseases of the pulmonary vasculature, airways, or ...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/00045415-200209000-00003
更新日期:2002-09-01 00:00:00
abstract::Vitamin K antagonists (VKAs) such as warfarin have traditionally been the major therapeutic option for anticoagulation in clinical practice. VKAs are effective and extensively recommended for the prevention of venous and arterial thromboembolism in cardiovascular disease. Despite its effectiveness, warfarin is limited...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e3182503e2d
更新日期:2012-09-01 00:00:00
abstract::The introduction of new medicines to treat pulmonary vascular disease has renewed interest in the management of children with idiopathic pulmonary arterial hypertension. We now have a practical classification of pulmonary hypertension, improved diagnostic techniques, and internationally recognized diagnostic and manag...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e3181ce03df
更新日期:2010-03-01 00:00:00
abstract::Cardiovascular disease is the leading cause of morbidity and mortality among women in industrialized nations. Optimizing cardiovascular risk reduction is therefore of paramount importance, particularly among postmenopausal women, in whom the incidence of cardiovascular disease is highest. Accumulated data from a serie...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/00045415-200301000-00003
更新日期:2003-01-01 00:00:00
abstract::Cardiac allograft vasculopathy (CAV), characterized by diffuse intimal thickening and luminal narrowing in the arteries of the allograft, is the leading cause of morbidity and mortality in cardiac transplant recipients. Many transplant centers perform routine annual surveillance coronary angiography. However, angiogra...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e3181fbde2f
更新日期:2011-01-01 00:00:00
abstract::Differences in the overall mortality for acute infarction in women vs men have been appreciated for some time. Some of these differences are based on the age at the time of presentation of women compared with men. Excess mortality in women is most clear at the younger end of the age spectrum. More careful examination ...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/00045415-200008040-00009
更新日期:2000-07-01 00:00:00
abstract::Acute pericarditis (AP) is basically a clinical diagnosis. Although specific electrocardiographic (ECG) manifestations may indeed point to its diagnosis, sole reliance on such findings in isolation of the clinical setting, however, is often the common pitfall that could lead to a misguided diagnosis. We briefly review...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/01.crd.0000210645.89717.34
更新日期:2007-01-01 00:00:00
abstract::The differentiation of left ventricular pseudoaneurysm from true aneurysm is sometimes difficult. Given the propensity for pseudoaneurysms to rupture leading to cardiac tamponade, shock, and death, compared with a more benign natural history for true aneurysms, accurate diagnosis of these conditions is clinically impo...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/01.crd.0000233756.66532.45
更新日期:2006-11-01 00:00:00
abstract::Cardiovascular disease is the leading cause of death in women in most developed countries of the world. Even though cardiovascular deaths of men in the United States have been declining, until recently the number of cardiovascular deaths in US women was on the rise, with 1 in 3 women dying from heart disease. Over the...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e31815cb185
更新日期:2008-01-01 00:00:00
abstract::Atrial fibrillation (AF), a very common cardiac arrhythmia, is a well-recognized predisposing factor for embolic stroke. While warfarin remains the cornerstone of anticoagulant treatment in patients with AF, it is often underutilized because of increased bleeding complications and frequent monitoring requirements. It ...
journal_title:Cardiology in review
pub_type: 杂志文章,评审
doi:10.1097/CRD.0b013e3181e53abb
更新日期:2010-09-01 00:00:00
abstract::The physiologic effect of the sauna in human beings has been studied extensively, but only recently have there been studies to suggest sauna can be an effective therapeutic modality for patients with cardiovascular disease, especially for those with congestive heart failure. The data reported to date have been promisi...
journal_title:Cardiology in review
pub_type: 杂志文章
doi:10.1097/01.crd.0000124844.56479.05
更新日期:2004-11-01 00:00:00