Hydrolyzates of silkworm pupae (Bombyx mori) protein is a new source of angiotensin I-converting enzyme inhibitory peptides (ACEIP).

abstract：BACKGROUND:Carbon nanotubes (CNTs) have been considered highly successful and proficient in terms of their mechanical, thermal and electrical functionalization and biocompatibility. In regards to their significant extent in bone regeneration, it has been determined that CNTs hold the capability to endure clinical appli...

journal_title：Current pharmaceutical biotechnology

authors： Ilbasmis-Tamer S,Ciftci H,Turk M,Degim T,Tamer U

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The present limitations related to the ocular administration of antifungal drugs for the treatment of fungal keratitis include poor ocular bioavailability, limited retention time, and low ocular tissues penetration. METHODS:This study aimed to prepare a novel ophthalmic voriconazole-loaded nanosuspension ba...

journal_title：Current pharmaceutical biotechnology

authors： Qin T,Dai Z,Xu X,Zhang Z,You X,Sun H,Liu M,Zhu H

更新日期：2020-08-20 00:00:00

abstract：:Lipid nanocapsules (LNCs) were designed more than 15 years ago to deliver lipophilic drugs to cells with non toxic excipients by mimicking lipoproteins. During the last 5 years these promising nanocarriers were re-designed to deliver nucleic acids to cancer cells. This short review sums up the features of LNCs and des...

journal_title：Current pharmaceutical biotechnology

authors： Lagarce F,Passirani C

更新日期：2016-01-01 00:00:00

abstract：:A variety of technologies can be used in the detection of contagious pathogens. In the early stage of an outbreak of a new infectious disease, rtPCR is advantageous over many other assays. The rtPCR can be developed either using low fidelity DNA polymerase or high fidelity DNA polymerase. The application of high fidel...

journal_title：Current pharmaceutical biotechnology

authors： Li K,Xiao L,Liu C,Zhang J,Sirois P

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Up to 25% of diabetic patients will develop a diabetic foot ulcer. Chronic wounds such as diabetic foot ulcers often fail to heal with conventional therapies. In recent years, it has been identified that chronic wounds are usually associated with elevated level of matrix metalloproteinases (MMPs). Doxycyclin...

journal_title：Current pharmaceutical biotechnology

authors： Xu DH,Zhu Z,Fang Y

更新日期：2017-01-01 00:00:00

abstract：:Control of VEGF signaling is an intense objective of pre-clinical and clinical studies in HCC disease with steadily increasing clinical application. Despite its emerging role, several aspects of anti-VEGF based treatments are poorly investigated, like the impact on tumor cells themselves, such as the effect on intrace...

journal_title：Current pharmaceutical biotechnology

authors： Raskopf E,Vogt A,Decker G,Hirt S,Daskalow K,Cramer T,Standop J,Gonzalez-Carmona MA,Sauerbruch T,Schmitz V

更新日期：2012-09-01 00:00:00

abstract：:Raman spectroscopy has long been used as a powerful tool for chemical composition analyses. Raman scattering light measurement has the advantage of being able to examine biomolecules in a nondestructive and non-labeling manner. However, molecular imaging of cells and tissues by using Raman microscopy had been hampered...

journal_title：Current pharmaceutical biotechnology

authors： Harada Y,Takamatsu T

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:We sought to evaluate the safety of imipenem and meropenem in the treatment of infections in neurosurgical patients. METHODS:An observational retrospective study was conducted of consecutive cases treated with imipenem from Sept. 2007 to Sept. 2009 and meropenem within 1 year from Sept. 2008 in Beijing Tiant...

journal_title：Current pharmaceutical biotechnology

authors： Wu Y,Chen K,Shi Z,Wang Q

更新日期：2014-01-01 00:00:00

abstract：:It is now widely believed that tumors originate from normal cells as a result of accumulated genetic/epigenetic changes. These alterations affect the signaling pathways at transcriptional and post-transcriptional level that drive cells into uncontrolled cell division, growth, and migration. Recent advancement of molec...

journal_title：Current pharmaceutical biotechnology

authors： Yamashita T,Honda M,Kaneko S

更新日期：2008-10-01 00:00:00

abstract：:Blood Brain Barrier (BBB) is the collection of vessels of blood with special properties of permeability that allow a limited range of drug and compounds to pass through it. The BBB plays a vital role in maintaining balance between intracellular and extracellular environment for brain. Brain Capillary Endothelial Cells...

