Abstract:
:The development and phenotypic expression of allergic airway disease depends on a complex interaction between genetic and several environmental factors, such as exposure to food, inhalant allergens and non-specific adjuvant factors (e.g. tobacco smoke, air pollution and infections). The first months of life seem to be a particularly vulnerable period and there is evidence that sensitisation is related to the level of allergen exposure during early life. At present, the combination of atopic heredity and elevated cord-blood IgE seems to result in the best predictive discrimination as regards development of allergic disease at birth. Early sensitisation, cow's milk allergy and atopic eczema are predictors for later development of allergic airway disease. Exposure to indoor allergens, especially house dust mite allergens, is a risk factor for sensitisation and development of asthma later in childhood in high-risk infants and infants with early atopic manifestations.
journal_name
Paediatr Respir Revjournal_title
Paediatric respiratory reviewsauthors
Halken Sdoi
10.1016/s1526-0542(03)00026-5keywords:
subject
Has Abstractpub_date
2003-06-01 00:00:00pages
128-34issue
2eissn
1526-0542issn
1526-0550pii
S1526054203000265journal_volume
4pub_type
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