Role of Antiplatelet Therapy and Anticoagulation in Nonischemic Cardiomyopathy.


:Heart failure continues to be a leading cause of morbidity and mortality throughout the United States. The pathophysiology of heart failure involves the activation of complex neurohormonal pathways, many of which mediate not only hypertrophy and fibrosis within ventricular myocardium and interstitium, but also activation of platelets and alteration of vascular endothelium. Platelet activation and vascular endothelial dysfunction may contribute to the observed increased risk of thromboembolic events in patients with chronic heart failure. However, current data from clinical trials do not support the routine use of chronic antiplatelet or oral anticoagulation therapy for ambulatory heart failure patients without other indications (atrial fibrillation and/or coronary artery disease) as the risk of bleeding seems to outweigh the potential benefit related to reduction in thromboembolic events. In this review, we consider the potential clinical utility of targeting specific pathophysiological mechanisms of platelet and vascular endothelial activation to guide clinical decision making in heart failure patients.


Cardiol Rev


Cardiology in review


Carazo M,Berger JS,Reyentovich A,Katz SD




Has Abstract


2016-09-01 00:00:00












  • Care of the Post-CABG Patient.

    abstract::An estimated 400,000 coronary artery bypass graft operations are performed annually in the United States. Saphenous vein grafts are the most commonly used conduits; however, graft failure is common. In contrast, left internal mammary artery grafts have more favorable long-term patency rates. Guidelines recommend aggre...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Collins D,Goldberg S

    更新日期:2020-01-01 00:00:00

  • Antithrombotic therapy in patients with heart valve prostheses.

    abstract::Heart valve prostheses carry a risk for thrombosis and require an antithrombotic strategy to prevent stroke, systemic embolism, and prosthetic valve thrombosis. Contemporary randomized trials to guide the clinician on the optimal anticoagulant treatment are scarce, and the validity of the historical data for current r...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Hermans H,Vanassche T,Herijgers P,Meuris B,Herregods MC,Van de Werf F,Verhamme P

    更新日期:2013-01-01 00:00:00

  • Cryptogenic Stroke: Making the Management Less Cryptic.

    abstract::Cryptogenic stroke (CS) accounts for 20% to 40% of ischemic strokes. CS is defined as a cortical infarct suggestive of an embolic stroke with no identifiable cardiac etiology, large vessel occlusive disease, or small vessel lacunar stroke. The likely etiologies for CS are patent foramen ovale (PFO) and paroxysmal atri...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Marks SJ,Khera S

    更新日期:2016-07-01 00:00:00

  • Role of infection in atherosclerosis and coronary artery disease: a new therapeutic target?

    abstract::There is growing evidence that inflammatory processes may be involved in the development of atherosclerosis and its complications. Viral and bacterial pathogens have been implicated as possible causative factors in the pathogenesis of coronary artery disease and postangioplasty restenosis. Antibiotic trials have been ...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Frishman WH,Ismail AA

    更新日期:2002-07-01 00:00:00

  • Acute pericarditis: diagnostic cues and common electrocardiographic manifestations.

    abstract::Acute pericarditis (AP) is basically a clinical diagnosis. Although specific electrocardiographic (ECG) manifestations may indeed point to its diagnosis, sole reliance on such findings in isolation of the clinical setting, however, is often the common pitfall that could lead to a misguided diagnosis. We briefly review...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Ariyarajah V,Spodick DH

    更新日期:2007-01-01 00:00:00

  • Endothelin as a clinical target in the treatment of systemic hypertension.

    abstract::Endothelin is a potent vasoconstrictor substance that also can exert proliferative, inflammatory, and fibrotic changes in blood vessels and other organs. It acts on tissues in a paracrine and autocrine fashion, with local production and regulation occurring in both endothelial and nonendothelial cells. Endothelin stim...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Prasad VS,Palaniswamy C,Frishman WH

    更新日期:2009-07-01 00:00:00

  • Idiopathic pulmonary arterial hypertension in childhood.

