Abstract:
:The major morbidity and mortality associated with cerebral palsy (CP) relates to respiratory compromise. This manifests through repeated pulmonary aspiration, airway colonization with pathogenic bacteria, the evolution of bronchiectasis and sleep disordered breathing. An accurate assessment involving a multidisciplinary approach and relatively simple interventions for these conditions can lead to significant improvements in the quality of life of children with CP as well as their parents and carers. This review highlights the more common problems and potential therapies with regard to suppurative lung disease and sleep disordered breathing in children with CP.
journal_name
Paediatr Respir Revjournal_title
Paediatric respiratory reviewsauthors
Fitzgerald DA,Follett J,Van Asperen PPdoi
10.1016/j.prrv.2008.10.003subject
Has Abstractpub_date
2009-03-01 00:00:00pages
18-24issue
1eissn
1526-0542issn
1526-0550pii
S1526-0542(08)00072-9journal_volume
10pub_type
杂志文章,评审abstract::The current global strategy for control of tuberculosis, Directly Observed Treatment, Short-course (DOTS) focuses, as a priority, on the management of patients with sputum smear positive tuberculosis. As tuberculosis in children is rarely sputum smear positive, this has led many to believe that children are not import...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/s1526-0542(04)90027-9
更新日期:2004-01-01 00:00:00
abstract::Outdoor air pollution is increasingly identified as a contributor to respiratory and cardiovascular disease. Pro-inflammatory particles and gases are inhaled deep into the lungs, and are associated with impaired lung growth and exacerbations of chronic respiratory diseases. The magnitude of these effects are of intere...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章
doi:10.1016/j.prrv.2018.03.005
更新日期:2018-09-01 00:00:00
abstract::Breaking the news to parents that their child has cystic fibrosis [CF] is most frequently given in the first few weeks of the baby's life as a result of newborn screening. This is optimal to reduce morbidity but can have a significant impact on the parents' mental wellbeing and the parent-child relationship. Parent fe...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2020.04.006
更新日期:2020-09-01 00:00:00
abstract::Asthma is a common disease in paediatrics and adults with a significant morbidity, mortality, and financial burden worldwide. Asthma is now recognized as a heterogeneous disease and emerging clinical and laboratory research has elucidated understanding of asthma's underlying immunology. The future of asthma is classif...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2019.08.002
更新日期:2020-11-01 00:00:00
abstract::Despite fundamental advances in the research on respiratory syncytial virus (RSV) since its initial identification almost 60 years ago, recurring failures in developing vaccines and pharmacologic strategies effective in controlling the infection have allowed RSV to become a leading cause of global infant morbidity and...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2015.05.005
更新日期:2015-09-01 00:00:00
abstract::Significant technological advancements have been achieved in radiology with the introduction of a branch speciality known as interventional radiology. Radiology has moved into the therapeutic arena, performing minimally invasive diagnostic and therapeutic procedures. The interventional radiologist can treat certain va...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1053/prrv.2000.0121
更新日期:2001-06-01 00:00:00
abstract::Inhaled nitric oxide (iNO) is a selective pulmonary vasodilator. In randomised trials, iNO increased gas exchange modestly and had no effect on the outcome (survival, chronic lung disease, CLD) in very low birth-weight (VLBW) infants. NO is an important component of the innate immune system and a lipid- soluble free r...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/s1526-0542(04)90047-4
更新日期:2004-01-01 00:00:00
abstract::Our aim was to obtain knowledge of how meteorological conditions affect community epidemics of respiratory syncytial virus (RSV) infection. We recorded year-round RSV activity in nine cities that differ markedly in geographic location and climate. We correlated local weather conditions with weekly or monthly RSV cases...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/S1526-0542(09)70004-1
更新日期:2009-06-01 00:00:00
abstract::The development and phenotypic expression of allergic airway disease depends on a complex interaction between genetic and several environmental factors, such as exposure to food, inhalant allergens and non-specific adjuvant factors (e.g. tobacco smoke, air pollution and infections). The first months of life seem to be...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/s1526-0542(03)00026-5
更新日期:2003-06-01 00:00:00
abstract::Bronchiolitis is a common disease in infancy, mostly due to Respiratory Syncytial Virus and Rhinovirus. In addition to acute infection, viral bronchiolitis is responsible for sequelae including recurrent wheezing and asthma. The analysis of the viral characteristics and of the pathogenesis of the infection shows diffe...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2016.11.006
更新日期:2017-09-01 00:00:00
abstract::The term atelectasis describes a state of collapsed and non-aerated region of the lung parenchyma, which is otherwise normal. This pathological condition is usually associated with several pulmonary and chest disorders and represents a manifestation of the underlying disease, not a disease per se. Atelectasis may occu...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1053/prrv.2000.0059
更新日期:2000-09-01 00:00:00
abstract::One of the most active areas of research in medicine today is stem cell biology. This review introduces the reader to the field of stem cell biology and its therapeutic potential. More importantly, the potential application of stem cell therapy in acute lung injury will be explored. ...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2006.03.009
更新日期:2006-06-01 00:00:00
abstract::Obesity is a significant public health problem worldwide, and it has been identified as an independent risk factor for asthma in both adults and children. Not only does obesity increase asthma risk, but it is also associated with decreased asthma-related quality of life, worsened symptoms and asthma control, increased...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2020.02.007
更新日期:2020-03-06 00:00:00
abstract::Dysfunctional breathing, hyperventilation and vocal cord dysfunction are frequently seen in children and adults. The prevalence is unknown. There are no standardized diagnostic criteria, and for now, effective exclusion of organic disease leaves the diagnosis of dysfunctional breathing. Therapy is mainly focussed on e...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2010.09.003
