Single-molecule detection and probe strategies for rapid and ultrasensitive genomic detection.

abstract：BACKGROUND:In this study, local sustainable enzyme sources involving excised digestive juice of African land snail and yeast were utilized to achieve the simultaneous saccharification (SSF) and fermentation (SSF) of plantain pseudostem (PPS) waste, and afterwards their effects on terpenoids using gas chromatography cou...

journal_title：Current pharmaceutical biotechnology

authors： Uchenna AP,Charity ON,Abbey B

更新日期：2019-01-01 00:00:00

abstract：:Tryparedoxin peroxidase (TryP) is a key enzyme of the trypanothione-dependent metabolism for removal of oxidative stress in leishmania. These enzymes function as antioxidants through their peroxidase and peroxynitrite reductase activities. Inhibitors of this enzyme are presumed to be antilesihmania drugs and structura...

journal_title：Current pharmaceutical biotechnology

authors： Singh BK,Dubey VK

更新日期：2009-09-01 00:00:00

abstract：:The aim of the present article was to review the role of the placenta function in the transfer of immunosuppressants and monoclonal antibodies used for the treatment of inflammatory bowel disease, as well as the available data regarding the safety of these therapies during pregnancy. Methotrexate can cause congenital ...

journal_title：Current pharmaceutical biotechnology

authors： Chaparro M,Gisbert JP

更新日期：2011-05-01 00:00:00

abstract：:In many signaling pathways, various factors have been isolated by molecular genetic studies and wholegenome analysis. Understanding the interactions among these factors is crucial to understanding the signaling process as a whole. Recent studies on auxin signaling in the regulation of plant growth and development have...

journal_title：Current pharmaceutical biotechnology

authors： Muto H,Kinjo M

更新日期：2012-11-01 00:00:00

abstract：:We aim to determine the regulation of apoptosis by paclitaxel-induced and understand cancer dynamics to treatment targets for HeLa cells by identifying decrease/increase genes expression on HeLa cells. In this study, the anti-tumor effects of Paclitaxel (PAC) on HeLa cells have been studied in order to determine the c...

journal_title：Current pharmaceutical biotechnology

authors： Serbes U,Ozsoylemez OD,Ozcan G

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis (RA) is a common connective tissue disease, characteristic of chronic and invasive synovitis in single or multiple joints and vasculitis. RA is a heterogeneous disease with unclear pathogenesis. Therefore, exploring the etiology and pathogenesis of the disease is essential for identifyin...

journal_title：Current pharmaceutical biotechnology

authors： Liu J,Wang X,Wang S,Liu F

更新日期：2020-10-01 00:00:00

abstract：AIMS:Globally Scientists are working to find more efficient antimicrobial drugs to treat microbial infections and kill drug-resistant bacteria. BACKGROUND:Despite the availability of numerous antimicrobial drugs bacterial infections still poses a serious threat to global health. Due to a constant decline in the effect...

journal_title：Current pharmaceutical biotechnology

authors： Khan K,Qureshi MA,Azam A,Moinuddin,Musarrat J,Javed S

更新日期：2021-01-18 00:00:00

abstract：:The triterpenes α- and β-amyrins display important pharmacological activities. As a result of their high hydrophobia, they present low water solubility and reflect poor oral bioavailability. Different techniques can be used for the improvement of amyrins solubility, one of them is the use of nanoemulsions. Therefore, ...

journal_title：Current pharmaceutical biotechnology

authors： Rodrigues IV,Seibert JB,Carneiro SP,de Souza GH,dos Santos OD,Lopes NP

更新日期：2013-01-01 00:00:00

abstract：:Data obtained through high-throughput technologies have gradually revealed that a unique stratified epithelial architecture of human skin along with the antioxidant-response pathways provided vital defensive mechanisms against UV radiation. However, it is noteworthy that skin is a major target for toxic insult by UV r...

journal_title：Current pharmaceutical biotechnology

authors： Farooqi AA,Li RN,Huang HW,Ismail M,Yuan SS,Wang HM,Liu JR,Tang JY,Chang HW

更新日期：2015-01-01 00:00:00

abstract：:Assessment of immunogenicity is a major aspect in evaluating the safety of biological therapeutic proteins. It is important to evaluate the immunogenic potential of the biologics in an appropriate fashion using clearly defined strategy and clinical trials. The studies must include the appropriate risk assessment proce...