    abstract::The introduction of new medicines to treat pulmonary vascular disease has renewed interest in the management of children with idiopathic pulmonary arterial hypertension. We now have a practical classification of pulmonary hypertension, improved diagnostic techniques, and internationally recognized diagnostic and manag...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Haworth SG

    更新日期:2010-03-01 00:00:00

  • A novel approach to left atrial appendage exclusion: the WATCHMAN device.

    abstract::Atrial fibrillation (AF), a very common cardiac arrhythmia, is a well-recognized predisposing factor for embolic stroke. While warfarin remains the cornerstone of anticoagulant treatment in patients with AF, it is often underutilized because of increased bleeding complications and frequent monitoring requirements. It ...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Gorodnitskiy A,Lucariello RJ,Aizer A,Coppola JT

    更新日期:2010-09-01 00:00:00

  • Chagas heart disease: report on recent developments.

    abstract::Chagas disease, caused by the parasite Trypanosoma cruzi, is an important cause of cardiac disease in endemic areas of Latin America. It is now being diagnosed in nonendemic areas because of immigration. Typical cardiac manifestations of Chagas disease include dilated cardiomyopathy, congestive heart failure, arrhythm...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Machado FS,Jelicks LA,Kirchhoff LV,Shirani J,Nagajyothi F,Mukherjee S,Nelson R,Coyle CM,Spray DC,de Carvalho AC,Guan F,Prado CM,Lisanti MP,Weiss LM,Montgomery SP,Tanowitz HB

    更新日期:2012-03-01 00:00:00

  • Heart Failure With Preserved Ejection Fraction: What Is in a Name?

    abstract::Evidence-based management of heart failure (HF) with preserved left ventricular ejection fraction (LVEF; HFpEF) remains a major gap in the care of patients with HF. Clinical trials directed toward the population with HFpEF have been disappointing, although renin-angiotensin-aldosterone system blockade appears to preve...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Jumean MF,Konstam MA

    更新日期:2015-07-01 00:00:00

  • The cost-effectiveness of argatroban treatment in heparin-induced thrombocytopenia: the effect of early versus delayed treatment.

    abstract::A decision-tree analysis was used to estimate the average cost per patient using the direct thrombin inhibitor argatroban for early treatment (<48 hours after thrombocytopenia onset) compared with delayed treatment (> or =48 hours after thrombocytopenia onset) of immune-mediated heparin-induced thrombocytopenia (HIT) ...

    journal_title:Cardiology in review

    pub_type: 杂志文章


    authors: Arnold RJ,Kim R,Tang B

    更新日期:2006-01-01 00:00:00

  • Radiation-induced heart disease.

    abstract::Radiation-induced heart disease (RIHD) is becoming an increasing concern for patients and clinicians alike as the use of radiation therapy for the treatment of certain malignancies increases, and patient mortality secondary to neoplasms of the thorax, in particular Hodgkin's lymphoma and breast cancer, decreases. The ...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Filopei J,Frishman W

    更新日期:2012-07-01 00:00:00

  • Role of magnesium in cardiovascular diseases.

    abstract::Magnesium, the fourth most abundant cation in the human body, is involved in several essential physiological, biochemical, and cellular processes regulating cardiovascular function. It plays a critical role in modulating vascular smooth muscle tone, endothelial cell function, and myocardial excitability and is thus ce...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Kolte D,Vijayaraghavan K,Khera S,Sica DA,Frishman WH

    更新日期:2014-07-01 00:00:00

  • Apixaban: a new factor Xa inhibitor for stroke prevention in patients with nonvalvular atrial fibrillation.

    abstract::Atrial fibrillation (AF) is an independent risk factor for ischemic stroke occurrence, severity, recurrence, and mortality. Anticoagulation therapy for the prevention of thromboembolism is critical in patients with AF who are at risk of stroke. Warfarin has been an efficacious anticoagulant for this purpose, but its u...

