A role for both RB and p53 in the regulation of human cellular senescence.


:We present evidence for the possible involvement of both the RB and p53 proteins in the regulation of cellular senescence. Human fibroblasts immortalized with an inducible SV40 T-antigen become senescent following the de-induction of T-antigen. Plasmids expressing an alternative source of intact T-antigen restore proliferation but T-antigen deletion mutants lacking either the RB or p53 binding domains are unable to do so. Similarly, combinations of adenovirus E1A + E1B or human papillomavirus E6 + E7 genes are able to replace T-antigen functions and permit cell proliferation, whereas the individual genes do not. These results are discussed in terms of a two-stage model for the escape from in vitro cellular senescence.


Exp Cell Res


Shay JW,Pereira-Smith OM,Wright WE





Has Abstract


1991-09-01 00:00:00














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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Takeuchi K,Tsuji T,Hakomori S,Irimura T

    更新日期:1994-03-01 00:00:00

  • Glorin-regulated protein synthesis in Polyspondylium violaceum.

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    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Kopachik W

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    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Leprat P,Ratinaud MH,Maftah A,Petit JM,Julien R

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    journal_title:Experimental cell research

    pub_type: 杂志文章,评审


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章,评审


    authors: Nicolson GL

    更新日期:1993-02-01 00:00:00

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    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Hong SK,Jeong JH,Chan AM,Park JI

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    authors: DeJesus V,Rios I,Davis C,Chen Y,Calhoun D,Zakeri Z,Hubbard K

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    journal_title:Experimental cell research

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Wang G,Li Y,Wang XY,Han Z,Chuai M,Wang LJ,Ho Lee KK,Geng JG,Yang X

    更新日期:2013-05-01 00:00:00

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    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: van Velzen AG,Suzuki H,Kodama T,van Berkel TJ

    更新日期:1999-07-10 00:00:00