journal_title：Current pharmaceutical biotechnology

authors： Kaliyaperumal A,Jing S

更新日期：2009-06-01 00:00:00

abstract：:Unlike any other cell type, T cells have a unique potential to eliminate cancer cells and to eventually cure cancer patients. As a result, researchers have made extensive efforts over the past three decades to develop therapeutics with the potential to mount T cell responses against cancer cells. One way in which such...

journal_title：Current pharmaceutical biotechnology

authors： Baeuerle PA,Itin C

更新日期：2012-06-01 00:00:00

abstract：:In this review, the compartments of the vasculature will be discussed with respect to their potential contribution to the build-up of a differentiated and functionally meaningful vessel system. Chronic ischemia of muscle tissue results in microvessel rarification, which represents a potential therapeutic target, given...

journal_title：Current pharmaceutical biotechnology

authors： Kupatt C

更新日期：2007-02-01 00:00:00

abstract：:With eleven therapeutic antibodies approved worldwide and many more in clinical trials, research on antibody engineering has continued to escalate and expand. This review covers recent progress in generation of antibodies by ex vivo methods, systems for screening these, and the quest for higher affinity, more stable, ...

journal_title：Current pharmaceutical biotechnology

authors： Presta LG

更新日期：2002-09-01 00:00:00

abstract：:Calendula officinalis of family Asteraceae, also known as marigold, has been widely used from time immemorial in Indian and Arabic cultures as an anti-inflammatory agent to treat minor skin wound and infections, burns, bee stings, sunburn and cancer. At a relatively high dose, calendula can lower blood pressure and ch...

journal_title：Current pharmaceutical biotechnology

authors： Ray D,Mukherjee S,Falchi M,Bertelli A,Das DK

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Tamarix Articulata (T. articulata), commonly known as Tamarisk or Athal in Arabic region, belongs to the Tamaricaece species. It is an important halophytic medicinal plant and a good source of polyphenolic phytochemical(s). In traditional medicines, T. articulata extract is commonly used, either singly or in...

journal_title：Current pharmaceutical biotechnology

authors： Alnuqaydan AM,Rah B

更新日期：2019-01-01 00:00:00

abstract：:The number of diseases found to be associated with defects of the mitochondrial genome has grown significantly over the last decade. Despite major advances in understanding mtDNA defects at the genetic and biochemical level, there is no satisfactory treatment for the vast majority of patients available. This is largel...

journal_title：Current pharmaceutical biotechnology

authors： Weissig V,Torchilin VP

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Active principles from natural sources, in the form of extracts and natural compounds, provide an infinite number of bioactive compounds with consummate disposal of chemical diversity. These compounds and active principles are of utmost importance in the discovery of drugs of biological origin particularly, ...

journal_title：Current pharmaceutical biotechnology

authors： Das G,Patra JK,Kang SS,Shin HS

更新日期：2021-01-22 00:00:00

abstract：:Wound healing is a complex process that consists of several phases that range from coagulation, inflammation, accumulation of radical substances, to proliferation, formation of fibrous tissues and collagen, contraction of wound with formation of granulation tissue and scar. Since antiquity, vegetable substances have b...

journal_title：Current pharmaceutical biotechnology

authors： Tejada S,Manayi A,Daglia M,Nabavi SF,Sureda A,Hajheydari Z,Gortzi O,Pazoki-Toroudi H,Nabavi SM

更新日期：2016-07-21 00:00:00

abstract：:Discovery of disease specific biomarkers in human body fluids has become an important challenge in clinical proteomics. Facing the increasing threat of degenerative and disabling diseases like cancer, cardiovascular, neurological and inflammatory diseases in large parts of the world's population, there is an urgent ne...

journal_title：Current pharmaceutical biotechnology

authors： Berven FS,Flikka K,Berle M,Vedeler C,Ulvik RJ

更新日期：2006-06-01 00:00:00

abstract：:Tissue engineering is a rapidly developing field applying the disciplines of cell biology, developmental biology, molecular biology and biomimetic engineering to regenerate new tissues for replacement therapies in clinical contexts. To aid in the elicitation and reiteration of the processes of morphogenesis of tissues...

journal_title：Current pharmaceutical biotechnology

authors： Ripamonti U,Tasker JR

更新日期：2000-07-01 00:00:00

abstract：PURPOSE:Previous studies in humans concluded that a multigenic model including specific FSHR, ESR1 and ESR2 genotype patterns may partially explain the poor response to FSH. The aim of our study is to analyse three different loci -polymorphisms in ESR1 Pvu II, ESR2 Rsa I and Ser680Asn FSH receptor gene- in a Greek popu...

