[Neuropsychological sequelae in children with AML treated with or without prophylactic CNS-irradiation].

Abstract:

BACKGROUND:In study AML-BFM 87 the relapse rate was lower in patients receiving cranial irradiation (CRT). However, CRT has always been associated with adverse cognitive side effects. Therefore, the impact of CRT on neuropsychological function in children with AML was retrospectively evaluated. PATIENTS:We tested 53 children (30 boys, 23 girls) treated according to the AML-BFM-87 protocol (median age at diagnosis: 8.5 years, range 0.3 - 17.5; median time since diagnosis: 5.7 yrs, 3.8 - 10.7 yrs). To avoid any bias from additional therapy elements, patients with relapse or initial CNS involvement and transplanted patients were excluded (n=32). Our cohort was representative of the total group of 104 long term survivors of study AML-BFM 87. CNS prophylaxis consisted of ARA-C i.th., high dose ARA-C i. v. and either no CRT (n=15) or CRT (n=38) at a dose of 12 - 18 Gy depending on age. METHODS:Neuropsychological function was evaluated by psychological tests of attention and concentration (test d2 by Brickenkamp) and an intelligence test (Progressive Matrices by Raven). In addition, patients and their parents were interviewed about the occurrence of learning problems, subjective deficits in concentration and physical impairment. RESULTS:In the total group, no significant differences were seen between irradiated and non-irradiated patients regarding the psychological tests. However, the irradiated patients scored below the non-irradiated control group in test "d2" (concentration: 41st vs. 59th percentile). In the interview, irradiated patients tended to report more learning problems (lp) (10/36 vs. 1/14; p=0.15) and subjective deficits in concentration (con). In irradiated girls (con: 6/15 vs. 0/8; p=0.06; lp: 5/15 vs. 0/8; p=0.12) and younger patients (0 - 5 years at diagnosis; con: 7/12 vs. 2/9; p=0.18; lp 3/10 vs. 1/9; p=0.18) this trend was even more pronounced. CONCLUSION:Children with AML and CRT had no significant intellectual impairment in standardized tests when compared to non-irradiated patients. However, more irradiated patients reported learning problems and subjective concentration deficits.

journal_name

Klin Padiatr

journal_title

Klinische Padiatrie

authors

Reinhardt D,Thiele C,Creutzig U,AML-BFM-Studiengruppe.

doi

10.1055/s-2002-19861

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

22-9

issue

1

eissn

0300-8630

issn

1439-3824

journal_volume

214

pub_type

杂志文章
  • [Transient erythroblastopenia].

    abstract::5 patients 10 to 20 months old with severe normochromic, normocytic anemia and reticulocytopenia are reported. All patients recovered within 10 days to 5 weeks. No steroid therapy was given. Failure to recognize the clinical entity leads to unnecessary diagnostic and therapeutic procedures including the transfusion of...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1033918

    authors: Schneider H,Jobke A,Niederhoff H,Künzer W

    更新日期:1985-01-01 00:00:00

  • [Progressive combined immunity defect with ectomesodermal dysplasia (author's transl)].

    abstract::A boy with dysplastic features had to be treated for recurrent diarrhoea and bronchitis since his tenth month of life. Defects in humoral and cellular immunity were found. The ecto-mesodermal abnormalities are so characteristic that in connection with the immunological changes it seems to be justified to assume a yet ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:

    authors: Tympner KD,Belohradsky B,Eife R,Klose PK

    更新日期:1978-11-01 00:00:00

  • Hematopoietic stem cell transplantation for severe combined immunodeficiency.

    abstract::Severe combined immunodeficiency (SCID) is a heterogeneous group of congenital diseases characterized by their presentation with life threatening infections in the first months of life. The clinical presentation and the therapeutic outcome is influenced by multiple factors: the genetic defect, infectious complications...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章,评审

    doi:10.1055/s-0031-1287826

    authors: Hönig M,Schulz A,Friedrich W

    更新日期:2011-11-01 00:00:00

  • Pathology and molecular biology of teratomas in childhood and adolescence.

    abstract::The biologic behaviour of teratomas depends on various interdependent clinical and epidemiologic variables such as the age at diagnosis, sex, tumor site, histology which all correlate to different cytogenetic and molecular biologic aberrations. Thus, testicular teratomas of infancy are generally benign. Accordingly, p...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2006-942271

    authors: Harms D,Zahn S,Göbel U,Schneider DT

    更新日期:2006-11-01 00:00:00

  • [Comparison of chemotherapy alone with allogeneic bone marrow transplantation in first full remission in children with acute myeloid leukemia in the AML-BFM-83 and AML-BFM-87 studies--matched pair analysis].

