MiR-93-5p inhibits the EMT of breast cancer cells via targeting MKL-1 and STAT3.

abstract：:Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase that plays a key role in cellular processes such as cell adhesion, migration, proliferation and survival. Recent studies have also implicated FAK in the regulation of cell-cell adhesion. Here, evidence is presented showing that siRNA-mediated suppression of...

journal_title：Experimental cell research

authors： Playford MP,Vadali K,Cai X,Burridge K,Schaller MD

更新日期：2008-10-15 00:00:00

abstract：:Cells undergoing apoptosis are recognized and rapidly phagocytosed by macrophages before their degradation, thus preventing the inflammatory reaction and protecting tissues from the damaging effects of released potentially harmful intracellular contents. In spite of growing interest in the mechanisms leading to the en...

journal_title：Experimental cell research

authors： Falasca L,Bergamini A,Serafino A,Balabaud C,Dini L

更新日期：1996-04-10 00:00:00

abstract：:Bone morphogenetic protein-4 (BMP-4) is a member of the transforming growth factor-beta (TGF-beta) supergene family and is characterized by its ability to induce singly de novo cartilage and bone in vivo. The influence of recombinant bone morphogenetic protein-4 and some related members, TGF-beta 1, activin A, and inh...

journal_title：Experimental cell research

authors： Luyten FP,Chen P,Paralkar V,Reddi AH

更新日期：1994-02-01 00:00:00

abstract：:The technique of fiber DNA measurement was used to study the possibility that the lengthening of the DNA "S" phase previously reported for mouse premeiotic spermatogonia was due to a reduced number of initiation sites. The mean replicon size of neonatal mouse preleptotene cells was similar to sizes reported for adult ...

journal_title：Experimental cell research

authors： Jagiello G,Sung WK,Van't Hof J

更新日期：1983-07-01 00:00:00

abstract：:In many eukaryotic organisms, initiation of DNA synthesis is associated with a major control point within the cell cycle and reflects the commitment of the cell to the DNA replication-division portion of the cell cycle. In Paramecium, the timing of DNA synthesis initiation is established prior to fission during the pr...

journal_title：Experimental cell research

authors： Ching AS,Berger JD

更新日期：1986-11-01 00:00:00

abstract：:The results of Phase I/II clinical trials indicate that ricin A-chain-containing immunotoxins cause vascular leak syndrome, characterized by hypoalbuminemia with resultant weight gain and edema. Vascular leak syndrome may be a dose-limiting factor during treatment with ricin A-chain-containing immunotoxins. In this re...

journal_title：Experimental cell research

authors： Soler-Rodríguez AM,Ghetie MA,Oppenheimer-Marks N,Uhr JW,Vitetta ES

更新日期：1993-06-01 00:00:00

abstract：:We examined the relationship of cellular oncogene c-myc and transferrin receptor (TfR) gene expression to cell proliferation and cell cycle progression during myeloid differentiation in the HL-60 myeloid leukemia cell line. In order to determine levels of mRNA for these genes in HL-60 cells induced to differentiate al...

journal_title：Experimental cell research

authors： Barker KA,Newburger PE

更新日期：1990-01-01 00:00:00

abstract：:The highest activity of poly(ADP-ribose) synthetase was found in the testis among several rat tissues tested. Subcellular fractionation of the testis demonstrated that the synthetase was localized primarily in the nucleus and partially in the microsomal-ribosomal fraction. This result was confirmed by immunocytochemic...

journal_title：Experimental cell research

authors： Concha II,Figueroa J,Concha MI,Ueda K,Burzio LO

更新日期：1989-02-01 00:00:00

abstract：:For cancer metastasis, tumor cells present in the circulation must first adhere to the endothelium. Integrins play a central role in leukocyte adhesion to the endothelium and subsequent migration into tissues. The majority of tumor cells derived from solid cancers, including breast cancer, do not express integrins. We...

journal_title：Experimental cell research

authors： Mine S,Fujisaki T,Kawahara C,Tabata T,Iida T,Yasuda M,Yoneda T,Tanaka Y

更新日期：2003-08-01 00:00:00

abstract：:Contraction of 3D collagen matrices by fibroblasts frequently is used as an in vitro model of wound closure. Different iterations of the model - all conventionally referred to as "contraction" - involve different morphological patterns. During floating matrix contraction, cells initially are round without stress fiber...

journal_title：Experimental cell research

authors： Liu Z,Ho CH,Grinnell F

更新日期：2014-08-15 00:00:00

abstract：:Hepatocytes from adult rats were cultured on poly-HEMA-coated surface to form spheroids in hormonally defined media as previously shown with newborn rat hepatocytes. Spheroidal aggregates of adult rat hepatocytes were morphologically similar to those of newborn rat hepatocytes and could also form a monolayer of unifor...