journal_title：Current pharmaceutical biotechnology

authors： Anagnostou E,Mavrogianni D,Theofanakis C,Drakakis P,Bletsa R,Demirol A,Gurgan T,Antsaklis A,Loutradis D

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:With the improvements in living standards, height is getting more attention. Malnutrition is one of the main causes of children's short stature, therefore nutritional intervention in adolescence is the key to prevent short stature. The peptides from Antarctic krill (AKPs), the ideal protein model, act in bon...

journal_title：Current pharmaceutical biotechnology

authors： Dai Y,Li Z,Fu M,Li Y,Xue C,Wang J

更新日期：2020-06-12 00:00:00

abstract：BACKGROUND:Diabetes mellitus is the most common disease in Egypt. In this context, Beta vulgaris subspecies cicla L. var. flavescens is an edible plant that has been used in traditional medicine as a therapy for treating some diseases. OBJECTIVES:The current study was performed to evaluate the antibacterial and potent...

journal_title：Current pharmaceutical biotechnology

authors： Mohammed HS,Abdel-Aziz MM,Abu-Baker MS,Saad AM,Mohamed MA,Ghareeb MA

更新日期：2019-01-01 00:00:00

abstract：:Understanding and consequently treating neuropathic pain effectively is a challenge for modern medicine, as unlike inflammation, which can be controlled relatively well, chronic pain due to nerve injury is refractory to most current therapeutics. Here we define a target pathway for a new class of analgesics, tetrahydr...

journal_title：Current pharmaceutical biotechnology

authors： Latremoliere A,Costigan M

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Three clones of Cabernet Franc (Nos. 02, 010 and 012) were selected in the last phase of clonal selection in Serbia. Wines made from each clone were assessed for quality parameters and taste during five consecutive vintages (2008-2012) and compared to the standard. The wine quality was determined based on th...

journal_title：Current pharmaceutical biotechnology

authors： Popovic-Djordjevic J,Pejin B,Dramicanin A,Jovic S,Vujovic D,Zunic D,Ristic R

更新日期：2017-01-01 00:00:00

abstract：:Mammalian cells are involved in a range of biotechnological applications and more recently have been increasingly exploited in regenerative medicine. Critical to successful applications involving mammalian cells are their long-term storage and transport, for which cryopreservation in liquid nitrogen is the most freque...

journal_title：Current pharmaceutical biotechnology

authors： Chau DY,Dennis AR,Lin H,Zeitler JA,Tunnacliffe A

更新日期：2015-01-01 00:00:00

abstract：:In order to valorize novel biotechnology innovations, there is a need to evaluate ex-ante their market potential. A case in point is biofortification, i.e. the enhancement of the micronutrient content of staple crops through conventional or genetic breeding techniques. In a recent article in Nature Biotechnology, for ...

journal_title：Current pharmaceutical biotechnology

authors： De Steur H,Blancquaert D,Gellynck X,Lambert W,Van Der Straeten D

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:The goals of this study were to observe how luteolin protects endothelial cells (ECs) from injury stimulated by Angiotensin II (Ang II), investigate the role of vascular endothelial dysfunction in vascular smooth muscle cell proliferation and migration in vitro and investigate its primary mechanism of action....

journal_title：Current pharmaceutical biotechnology

authors： Ding H,Li D,Zhang Y,Zhang T,Zhu H,Xu T,Luo Y,Wang C

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:The work was performed to investigate the feasibility of preparing ocular inserts loaded with Poly-ε-Caprolactone (PCL) nanoparticles as a sustained ocular delivery system. METHODS:First, Atorvastatin Calcium-Poly-ε-Caprolactone (ATC-PCL) nanoparticles were prepared and characterized. Then, the optimized nanop...

journal_title：Current pharmaceutical biotechnology

authors： Girgis GNS

更新日期：2020-01-01 00:00:00

abstract：AIMS:Candida species is the common cause of opportunistic fungal infections all over the world with increased mortality and morbidity especially in immunosuppressed patients. Fluconazole is the first line therapy for candidiasis. The antifungal resistance pattern in high-risk patients is a major concern. The present st...

journal_title：Current pharmaceutical biotechnology

authors： Paul S,Mohanram K,Kannan I

更新日期：2018-01-01 00:00:00