Role of Antiplatelet Therapy and Anticoagulation in Nonischemic Cardiomyopathy.


:Heart failure continues to be a leading cause of morbidity and mortality throughout the United States. The pathophysiology of heart failure involves the activation of complex neurohormonal pathways, many of which mediate not only hypertrophy and fibrosis within ventricular myocardium and interstitium, but also activation of platelets and alteration of vascular endothelium. Platelet activation and vascular endothelial dysfunction may contribute to the observed increased risk of thromboembolic events in patients with chronic heart failure. However, current data from clinical trials do not support the routine use of chronic antiplatelet or oral anticoagulation therapy for ambulatory heart failure patients without other indications (atrial fibrillation and/or coronary artery disease) as the risk of bleeding seems to outweigh the potential benefit related to reduction in thromboembolic events. In this review, we consider the potential clinical utility of targeting specific pathophysiological mechanisms of platelet and vascular endothelial activation to guide clinical decision making in heart failure patients.


Cardiol Rev


Cardiology in review


Carazo M,Berger JS,Reyentovich A,Katz SD




Has Abstract


2016-09-01 00:00:00












  • Treating Diuretic Resistance: An Overview.

    abstract::Loop diuretics are central to the management of fluid overload in acute decompensated heart failure. However, a variance in the response to loop diuretics can alter a patient's clinical course and has an adverse effect on clinical outcomes. Thus, a diminished response to loop diuretics is an important clinical issue. ...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Bowman BN,Nawarskas JJ,Anderson JR

    更新日期:2016-09-01 00:00:00

  • The Sexual Dimorphism of High Blood Pressure.

    abstract::There is a sexual dimorphism in blood pressure: men tend to have higher blood pressures than women with functional ovaries, whereas ovariectomy or menopause tends to abolish the sexual dimorphism and cause women to develop a "male" pattern of blood pressure. Synthetic estrogens and progestins, found in oral contracept...

    journal_title:Cardiology in review

    pub_type: 杂志文章


    authors: Calhoun DA,Oparil S

    更新日期:1998-11-01 00:00:00

  • Ambulatory electrocardiology.

    abstract::About 50 years ago, Norman Jefferis Holter invented a device that opened the possibility of recording heart activity over long periods of time. This invention, together with the rapid developments in electronics, has enabled a revolutionary change in the diagnosis and management of cardiac diseases. Ambulatory cardiac...

    journal_title:Cardiology in review

    pub_type: 历史文章,杂志文章,评审


    authors: Romero I

    更新日期:2013-09-01 00:00:00

  • Sauna as a therapeutic option for cardiovascular disease.

    abstract::The physiologic effect of the sauna in human beings has been studied extensively, but only recently have there been studies to suggest sauna can be an effective therapeutic modality for patients with cardiovascular disease, especially for those with congestive heart failure. The data reported to date have been promisi...

    journal_title:Cardiology in review

    pub_type: 杂志文章


    authors: Nguyen Y,Naseer N,Frishman WH

    更新日期:2004-11-01 00:00:00

  • Coronary artery rupture associated with amphetamine abuse.

    abstract::We report a case of spontaneous coronary artery rupture associated with amphetamine abuse in a 31-year-old woman. The patient presented to the emergency department with sudden onset of central chest pain and a normal electrocardiogram. Cardiac enzymes were consistent with acute myocardial infarction. Drug screening wa...

    journal_title:Cardiology in review

    pub_type: 杂志文章


    authors: Brennan K,Shurmur S,Elhendy A

    更新日期:2004-09-01 00:00:00

  • Cryptogenic Stroke: Making the Management Less Cryptic.

    abstract::Cryptogenic stroke (CS) accounts for 20% to 40% of ischemic strokes. CS is defined as a cortical infarct suggestive of an embolic stroke with no identifiable cardiac etiology, large vessel occlusive disease, or small vessel lacunar stroke. The likely etiologies for CS are patent foramen ovale (PFO) and paroxysmal atri...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Marks SJ,Khera S

