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Developmental programming of CpG island methylation profiles in the human genome.

Abstract：

:CpG island-like sequences are commonly thought to provide the sole signals for designating constitutively unmethylated regions in the genome, thus generating open chromatin domains within a sea of global repression. Using a new database obtained from comprehensive microarray analysis, we show that unmethylated regions (UMRs) seem to be formed during early embryogenesis, not as a result of CpG-ness, but rather through the recognition of specific sequence motifs closely associated with transcription start sites. This same system probably brings about the resetting of pluripotency genes during somatic cell reprogramming. The data also reveal a new class of nonpromoter UMRs that become de novo methylated in a tissue-specific manner during development, and this process may be involved in gene regulation. In short, we show that UMRs are an important aspect of genome structure that have a dynamic role in development.

journal_name

Nat Struct Mol Biol

journal_title

Nature structural & molecular biology

authors

Straussman R,Nejman D,Roberts D,Steinfeld I,Blum B,Benvenisty N,Simon I,Yakhini Z,Cedar H

doi

10.1038/nsmb.1594

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

564-71

issue

5

eissn

1545-9993

issn

1545-9985

pii

nsmb.1594

journal_volume

16

pub_type

杂志文章

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