Abstract:
:With the advent of improved antenatal imaging over the past 10 years, the diagnosis, assessment and management of congenital cystic lung abnormalities have changed. These were once considered the exclusive domain of the surgeon, who had the authority to operate on all congenital cystic lung abnormalities regardless of size or clinical signs in order to avoid the risk of cancer and improve lung growth in even asymptomatic infants. Clinicians are reconsidering this approach in the light of an appreciation of the spontaneous improvement and possible resolution that occurs over months to years with many of these lesions. The risks of subsequent cancer are poorly understood and probably overstated, whereas the magnitude of compensatory lung growth is poorly defined in the majority of children with small unilateral congenital cystic abnormalities. The evolution of regional, national and ideally international databases will provide much-needed longitudinal data to better inform clinicians of the optimal way in which to manage these children.
journal_name
Paediatr Respir Revjournal_title
Paediatric respiratory reviewsauthors
Fitzgerald DAdoi
10.1016/j.prrv.2006.10.001subject
Has Abstractpub_date
2007-03-01 00:00:00pages
67-76issue
1eissn
1526-0542issn
1526-0550pii
S1526-0542(06)00456-8journal_volume
8pub_type
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journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
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journal_title:Paediatric respiratory reviews
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journal_title:Paediatric respiratory reviews
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journal_title:Paediatric respiratory reviews
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doi:10.1016/j.prrv.2015.09.006
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journal_title:Paediatric respiratory reviews
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doi:10.1053/prrv.2000.0121
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journal_title:Paediatric respiratory reviews
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journal_title:Paediatric respiratory reviews
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journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
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journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
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journal_title:Paediatric respiratory reviews
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journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
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journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
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journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2010.09.003
更新日期:2011-03-01 00:00:00
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journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:
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journal_title:Paediatric respiratory reviews
pub_type: 评论,杂志文章,评审
doi:10.1016/j.prrv.2007.10.002
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journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2006.06.003
更新日期:2006-09-01 00:00:00
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journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2020.11.001
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journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2020.02.007
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journal_title:Paediatric respiratory reviews
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journal_title:Paediatric respiratory reviews
pub_type: 杂志文章
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journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2013.11.003
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journal_title:Paediatric respiratory reviews
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journal_title:Paediatric respiratory reviews
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journal_title:Paediatric respiratory reviews
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journal_title:Paediatric respiratory reviews
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abstract::Whilst substantial progress has been made in the treatment of cystic fibrosis, the disease still carries a significant burden in terms of symptoms, requirement for treatment and early mortality. The last decade has witnessed a new era in the development of small molecule drugs targeting the CFTR protein, which for the...
journal_title:Paediatric respiratory reviews
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abstract::Primary ciliary dyskinesia (PCD) is a rare, autosomal recessive condition. The signs and symptoms are due to congenital abnormalities of ciliary structure and function, resulting in impaired mucociliary clearance. This affects the ciliated epithelium lining the nose, sinuses, Eustachian tube and airways. As a conseque...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2008.10.001
更新日期:2009-06-01 00:00:00