    abstract::16 patients of studies AML-BFM-83 and -87 with allogeneic bone marrow transplantation (BMT) in first complete remission (CR) were compared with matched controls with postremission chemotherapy (CT-MC). CT-MC were selected from 250 non-grafted patients with a minimum of remission duration corresponding to the median in...

    journal_title:Klinische Padiatrie

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1055/s-2007-1025355

    authors: Creutzig U,Bender-Götze C,Klingebiel T,Ebell W,Friedrich W,Stollmann-Gibbels B,Schmidt H,Suttorp M,Gratwohl A,Heyen P

    更新日期:1992-07-01 00:00:00

  • [Intrapericardial diaphragmatic hernia].

    abstract::Report of a case with congenital right sided intrapericardial diaphragmatic hernia. This type of a congenital diaphragmatic hernia occurs only rarely. Until 1984 30 cases are recorded in the available literature. ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1033888

    authors: Langer R,Kaufmann HJ

    更新日期:1986-07-01 00:00:00

  • [Ductus aneurysm as a rare cause of inspiratory stridor in the newborn infant].

    abstract::A paralysis of the left vocal cord was seen by laryngoscopy in a 3-days-old boy with inspiratory stridor. A ductus aneurysm was established by angiocardiography, which was believed to be the cause of the vocal cord paralysis. Within 8 days after the angiocardiography the aneurysm became smaller and the stridor disappe...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1026854

    authors: Scharf J,Richter K,Singer H,Deeg KH

    更新日期:1986-01-01 00:00:00

  • [Elimination of fat emulsions of various concentrations from the blood. Observational study in the intravenous administration of Lipovenös 10% and 20% in premature infants with very low birth weight].

    abstract::Within the scope of an observation study 40 premature low birth weight infants requiring parenteral nutrition received either 10% or 20% lipid emulsions (Lipovenös) for 7 days. The 10% lipid emulsion differs from the 20% lipid emulsion in the higher phospholipid/triglyceride-ratio (0.06 resp. 0.12). Lipid infusion was...

    journal_title:Klinische Padiatrie

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1055/s-2007-1025318

    authors: Hanssler L,Schlotzer E,Blenkers B,Roll C,Zhou C,Kordass U

    更新日期:1992-01-01 00:00:00

  • [Fertility Preservation in Prepubertal und Pubertal Children and Adolescents].

    abstract:BACKGROUND:Due to rising survival rates in cancer and autoimmune diseases fertility preservation before gonadotoxic therapies has become increasingly important. Although fertility can be significantly affected by gonadotoxic therapies, the possibility of fertility preservation during childhood has not been sufficiently...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-0044-100396

    authors: Sänger N,Jarisch A,Ochsendorf F,Klingebiel T,Liebenthron J,Kliesch S,von Wolff M

    更新日期:2018-02-08 00:00:00

  • [A rare combination of partial trisomy 9 with pulmonary atresia].

    abstract::We report of an previously unpublished combination of partial trisomy 9 and a membranous pulmonary atresia with a large conotruncal ventricular septal defect. The dystrophic female, term newborn presented after delivery with microcephaly, prominent nose and several other facial and skeletal deformities. The echocardio...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1043941

    authors: Nekarda T,Kececioglu D,Kehl HG,Gehrmann J,Miny P,Vogt J

    更新日期:1997-05-01 00:00:00

  • [Hepatotoxicity of valproic acid treatment].

    abstract::Hepatotoxicity of valproic acid (VPA) is reported in a psychomotor retarded boy. A four-month antiepileptic therapy was followed by a combined VPA/phenytoin treatment where-upon, two months later, the patient died in a hepatic coma. In the final state the metabolic pattern of VPA was still found within the normal rang...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034017

    authors: Keulen FP,Kochen W

    更新日期:1985-09-01 00:00:00

  • [Quality standards and their assurance for study centers in the competence network malignant lymphoma].

    abstract:BACKGROUND:The aim of most of the trials of the Competence Network Malignant Lymphoma is to optimize the standard treatment of lymphoma using only registered drugs in the case of medicinal therapies (quality assurance protocols). In contrast to regulatory trials, special regulations for quality assurance protocols are ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2003-45493

    authors: Pfistner B,Mehl C,Klöss M,Löffler M,Herrmann-Frank A,Diehl V

    更新日期:2003-11-01 00:00:00

  • [Neonatal suppurative parotitis].

