Proteomic-based biomarker discovery with emphasis on cerebrospinal fluid and multiple sclerosis.

abstract：:As sessile and filter-feeding metazoans, marine sponges represent an ecologically important and highly diverse component of marine benthic communities throughout the world. It has been suggested that marine sponges are hosts to many microorganisms which can constitute up to 40-60% of its biomass. Recently, sponges hav...

journal_title：Current pharmaceutical biotechnology

authors： Santos-Gandelman JF,Giambiagi-deMarval M,Oelemann WM,Laport MS

更新日期：2014-01-01 00:00:00

abstract：:The number of diseases found to be associated with defects of the mitochondrial genome has grown significantly over the last decade. Despite major advances in understanding mtDNA defects at the genetic and biochemical level, there is no satisfactory treatment for the vast majority of patients available. This is largel...

journal_title：Current pharmaceutical biotechnology

authors： Weissig V,Torchilin VP

更新日期：2000-12-01 00:00:00

abstract：:It is now widely believed that tumors originate from normal cells as a result of accumulated genetic/epigenetic changes. These alterations affect the signaling pathways at transcriptional and post-transcriptional level that drive cells into uncontrolled cell division, growth, and migration. Recent advancement of molec...

journal_title：Current pharmaceutical biotechnology

authors： Yamashita T,Honda M,Kaneko S

更新日期：2008-10-01 00:00:00

abstract：:Gene therapy is a potential treatment for severe inherited disorders for which there is little hope of finding a conventional cure. These include lethal diseases like immunodeficiencies and metabolic disorders, and non lethal conditions associated to poor quality of life and life-long symptomatic treatments, like musc...

journal_title：Current pharmaceutical biotechnology

authors： Cavazza A,Mavilio F

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Recently, spinel structures (AB2O4) nanoparticles (NPs) having binary and ternary mixtures of metal oxides were established as promising redox catalysts. Due to the presence of two mixed valence metal cations transport of electrons takes place easily between multiple transition-metal cations with relatively ...

journal_title：Current pharmaceutical biotechnology

authors： Patel AR,Sereda G,Banerjee S

更新日期：2020-11-17 00:00:00

abstract：:The low sensitivity is the major disadvantage of MRI as compared to PET. Therefore, amplification strategies are necessary for specific pathway labeling. This survey is aimed at exploring different routes to the entrapment of Gd(III) chelates in various type of cells at amounts sufficiently large to allow MRI visualiz...

journal_title：Current pharmaceutical biotechnology

authors： Aime S,Barge A,Cabella C,Crich SG,Gianolio E

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Biologic drugs, introduced in clinical practice almost twenty years ago, represent nowadays a prominent treatment option in patients with chronic inflammatory arthritis, such as Rheumatoid Arthritis, Psoriatic Arthritis and Spondyloarthritis, that include ankylosing spondylitis and non-radiographic axial spo...

journal_title：Current pharmaceutical biotechnology

authors： Luchetti MM,Benfaremo D,Gabrielli A

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Burn is still an important global public health challenge. Wound colonization of antibiotic resistant bacteria such as Acinetobacter baumannii can lead to high morbidity and mortality in burn patients. The aim of this study was to evaluate the inhibitory effect of tazobactam on efflux pump, which can cause a...

journal_title：Current pharmaceutical biotechnology

authors： Azimi L,Tahbaz SV,Alaghehbandan R,Alinejad F,Lari AR

更新日期：2020-01-01 00:00:00

abstract：:The blood-brain barrier (BBB), which impedes drug penetration into the central nervous system, is composed of specific structures formed by brain capillary endothelial cells and sheathed by astrocytic end-feet through basement membrane. Many brain drug delivery strategies have focused on adsorptive-mediated transcytos...

journal_title：Current pharmaceutical biotechnology

authors： Lu W

更新日期：2012-09-01 00:00:00

abstract：:In order to valorize novel biotechnology innovations, there is a need to evaluate ex-ante their market potential. A case in point is biofortification, i.e. the enhancement of the micronutrient content of staple crops through conventional or genetic breeding techniques. In a recent article in Nature Biotechnology, for ...

journal_title：Current pharmaceutical biotechnology

authors： De Steur H,Blancquaert D,Gellynck X,Lambert W,Van Der Straeten D

更新日期：2012-12-01 00:00:00

abstract：:Calcium-sensing receptor (CaSR), a member of family C of the G protein-coupled receptors, is expressed most abundantly in the parathyroid glands and kidney. It plays key role in these two organs because it senses changes in extracellular calcium and regulates PTH secretion and calcium reabsorption to suit the extracel...

