Early sensitisation and development of allergic airway disease - risk factors and predictors.

Abstract:

:The development and phenotypic expression of allergic airway disease depends on a complex interaction between genetic and several environmental factors, such as exposure to food, inhalant allergens and non-specific adjuvant factors (e.g. tobacco smoke, air pollution and infections). The first months of life seem to be a particularly vulnerable period and there is evidence that sensitisation is related to the level of allergen exposure during early life. At present, the combination of atopic heredity and elevated cord-blood IgE seems to result in the best predictive discrimination as regards development of allergic disease at birth. Early sensitisation, cow's milk allergy and atopic eczema are predictors for later development of allergic airway disease. Exposure to indoor allergens, especially house dust mite allergens, is a risk factor for sensitisation and development of asthma later in childhood in high-risk infants and infants with early atopic manifestations.

journal_name

Paediatr Respir Rev

authors

Halken S

doi

10.1016/s1526-0542(03)00026-5

keywords:

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

128-34

issue

2

eissn

1526-0542

issn

1526-0550

pii

S1526054203000265

journal_volume

4

pub_type

杂志文章,评审
  • Non-invasive home ventilation.

    abstract::Non-invasive ventilation (NIV) provides significant advantages to the paediatrician who cares for children with chronic ventilatory insufficiency and who would like to manage these children in the home environment. There is a growing experience in the use of NIV in the management of children with upper airway obstruct...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1053/prrv.2000.0035

    authors: Wallis C

    更新日期:2000-06-01 00:00:00

  • Telemedicine is the way forward for the management of cystic fibrosis- the case against.

    abstract::It is reasonable to suggest that Telemedicine could help in the management of chronic diseases by giving patients more flexibility to remain at home with opportunities to forward electronic data to healthcare professionals, reduce hospital emergency attendances and reduce overall costs. The reality, particularly in cy...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2017.03.005

    authors: Lenney W

    更新日期:2018-03-01 00:00:00

  • The relationship of meteorological conditions to the epidemic activity of respiratory syncytial virus.

    abstract::Our aim was to obtain knowledge of how meteorological conditions affect community epidemics of respiratory syncytial virus (RSV) infection. We recorded year-round RSV activity in nine cities that differ markedly in geographic location and climate. We correlated local weather conditions with weekly or monthly RSV cases...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/S1526-0542(09)70004-1

    authors: Welliver R

    更新日期:2009-06-01 00:00:00

  • Community-acquired pneumonia.

    abstract::Pneumonia is highly prevalent in both developed and developing countries. In this review we list the main organisms affecting children with pneumonia and we propose a summary of the best possible diagnostic and therapeutic measures. ...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2006.04.221

    authors: Stein RT,Marostica PJ

    更新日期:2006-01-01 00:00:00

  • Microbiological diagnostic procedures in respiratory infections: mycobacterial infections.

    abstract::This article will review traditional and newer microbiological techniques for the diagnosis of mycobacterial respiratory infections. It will concentrate on the diagnosis of infections due to Mycobacterium tuberculosis, the main mycobacterium causing respiratory infections of clinical and public health importance. The ...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2007.07.002

    authors: Andresen D

    更新日期:2007-09-01 00:00:00

  • Disease-modifying drug therapy in cystic fibrosis.

    abstract::Whilst substantial progress has been made in the treatment of cystic fibrosis, the disease still carries a significant burden in terms of symptoms, requirement for treatment and early mortality. The last decade has witnessed a new era in the development of small molecule drugs targeting the CFTR protein, which for the...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2017.03.008

    authors: Harman K,Dobra R,Davies JC

    更新日期:2018-03-01 00:00:00

  • Respiratory muscle testing in children.

    abstract::The range of techniques available to assess respiratory muscles weakness has greatly expanded over recent years. Respiratory muscle tests can be divided into non-invasive tests, such as lung function parameters, maximal static pressures and sniff nasal pressure and invasive tests, such as transdiaphragmatic pressures ...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s1526-0542(03)00051-4

    authors: Fauroux B

    更新日期:2003-09-01 00:00:00

  • Pediatric polysomnography-A review of indications, technical aspects, and interpretation.

    abstract::Polysomnography is an elaborate diagnostic test composed of numerous data-collecting sensors working concomitantly to aid in the evaluation of varied sleep disorders in all age groups. Polysomnography is the study of choice for the assessment of pediatric sleep-disordered breathing, including obstructive sleep apnea s...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2019.09.009

    authors: Stowe RC,Afolabi-Brown O

    更新日期:2020-04-01 00:00:00

  • Nitric oxide in critical respiratory failure of very low birth weight infants.