    更新日期:2016-07-01 00:00:00

  • Chest pain from gastroesophageal reflux disease in patients with coronary artery disease.

    abstract::Management of patients with coronary artery disease is a major challenge for physicians, patients, and the healthcare system. Chest pain experienced by patients with coronary disease can be of noncardiac origin, and symptoms frequently related to gastroesophageal etiologies. The distal esophagus and the heart share a ...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Liuzzo JP,Ambrose JA

    更新日期:2005-07-01 00:00:00

  • Indications for and long-term survival in patients with automatic implantable cardioverter-defibrillators.

    abstract::Automatic implantable cardioverter-defibrillators (AICDs) were implanted in 378 men and 95 women, mean age 69 +/- 12 years. At 3.6-year follow up, survival was 76% in patients who had an AICD because of cardiac arrest as a result of ventricular fibrillation or ventricular tachycardia not resulting from a transient or ...

    journal_title:Cardiology in review

    pub_type: 杂志文章


    authors: Aronow WS,Sorbera C,Chagarlamudi A,Tabandeh H,Gupta S,Cohen M

    更新日期:2005-01-01 00:00:00

  • Percutaneous mitral heart valve repair--MitraClip.

    abstract::Mitral regurgitation (MR) is the most common cardiac valvular disease in the United States. Approximately 4 million people have severe MR and roughly 250,000 new diagnoses of MR are made each year. Mitral valve surgery is the only treatment that prevents progression of heart failure and provides sustained symptomatic ...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Doshi JV,Agrawal S,Garg J,Paudel R,Palaniswamy C,Doshi TV,Gotsis W,Frishman WH

    更新日期:2014-11-01 00:00:00

  • Valvular aortic stenosis in the elderly.

    abstract::Elderly patients with valvular aortic stenosis have an increased prevalence of coronary risk factors, of coronary artery disease, and evidence of other atherosclerotic vascular diseases. Statins may reduce the progression of aortic stenosis (AS). Angina pectoris, syncope or near syncope, and congestive heart failure a...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Aronow WS

    更新日期:2007-09-01 00:00:00

  • Ayurveda and Yoga in Cardiovascular Diseases.

    abstract::Ayurveda is derived from 2 Sanskrit words, namely, "Ayus" and "Veda," meaning life and knowledge, respectively. It literally means science of life. Ayurveda, of which yoga is an integral part, is widely practiced in India and is gaining acceptance in many countries around the world. It is a comprehensive and a holisti...

    journal_title:Cardiology in review

    pub_type: 杂志文章


    authors: Mamtani R,Mamtani R

    更新日期:2004-09-01 00:00:00

  • The cost-effectiveness of argatroban treatment in heparin-induced thrombocytopenia: the effect of early versus delayed treatment.

    abstract::A decision-tree analysis was used to estimate the average cost per patient using the direct thrombin inhibitor argatroban for early treatment (<48 hours after thrombocytopenia onset) compared with delayed treatment (> or =48 hours after thrombocytopenia onset) of immune-mediated heparin-induced thrombocytopenia (HIT) ...

    journal_title:Cardiology in review

    pub_type: 杂志文章


    authors: Arnold RJ,Kim R,Tang B

    更新日期:2006-01-01 00:00:00

  • Cardiac allograft vasculopathy: advances in diagnosis.

    abstract::Cardiac allograft vasculopathy (CAV), characterized by diffuse intimal thickening and luminal narrowing in the arteries of the allograft, is the leading cause of morbidity and mortality in cardiac transplant recipients. Many transplant centers perform routine annual surveillance coronary angiography. However, angiogra...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Cai Q,Rangasetty UC,Barbagelata A,Fujise K,Koerner MM

    更新日期:2011-01-01 00:00:00

  • The Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: What's New? What's Different?