journal_title：Current pharmaceutical biotechnology

authors： Vezzoli G,Soldati L,Gambaro G

更新日期：2009-04-01 00:00:00

abstract：:After a tooth extraction both hard and soft tissues undergo dimensional changes. The use of a ridge preservation technique at the moment of the tooth extraction could help could help to prevent the volume loss, thus simplifying the subsequent prosthetic and/or implant therapy. Some studies were conducted in order to e...

journal_title：Current pharmaceutical biotechnology

authors： Alfonsi F,Borgia V,Iezzi G,Piattelli A,Covani U,Tonelli P,Barone A

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:We sought to evaluate the safety of imipenem and meropenem in the treatment of infections in neurosurgical patients. METHODS:An observational retrospective study was conducted of consecutive cases treated with imipenem from Sept. 2007 to Sept. 2009 and meropenem within 1 year from Sept. 2008 in Beijing Tiant...

journal_title：Current pharmaceutical biotechnology

authors： Wu Y,Chen K,Shi Z,Wang Q

更新日期：2014-01-01 00:00:00

abstract：:Proliposomes are phospholipid based drug delivery systems that are finding important applications in the field of pharmaceutics. Proliposomes have been extensively studied as a potential carrier for oral delivery of drugs with poor bioavailability, but the mechanism of absorption and cellular uptake pathways has not y...

journal_title：Current pharmaceutical biotechnology

authors： Nekkanti V,Venkatesan N,Betageri GV

更新日期：2015-01-01 00:00:00

abstract：:Blood Brain Barrier (BBB) is the collection of vessels of blood with special properties of permeability that allow a limited range of drug and compounds to pass through it. The BBB plays a vital role in maintaining balance between intracellular and extracellular environment for brain. Brain Capillary Endothelial Cells...

journal_title：Current pharmaceutical biotechnology

authors： Saxena D,Sharma A,Siddiqui MH,Kumar R

更新日期：2019-01-01 00:00:00

abstract：:Intra-uterine growth retardation (IUGR) represents one of the major problems in perinatal medicine. IUGR is one of main causes of perinatal mortality and morbidity. A huge number and variety of established and possible causes of IUGR have been described. There are currently no data about effective treatment of this fe...

journal_title：Current pharmaceutical biotechnology

authors： Mierzynski R,Dluski D,Darmochwal-Kolarz D,Poniedziałek-Czajkowska E,Leszczynska-Gorzelak B,Kimber-Trojnar Z,Agnieszka-Wankowicz,Oleszczuk J

更新日期：2016-01-01 00:00:00

abstract：:Excessive cell proliferation contributes to the pathobiology of human diseases with a high health and socio-economic impact, including cancer and vascular occlusive diseases (e. g., atherosclerosis, in-stent restenosis, transplant vasculopathy, and vessel bypass graft failure). Recent advances in the understanding of ...

journal_title：Current pharmaceutical biotechnology

authors： Ivorra C,Samyn H,Edo MD,Castro C,Sanz-González SM,Déez-Juan A,Andrés V

更新日期：2003-02-01 00:00:00

abstract：:Understanding and consequently treating neuropathic pain effectively is a challenge for modern medicine, as unlike inflammation, which can be controlled relatively well, chronic pain due to nerve injury is refractory to most current therapeutics. Here we define a target pathway for a new class of analgesics, tetrahydr...

journal_title：Current pharmaceutical biotechnology

authors： Latremoliere A,Costigan M

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus is the most common disease in Egypt. In this context, Beta vulgaris subspecies cicla L. var. flavescens is an edible plant that has been used in traditional medicine as a therapy for treating some diseases. OBJECTIVES:The current study was performed to evaluate the antibacterial and potent...

journal_title：Current pharmaceutical biotechnology

authors： Mohammed HS,Abdel-Aziz MM,Abu-Baker MS,Saad AM,Mohamed MA,Ghareeb MA

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:Advanced gastrointestinal stromal tumours (GISTs) are treated with tyrosine kinase inhibitors, which also have antiangiogenic properties. Dual-energy CT (DECT) allows to acquire semi-quantitative iodine images which might correlate with blood pool and tumor vascularity. In this feasibility-study, we correlated ...

journal_title：Current pharmaceutical biotechnology

authors： Schramm N,Schlemmer M,Englhart E,Hittinger M,Becker C,Reiser M,Berger F

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Cancer is the leading cause of death worldwide and the current mode of cancer treatment causes side effects on normal cells and are still the key challenges in its' treatment. However, natural products or active compounds of medicinal plants have shown to be safe, affordable, and effective in diseases cure. ...

