Understanding the immunology of asthma: Pathophysiology, biomarkers, and treatments for asthma endotypes.

Abstract:

:Asthma is a common disease in paediatrics and adults with a significant morbidity, mortality, and financial burden worldwide. Asthma is now recognized as a heterogeneous disease and emerging clinical and laboratory research has elucidated understanding of asthma's underlying immunology. The future of asthma is classifying asthma by endotype through connecting discernible characteristics with immunological mechanisms. This comprehensive review of the immunology of asthma details the currently known pathophysiology and clinical practice biomarkers in addition to forefront biologic and targeted therapies for all of the asthma endotypes. By understanding the immunology of asthma, practitioners will be able to diagnose patients by asthma endotype and provide personalized, biomarker-driven treatments to effectively control patients' asthma.

journal_name

Paediatr Respir Rev

authors

Gans MD,Gavrilova T

doi

10.1016/j.prrv.2019.08.002

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

118-127

eissn

1526-0542

issn

1526-0550

pii

S1526-0542(19)30081-8

journal_volume

36

pub_type

杂志文章,评审
  • Immune and inflammatory response in bronchiolitis due to respiratory Syncytial Virus and Rhinovirus infections in infants.

    abstract::Bronchiolitis is a common disease in infancy, mostly due to Respiratory Syncytial Virus and Rhinovirus. In addition to acute infection, viral bronchiolitis is responsible for sequelae including recurrent wheezing and asthma. The analysis of the viral characteristics and of the pathogenesis of the infection shows diffe...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2016.11.006

    authors: Vandini S,Calamelli E,Faldella G,Lanari M

    更新日期:2017-09-01 00:00:00

  • Thoracic interventional radiology in children.

    abstract::Significant technological advancements have been achieved in radiology with the introduction of a branch speciality known as interventional radiology. Radiology has moved into the therapeutic arena, performing minimally invasive diagnostic and therapeutic procedures. The interventional radiologist can treat certain va...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1053/prrv.2000.0121

    authors: John P

    更新日期:2001-06-01 00:00:00

  • Newer treatment modalities for pediatric obstructive sleep apnea.

    abstract::The obstructive sleep apnea syndrome is common and its prevalence is expected to increase with the current obesity epidemic. If left untreated, it is associated with important morbidity such as growth failure, neurocognitive impairment, systemic and pulmonary hypertension, and endothelial dysfunction. Recent research ...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2012.05.006

    authors: Tapia IE,Marcus CL

    更新日期:2013-09-01 00:00:00

  • Pediatric asthma: how significant it is for the whole life?

    abstract::Asthma is most frequent chronic disease in childhood. Childhood asthma frequently persists to adulthood and the available evidence suggests that the severity of childhood asthma predicts the severity of asthma in the adulthood. To prevent long term remodeling of the airways and improve prognosis, early diagnosis and t...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2006.04.171

    authors: Pohunek P

    更新日期:2006-01-01 00:00:00

  • Diabetes in cystic fibrosis.

    abstract::Cystic fibrosis related diabetes (CFRD) is a common complication of cystic fibrosis, caused by a fall in insulin secretion with age in individuals with pancreatic insufficiency. CFRD is associated with worse clinical status and increased mortality. Treatment of CFRD with insulin results in sustained improvements in lu...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章

    doi:10.1016/j.prrv.2013.02.002

    authors: Bridges N

    更新日期:2013-05-01 00:00:00

  • Clinical outcomes of congenital lung abnormalities.

    abstract::Individually, congenital abnormalities of the lung are rare but collectively they form an important group of conditions. The range of malformations is broad and the clinical impact is very variable, depending on the degree of malformation. This article groups these conditions under their traditional headings and consi...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1053/prrv.2000.0072

    authors: Wallis C

    更新日期:2000-12-01 00:00:00

  • New specimens and laboratory diagnostics for childhood pulmonary TB: progress and prospects.

    abstract::Childhood pulmonary TB (PTB) is under diagnosed, in part due to difficulties in obtaining microbiological confirmation. However, given the poor specificity of clinical diagnosis, microbiological confirmation and drug susceptibility testing is important in guiding appropriate therapy especially in the context of drug r...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2010.09.008

    authors: Nicol MP,Zar HJ

    更新日期:2011-03-01 00:00:00

  • Neurocognitive and Behavioural Outcomes Following Intervention for Obstructive Sleep Apnoea Syndrome in Children.

    abstract::The obstructive sleep apnoea syndrome (OSAS) is common in children and results in several complications when untreated. Considering that children are undergoing important brain development, recent research has focused on neurocognitive and behavioural (NCB) complications of OSAS. Studies have shown that treatment of p...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2016.05.004

    authors: Konstantinopoulou S,Tapia IE

    更新日期:2016-09-01 00:00:00

  • What does imaging the chest tell us about bronchopulmonary dysplasia?

