The Use of Biomarkers in Sepsis: A Systematic Review.

abstract：:Bone is among the most common locations of metastasis and therefore represents an important clinical target for diagnostic follow-up in cancer patients. In the pathogenesis of bone metastases, disseminated tumor cells proliferating in bone interact with the local microenvironment stimulating or inhibiting osteoclast a...

journal_title：Current pharmaceutical biotechnology

authors： Bauerle T,Komljenovic D,Semmler W

更新日期：2012-03-01 00:00:00

abstract：:Interleukin (IL)-7 is a cytokine inducing the Janus Kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway. As a consequence of IL-7 activating this pathway, STAT5 is phosphorylated. In pharmaceutical quality control, the potency of biopharmaceuticals is commonly assessed by proliferation assays....

journal_title：Current pharmaceutical biotechnology

authors： Zumpe C,Engel K,Wiedemann N,Metzger AU,Pischetsrieder M,Bachmann CL

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:Advanced gastrointestinal stromal tumours (GISTs) are treated with tyrosine kinase inhibitors, which also have antiangiogenic properties. Dual-energy CT (DECT) allows to acquire semi-quantitative iodine images which might correlate with blood pool and tumor vascularity. In this feasibility-study, we correlated ...

journal_title：Current pharmaceutical biotechnology

authors： Schramm N,Schlemmer M,Englhart E,Hittinger M,Becker C,Reiser M,Berger F

更新日期：2011-04-01 00:00:00

abstract：:We aim to determine the regulation of apoptosis by paclitaxel-induced and understand cancer dynamics to treatment targets for HeLa cells by identifying decrease/increase genes expression on HeLa cells. In this study, the anti-tumor effects of Paclitaxel (PAC) on HeLa cells have been studied in order to determine the c...

journal_title：Current pharmaceutical biotechnology

authors： Serbes U,Ozsoylemez OD,Ozcan G

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Although the stability of proteins is of significance to maintain protein function for therapeutical applications, this remains a challenge. Herein, a general method of preserving protein stability and function was developed using gelatin films. METHODS:Enzymes immobilized onto films composed of gelatin and...

journal_title：Current pharmaceutical biotechnology

authors： Zhang L,Shen Y,Lu W,Guo L,Xiang M,Zhang D

更新日期：2020-01-01 00:00:00

abstract：:Conventional biochemical assays are performed via an averaging procedure with the lysate of a large number of target cells; however, the averaged data lose information regarding the heterogeneity of individual cells. For quantitative assay of single cells, it is necessary to isolate single cells, extract cellular comp...

journal_title：Current pharmaceutical biotechnology

authors： Sasaki A,Sakata H,Kinjo M

更新日期：2010-01-01 00:00:00

abstract：:One of the most surprising aspects of neural development is that cells do not remain in their birthplace but actively migrate along a variety of routes to their final destinations. This review traces past, present, and future techniques used to analyze progenitor cell migration in the brain, and also discusses their r...

journal_title：Current pharmaceutical biotechnology

authors： Comte I,Tran PB,Szele FG

更新日期：2007-06-01 00:00:00

abstract：:The IMiDs represent a new proprietary class of thalidomide analogues that possess greater potency and less toxicity than the parent compound. As a group, these agents share the pharmacologic property of modulating cellular response to ligand activation, the precise biologic effect of which is cell lineage and stimulan...

journal_title：Current pharmaceutical biotechnology

authors： Kale V,List AF

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Tamarix Articulata (T. articulata), commonly known as Tamarisk or Athal in Arabic region, belongs to the Tamaricaece species. It is an important halophytic medicinal plant and a good source of polyphenolic phytochemical(s). In traditional medicines, T. articulata extract is commonly used, either singly or in...

journal_title：Current pharmaceutical biotechnology

authors： Alnuqaydan AM,Rah B

更新日期：2019-01-01 00:00:00

abstract：:Elaboration of the structure of TRPV1 and its functional relationship with channel activity is a work in progress, with much remaining to be done before the structure-function relationship of TRPV1 is comprehensively elicited. The result is that the present state of knowledge can reasonably be described as a patch-wor...

