15 parameters of coagulation and fibrinolysis in children with type I diabetes mellitus (onset period).

Abstract:

:15 parameters of coagulation and fibrinolysis were investigated in 38 children with type I diabetes mellitus without clinical signs of diabetic angiopathy. Compared to an age matched non diabetic control group spontaneous platelet aggregation was enhanced, plasma levels for factor VIII C, von Willebrand factor, antithrombin III and C-1-inactivator were elevated, alpha-2-macroglobulin was decreased at onset of the disease. During remission (3, 6, 12 months) these changes reverted to normal. Alpha-2-antiplasmin decreased after 12 months. If, during partial remission, diabetic duration was longer than one year an increase of factor VIII C was seen again. In comparison to the controls no significant alterations were found for ristocetin cofactor, fibrinogen, plasminogen and alpha-1-antichymotrypsin. It seems likely that changes in plasmatic coagulation, fibrinolysis and platelet function during the onset period of diabetes mellitus type I are due to metabolic changes and precede diabetic angiopathy.

journal_name

Klin Padiatr

journal_title

Klinische Padiatrie

authors

Koert M,Nowak-Göttl U,Kreuz W,Grüttner HP,Kornhuber B,Breddin HK

doi

10.1055/s-2007-1025468

subject

Has Abstract

pub_date

1991-11-01 00:00:00

pages

429-32

issue

6

eissn

0300-8630

issn

1439-3824

journal_volume

203

pub_type

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