    journal_title:Cardiology in review

    pub_type: 杂志文章


    authors: Lam S

    更新日期:2013-07-01 00:00:00

  • Valvular aortic stenosis in the elderly.

    abstract::Elderly patients with valvular aortic stenosis have an increased prevalence of coronary risk factors, of coronary artery disease, and evidence of other atherosclerotic vascular diseases. Statins may reduce the progression of aortic stenosis (AS). Angina pectoris, syncope or near syncope, and congestive heart failure a...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Aronow WS

    更新日期:2007-09-01 00:00:00

  • Work-related psychosocial factors and the development of ischemic heart disease: a systematic review.

    abstract::The literature on the relationship between work-related psychosocial factors and the development of ischemic heart disease (IHD) was systematically reviewed: 33 articles presented 51 analyses of studies involving male participants, 18 analyses involving female participants, and 8 analyses with both genders. Twenty of ...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Eller NH,Netterstrøm B,Gyntelberg F,Kristensen TS,Nielsen F,Steptoe A,Theorell T

    更新日期:2009-03-01 00:00:00

  • Myocardial viability and microvascular obstruction: role of cardiac magnetic resonance imaging.

    abstract::Established coronary artery disease has a prevalence of 7% in adult Americans, accounting for 16 million people. As morbidity and mortality rates have risen, research efforts to identify the pathophysiologic mechanisms of systolic dysfunction have risen in parallel. The current goal is to develop new therapeutic strat...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Romero J,Lupercio F,Haramati LB,Garcia MJ,Lucariello RJ

    更新日期:2014-09-01 00:00:00

  • Ticagrelor: a novel reversible oral antiplatelet agent.

    abstract::The complex mechanism of platelet activation creates an optimal target for pharmacological treatment in patients with acute coronary syndromes. Current antiplatelet medications that are used in addition to aspirin include the thienopyridines, clopidogrel and prasugrel, but there are several limitations to the use of t...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Nawarskas JJ,Clark SM

    更新日期:2011-03-01 00:00:00

  • Relaxin: a new approach for the treatment of acute congestive heart failure.

    abstract::Relaxin, a naturally-occurring hormone in the insulin family, was discovered to have a physiologic role in pregnancy. Named initially for its relaxing effect on the pubic ligament, relaxin receptors have since been found to be widely distributed in many organs in both males and females. Acting through multiple pathway...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Grossman J,Frishman WH

    更新日期:2010-11-01 00:00:00

  • Postmenopausal women and cardiovascular risk: impact of hormone replacement therapy.

    abstract::The increased life expectancy of women living in industrialized countries is associated with an increase in diseases dependent or facilitated by a state of estrogen deficiency, such as cardiovascular and cerebrovascular diseases. Several studies have shown that estrogen replacement therapy reduces the occurrence of co...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Rosano GM,Fini M

    更新日期:2002-01-01 00:00:00

  • Ayurveda and Yoga in Cardiovascular Diseases.

    abstract::Ayurveda is derived from 2 Sanskrit words, namely, "Ayus" and "Veda," meaning life and knowledge, respectively. It literally means science of life. Ayurveda, of which yoga is an integral part, is widely practiced in India and is gaining acceptance in many countries around the world. It is a comprehensive and a holisti...

    journal_title:Cardiology in review

    pub_type: 杂志文章


    authors: Mamtani R,Mamtani R

    更新日期:2004-09-01 00:00:00

  • Third-Generation LVADs: Has Anything Changed?

    abstract::The field of durable left ventricular assist devices has advanced dramatically since its introduction into the clinical realm. From the first-generation pulsatile HeartMate XVE device to the second-generation continuous axial flow HeartMate-2 to the current third-generation centrifugal flow devices, the left ventricul...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Levine A,Gass A

    更新日期:2019-11-01 00:00:00

  • Glucose-insulin-potassium therapy in the era of coronary revascularization.

