Role of Antiplatelet Therapy and Anticoagulation in Nonischemic Cardiomyopathy.

Abstract:

:Heart failure continues to be a leading cause of morbidity and mortality throughout the United States. The pathophysiology of heart failure involves the activation of complex neurohormonal pathways, many of which mediate not only hypertrophy and fibrosis within ventricular myocardium and interstitium, but also activation of platelets and alteration of vascular endothelium. Platelet activation and vascular endothelial dysfunction may contribute to the observed increased risk of thromboembolic events in patients with chronic heart failure. However, current data from clinical trials do not support the routine use of chronic antiplatelet or oral anticoagulation therapy for ambulatory heart failure patients without other indications (atrial fibrillation and/or coronary artery disease) as the risk of bleeding seems to outweigh the potential benefit related to reduction in thromboembolic events. In this review, we consider the potential clinical utility of targeting specific pathophysiological mechanisms of platelet and vascular endothelial activation to guide clinical decision making in heart failure patients.

journal_name

Cardiol Rev

journal_title

Cardiology in review

authors

Carazo M,Berger JS,Reyentovich A,Katz SD

doi

10.1097/CRD.0000000000000094

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

211-7

issue

5

eissn

1061-5377

issn

1538-4683

journal_volume

24

pub_type

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