journal_title：Experimental cell research

authors： Tong JZ,De Lagausie P,Furlan V,Cresteil T,Bernard O,Alvarez F

更新日期：1992-06-01 00:00:00

abstract：:Nucleotide sugar transporters play a central role in the process of glycosylation. They are responsible for the translocation of nucleotide sugars from the cytosol, their site of synthesis, into the Golgi apparatus where the activated sugars serve as substrates for a variety of glycosyltransferases. We and others have...

journal_title：Experimental cell research

authors： Lühn K,Laskowska A,Pielage J,Klämbt C,Ipe U,Vestweber D,Wild MK

更新日期：2004-12-10 00:00:00

abstract：:Multipotent human bone marrow stromal cells (hBMSCs) are the common progenitors of osteoblasts and adipocytes. A shift in hBMSC differentiation in favor of adipogenesis may contribute to the bone loss and marrow fat accumulation observed in aging and osteoporosis. Hence, the identification of factors modulating marrow...

journal_title：Experimental cell research

authors： Le Blanc S,Simann M,Jakob F,Schütze N,Schilling T

更新日期：2015-11-01 00:00:00

abstract：:It has been suggested that DNA organized into replication foci during S-phase remains stably aggregated in non-S-phase cells and that these stable aggregates provide fundamental units of nuclear or chromosome architecture [C. Meng and R. Berezney (1991) J. Cell Biol. 115, 95a; E. Sparvoli et al. (1994) J. Cell Sci. 10...

journal_title：Experimental cell research

authors： Zink D,Bornfleth H,Visser A,Cremer C,Cremer T

更新日期：1999-02-25 00:00:00

abstract：:Cancer cell survival is frequently dependent on the elevated levels of members of the Bcl-2 family of prosurvival proteins that bind to and inactivate BH3-domain pro-apoptotic cellular proteins. Small molecules that inhibit the protein-protein interactions between prosurvival and proapoptotic Bcl-2 family members (so-...

journal_title：Experimental cell research

authors： Modugno M,Banfi P,Gasparri F,Borzilleri R,Carter P,Cornelius L,Gottardis M,Lee V,Mapelli C,Naglich JG,Tebben A,Vite G,Pastori W,Albanese C,Corti E,Ballinari D,Galvani A

更新日期：2015-03-15 00:00:00

abstract：:NRK rat cells infected with a transformation-defective, temperature-sensitive (ts) mutant of the avian sarcoma virus could not proliferate in Ca2+-deficient medium at a nonpermissive temperature (40 degrees C) that inactivated the viral pp60v-src-transforming product and rendered the cells phenotypically untransformed...

journal_title：Experimental cell research

authors： Durkin JP,Whitfield JF

更新日期：1985-04-01 00:00:00

abstract：:We have studied the morphological alterations of the lysosomal compartment in rat hepatocytes following intraperitoneal administration of leupeptin, using electron microscopy and cytochemical techniques. At 30 min after the injection, autophagic vacuoles (autophagosomes and autolysosomes), containing cytoplasmic organ...

journal_title：Experimental cell research

authors： Ishikawa T,Furuno K,Kato K

更新日期：1983-03-01 00:00:00

abstract：:Endocytosis is inhibited by overexpression of either dynamin-1 or dynamin-2 mutants because both isoforms form heterotetramers with endogenous dynamin-2 and interfere with its function. By contrast, other phenotypes, which are specifically triggered by overexpression of dynamin-2, but not dynamin-1 are likely to refle...

journal_title：Experimental cell research

authors： Soulet F,Schmid SL,Damke H

更新日期：2006-11-01 00:00:00

abstract：:Olfactory ensheathing cells (OECs) are a type of glial cells with morphological plasticity in the olfactory system. Cultured OECs display the process-bearing and flattened shape. Our previous studies have shown that the frontal application of Slit-2 gradient induced the collapse of leading front, and reversed the soma...

journal_title：Experimental cell research

authors： Wang Y,Huang ZH

更新日期：2012-09-10 00:00:00

abstract：:Lithium exerts neuroprotective actions that involve the inhibition of glycogen synthase kinase-3beta (GSK-3beta). Otherwise, recent studies suggest that sustained GSK-3beta inhibition is a hallmark of tumorigenesis. In this context, the present study was undertaken to examine whether lithium modulated cancer cell sens...

journal_title：Experimental cell research

authors： Beurel E,Kornprobst M,Blivet-Van Eggelpoël MJ,Ruiz-Ruiz C,Cadoret A,Capeau J,Desbois-Mouthon C

