Immunomodulation confers herbicide resistance in plants.

Abstract:

:In order to create a novel mechanism for herbicide resistance in plants, we expressed a single-chain antibody fragment (scFv) in tobacco with specific affinity to the auxinic herbicide picloram. Transgenic tobacco plants and seedlings expressing this scFv against picloram were protected from its effect in a dose-dependent manner. This is the first successful use of an antibody to confer in vivo resistance to a low molecular weight xenobiotic (i.e. < 1000 Da). Our results suggest the possibility for a generic antibody-based approach to create crops resistant to low molecular weight xenobiotics for subsequent use in the bioremediation of contaminated soils, crop protection and as novel selectable markers.

journal_name

Plant Biotechnol J

authors

Almquist KC,Niu Y,McLean MD,Mena FL,Yau KY,Brown K,Brandle JE,Hall JC

doi

10.1111/j.1467-7652.2004.00060.x

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

189-97

issue

3

eissn

1467-7644

issn

1467-7652

pii

PBI060

journal_volume

2

pub_type

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