[Arteriovenous intracranial and extracranial angiomas in infants and children (author's transl)].

abstract：:We have performed in situ hybridization (ISH) studies predominantly on paraffin sections and on isolated nuclei of 22 pediatric germ cell tumors (GCTs) from 18 patients including 4 recurrences from three patients. In addition, we performed conventional cytogenetic analyses in three tumor samples. Because reports on cy...

journal_title：Klinische Padiatrie

authors： Stock C,Ambros IM,Strehl S,Zoubek A,Fink FM,Gadner H,Ambros PF

更新日期：1995-07-01 00:00:00

abstract：:We identified betulinic acid (BetA) as a new cytotoxic agent active against neuroectodermal tumor cells including neuroblastoma, medulloblastoma, glioblastoma and Ewing's sarcoma cells representing the most common solid tumors of childhood. BetA induced apoptosis independent of wild-type p53 protein and accumulation o...

journal_title：Klinische Padiatrie

authors： Fulda S,Jeremias I,Pietsch T,Debatin KM

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Autism spectrum disorders (ASDs) are a group of developmental disabilities in childhood and adolescence. Beside genetic predisposition also environmental influences may contribute to the ASD pathogenesis. Family members of children and adolescents with ASD often ask for specific diets to alleviate ASD-associ...

journal_title：Klinische Padiatrie

authors： Sausmikat J,Smollich M

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:One of the strongest predictive factors for therapy outcome in childhood acute lymphoblastic leukaemia (ALL), treated according to ALL-BFM protocols, is the response to initial prednisone treatment. Prednisone response is characterized by the peripheral leukaemic blast count. The threshold value for the char...

journal_title：Klinische Padiatrie

authors： Lauten M,Stanulla M,Zimmermann M,Welte K,Riehm H,Schrappe M

更新日期：2001-07-01 00:00:00

abstract：:We report on a 13.2 years old boy who was treated for tall stature (expected target height of 204.8 +/- 5.4 cm) with high dose of testosterone. Therapy for height reduction was started with testosterone injections (250 mg Testoviron Depot i.m.) once a week. There occurred no side effects during 6 months of treatment. ...

journal_title：Klinische Padiatrie

authors： Weimann E,Böhles HJ

更新日期：1999-09-01 00:00:00

abstract：:Background For the new cystic fibrosis (CF) newborn screening program in Germany the Federal Joint Committee (G-BA) implemented a new screening protocol using immunoreactive trypsinogen (IRT) as first and pancreatitis associated protein (PAP) as second tier. Gene analysis with a panel of 31 CFTR-mutations is used as t...

journal_title：Klinische Padiatrie

authors： Sommerburg O,Stahl M,Hammermann J,Okun JG,Kulozik A,Hoffmann G,Mall M

更新日期：2017-03-01 00:00:00

abstract：UNLABELLED:After corrective surgery for congenital heart defects (CHD) many patients suffer from residual defects, some with reduced cardiorespiratory capacity and possible impairment of their health related quality of life (HRQoL). The aim of our study is to evaluate, how children after surgery for CHD rate their HRQo...

journal_title：Klinische Padiatrie

authors： Heusch A,Calaminus G,Kahl J,Schmidt K

更新日期：2014-09-01 00:00:00

abstract：:The prevalence of antibodies to hepatitis C virus recombinant antigen c100-3 was determined in 82 pediatric patients with malignant diseases who received blood transfusions as support during their chemotherapy. By prescreening, 12 of 82 patients were repeatedly positive. No positive correlation was established neither...

journal_title：Klinische Padiatrie

authors： Schneppenheim R,Rautenberg P,Behnke H,Vietor K

更新日期：1991-07-01 00:00:00

abstract：:We examined the effectiveness of a high-dose Immunglobulin therapy in 8 patients with idiopathic thrombocytopenic purpura (ITP) and measured the number, the morphology and the function of Thrombocytes as well as thrombocyte dependent clotting parameters. 0.5 g/kg/B.W. 7s-Immunglobulin (7s-IgG) per treatment led to nor...

journal_title：Klinische Padiatrie

authors： Wahlen W,Graf N,Nienhaus KH,Müller J

更新日期：1983-01-01 00:00:00

abstract：:The GPOH-MAHO trials designed in 3/82 and 7/88 for treatment of childhood testicular germ cell tumors registered 3/92 105 pts. In MAHO 82 study 57 pts. and in MAHO 88 study 48 pts. were treated. Histologically 60% of the tumors revealed yolk sac tumors (YST), 22% teratomas (TD) and 18% malignant teratomas (MTI, MTU, M...