更新日期：2004-11-01 00:00:00

abstract：:Oncogenic EGFRvIII is a naturally occurring oncoprotein and is expressed in about 40-50% of human glioblastomas, particularly those that arise de novo. To understand the molecular mechanisms by which this oncoprotein alters transforming phenotypes, and since our previous work indicated that SHP-2 protein tyrosine phos...

journal_title：Experimental cell research

authors： Zhan Y,Counelis GJ,O'Rourke DM

更新日期：2009-08-15 00:00:00

abstract：:Accumulating evidence indicates that elevated S100P promotes the pathogenesis of cancers, including colon cancer. S100P exerts its effects by binding to and activating the Receptor for Advance Glycation End-products (RAGE). The effects of up-regulated S100P/RAGE signaling on cell functions are well documented. Despite...

journal_title：Experimental cell research

authors： Onyeagucha BC,Mercado-Pimentel ME,Hutchison J,Flemington EK,Nelson MA

更新日期：2013-08-01 00:00:00

abstract：:Progressive pathophysiologic modifications of endothelial cells are associated with aging. In vitro, endothelial cell senescence is accompanied by the failure to proliferate as well as by perturbations in gene expression. Here we show that (i) senescence enhances monoblastoid U937 cell adhesion to the endothelial mono...

journal_title：Experimental cell research

authors： Maier JA,Statuto M,Ragnotti G

更新日期：1993-09-01 00:00:00

abstract：:With multiple divisions in culture, normal diploid cells suffer a loss of growth potential that leads to replicative senescence and a finite replicative capacity. Using quantitative RT-PCR, we have monitored mRNA expression levels of c-fos, c-jun, JunB, c-myc, p53, H-ras, and histone H4 during the replicative senescen...

journal_title：Experimental cell research

authors： Irving J,Feng J,Wistrom C,Pikaart M,Villeponteau B

更新日期：1992-09-01 00:00:00

abstract：:Cytokeratin 19 (CK19) is widely used as a biomarker for the detection of disseminated tumor cells in blood and bone marrow, and its positivity is considered as an independent prognostication indicator in cancer patients. However, its role in breast cancer progression remains unknown. We had established a stable CK19-e...

journal_title：Experimental cell research

authors： Bambang IF,Lu D,Li H,Chiu LL,Lau QC,Koay E,Zhang D

更新日期：2009-07-01 00:00:00

abstract：:After epithelial disruption by tissue injury, keratinocytes migrate from the wound edge into a provisional matrix. This process is stimulated by growth factors that signal through epidermal growth factor (EGF) receptor, including EGF, heparin-binding EGF-like growth factor (HB-EGF) and transforming growth factor-alpha...

journal_title：Experimental cell research

authors： Koivisto L,Jiang G,Häkkinen L,Chan B,Larjava H

更新日期：2006-09-10 00:00:00

abstract：:When micromeres isolated from the 16-cell stage of Strongylocentrotus purpuratus are cultured in sea water containing 3.5% horse serum, they produce spicules at approximately the same time as in normal development. The serum requirement of the micromeres has been investigated by adding serum at varying intervals after...

journal_title：Experimental cell research

authors： McCarthy RA,Spiegel M

更新日期：1983-12-01 00:00:00

abstract：:The sodium-coupled bicarbonate cotransporter 1 (NBCe1) plays an essential role in the maintenance of acid-base homeostasis in the human body. However, little research has been done regarding the modification of NBCe1. Nedd4-2 is one of the most important ubiquitin E3 ligases in the kidney where it is responsible for m...

journal_title：Experimental cell research

authors： Tu J,Zhang B,Fang G,Chang W,Zhao Y

更新日期：2020-05-15 00:00:00

abstract：:Increased protein aggregation and altered cell signaling accompany many neurodegenerative diseases including Huntington's disease (HD). Cell stress is counterbalanced by signals mediating cell repair but the identity of these are not fully understood. We show here that the mammalian target of rapamycin (mTOR) pathway ...

journal_title：Experimental cell research

authors： Hyrskyluoto A,Reijonen S,Kivinen J,Lindholm D,Korhonen L

更新日期：2012-01-01 00:00:00

abstract：:Prior studies have shown that synthetic peptides representing the domain of thrombin responsible for high-affinity binding to fibroblasts stimulate chemotactic and cell proliferative signals through a nonproteolytic mechanism. One of these peptides, TP508, has recently been shown to be chemotactic for neutrophils, to ...

journal_title：Experimental cell research

authors： Sower LE,Payne DA,Meyers R,Carney DH

更新日期：1999-03-15 00:00:00