    abstract::Hypertension remains a major cause of cardiovascular morbidity and mortality in the United States. Disturbing trends have been reported recently and include declining rates of successful blood pressure control and increasing rates of stroke, congestive heart failure, and hypertension-associated end-stage renal disease...

    journal_title:Cardiology in review

    pub_type: 杂志文章


    authors: Canzanello VJ,Sheps SG

    更新日期:1998-10-01 00:00:00

  • Women do benefit from lipid lowering: latest clinical trial data.

    abstract::Cardiovascular disease is the leading cause of morbidity and mortality among women in industrialized nations. Optimizing cardiovascular risk reduction is therefore of paramount importance, particularly among postmenopausal women, in whom the incidence of cardiovascular disease is highest. Accumulated data from a serie...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Mostaghel E,Waters D

    更新日期:2003-01-01 00:00:00

  • Evacetrapib: Another CETP Inhibitor for Dyslipidemia With No Clinical Benefit.

    abstract::Evacetrapib is a cholesteryl ester transfer protein (CETP) inhibitor that has been recently studied as a cholesterol modifying agent to reduce cardiovascular risk and mortality in high risk cardiovascular disease patients. Evacetrapib acts to decrease lipid exchange through CETP inhibition. CETP acts to transfer chole...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Eyvazian VA,Frishman WH

    更新日期:2017-03-01 00:00:00

  • Epigenetic regulation in heart failure: part II DNA and chromatin.

    abstract::Epigenetic regulatory mechanisms play key roles in cardiac development, differentiation, homeostasis, response to stress and injury, and disease. Human heart failure (HF) epigenetic regulatory mechanisms have not been deciphered to date. This 2-part review distills the rapidly evolving research focused on human HF epi...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: DiSalvo TG

    更新日期:2015-11-01 00:00:00

  • Heat shock proteins in cardiovascular disease a new therapeutic target.

    abstract::Cells have the capability of defending themselves from various stressors by activating a genetic program with the production of substances known as heat shock proteins and their regulatory partners, the heat shock transcription factors. In this article, heat shock proteins are discussed, including their roles in patho...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Gupta M,Vavasis C,Frishman WH

    更新日期:2004-01-01 00:00:00

  • Radiation-induced heart disease.

    abstract::Radiation-induced heart disease (RIHD) is becoming an increasing concern for patients and clinicians alike as the use of radiation therapy for the treatment of certain malignancies increases, and patient mortality secondary to neoplasms of the thorax, in particular Hodgkin's lymphoma and breast cancer, decreases. The ...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Filopei J,Frishman W

    更新日期:2012-07-01 00:00:00

  • Role of infection in atherosclerosis and coronary artery disease: a new therapeutic target?

    abstract::There is growing evidence that inflammatory processes may be involved in the development of atherosclerosis and its complications. Viral and bacterial pathogens have been implicated as possible causative factors in the pathogenesis of coronary artery disease and postangioplasty restenosis. Antibiotic trials have been ...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Frishman WH,Ismail AA

    更新日期:2002-07-01 00:00:00

  • Vorapaxar: A Protease-Activated Receptor Antagonist for the Prevention of Thrombotic Events.

    abstract::Antiplatelet therapy reduces the risks for cardiovascular morbidity and mortality in patients with atherosclerotic disease, and it is also beneficial in managing peripheral arterial disease (PAD). These agents work through various therapeutic pathways to achieve antithrombotic effects. Although single- or two-drug reg...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Lam S,Tran T

    更新日期:2015-09-01 00:00:00

  • Effect of an ongoing educational program on the use of antiplatelet drugs, beta-blockers, angiotensin-converting enzyme inhibitors, and lipid-lowering drugs in patients with coronary artery disease seen in an academic cardiology clinic.

    abstract::The effect of an ongoing educational program on the use of cardiovascular drugs in patients with coronary artery disease without contraindications to these drugs seen in an academic cardiology clinic was assessed in 100 patients seen during the 6-month period prior to the educational program and in 200 patients seen 9...