    abstract::Glucose-insulin-potassium (GIK) utilization in the treatment of acute myocardial infarction (AMI) has been studied since the early 1960s with varying results. It is well established that ischemic myocardial cells convert from aerobic metabolism of glucose to toxic anaerobic free fatty acid (FFA) metabolism for the pro...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Leos CL,Griego JE,Anderson JR

    更新日期:2005-09-01 00:00:00

  • Treating Diuretic Resistance: An Overview.

    abstract::Loop diuretics are central to the management of fluid overload in acute decompensated heart failure. However, a variance in the response to loop diuretics can alter a patient's clinical course and has an adverse effect on clinical outcomes. Thus, a diminished response to loop diuretics is an important clinical issue. ...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Bowman BN,Nawarskas JJ,Anderson JR

    更新日期:2016-09-01 00:00:00

  • Sudden Cardiac Death in Hypertrophic Cardiomyopathy.

    abstract::Hypertrophic cardiomyopathy (HCM) is a heart disease characterized by hypertrophy of the left ventricular myocardium and is most often caused by mutations in sarcomere genes. The structural and functional abnormalities are not explained by flow-limiting coronary artery disease or loading conditions. The disease affect...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Adamczak DM,Oko-Sarnowska Z

    更新日期:2018-05-01 00:00:00

  • Towards a Saphenous Vein Graft Moratorium.

    abstract::Atherosclerosis develops and rapidly progresses in saphenous veins grafts after coronary bypass surgery. In contrast to native coronary artery, percutaneous revascularization does not impede the progression of saphenous vein atherosclerosis and saphenous vein graft failure commonly ensues. The protracted patency of ar...

    journal_title:Cardiology in review

    pub_type: 杂志文章


    authors: Motwani A,Ayinapudi K,Singh T,Maini R,Hendel R,Le Jemtel TH

    更新日期:2020-09-01 00:00:00

  • Reverse Remodeling in Systolic Heart Failure.

    abstract::Left ventricular (LV) remodeling is the most common term used to describe the functional, structural, myocellular, and interstitial changes that occur in response to myocardial injury and/or chronic changes in myocardial loading conditions. Progression of LV remodeling over time in response to neurohormonal activation...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Saraon T,Katz SD

    更新日期:2015-07-01 00:00:00

  • Newer anticoagulants in cardiovascular disease: a systematic review of the literature.

    abstract::Vitamin K antagonists (VKAs) such as warfarin have traditionally been the major therapeutic option for anticoagulation in clinical practice. VKAs are effective and extensively recommended for the prevention of venous and arterial thromboembolism in cardiovascular disease. Despite its effectiveness, warfarin is limited...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Maan A,Padmanabhan R,Shaikh AY,Mansour M,Ruskin JN,Heist EK

    更新日期:2012-09-01 00:00:00

  • Periprocedural Management of Direct Oral Anticoagulants Surrounding Cardioversion and Invasive Electrophysiological Procedures.

    abstract::As direct oral anticoagulants (DOACs) have demonstrated favorable efficacy and safety outcomes compared with vitamin K antagonists for the treatment and prevention of venous thromboembolism and the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, their role in the management...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Finks SW,Dobesh PP,Trujillo TC,Crossley GH

    更新日期:2018-09-01 00:00:00

  • Prediction of moderate or severe pulmonary hypertension by main pulmonary artery diameter and main pulmonary artery diameter/ascending aorta diameter in pulmonary embolism.

    abstract::We investigated the accuracy of computed tomographic measurements of main pulmonary artery diameter (MPAD) and of MPAD/ascending aorta diameter (AAD) in predicting moderate or severe pulmonary hypertension in 190 patients with acute pulmonary embolism. A pulmonary artery systolic pressure of > or = 50 mm Hg measured b...

    journal_title:Cardiology in review

    pub_type: 临床试验,杂志文章


    authors: Sanal S,Aronow WS,Ravipati G,Maguire GP,Belkin RN,Lehrman SG

    更新日期:2006-09-01 00:00:00