    abstract::Bronchopulmonary dysplasia (BPD) is a common complication of preterm birth. Chest imaging is important in making the diagnosis of BPD, and in assessing for complications. More recently computerised tomography (CT) scanning has provided insights in to the pathophysiology of BPD. Studies in infants, young and school age...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2010.05.005

    authors: Wilson AC

    更新日期:2010-09-01 00:00:00

  • Air pollution during pregnancy and lung development in the child.

    abstract::Air pollution exposure has increased extensively in recent years and there is considerable evidence that exposure to particulate matter can lead to adverse respiratory outcomes. The health impacts of exposure to air pollution during the prenatal period is especially concerning as it can impair organogenesis and organ ...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2016.08.008

    authors: Korten I,Ramsey K,Latzin P

    更新日期:2017-01-01 00:00:00

  • Outdoor air pollution and cystic fibrosis.

    abstract::Outdoor air pollution is increasingly identified as a contributor to respiratory and cardiovascular disease. Pro-inflammatory particles and gases are inhaled deep into the lungs, and are associated with impaired lung growth and exacerbations of chronic respiratory diseases. The magnitude of these effects are of intere...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章

    doi:10.1016/j.prrv.2018.03.005

    authors: Brugha R,Edmondson C,Davies JC

    更新日期:2018-09-01 00:00:00

  • Pediatric polysomnography-A review of indications, technical aspects, and interpretation.

    abstract::Polysomnography is an elaborate diagnostic test composed of numerous data-collecting sensors working concomitantly to aid in the evaluation of varied sleep disorders in all age groups. Polysomnography is the study of choice for the assessment of pediatric sleep-disordered breathing, including obstructive sleep apnea s...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2019.09.009

    authors: Stowe RC,Afolabi-Brown O

    更新日期:2020-04-01 00:00:00

  • Respiratory viruses in the intensive care unit.

    abstract::Respiratory viruses cause a number of clinical 'syndromes' in the intensive care unit with different viruses being able to produce similar clinical pictures. Our main presenting problems are upper airway (e.g. croup and tracheitis), lower airway with intrapulmonary shunt (e.g. bronchitis and pneumonia), lower airway w...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:

    authors: Roe M,O'Donnell DR,Tasker RC

    更新日期:2003-09-01 00:00:00

  • Journey towards a personalised medicine approach for OSA: Can a similar approach to adult OSA be applied to paediatric OSA?

    abstract::The concept of personalised medicine is likely to revolutionise the treatment of adult obstructive sleep apnoea as a result of recent advances in the understanding of disease heterogeneity by identifying clinical phenotypes, pathophysiological endotypes, biomarkers and treatable traits. Children with the condition sho...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2020.01.002

    authors: Siriwardhana LS,Nixon GM,Horne RSC,Edwards BA

    更新日期:2020-11-01 00:00:00

  • A systematic review of studies examining the rate of lung function decline in patients with cystic fibrosis.

    abstract::A systematic review was performed (i) to describe the reported overall rate of progression of CF lung disease quantified as FEV1%predicted decline with age, (ii) to summarise identified influencing risk factors and (iii) to review methods used to analyse CF lung disease progression data. A search of publications provi...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2016.03.002

    authors: Harun SN,Wainwright C,Klein K,Hennig S

    更新日期:2016-09-01 00:00:00

  • The destructive combination of Scediosporium apiosperum lung disease and exuberant inflammation in cystic fibrosis.

    abstract::This paper describes a patient whose decline over two years was precipitous, from an active independent life with lung function (FEV1) above 50% to requiring transplantation. The main pathogen on sputum culture throughout that period was Scediosporium apiosperum. The epidemiology pathogenicity and treatment of this fu...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章

    doi:10.1016/j.prrv.2013.02.004

    authors: Russell GK,Gadhok R,Simmonds NJ

    更新日期:2013-05-01 00:00:00

  • Urban air pollution and respiratory infections.

    abstract::Public awareness of the impact of air quality on health is increasing worldwide. Indoor and outdoor air pollutants impair children's growing lungs, and increase the risk of respiratory infections. In many cities, children face indoor air pollution from fuels used for cooking and heating, as well as outdoor pollution f...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2014.03.001

    authors: Brugha R,Grigg J

    更新日期:2014-06-01 00:00:00

  • Tracheostomy care in the home.

    abstract::There are hardly any controlled studies in paediatric tracheostomy care; instead, most established standards, procedures and details have been elaborated at the bedside by trial and error. Once the appropriate tube is chosen, tube care consists of tube change, fixation, management of secretions, humidification of insp...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2006.06.003

    authors: Oberwaldner B,Eber E

    更新日期:2006-09-01 00:00:00

  • Children and the global tuberculosis situation.

    abstract::The current global strategy for control of tuberculosis, Directly Observed Treatment, Short-course (DOTS) focuses, as a priority, on the management of patients with sputum smear positive tuberculosis. As tuberculosis in children is rarely sputum smear positive, this has led many to believe that children are not import...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s1526-0542(04)90027-9

    authors: Enarson DA

    更新日期:2004-01-01 00:00:00

  • Principles of medicating children with neurodevelopmental and sleep disorders--a review.

