Inhibitory effects of sulfamic acid on three thiosulfate-oxidizing chemolithotrophs.

Abstract:

:Sulfamate is an analogue of thiosulfate, and the sodium and potassium salts of sulfamic acid inhibited the chemolithoautotrophic growth on thiosulfate of Acidithiobacillus ferrooxidans and Halothiobacillus neapolitanus. The chemo-organotrophic growth of Paracoccus versutus on sucrose was similarly inhibited by sulfamate. Thiosulfate oxidation by suspensions of H. neapolitanus was, however, unaffected by sulfamate, showing that sulfamate did not directly affect thiosulfate uptake, activation or oxidation. Inhibition of P. versutus was not relieved by cysteine and methionine, indicating that sulfate uptake and sulfur amino acid biosynthesis were not directly affected by sulfamate. Sulfamate was not degraded by any of the bacteria, and so could not serve as an alternative to thiosulfate as an energy-yielding substrate. Sulfamate is also an analogue of ammonia and might act like hydrazine by inhibiting ammonium uptake or an essential enzyme activity.

journal_name

FEMS Microbiol Lett

authors

Lusty JR,Hughes MN,Kelly DP

doi

10.1111/j.1574-6968.2006.00437.x

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

70-3

issue

1

eissn

0378-1097

issn

1574-6968

pii

FML437

journal_volume

264

pub_type

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