    abstract::Inhaled nitric oxide (iNO) is a selective pulmonary vasodilator. In randomised trials, iNO increased gas exchange modestly and had no effect on the outcome (survival, chronic lung disease, CLD) in very low birth-weight (VLBW) infants. NO is an important component of the innate immune system and a lipid- soluble free r...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s1526-0542(04)90047-4

    authors: Hallman M,Aikio O

    更新日期:2004-01-01 00:00:00

  • Cystic fibrosis: Diagnosis and management - NICE guideline 78.

    abstract::NICE produced a guideline for the diagnosis and management of CF (NG78) in October 2017. This paper describes the process of producing the guideline and highlights some of the areas covered by it, including ideas for further research and tools that can be used by purchasers to help improve CF care. ...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2019.02.006

    authors: Walshaw MJ

    更新日期:2019-08-01 00:00:00

  • Epidemiology of severe acute respiratory syndrome (SARS): adults and children.

    abstract::Severe acute respiratory syndrome (SARS) is a newly described respiratory infection with pandemic potential. The causative agent is a new strain of coronavirus most likely originating from wild animals. This disease first emerged in November 2002 in Guangdong Province, China. Early in the outbreak the infection had be...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2004.07.011

    authors: Zhong NS,Wong GW

    更新日期:2004-12-01 00:00:00

  • Breaking the diagnosis of cystic fibrosis to parents: A process not a one-off event.

    abstract::Breaking the news to parents that their child has cystic fibrosis [CF] is most frequently given in the first few weeks of the baby's life as a result of newborn screening. This is optimal to reduce morbidity but can have a significant impact on the parents' mental wellbeing and the parent-child relationship. Parent fe...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2020.04.006

    authors: Bryon M

    更新日期:2020-09-01 00:00:00

  • Long term cardiovascular consequences of chronic lung disease of prematurity.

    abstract::Pulmonary arterial (PA) hypertension in preterm infant is an important consequence of chronic lung disease of prematurity (CLD) arising mainly due to impaired alveolar development and dysregulated angiogenesis of the pulmonary circulation. Although PA pressure and resistance in these children normalise by school age, ...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2012.08.003

    authors: Poon CY,Edwards MO,Kotecha S

    更新日期:2013-12-01 00:00:00

  • What does imaging the chest tell us about bronchopulmonary dysplasia?

    abstract::Bronchopulmonary dysplasia (BPD) is a common complication of preterm birth. Chest imaging is important in making the diagnosis of BPD, and in assessing for complications. More recently computerised tomography (CT) scanning has provided insights in to the pathophysiology of BPD. Studies in infants, young and school age...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2010.05.005

    authors: Wilson AC

    更新日期:2010-09-01 00:00:00

  • Biomarkers of respiratory syncytial virus (RSV) infection: specific neutrophil and cytokine levels provide increased accuracy in predicting disease severity.

    abstract::Despite fundamental advances in the research on respiratory syncytial virus (RSV) since its initial identification almost 60 years ago, recurring failures in developing vaccines and pharmacologic strategies effective in controlling the infection have allowed RSV to become a leading cause of global infant morbidity and...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2015.05.005

    authors: Brown PM,Schneeberger DL,Piedimonte G

    更新日期:2015-09-01 00:00:00

  • CFTR modulator therapy in patients with cystic fibrosis and an organ transplant.

    abstract::CFTR modulators are a class of drugs which directly target the defective CFTR protein in cystic fibrosis (CF), improving its function with resultant clinical improvements. Currently these drugs are confined to people with a limited selection of genetic mutations. New modulators are in development which will lead to th...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2018.04.003

    authors: Mitchell RM,Jones AM,Barry PJ

    更新日期:2018-06-01 00:00:00

  • Cystic fibrosis: Priorities and progress for future therapies.

    abstract::Significant improvement in the survival of patients with CF has been achieved in the last decades. The improved clinical status of the patients is mainly the result of a better understanding of the natural course of infection and inflammation in CF that has led to the implementation of strategies that increase the lif...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2017.06.004

    authors: Kerem E

    更新日期:2017-09-01 00:00:00

  • Cough in children: when does it matter?

    abstract::Cough is a common presenting symptom to paediatricians and paediatric respiratory physicians. The causes of chronic cough in childhood are significantly different from those in adults, and a different approach to diagnosis and management is needed. In most cases cause can be identified or a satisfactory label given. T...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2005.11.008

    authors: Massie J

    更新日期:2006-03-01 00:00:00

  • The burden of asthma in children: an Australian perspective.

    abstract::The burden of asthma among children is high in Australia compared with many other countries. Recent data show that 14-16% of children report a diagnosis of asthma that remains a problem. Boys, children under the age of 5 years and urban indigenous children experience a greater burden of asthma than other children. Mor...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2004.11.004

    authors: Poulos LM,Toelle BG,Marks GB

    更新日期:2005-03-01 00:00:00

  • Chylothorax: diagnosis and management in children.