journal_title：Current pharmaceutical biotechnology

authors： Saxena D,Sharma A,Siddiqui MH,Kumar R

更新日期：2019-01-01 00:00:00

abstract：:A novel steroidal oxime (SO) was synthesized using an economic method and then characterized by Fourier transform infrared (FTIR) and 1H nuclear magnetic resonance (NMR). When dispersed in pure water, SO can self-assemble into a nano-scale circular structure which was verified by dynamic light scattering (DLS) and tra...

journal_title：Current pharmaceutical biotechnology

authors： Chou TH,Chen CW

更新日期：2015-01-01 00:00:00

abstract：:Tuberculosis (TB) is a disease of global concern. About one third of the world population is infected with Mycobacterium tuberculosis. Every year, approximately 8 million people get the disease and 2 million die of TB. The currently available vaccine against TB is the attenuated strain of Mycobacterium bovis, Bacillus...

journal_title：Current pharmaceutical biotechnology

authors： Mustafa AS

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Although the stability of proteins is of significance to maintain protein function for therapeutical applications, this remains a challenge. Herein, a general method of preserving protein stability and function was developed using gelatin films. METHODS:Enzymes immobilized onto films composed of gelatin and...

journal_title：Current pharmaceutical biotechnology

authors： Zhang L,Shen Y,Lu W,Guo L,Xiang M,Zhang D

更新日期：2020-01-01 00:00:00

abstract：AIMS:The present study aims to determine the antimicrobial efficacy of Alphonsea madraspatana leaves extract against selected uropathogens. BACKGROUND:The plant Alphonsea madraspatana is an endangered species, reported to exhibit high antimicrobial activity due to the presence of phenolic compounds. Prevalence of high...

journal_title：Current pharmaceutical biotechnology

authors： Sahu A,Ghosh G,Rath G

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Vulvar Lichen Sclerosus (VLS) is a chronic inflammatory disease with a huge impact on a person's quality of life. A correct therapy is required for relieving symptoms, reversing signs and preventing further anatomical changes. OBJECTIVE:The main objective of the present paper is to provide suggestions for t...

journal_title：Current pharmaceutical biotechnology

authors： Borghi A,Corazza M

更新日期：2021-01-01 00:00:00

abstract：:Gene targeting can be loosely defined as a process through which a specific chromosomal sequence is recognized and bound by a reagent designed for the purpose. The endpoint may be modulation of events at the target, such as transcription, or a permanent change in sequence at the site. A facile strategy for mammalian c...

journal_title：Current pharmaceutical biotechnology

authors： Seidman MM

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Restoration of blood flow during ischemic stroke leads to cerebral ischemia reperfusion injury (CIRI) by activating neuroinflammatory cascades. Pomelo peel volatile oil (PPVO) extracted from Citrus maxima (Burm.) from the genus Rutaceae, comprises some anti-inflammatory ingredients, such as limonene and β-my...

journal_title：Current pharmaceutical biotechnology

authors： Tian XY,Xie L,Wang WY,Zou XS,Zhao GY,Chen MH

更新日期：2020-12-30 00:00:00

abstract：BACKGROUND:`Herbal mixtures` containing synthetic cannabinoid receptor agonists (SCRAs) are promoted as legal alternative to marihuana and are easily available via the Internet. Keeping analytical methods for the detection of these SCRAs up-to-date is a continuous challenge for clinicians and toxicologists due to the h...

journal_title：Current pharmaceutical biotechnology

authors： Hutter M,Broecker S,Kneisel S,Franz F,Brandt SD,Auwarter V

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:The aim of the work was to evaluate the effect of moderate physical exercise on the response of circulating phagocytes to the antineoplastic drug NSC 631570. METHODS:Eight healthy adult men aged 23 ± 2 years were recruited to participate in the study; NSC 631570 was administered i.v. in a single therapeutic ...

journal_title：Current pharmaceutical biotechnology

authors： Skivka LM,Fedorchuk OG,Susak YM,Susak MY,Malanchuk OM,Rudyk MP,Nowicky YW

更新日期：2015-01-01 00:00:00

abstract：:The ubiquitin-proteasome pathway (UPP) is the major non-lysosomal proteolytic system in the cytosol and nucleus of all eukaryotic cells. Bortezomib (also known as PS-341 and Velcade) is a proteasome inhibitor, a novel class of cancer therapies. Bortezomib blocks multi-ubiquitinated protein degradation by inhibiting 26...