journal_title：Klinische Padiatrie

authors： Haas RJ,Schmidt P,Göbel U,Harms D

更新日期：1993-07-01 00:00:00

abstract：:We report about a premature infant with a De Barsy-Moens-Dierckx-syndrome, which is a rare cutaneo-oculo-cerebral malformation-syndrome. It is defined by the combination of a progeroid aspect, cutis laxa, growth retardation, cornea clouding, mental retardation and athetoid movements. Furthermore, the reported case sho...

journal_title：Klinische Padiatrie

authors： Schierenberg M,Donné W,Schiafone P,Bald R,Gembruch U,Hansmann M,Rister M

更新日期：1994-11-01 00:00:00

abstract：:We report the first case of non-immune hydrops fetalis (NIHF) with trisomy 15q11/17q22.5 resulting from a familial translocation 15/17. Furthermore the cytogenetic findings of 50 cases with hydrops fetalis are presented. Of the 30 cytogenetic analyzable cases 7 showed chromosomal abnormalities (4x45,X; 2x47,XY,+21; 1x...

journal_title：Klinische Padiatrie

authors： Schmid G,Haverkamp F,Rechmann J,Schwanitz G,Zerres K,Hansmann M,Kowalewski S

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND:Acute viral bronchiolitis is a frequent disease in infancy. There is little knowledge on medical care of severely affected infants in different European countries. PATIENTS:Infants (n=146) with bronchiolitis requiring respiratory support in winter season 2015/2016 treated in either one of two regions in Cen...

journal_title：Klinische Padiatrie

authors： Dohna-Schwake C,Mücher K,Stehling F,Rothoeft T,Roll C,Brevis Nuńez F,Seiffert P,Heister P,Hofmann M,Stein A,Jacobs A,Zuzak T,Durand P,Felderhoff-Müser U,Tissières P

更新日期：2018-09-01 00:00:00

abstract：:Cytological examination of cerebrospinal fluid needs special techniques of cell collecting and staining. On condition of realizing the methodical requirements cytology of the cerebrospinal fluid brings more advancement in diagnostics than other laboratory examinations. The advantages of this procedure are: 1. Meningit...

journal_title：Klinische Padiatrie

authors： Harms D

更新日期：1975-03-01 00:00:00

abstract：:To evaluate the impact of megatherapy on the outcome of high risk neuroblastoma, 39 patients with stage IV neuroblastoma, who underwent megatherapy, were analyzed retrospectively and compared to 49 patients, who continued chemotherapy according to the German cooperative trial NB85. The groups were comparable concernin...

journal_title：Klinische Padiatrie

authors： Hero B,Kremens B,Klingebiel T,Bender-Götze C,Burdach S,Schrappe M,Berthold F

更新日期：1997-07-01 00:00:00

abstract：:Postoperative neurosonography was performed in 69 babies and children after osteoclastic neurosurgery for primary cerebral tumors. Astrocytoma of the posterior fossa (26 cases) and medulloblastoma (25 cases) were frequent histological findings. Early postoperative bed-side examinations revealed reliably complications ...

journal_title：Klinische Padiatrie

authors： Dittrich M,Gutjahr P,Dinkel E,Higer HP,Müller W

更新日期：1987-11-01 00:00:00

abstract：:Members of the histone deacetylase (HDAC) family exhibit great promise as potential drug targets in pediatric tumors including neuroblastoma, medulloblastoma, ependymoma and Ewing's sarcoma. HDAC inhibitors of various structural classes have shown anti-tumoral effects in pre-clinical pediatric tumor models as single a...

journal_title：Klinische Padiatrie

authors： Witt O,Milde T,Deubzer HE,Oehme I,Witt R,Kulozik A,Eisenmenger A,Abel U,Karapanagiotou-Schenkel I

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:In study AML-BFM 87 the relapse rate was lower in patients receiving cranial irradiation (CRT). However, CRT has always been associated with adverse cognitive side effects. Therefore, the impact of CRT on neuropsychological function in children with AML was retrospectively evaluated. PATIENTS:We tested 53 c...

journal_title：Klinische Padiatrie

authors： Reinhardt D,Thiele C,Creutzig U,AML-BFM-Studiengruppe.

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:The prognosis of children with multisystem Langerhans cell histiocytosis (LCH) has improved with the application of chemotherapy. However, treatment strategies used varied from conservative approach with treatment only during disease exacerbation to intensive chemotherapy starting immediately after diagnosis...

journal_title：Klinische Padiatrie

authors： Minkov M,Grois N,Heitger A,Pötschger U,Westermeier T,Gadner H

更新日期：2000-07-01 00:00:00

abstract：:The increasing importance of radiotherapy in tumor of childhood demands the investigation and consideration of the psychological aspects of this afflicting therapy. In this paper the results obtained by questioning and observing 28 children of different ages, their parents, attendants and employees of several radiolog...