    abstract::Conflict between the demands of the environment in which a child lives and the child's intrinsic sleep signature, produces stress-behaviour difficulties in the child. Distorted development, especially distorted brain development, often leads to distorted intrinsic sleep signatures. The sleep-behaviour outcome, arising...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2013.08.001

    authors: Nunn K

    更新日期:2014-03-01 00:00:00

  • Effects of childhood respiratory diseases on the anatomical and functional development of the respiratory system.

    abstract::The anatomical and functional development of the lung appears especially vulnerable to a whole range of insults during gestation and the first few years of life. A significant proportion of adult lung disease originates in utero or early infancy. Most publications on this topic are descriptive retrospective studies. A...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s1526-0542(02)00311-1

    authors: Merkus PJ

    更新日期:2003-03-01 00:00:00

  • Options for assessing and measuring chest wall motion.

    abstract::Assessing chest wall motion is a basic and vital component in managing the child with respiratory problems, whether these are due to pathology in the lungs, airways, chest wall or muscles. Since the 1960s, clinical assessment has been supplemented with an ever-growing range of technological options for measuring chest...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2014.10.006

    authors: Seddon P

    更新日期:2015-01-01 00:00:00

  • Use of steroids in the perinatal period.

    abstract:INTRODUCTION:Corticosteroids can be used prenatally to mature the fetal lungs and postnatally to treat or prevent chronic lung disease (CLD). Randomised controlled trials have been performed to evaluate the benefits and risks of perinatal corticosteroid therapy. METHODS:Systematic reviews of randomised controlled tria...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s1526-0542(04)90057-7

    authors: Halliday HL

    更新日期:2004-01-01 00:00:00

  • Pulmonary complications of endocrine and metabolic disorders.

    abstract::There are many important respiratory manifestations of endocrine and metabolic diseases in children. Acute and chronic pulmonary infections are the most common respiratory abnormalities in patients with diabetes mellitus, although cardiogenic and non-cardiogenic pulmonary oedema are also possible. Pseudohypoaldosteron...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2011.01.004

    authors: Milla CE,Zirbes J

    更新日期:2012-03-01 00:00:00

  • The burden of asthma in children: an Australian perspective.

    abstract::The burden of asthma among children is high in Australia compared with many other countries. Recent data show that 14-16% of children report a diagnosis of asthma that remains a problem. Boys, children under the age of 5 years and urban indigenous children experience a greater burden of asthma than other children. Mor...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2004.11.004

    authors: Poulos LM,Toelle BG,Marks GB

    更新日期:2005-03-01 00:00:00

  • Pediatric donation after circulatory determination of death (pDCD): A narrative review.

    abstract::Pediatric donation after circulatory death (pDCD) is an established pathway for organ donation. It remains, however, a relatively rare event worldwide, and most clinicians outside of the pediatric intensive care unit (PICU) are unfamiliar with it. The goal of this review is to introduce the processes and concepts of p...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2018.03.006

    authors: Weiss MJ,Sherry W,Hornby L

    更新日期:2019-02-01 00:00:00

  • Non-invasive home ventilation.

    abstract::Non-invasive ventilation (NIV) provides significant advantages to the paediatrician who cares for children with chronic ventilatory insufficiency and who would like to manage these children in the home environment. There is a growing experience in the use of NIV in the management of children with upper airway obstruct...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1053/prrv.2000.0035

    authors: Wallis C

    更新日期:2000-06-01 00:00:00

  • Congenital upper airway obstruction.

    abstract::Most causes of upper airway obstruction are rare in the neonatal period and during infancy. They may, however, cause major respiratory problems either initially or during the first few weeks of life. It is important to recognise these problems at an early stage so that appropriate measures to overcome airway obstructi...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2003.10.001

    authors: Dinwiddie R

    更新日期:2004-03-01 00:00:00

  • Allergic bronchopulmonary aspergillosis in paediatric cystic fibrosis patients.

    abstract::Allergic bronchopulmonary aspergillosis (ABPA) is a severe complication in children, adolescents and adults with cystic fibrosis (CF), the prevalence of which ranges from 6-25%. The disease is the result of the colonisation of the respiratory tract by fungi of the genus Aspergillus, commonly Aspergillus fumigatus, and...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2005.09.003

    authors: de Almeida MB,Bussamra MH,Rodrigues JC

    更新日期:2006-03-01 00:00:00

  • Gene and cell therapy for cystic fibrosis.

    abstract::Since the discovery of the CF gene over a decade ago, several groups worldwide have explored the potential of gene therapy, the insertion of a normal copy of the gene into the respiratory epithelium. Both viral and synthetic gene transfer agents have been designed to this end, although problems with repeat application...

    journal_title:Paediatric respiratory reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.prrv.2006.04.214

    authors: Davies JC

    更新日期:2006-01-01 00:00:00