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Macrophage characteristics of stem cells revealed by transcriptome profiling.

Abstract：

:We previously showed that the phenotypes of adipocyte progenitors and macrophages were close. Using functional analyses and microarray technology, we first tested whether this intriguing relationship was specific to adipocyte progenitors or could be shared with other progenitors. Measurements of phagocytic activity and gene profiling analysis of different progenitor cells revealed that the latter hypothesis should be retained. These results encouraged us to pursue and to confirm our analysis with a gold-standard stem cell population, embryonic stem cells or ESC. The transcriptomic profiles of ESC and macrophages were clustered together, unlike differentiated ESC. In addition, undifferentiated ESC displayed higher phagocytic activity than other progenitors, and they could phagocytoze apoptotic bodies. These data suggest that progenitors and stem cells share some characteristics of macrophages. This opens new perspectives on understanding stem cell phenotype and functionalities such as a putative role of stem cells in tissue remodeling by discarding dead cells but also their immunomodulation or fusion properties.

journal_name

Exp Cell Res

journal_title

Experimental cell research

authors

Charrière GM,Cousin B,Arnaud E,Saillan-Barreau C,André M,Massoudi A,Dani C,Pénicaud L,Casteilla L

doi

10.1016/j.yexcr.2006.06.034

subject

Has Abstract

pub_date

2006-10-15 00:00:00

pages

3205-14

issue

17

eissn

0014-4827

issn

1090-2422

pii

S0014-4827(06)00214-X

journal_volume

312

pub_type

杂志文章

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