journal_title：Klinische Padiatrie

authors： Poehler A,Riedesser P,Jobke A,Wannenmacher M

更新日期：1981-05-01 00:00:00

abstract：:A report was made of three patients who exhibited pronounced heptosplenomegaly at the time of hospital admission: a six-year-old girl and two brothers, 1 year 4 months and 4 years 4 months of age. As is typical for Niemann-Pick disease, foam cells were found in the bone marrow and the liver biopsy specimens for the th...

journal_title：Klinische Padiatrie

authors： Priscu R,Pancu L,Balan A,Petrescu TC,Iacob C

更新日期：1977-11-01 00:00:00

abstract：BACKGROUND:Burning pain of red and warm hands and/or feet are the classical symptoms of erythromelalgia. CASE REPORT:We describe the symptoms of acute idiopathic erythromelalgia and arterial hypertension in a five-year-old boy. Five days after a gastroenteritis the patient developed burning hands and feet in combinati...

journal_title：Klinische Padiatrie

authors： Zenz W,Zöhrer B,Zobel G,Schulze-Bauer C

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Pachyonychia congenita is considered to be a genodermatosis of autosomal inheritance. It is characterized by nail hypertrophy, shortly present after birth. Later on follicular keratosis of the extremities and hyperkeratosis of palms and soles can be found. HISTORY AND CLINICAL FINDINGS:We report a child wit...

journal_title：Klinische Padiatrie

authors： Wimmershoff MB,Stolz W,Schiffner R,Landthaler M

更新日期：1999-05-01 00:00:00

abstract：:Infectious heart diseases in childhood are--with less than 1% of hospital admissions--rare, but serious diseases. Among several causes of myocarditis in our region virus myocarditis plays the most important role. Besides of the acute course an autoimmune mediated chronic myocarditis and the transition to dilated cardi...

journal_title：Klinische Padiatrie

authors： Schmaltz AA

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Disproportionate short stature may impair the quality of life (QoL) of patients and their families. This study aimed to evaluate a self-help supported counseling concept to increase the QoL of the participants. METHODS:QoL data from 58 children/adolescents (8-17 years) with a diagnosis of achondroplasia was...

journal_title：Klinische Padiatrie

authors： Rohenkohl AC,Sommer R,Kahrs S,Bullinger M,Klingebiel KH,Quitmann JH

更新日期：2016-01-01 00:00:00

abstract：:Centralized treatment of critically ill pediatric patients and related problems are presented. Pediatric intensive care allows to overbridge deranged or interrupted organ functions while simultaneously treating the disease causing the disturbance. Its efficiency depends on continuity of medical care. Medical and nursi...

journal_title：Klinische Padiatrie

authors： Wille L

更新日期：1980-09-01 00:00:00

abstract：:The therapy of complicated Kaposiform hemangioendothelioma (KHE) is still difficult. We present the first case of laryngomalacia with simultaneous mammalian target of Rapamycin (mTOR)-positive KHE of the neck and thoracic inlet and concurrent Kasabach-Meritt Phenomenon (KMP) in an 11-month-old boy suffering life-threa...

journal_title：Klinische Padiatrie

authors： Schroeder U,Lauten M,Stichtenoth G,Gebhard MP,Buchholz M,Kaiser MM

更新日期：2014-11-01 00:00:00

abstract：:This is a case-report about a 4 year old boy with "cherry red" epiglottis, purulent meningitis and pleuropneumonia. Purulent meningitis and pleuropneumonia are not complications of treatment of "cherry red" epiglottis but an entity caused by Hemophilus influenzae-infection and is called Kleinschmidt's syndrome (Hemoph...

journal_title：Klinische Padiatrie

authors： Freudenberg V,Wolf H

更新日期：1976-07-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a rare malignant tumor arising from epithelial cells of the nasopharynx. Its incidence is highest in Southeast Asia. Age distribution of NPC is bimodal, with one peak in young adolescents and another in patients 55-59 years of age. EBV appears to be the primary etiologic agent in the ...

journal_title：Klinische Padiatrie

authors： Kontny U,Franzen S,Behrends U,Bührlen M,Christiansen H,Delecluse H,Eble M,Feuchtinger T,Gademann G,Granzen B,Kratz CP,Lassay L,Leuschner I,Mottaghy FM,Schmitt C,Staatz G,Timmermann B,Vorwerk P,Wilop S,Wolff HA,Mer

更新日期：2016-04-01 00:00:00

abstract：UNLABELLED:It was the aim of the cooperative therapy study HD-82 for children with Hodgkin's disease to reduce chemo- and radiotherapy and to investigate of a strategy for selective splenectomy previously developed in the Hodgkin study HD-78. Between December 1981 and December 1984 207 patients (131 boys and 76 girls) ...

journal_title：Klinische Padiatrie

authors： Schellong G,Brämswig J,Ludwig R,Gerein V,Jobke A,Jürgens H,Kabisch H,Stollmann B,Weinel P,Gadner H

更新日期：1986-05-01 00:00:00