journal_title：Current pharmaceutical biotechnology

authors： Almatroodi SA,Almatroudi A,Alsahli MA,Khan AA,Rahmani AH

更新日期：2020-01-01 00:00:00

abstract：:A variety of methods including penetrating enhancers, enzyme inhibitors, as well as cargo mediated drug delivery have been explored to improve the intolerance of parenteral administrated insulin, but little success has been achieved so far. Under this background, cell penetrating peptides (CPPs), with their ability to...

journal_title：Current pharmaceutical biotechnology

authors： Liu E,Sheng J,Ye J,Wang Y,Gong J,Yang VC,Wang J,He H

更新日期：2014-01-01 00:00:00

abstract：:Xylitol is an important polyalcohol suitable for use in odontological, medical and pharmaceutical products and as an additive in food. The first studies on the efficacy of xylitol in the control and treatment of infections started in the late 1970s and it is still applied for this purpose, with safety and very little ...

journal_title：Current pharmaceutical biotechnology

authors： Ferreira AS,Silva-Paes-Leme AF,Raposo NR,da Silva SS

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Despite the extended laboratory and clinical study of sepsis, its diagnosis remains a clinical challenge. The initiation of sepsis activates many different biochemical and immunological pathways being expressed by alterations of various molecules in human tissues. The detection and measurement of the concent...

journal_title：Current pharmaceutical biotechnology

authors： Giannakopoulos K,Hoffmann U,Ansari U,Bertsch T,Borggrefe M,Akin I,Behnes M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Vulvar Lichen Sclerosus (VLS) is a chronic inflammatory disease with a huge impact on a person's quality of life. A correct therapy is required for relieving symptoms, reversing signs and preventing further anatomical changes. OBJECTIVE:The main objective of the present paper is to provide suggestions for t...

journal_title：Current pharmaceutical biotechnology

authors： Borghi A,Corazza M

更新日期：2021-01-01 00:00:00

abstract：:Platelet-rich plasma (PRP) is widely used to promote tissue repair and accelerate osteogenesis, but there is no agreement about its mechanism of action. We characterized the modulatory effect of PRP on the in vitro osteoblast model SaOS-2, by using cell motility/chemoattraction and osteogenesis/mineralization assays, ...

journal_title：Current pharmaceutical biotechnology

authors： Martinotti S,Mazzucco L,Balbo V,Patrone M,Mozzati M,Ranzato E,Burlando B

更新日期：2014-01-01 00:00:00

abstract：:Herpes simplex virus (HSV) is a well-known vector that is often used for gene therapy to treat cancers. The most attractive feature of HSV is its ability to destroy tumors through a distinctive oncolytic mechanism where the virus can destroy cancer cells via cell lysis, a killing function that no anti-cancer drugs can...

journal_title：Current pharmaceutical biotechnology

authors： Wong J,Lee C,Zhang K,Rennie PS,Jia W

更新日期：2012-07-01 00:00:00

abstract：:Silkworm pupae protein is a good source of high quality protein. The hydrolyzates of silkworm pupae protein catalyzed by neutrase, pepsin, acidic protease (Asperqiius usamii NO. 537), flavourzyme, alcalase, and trypsin with inhibitory activity on angiotensin I-converting enzyme (ACE) were identified by HPLC. The hydro...

journal_title：Current pharmaceutical biotechnology

authors： Wang W,Shen S,Chen Q,Tanga B,He G,Ruan H,Das UN

更新日期：2008-08-01 00:00:00

abstract：:Beyond their originally sole mechanical function, current drug-eluting stents (DES) implement the concept of local drug delivery for the re-opening of stenotic arterial vessels, and for prevention of in-stent restenosis as one of the major limitations of conventional bare metal stents (BMS). Current DES consist of a p...

journal_title：Current pharmaceutical biotechnology

authors： Sternberg K,Grabow N,Petersen S,Weitschies W,Harder C,Ince H,Kroemer HK,Schmitz KP

更新日期：2013-01-01 00:00:00

abstract：:A review of the developments on the analysis of residues of avermectins and milbemycins (both macrocyclic lactones) is presented. The macrocyclic lactones (MLs) are an important class of chemicals, which are used worldwide as veterinary drugs and as crop protection agents. As a result, residues of MLs are important fr...

journal_title：Current pharmaceutical biotechnology

authors： Danaher M,Radeck W,Kolar L,Keegan J,Cerkvenik-Flajs V

更新日期：2012-05-01 00:00:00