journal_title：Current pharmaceutical biotechnology

authors： Roccaro AM,Hideshima T,Richardson PG,Russo D,Ribatti D,Vacca A,Dammacco F,Anderson KC

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:In the present study, Solenostemma argel effervescent tablets were prepared from Argel methanolic extract. METHODS:The tablets were examined for their ability to impede carbon tetrachloride (CCl4)-induced lipid peroxidation in mice liver. The antioxidant activities of the enzymes; super-oxide dismutase (SOD)...

journal_title：Current pharmaceutical biotechnology

authors： Suliman RS,Ali HS,Alhelal K,Almutairi W,Alnasser S,Omer M,Suliman R,Algebali A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Enterotoxigenic Escherichia coli (ETEC) is the main cause of fatal diarrhea in piglets during the first week of life and over the time of weaning. Pathogenesis of ETEC-causing diarrhea involves intestinal colonization mediated by fimbriae. Although, both IgY and egg yolk phosvitin (PV) possess antimicrobial ...

journal_title：Current pharmaceutical biotechnology

authors： Gujral N,Yoo H,Bamdad F,Lee KY,Suh JW,Sunwoo H

更新日期：2017-01-01 00:00:00

abstract：:Tissue engineering is a rapidly developing field applying the disciplines of cell biology, developmental biology, molecular biology and biomimetic engineering to regenerate new tissues for replacement therapies in clinical contexts. To aid in the elicitation and reiteration of the processes of morphogenesis of tissues...

journal_title：Current pharmaceutical biotechnology

authors： Ripamonti U,Tasker JR

更新日期：2000-07-01 00:00:00

abstract：:Better understanding of protein higher order structures (HOS) is of major interest to researchers in the field of biotechnology and biopharmaceutics. Monitoring a protein's HOS is crucial towards understanding the impact of molecular conformation on the biotechnological application. In addition, maintaining the HOS is...

journal_title：Current pharmaceutical biotechnology

authors： Nagarkar RP,Murphy BM,Yu X,Manning MC,Al-Azzam WA

更新日期：2013-01-01 00:00:00

abstract：:The metastatic cascade and colonization remains a major challenge in clinical therapeutics. The formation of metastasis has many rate limiting steps. The expression of metastases initiation genes in primary tumors is driven by the need for cell motility, invasiveness, handling the shear stress in the vasculature and l...

journal_title：Current pharmaceutical biotechnology

authors： Gueron G,De Siervi A,Vazquez E

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Tamarix Articulata (T. articulata), commonly known as Tamarisk or Athal in Arabic region, belongs to the Tamaricaece species. It is an important halophytic medicinal plant and a good source of polyphenolic phytochemical(s). In traditional medicines, T. articulata extract is commonly used, either singly or in...

journal_title：Current pharmaceutical biotechnology

authors： Alnuqaydan AM,Rah B

更新日期：2019-01-01 00:00:00

abstract：:In this review, the compartments of the vasculature will be discussed with respect to their potential contribution to the build-up of a differentiated and functionally meaningful vessel system. Chronic ischemia of muscle tissue results in microvessel rarification, which represents a potential therapeutic target, given...

journal_title：Current pharmaceutical biotechnology

authors： Kupatt C

更新日期：2007-02-01 00:00:00

abstract：:Pulmonary fibrosis is an unremitting degenerative lung disease that has an associated high mortality. The major pathological features include the growth of fibroblasts, emergence of myofibroblasts and their production of extracellular matrix that distorts the peripheral lung tissue and impairs respiratory function. Ef...

journal_title：Current pharmaceutical biotechnology

authors： Glasser SW,Senft AP

更新日期：2011-09-01 00:00:00

abstract：:Increasing evidence shows that the interaction between neoplastic cells and the surrounding stroma is a critical factor in solid tumor growth. The tumor stroma is made up of diverse cellular populations including macrophages, lymphocytes, vascular cells, and carcinoma-associated fibroblasts. The complex interactions b...

journal_title：Current pharmaceutical biotechnology

authors： Anton K,Glod J

更新日期：2009-02-01 00:00:00

abstract：:Melanogenesis is simply defined as production of melanin in melanosomes by melanocytes through a complex process. Melanin, a pigment derived from L-tyrosine, comes into two forms, namely eumelanin (brownish to black) and pheomelanin (red to yellow). Melanin synthesis starts via the hydroxylation of L-tyrosine to L-3,4...

journal_title：Current pharmaceutical biotechnology

authors： Orhan IE,Deniz FSS

更新日期：2020-12-10 00:00:00