Abstract：
OBJECTIVE:To analyze the potential role of extraovarian factors such as endometrium in the reproductive outcome of obese patients. DESIGN:Retrospective study. SETTING:University-affiliated infertility clinic, between January 2001 and July 2005. PATIENT(S):Women undergoing a total of 2656 first ovum donation (OD) cycles with good quality embryos. INTERVENTION(S):The oocyte donors underwent controlled ovarian hyperstimulation, and recipients received a well-established hormonal replacement therapy for endometrial preparation. In vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) was performed according to semen characteristics. All first cycles (n = 2656) of ovum donation used good quality embryos and were divided into groups according to body mass index: <20 kg/m(2) (n = 471), 20 to 24.9 kg/m(2) (n = 1613), 25 to 29.9 kg/m(2) (n = 450), and > or =30 kg/m(2) (n = 122). MAIN OUTCOME MEASURE(S):The recipient body mass index groups were compared regarding IVF outcome. RESULT(S):The rates of implantation, pregnancy, miscarriage, and ongoing pregnancy were similar among the body mass index groups, although there was a negative trend when body mass index increased. Ongoing pregnancy rates per cycle were poorer in the overweight and obese groups than in the underweight and normal groups. In addition, women under 25 kg/m(2) presented an ongoing pregnancy rate per cycle of 45.5%, compared with 38.3% for those with > or =25 kg/m(2). CONCLUSION(S):Excess weight exerts an extraovarian detrimental effect. The role of the endometrium or its environment seems to be subtle but should be taken into account.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Bellver J,Melo MA,Bosch E,Serra V,Remohí J,Pellicer Adoi
10.1016/j.fertnstert.2006.11.162subject
Has Abstractpub_date
2007-08-01 00:00:00pages
446-51issue
2eissn
0015-0282issn
1556-5653pii
S0015-0282(06)04702-9journal_volume
88pub_type
杂志文章abstract：:A couple may be considered to have fertility problems if they have been trying to conceive for over 1 year with no success. Worldwide, the inability to have children affects 10% to 15% of all couples. Subfertility can be divided into either male or female factor, or both partners can be affected. However, for some cou...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
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更新日期：2018-09-01 00:00:00
abstract：OBJECTIVE:To determine whether in vitro fertilization with preimplantation genetic screening (IVF/PGS) is cost effective compared with expectant management in achieving live birth for patients with unexplained recurrent pregnancy loss (RPL). DESIGN:Decision analytic model comparing costs and clinical outcomes. SETTIN...
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更新日期：2015-05-01 00:00:00
abstract：OBJECTIVE:The aim of this article is to summarize the recommended updates to the 2001 Stages of Reproductive Aging Workshop (STRAW) criteria. The 2011 STRAW + 10 reviewed advances in understanding of the critical changes in hypothalamic-pituitary-ovarian function that occur before and after the final menstrual period. ...
journal_title：Fertility and sterility
pub_type： 共识发展会议,杂志文章,实务指引
doi：10.1016/j.fertnstert.2012.01.128
更新日期：2012-04-01 00:00:00
abstract：:D-group chromosome translocations have been associated in isolated cases with infertility in males. In this study, we demonstrated the effect of a translocated D-group chromosome on spermatogenesis as it had segregated among three male members of one family. Although the father, who carried the translocation, was obvi...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)41651-1
更新日期：1976-02-01 00:00:00
abstract：:Sixty infertile women underwent infertility surgery followed by "second-look laparoscopy" (SLL). All these women had undergone detailed fertility workups, including a diagnostic laparoscopy prior to surgery. The tuboovarian adhesive disease was staged according to the severity of the disease and compared with findings...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1982-09-01 00:00:00
abstract：:The hyperandrogenic-insulin-resistant acanthosis nigricans syndrome affects between 2% and 5% of hirsute women and is characterized by INS resistance, elevated INS levels, acanthosis nigricans, and androgen excess. These patients' response to therapy is unclear, although long-acting GnRH-a suppression has been propose...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：OBJECTIVE:To determine the efficacy of combined l-carnitine and l-acetyl-carnitine therapy in infertile males with oligo-astheno-teratozoospermia. DESIGN:Placebo-controlled double-blind randomized trial. SETTING:University tertiary referral center. PATIENT(S):Sixty infertile patients (aged 20-40 years) with the foll...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2003.10.034