更新日期:2011-03-01 00:00:00
abstract::There are multiple aetiologies for childhood bronchiectasis unrelated to cystic fibrosis. Some of these aetiologies, such as those predisposing to recurrent lung infections, e.g. immunodeficiencies, require treatment of the underlying condition and disease-specific pulmonary pathogens within the airway. Regardless of ...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章
doi:10.1016/j.prrv.2010.10.012
更新日期:2011-06-01 00:00:00
abstract::Pulmonary arterial (PA) hypertension in preterm infant is an important consequence of chronic lung disease of prematurity (CLD) arising mainly due to impaired alveolar development and dysregulated angiogenesis of the pulmonary circulation. Although PA pressure and resistance in these children normalise by school age, ...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2012.08.003
更新日期:2013-12-01 00:00:00
abstract::There are many important respiratory manifestations of endocrine and metabolic diseases in children. Acute and chronic pulmonary infections are the most common respiratory abnormalities in patients with diabetes mellitus, although cardiogenic and non-cardiogenic pulmonary oedema are also possible. Pseudohypoaldosteron...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2011.01.004
更新日期:2012-03-01 00:00:00
abstract::The burden of asthma among children is high in Australia compared with many other countries. Recent data show that 14-16% of children report a diagnosis of asthma that remains a problem. Boys, children under the age of 5 years and urban indigenous children experience a greater burden of asthma than other children. Mor...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2004.11.004
更新日期:2005-03-01 00:00:00
abstract::There have been major advances in the surgery for oesophageal atresia (OA) and tracheo-oesophageal fistula(TOF) with survival now exceeding 90%. The standard open approach to OA and distal TOF has been well described and essentially unchanged for the last 60 years. Improved survival in recent decades is most attributa...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2016.04.003
更新日期:2016-06-01 00:00:00
abstract::NICE produced a guideline for the diagnosis and management of CF (NG78) in October 2017. This paper describes the process of producing the guideline and highlights some of the areas covered by it, including ideas for further research and tools that can be used by purchasers to help improve CF care. ...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2019.02.006
更新日期:2019-08-01 00:00:00
abstract::Childhood pulmonary TB (PTB) is under diagnosed, in part due to difficulties in obtaining microbiological confirmation. However, given the poor specificity of clinical diagnosis, microbiological confirmation and drug susceptibility testing is important in guiding appropriate therapy especially in the context of drug r...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2010.09.008
更新日期:2011-03-01 00:00:00
abstract::Severe acute respiratory syndrome (SARS) is a newly described respiratory infection with pandemic potential. The causative agent is a new strain of coronavirus most likely originating from wild animals. This disease first emerged in November 2002 in Guangdong Province, China. Early in the outbreak the infection had be...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2004.07.011
更新日期:2004-12-01 00:00:00
abstract::The obstructive sleep apnea syndrome is common and its prevalence is expected to increase with the current obesity epidemic. If left untreated, it is associated with important morbidity such as growth failure, neurocognitive impairment, systemic and pulmonary hypertension, and endothelial dysfunction. Recent research ...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2012.05.006
更新日期:2013-09-01 00:00:00
abstract::The thorax consists of the rib cage and the respiratory muscles. It houses and protects the various intrathoracic organs such as the lungs, heart, vessels, esophagus, nerves etc. It also serves as the so-called "respiratory pump" that generates the movement of air into the lungs while it prevents their total collapse ...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2013.12.003
更新日期:2014-09-01 00:00:00
abstract::There are hardly any controlled studies in paediatric tracheostomy care; instead, most established standards, procedures and details have been elaborated at the bedside by trial and error. Once the appropriate tube is chosen, tube care consists of tube change, fixation, management of secretions, humidification of insp...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2006.06.003
更新日期:2006-09-01 00:00:00
abstract::The lung is continually at risk of exposure to noxious environmental agents and respiratory pathogens. An elaborate series of defence mechanisms have been developed to protect the airways from these insults. The lower respiratory tract is protected by local mucociliary mechanisms that involve the integration of the ci...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1053/prrv.2000.0009
更新日期:2000-03-01 00:00:00
abstract::With the advent of improved antenatal imaging over the past 10 years, the diagnosis, assessment and management of congenital cystic lung abnormalities have changed. These were once considered the exclusive domain of the surgeon, who had the authority to operate on all congenital cystic lung abnormalities regardless of...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2006.10.001
更新日期:2007-03-01 00:00:00
abstract::The obstructive sleep apnoea syndrome (OSAS) is common in children and results in several complications when untreated. Considering that children are undergoing important brain development, recent research has focused on neurocognitive and behavioural (NCB) complications of OSAS. Studies have shown that treatment of p...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2016.05.004
更新日期:2016-09-01 00:00:00
abstract::Public awareness of the impact of air quality on health is increasing worldwide. Indoor and outdoor air pollutants impair children's growing lungs, and increase the risk of respiratory infections. In many cities, children face indoor air pollution from fuels used for cooking and heating, as well as outdoor pollution f...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/j.prrv.2014.03.001
更新日期:2014-06-01 00:00:00
abstract::The anatomical and functional development of the lung appears especially vulnerable to a whole range of insults during gestation and the first few years of life. A significant proportion of adult lung disease originates in utero or early infancy. Most publications on this topic are descriptive retrospective studies. A...
journal_title:Paediatric respiratory reviews
pub_type: 杂志文章,评审
doi:10.1016/s1526-0542(02)00311-1
更新日期:2003-03-01 00:00:00