Relaxin: a new approach for the treatment of acute congestive heart failure.

Abstract:

:Relaxin, a naturally-occurring hormone in the insulin family, was discovered to have a physiologic role in pregnancy. Named initially for its relaxing effect on the pubic ligament, relaxin receptors have since been found to be widely distributed in many organs in both males and females. Acting through multiple pathways, including the stimulation of gelatinases leading to activation of endothelin type B receptors and subsequently nitric oxide, relaxin has been shown to cause vasodilation. In animal models and studies in humans, relaxin has been shown to increase cardiac output and renal perfusion. Due to these effects, relaxin has been examined as a treatment for acute heart failure. The results of phase I and II trials have shown favorable clinical trends without any major adverse events, suggesting that relaxin has the potential to be an effective medication for acute heart failure in conjunction with or in place of current treatments.

journal_name

Cardiol Rev

journal_title

Cardiology in review

authors

Grossman J,Frishman WH

doi

10.1097/CRD.0b013e3181f493e3

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

305-12

issue

6

eissn

1061-5377

issn

1538-4683

pii

00045415-201011000-00006

journal_volume

18

pub_type

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