    journal_title:Cardiology in review

    pub_type: 杂志文章


    authors: Nayak D,Aronow WS

    更新日期:2005-03-01 00:00:00

  • Pacemakers and store security devices.

    abstract::The ever-increasing complexity of medical device therapy and installation of public electronic security systems demands vigilance in discerning interactions that may be harmful to patients during typical activities of daily living. Premature pacemaker stimulation, isolated skipped beats, or reversion to backup asynchr...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Harthorne JW

    更新日期:2001-01-01 00:00:00

  • Gender differences and the outcome of interventions for acute coronary syndromes.

    abstract::Differences in the overall mortality for acute infarction in women vs men have been appreciated for some time. Some of these differences are based on the age at the time of presentation of women compared with men. Excess mortality in women is most clear at the younger end of the age spectrum. More careful examination ...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Feldman T,Silver R

    更新日期:2000-07-01 00:00:00

  • Postmenopausal women and cardiovascular risk: impact of hormone replacement therapy.

    abstract::The increased life expectancy of women living in industrialized countries is associated with an increase in diseases dependent or facilitated by a state of estrogen deficiency, such as cardiovascular and cerebrovascular diseases. Several studies have shown that estrogen replacement therapy reduces the occurrence of co...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Rosano GM,Fini M

    更新日期:2002-01-01 00:00:00

  • Primary pulmonary hypertension and cor pulmonale.

    abstract::Primary pulmonary hypertension and cor pulmonale represent forms of precapillary pulmonary hypertension due to intrinsic lung disease. In the case of primary pulmonary hypertension, this is due to disease of the pulmonary vasculature while cor pulmonale is related to diseases of the pulmonary vasculature, airways, or ...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Lehrman S,Romano P,Frishman W,Rashid A,Dobkin J,Reichel J

    更新日期:2002-09-01 00:00:00

  • Implications of the New National Guidelines for Hypertension.

    abstract::Automated validated devices should be used for measuring blood pressure (BP). A systolic BP between 120 and 129 mm Hg with a diastolic BP < 80 mm Hg should be treated by lifestyle measures. Lifestyle measures plus BP lowering drugs should be used for secondary prevention of recurrent cardiovascular disease (CVD) event...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Aronow WS,Frishman WH

    更新日期:2018-03-01 00:00:00

  • Cardiac Applications of Dual-Energy Computed Tomography.

    abstract::Computed tomography is an established tool in the assessment of cardiac anatomy and function. As demonstrated by single photon emission computed tomography, positron emission tomography, and magnetic resonance, the noninvasive evaluation of coronary hemodynamics is an important step in guiding clinical management. Nev...

    journal_title:Cardiology in review

    pub_type: 杂志文章


    authors: Lempel M,Frishman WH

    更新日期:2019-07-01 00:00:00

  • Assessment of the Patient With Intracerebral Hemorrhage: A Review of the Literature.

    abstract::Spontaneous nontraumatic intracerebral hemorrhage is associated with high morbidity and mortality. Given the risk of rapid neurological deterioration, early identification with rapid neuroimaging is vital. Predictors of outcome, such as spot sign and intracerebral hemorrhage score, can help guide management goals. Man...

    journal_title:Cardiology in review

    pub_type: 杂志文章


    authors: Kurian C,Kaur K,Kaur G,Sahni R

    更新日期:2021-01-01 00:00:00

  • Neprilysin Inhibition and the Treatment of Heart Failure: Recent Steps in the Right Direction.

    abstract::Numerous investigators have attempted to target the natriuretic peptide system in the treatment of heart failure since it was first described over 30 years ago. The history of neprilysin inhibition as a treatment for heart failure has been characterized by numerous setbacks. Recently, the PARADIGM-HF trial has shown f...

    journal_title:Cardiology in review

    pub_type: 杂志文章,评审


    authors: Bartell N,Frishman WH

    更新日期:2017-11-01 00:00:00