Abstract:
:Synaptic transmission relies on an exquisitely orchestrated series of protein-protein interactions. Here we show that fusion driven by neuronal SNAREs is inhibited by the regulatory protein complexin. Furthermore, inner-leaflet mixing is strongly impaired relative to total lipid mixing, indicating that inhibition by complexin arrests fusion at hemifusion. When the calcium sensor synaptotagmin is added in the presence of calcium, inhibition by complexin is relieved and full fusion rapidly proceeds.
journal_name
Nat Struct Mol Bioljournal_title
Nature structural & molecular biologyauthors
Schaub JR,Lu X,Doneske B,Shin YK,McNew JAdoi
10.1038/nsmb1124subject
Has Abstractpub_date
2006-08-01 00:00:00pages
748-50issue
8eissn
1545-9993issn
1545-9985pii
nsmb1124journal_volume
13pub_type
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