更新日期：2004-06-01 00:00:00
abstract：OBJECTIVE:To assess the effect of gonadotropin-releasing hormone agonist (GnRH-a) on pituitary suppression, subsequent ovarian response, and results of in vitro fertilization (IVF) treatments in polycystic ovarian syndrome (PCOS) patients. DESIGN:Randomized prospective study. SETTING:In vitro fertilization program an...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)54847-x
更新日期：1992-02-01 00:00:00
abstract：OBJECTIVE:To test the hypothesis that an acute reduction in circulating insulin affects LH secretion in women with polycystic ovary syndrome (PCOS). DESIGN:Prospective study in normal and PCOS women. SETTING:General Clinical Research Centers at the University of Virginia, the Medical College of Virginia, and the Mass...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.11.109
更新日期：2007-07-01 00:00:00
abstract：:A large body of research confirms the vulnerable nature of spermatogenesis to relatively small increases in testicular temperature. Other physical properties of electromagnetic and ultrasound waves have additive or synergistic effects to those of heat and allow disruption of spermatogenic processes at minimal tempera...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/s0015-0282(16)59640-x
更新日期：1988-01-01 00:00:00
abstract：:We report the complications observed after transvaginal oocyte retrieval guided by ultrasound in 7,098 IVF cycles. The frequency of severe complications in our patients was 0.08%, of which four cases were intraperitoneal bleeding (0.06%) and two were cases of ovarian abscess (0.003%). ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.07.1054
更新日期：2011-01-01 00:00:00
abstract：OBJECTIVE:To determine a successful method of selecting patients for natural cycle IVF combined with in vitro maturation (IVM) of immature oocytes and to determine treatment efficacy. DESIGN:Retrospective analysis of IVF treatments. SETTING:Hospital IVF clinic. PATIENT(S):Women with infertility according to ovarian ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.01.066
更新日期：2009-04-01 00:00:00
abstract：:Many studies evaluating a possible relationship between inherited thrombophilia and the etiology of unexplained infertility have been performed recently. No significant difference in the prevalence of three genetic mutations associated with the increased risk of thrombophilia (Factor V Leiden G1691A, prothrombin G2021...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2009.10.014
更新日期：2010-07-01 00:00:00
abstract：OBJECTIVE:To investigate whether a poor rate of implantation after in vitro fertilization (IVF) was due to poor embryonic/endometrial synchrony during the original IVF cycle, we have cryopreserved reinseminated-fertilized embryos for later more synchronous replacement after thawing. The chance of implantation of fresh ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)54725-6
更新日期：1991-12-01 00:00:00
abstract：OBJECTIVE:To report a case of severe ovarian hyperstimulation syndrome (OHSS) after inadvertent GnRH long protocol/hMG stimulation in a pre-existing early pregnancy. DESIGN:Case report. SETTING:Private infertility clinic. PATIENT(S):A 28-year-old woman who conceived spontaneously following IVF and cryo-embryo transf...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2005.05.069
更新日期：2005-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of male age on the outcome of microdissection testicular sperm extraction (micro-TESE) and assisted reproductive technology. DESIGN:Clinical retrospective study. SETTING:Center for reproductive medicine at a tertiary university hospital. PATIENT(S):One thousand sixty-seven men with n...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.11.123
更新日期：2014-03-01 00:00:00
abstract：:The usefulness of a short-interval second-look laparoscopy (SLL) after ovarian surgery was examined. In 23 infertile women who had either bilateral wedge resection (BWR) of polycystic ovaries, an oophorocystectomy (OC), or resection of endometriomata (RE), adhesions were graded before and after surgery and before and ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)48975-2
更新日期：1985-11-01 00:00:00
abstract：OBJECTIVE:To characterize growth factor gene expression by passaged coculture cell lines demonstrated to enhance in vitro pre-embryo growth. DESIGN:Ribonucleic acids isolated from the isthmus, ampullary, and fimbriae portions of the human oviduct, and from buffalo rat liver cell monolayers were subjected to Northern a...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(97)81382-9
更新日期：1997-04-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of obesity on the outcome of testicular sperm extraction (TESE) and assisted reproductive technology. DESIGN:Clinical retrospective study. SETTING:Center for reproductive medicine at a tertiary-care university hospital. PATIENT(S):Nine hundred seventy patients with nonobstructive azo...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2012.10.025