    abstract::Chylothorax is the accumulation of chyle in the pleural space, as a result of damage to the thoracic duct. Chyle is milky fluid enriched with fat secreted from the intestinal cells and lymphatic fluid. Chylothorax in children, is most commonly seen as a complication of cardiothoracic surgery but may occur in newborns ...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2009.06.008

    authors: Soto-Martinez M,Massie J

    更新日期:2009-12-01 00:00:00

  • Options for assessing and measuring chest wall motion.

    abstract::Assessing chest wall motion is a basic and vital component in managing the child with respiratory problems, whether these are due to pathology in the lungs, airways, chest wall or muscles. Since the 1960s, clinical assessment has been supplemented with an ever-growing range of technological options for measuring chest...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2014.10.006

    authors: Seddon P

    更新日期:2015-01-01 00:00:00

  • Viral pneumoniae in children: incidence and aetiology.

    abstract::Community-acquired pneumonia remains a common and serious illness, which affects children of all age groups. The spectrum of causative organisms is wide and it differs according to the age of the patients. With the advent of new and improved diagnostic techniques our understanding of the aetiology of the disease has b...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s1526-0542(04)90037-1

    authors: Sinaniotis CA

    更新日期:2004-01-01 00:00:00

  • Vocal cord dysfunction in children.

    abstract::Vocal cord dysfunction is characterised by paradoxical vocal cord adduction that occurs during inspiration, resulting in symptoms of dyspnoea, wheeze, chest or throat tightness and cough. Although the condition is well described in children and adults, confusion with asthma often triggers the use of an aggressive trea...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2007.05.004

    authors: Noyes BE,Kemp JS

    更新日期:2007-06-01 00:00:00

  • Psychosocial issues in newborn screening for cystic fibrosis.

    abstract::Newborn screening for cystic fibrosis remains controversial because there is still little agreement that prophylactic interventions provide substantial long-term benefits. In such situations, where there are some medical benefits and the costs are not prohibitive, it is important to consider the psychosocial implicati...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s1526-0542(03)00086-1

    authors: Parsons EP,Bradley DM

    更新日期:2003-12-01 00:00:00

  • Local mucociliary defence mechanisms.

    abstract::The lung is continually at risk of exposure to noxious environmental agents and respiratory pathogens. An elaborate series of defence mechanisms have been developed to protect the airways from these insults. The lower respiratory tract is protected by local mucociliary mechanisms that involve the integration of the ci...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1053/prrv.2000.0009

    authors: Chilvers MA,O'Callaghan C

    更新日期:2000-03-01 00:00:00

  • Effects of childhood respiratory diseases on the anatomical and functional development of the respiratory system.

    abstract::The anatomical and functional development of the lung appears especially vulnerable to a whole range of insults during gestation and the first few years of life. A significant proportion of adult lung disease originates in utero or early infancy. Most publications on this topic are descriptive retrospective studies. A...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s1526-0542(02)00311-1

    authors: Merkus PJ

    更新日期:2003-03-01 00:00:00

  • Update on treatment of childhood bronchiectasis unrelated to cystic-fibrosis.

    abstract::There are multiple aetiologies for childhood bronchiectasis unrelated to cystic fibrosis. Some of these aetiologies, such as those predisposing to recurrent lung infections, e.g. immunodeficiencies, require treatment of the underlying condition and disease-specific pulmonary pathogens within the airway. Regardless of ...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章

    doi:10.1016/j.prrv.2010.10.012

    authors: Redding GJ

    更新日期:2011-06-01 00:00:00

  • Assessing and managing lung disease and sleep disordered breathing in children with cerebral palsy.

    abstract::The major morbidity and mortality associated with cerebral palsy (CP) relates to respiratory compromise. This manifests through repeated pulmonary aspiration, airway colonization with pathogenic bacteria, the evolution of bronchiectasis and sleep disordered breathing. An accurate assessment involving a multidisciplina...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2008.10.003

    authors: Fitzgerald DA,Follett J,Van Asperen PP

    更新日期:2009-03-01 00:00:00

  • Congenital upper airway obstruction.

    abstract::Most causes of upper airway obstruction are rare in the neonatal period and during infancy. They may, however, cause major respiratory problems either initially or during the first few weeks of life. It is important to recognise these problems at an early stage so that appropriate measures to overcome airway obstructi...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2003.10.001

    authors: Dinwiddie R

    更新日期:2004-03-01 00:00:00

  • Foreign body aspiration in children.

    abstract::Foreign body aspiration is a common accident in children and represents an important cause of morbidity and mortality. Diagnosis of this condition demands a high degree of suspicion since physical examination and basic radiology exams have low sensitivity. It is more frequent in children younger than 3 years of age, p...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s1526-0542(02)00265-8

    authors: Lima JA,Fischer GB

    更新日期:2002-12-01 00:00:00