    abstract::This report describes the case of a 10 days old newborn of a diabetic mother with gestosis, who developed erythema and swelling of the right cheek. A diagnosis of acute suppurative parotitis due to S. aureus was made. Following this case report the most important facts of epidemiology, pathogenesis, clinical manifesta...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2004-822675

    authors: Möckel A,Nissler K,Wilhelm T,Handrick W

    更新日期:2005-03-01 00:00:00

  • [Retrospective marker analyses performed with blood and bone marrow smears using an immunoenzyme procedure (alkaline phosphatase-anti-alkaline phosphatase technic)].

    abstract::In the present study the possibility of immunophenotyping of routinely prepared (air dried) peripheral blood and bone marrow smears is described after storage. The immunoenzymatical alkaline-phosphatase-anti-alkaline-phosphatase (APAAP)-method was carried out in differently stored blood smears (+4 degrees C and -80 de...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2007-1025311

    authors: Ebener U,Hauser S,Wehner S,Kornhuber B

    更新日期:1989-07-01 00:00:00

  • [Transcutaneous measurements of pO2 in newborns with RDS (author's transl)].

    abstract::pO2 was measured transcutaneously (commercially available Clark Electrode, Bioelectronics Roche) with two different electrode temperatures in new born infants. The correlation between paO2 (arteria radialis) and ptcO2 was bad (r= 0,74) with electrode temperature of 42 degrees C. When the electrode was heated to 44 deg...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:

    authors: Haschke F,Häckel F,Hohenauer L

    更新日期:1976-01-01 00:00:00

  • [Kleinschmidt's syndrome (author's transl)].

    abstract::This is a case-report about a 4 year old boy with "cherry red" epiglottis, purulent meningitis and pleuropneumonia. Purulent meningitis and pleuropneumonia are not complications of treatment of "cherry red" epiglottis but an entity caused by Hemophilus influenzae-infection and is called Kleinschmidt's syndrome (Hemoph...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:

    authors: Freudenberg V,Wolf H

    更新日期:1976-07-01 00:00:00

  • [Creatine kinase "NAC-activated": reference values for children (author's transl)].

    abstract::Reference values for 327 children aged between 1 day and 15 years are given for the revised standard method for the determination of serum creatine kinase (CK) activity by activation with N-acetylcysteine (NAC). No sex-dependence could be observed, but CK activity was found to vary markedly with age. The following val...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035606

    authors: Kupke IR,Tritschler W,Kather B,Bablok W

    更新日期:1980-07-01 00:00:00

  • [Predictors of follow-up course of asthma complaints in early childhood--results of a follow-up study].

    abstract::A follow-up study was undertaken to determine the predictors of the course of recurrent wheezing episodes in children (between 0 to 8 years). In 1991, 600 children with wheezing episodes had been recorded by physicians who participated in a sentinel practice network. On each consultation with the same physicians from ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1043843

    authors: Seidler A,Schlaud M,Raum E,Schwartz FW

    更新日期:1998-01-01 00:00:00

  • [The plasma-protein-binding of Clindamycin Cephazolin and Cephradin in neonates and adults (author's transl)].

    abstract::In pooled serum of 12 healthy adults and 12 neonates (blood taken from the umbilical cord) the free and protein-bound parts of Cephazolin, Cephradin and Clindamycin were tested by equilibrium dialysis in relation to the concentration of the antibiotic. In the serum of adults at a concentration of 36 mcg/ml the free p...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:

    authors: Kiosz D,Simon C,Malerczyk V

    更新日期:1975-01-01 00:00:00

  • [Social deprivation in early childhood: endangered development and prevention].

    abstract::In view of present-day knowledge and findings relating to the development of young children, the stimulating interaction between the child and its social and material surroundings must be considered of supreme importance. Any disturbance or radical restriction of the structure of social relationships can thus seriousl...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034076

    authors: Jungmann J

    更新日期:1984-09-01 00:00:00

  • Newly diagnosed immune thrombozytopenia--German guideline concerning initial diagnosis and therapy.

    abstract::Newly diagnosed immune thrombocytopenia occurs in 3-5/100 000 children < 14 y per year. Bleeding symptoms do not correlate with platelet count. Diagnostic approach includes history, clinical examination and analysis of blood count with blood smear by experienced hematologist. Additional investigations are only necessa...

    journal_title:Klinische Padiatrie

    pub_type: 共识发展会议,杂志文章

    doi:10.1055/s-0032-1306277

    authors: Eberl W,Dickerhoff R,Pediatric Committee of Society of Thrombosis and Hemostasis Research.