更新日期：2013-02-01 00:00:00
abstract：OBJECTIVE:In rodents, evidence suggests that the leptin system is mandatory for embryonic implantation. We aimed to investigate the functional relevance of the endometrial leptin receptor (OB-R) in the adhesion phase of human implantation. DESIGN:We used an in vitro model for embryonic adhesion, composed of a human en...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.12.028
更新日期：2007-10-01 00:00:00
abstract：OBJECTIVE:To study the incidence rate and hazard ratios of diabetes and prediabetes between women with PCOS and healthy subjects. DESIGN:Prospective population-based study. SETTING:Not applicable. PATIENT(S):Women with PCOS (n = 178) and eumenorrheic, nonhirsute, healthy women as controls (n = 1,524), all followed f...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2017.09.004
更新日期：2017-12-01 00:00:00
abstract：:The association between educational level and cycle outcomes was quantified by applying multivariable logistic and linear regression within a prospective cohort of 2,569 women commencing their first in vitro fertilization (IVF) cycle. Although a woman's educational attainment was not associated with the likelihood of ...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究
doi：10.1016/j.fertnstert.2011.05.015
更新日期：2011-06-30 00:00:00
abstract：OBJECTIVE:To explore the contribution of an altered structure of sperm mitochondria to human asthenozoospermia. DESIGN:A retrospective study. SETTING:Andrology Clinic, University of L'Aquila. PATIENT(S):Fifteen ejaculates with forward motility (FM) ≥ 50%, and 57 asthenozoospermic ejaculates (FM <50%, sperm vitality ...
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pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.07.1086
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:To compare endocrine profiles and IVF outcomes after using GnRH agonists (GnRHa) to trigger final oocyte maturation in women with polycystic ovary syndrome (PCOS) with other hyper-responders. DESIGN:Retrospective cohort study. SETTING:Academic center. PATIENT(S):Forty women with PCOS and 74 hyper-responder...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2014.09.042
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVE:To analyze the effectiveness of autologous endometrial coculture by the cycle day of the endometrial biopsy. DESIGN:Retrospective study. SETTING:University-based IVF center. PATIENT(S):Two hundred eight patients with multiple IVF failures. INTERVENTION(S):Embryos were split and randomly allocated to growt...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(02)03134-5
更新日期：2002-06-01 00:00:00
abstract：OBJECTIVE:To determine the prognostic impact of the nuclear status at the two-cell stage on intracytoplasmic sperm injection (ICSI) outcomes. DESIGN:Retrospective study. SETTING:Hospital. PATIENT(S):Only ICSI cycles with time-lapse monitoring of transferred embryos with known implantation/delivery data from November...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2016.09.022
更新日期：2017-01-01 00:00:00
abstract：:Endometrial polyps, adenomyosis, and leiomyomas are commonly encountered abnormalities frequently found in both fertile women and those with infertility. The clinician is frequently challenged to determine which of these entities, when found, is likely to impair fertility, and which are "innocent bystanders" unrelated...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2019.02.008
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVE:To investigate whether components of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway are present and active in human sperm. DESIGN:Comparative study. SETTING:Reproductive biology department. PATIENT(S):Nine sperm donors. INTERVENTION(S):Sperm were exposed to interfer...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(01)01896-9
更新日期：2001-08-01 00:00:00
abstract：:A new sperm isolation technique was studied in conjunction with the short-term freeze preservation of human spermatozoa. The isolation procedure yielded subpopulations of spermatozoa with very high percentage motility and progressive motility score, and which were virtually free of seminal debris. For 24 semen samples...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)42196-5
更新日期：1976-11-01 00:00:00
abstract：OBJECTIVE:To evaluate the role of saline infusion sonohysterography (SIS) in the investigation of uterine abnormalities and malformations in patients referred for infertility work-up compared with women with abnormal uterine bleeding (AUB). DESIGN:Prospective cohort study. SETTING:Academically oriented private practi...
journal_title：Fertility and sterility
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更新日期：2006-12-01 00:00:00