    更新日期:2012-04-01 00:00:00

  • [Diagnostic and differential-diagnostic considerations regarding the assessment of children's reactions within the scope of psychosocial care in paediatric oncology and haematology].

    abstract::Oncological diseases in children and adolescents represent a considerable burden for the children themselves and for their families. In order to position such concomitants of a life-threatening disease appropriately among the diagnostic options of psychosocial cancer care one is repeatedly confronted with the issue of...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2007-985872

    authors: Schreiber-Gollwitzer B,Gollwitzer K

    更新日期:2007-11-01 00:00:00

  • [Autoimmune hemolytic anaemia in childhood. Review and report of one case (author's transl)].

    abstract::Autoimmune hemolytic anaemia (AIHA) in childhood is associated with antibodies produced by the patient himself, which coat his red cells causing their hemolysis. Although in some cases no underlying disease could be found, in the majority of children a virus etiology is apparent. There are very few reports regarding t...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:

    authors: Haas RJ,Pöschl U,Christ M,Schaub J,Belohradsky BH

    更新日期:1977-05-01 00:00:00

  • [Children and Adolescents with Asthma Differ in Lung Function Parameters and Exhaled NO from Children and Adolescents with Obesity].

    abstract:BACKGROUND:The prevalence of asthma and overweight/obesity in children and adolescents is continuously increasing over the last decades. It remains unclear if overweight/obesity raises the risk of developing asthma or if an uncontrolled asthma increases the risk of developing overweight/obesity by restricting physical ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-0042-102254

    authors: Schmauck-Gómez JS,Menrath I,Kaiser MM,Herz A,Kopp MV

    更新日期:2016-07-01 00:00:00

  • [Lysozyme concentrations in the intestinal mucosa in malabsorption syndromes and chronic inflammatory intestinal diseases].

    abstract::Lysozyme levels were determined in the mucosa of gut in 80 children with chronic inflammatory bowel disease, malabsorption and acrodermatitis enteropathica.l Levels of lysozyme in the mucosa of colon were found to be significantly higher in cases with chronic inflammatory bowel disease, whereas in children with malabs...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2007-1025570

    authors: Dick W,Braun OH,Grosse KP,Riemann JF,Schmidt H

    更新日期:1984-01-01 00:00:00

  • [Bacterial cervical lymphadenitis--surgical aspects].

    abstract::In a retrospective study we evaluated clinical features and diagnostic impact of sonography, white blood cell count, C-reactive protein as well as bacterial etiology of children treated surgically for bacterial cervical lymphadenitis. We report on 38 children at the age between 2.5 months and 14 years who were admitte...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2003-41403

    authors: Tröbs RB,Gräfe G,Müller P,Handrick W

    更新日期:2003-07-01 00:00:00

  • Diagnostic and therapeutic considerations on inherited platelet disorders in neonates and children.

    abstract::Inherited disorders of platelets constitute a group of rare diseases that give rise to bleeding syndromes of variety severity, with more severe cases being first diagnosed during infancy and childhood. To appropriate diagnose a platelet function disorder during early childhood the knowledge of the physiological charac...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-0030-1249065

    authors: Schlegel N,Bardet V,Kenet G,Muntean W,Zieger B,Nowak-Göttl U,Working Group on Standardisation in Perinatal and Pediatric Hemostasis.

    更新日期:2010-05-01 00:00:00

  • [Psychosocial intellectual development of children with infantile cystinosis and cerebral atrophy (author's transl)].

    abstract::The psychosocial and intellectual development of 4 boys with nephropathic cystinosis and brain atrophy documented by cranial computerized tomography was investigated by use of biographical data and psychological tests (HAWIK, Deutscher Rechtschreibtest). Inspite of the brain atrophy the patients showed low-normal inte...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:

    authors: Ehrich JH,Wolff G,Stoeppler L,Heyer R,Offner G,Brodehl J

    更新日期:1979-09-01 00:00:00

  • [No motivation, no time, no money--does oncologic graduate and continuing education still have a future? Presentation at the 50th Scientific Session of the Society of Pediatric Oncology and Hematology within the scope of the KOK and PSAPOH general session

    abstract::For many years the nursing profession has been considered a dead-end street without any prospects of career advancement or continued qualification. This situation has thoroughly changed. Nursing as an academic specialty has been established in 24 colleges. Furthermore, on-the-job specialty training has become availabl...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1043896

    authors: Voss H

    更新日期:1998-07-01 00:00:00

  • [Integration of psychosocial services into the management of the child with cancer].

    abstract::The integration of colleagues from psychosocial occupations into the traditional team of doctors and nurses demands a holistic treatment concept, the general desire for interdisciplinary action, and readiness for patience in the process of mutual learning. The acceptance of the psychosocial services by the patient and...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1026726

    authors: Janssen F

    更新日期:1989-07-01 00:00:00