journal_title：Current pharmaceutical biotechnology

authors： Urban L,White JP,Nagy I

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Vancomycin is used mostly to overcome infections caused by methicillinresistant microorganisms. There are no well-established administration protocols for neonates and infants, so the leak of a specific administration regime in that population may lead to serum concentrations beyond the specified range. OBJ...

journal_title：Current pharmaceutical biotechnology

authors： Bidu NS,Fernandes BJD,Dias EJC,Filho JNC,Bastos REA,Godoy ALPC,Azeredo FJ,Pedreira JNR,Couto RD

更新日期：2019-01-01 00:00:00

abstract：:Signals relayed through G protein-coupled receptors (GPCR) play pivotal roles in human physiology and are important drug targets. About 40% of all GPCRs couple to the heterotrimeric G protein Gq. Biochemical studies as well as crystallography have improved our understanding of GqPCRs and their downstream partners. Her...

journal_title：Current pharmaceutical biotechnology

authors： Jalink K,Adjobo-Hermans MJ

更新日期：2014-01-01 00:00:00

abstract：:Recent research has shown that the endogenous gas hydrogen sulphide (H2S) is a signalling molecule of considerable biological potential and has been suggested to be involved in a vast number of physiological processes. In the vascular system, H2S is synthesized from cysteine by cystathionine-γ-lyase (CSE) in smooth mu...

journal_title：Current pharmaceutical biotechnology

authors： Skovgaard N,Gouliaev A,Aalling M,Simonsen U

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Alternative medicine is available for those diseases which cannot be treated by conventional medicine. Ayurveda and herbal medicines are important alternative methods in which the treatment is done with extracts of different medicinal plants. This work is concerned with the evaluation of anti-stress bioactiv...

journal_title：Current pharmaceutical biotechnology

authors： Daddam JR,Sreenivasulu B,Umamahesh K,Peddanna K,Rao DM

更新日期：2020-01-01 00:00:00

abstract：:The biliary secretion of bile acids is critical for multiple liver functions including digesting fatty nutrients and driving bile flow. When this process is impaired, the accumulating bile acids cause inflammatory liver injury. Multiple ABC transporters in the liver are key players to safeguard the hepatocyte and avoi...

journal_title：Current pharmaceutical biotechnology

authors： Wang R,Sheps JA,Ling V

更新日期：2011-04-01 00:00:00

abstract：AIMS:The present study aims to determine the antimicrobial efficacy of Alphonsea madraspatana leaves extract against selected uropathogens. BACKGROUND:The plant Alphonsea madraspatana is an endangered species, reported to exhibit high antimicrobial activity due to the presence of phenolic compounds. Prevalence of high...

journal_title：Current pharmaceutical biotechnology

authors： Sahu A,Ghosh G,Rath G

更新日期：2020-01-01 00:00:00

abstract：:The innate immune system protects against infectious microbes by the recognition of pathogen- associated molecular patterns, which serve to detect pathogens on the host cell surface or in endosomes by pattern recognition receptors such as Toll-like receptors, nucleotide-binding oligomerization domain-containing protei...

journal_title：Current pharmaceutical biotechnology

authors： Fischer S

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:With the improvements in living standards, height is getting more attention. Malnutrition is one of the main causes of children's short stature, therefore nutritional intervention in adolescence is the key to prevent short stature. The peptides from Antarctic krill (AKPs), the ideal protein model, act in bon...

journal_title：Current pharmaceutical biotechnology

authors： Dai Y,Li Z,Fu M,Li Y,Xue C,Wang J

更新日期：2020-06-12 00:00:00

abstract：:Xylitol is an important polyalcohol suitable for use in odontological, medical and pharmaceutical products and as an additive in food. The first studies on the efficacy of xylitol in the control and treatment of infections started in the late 1970s and it is still applied for this purpose, with safety and very little ...

journal_title：Current pharmaceutical biotechnology

authors： Ferreira AS,Silva-Paes-Leme AF,Raposo NR,da Silva SS

更新日期：2015-01-01 00:00:00

abstract：:MicroRNAs are small non-coding RNA molecules which do not code for proteins, but control the expression of a significant proportion of the genome. The microRNA expression differences of normal and malignant tissue, as well as the differences in various tumor entities qualify this RNA species as biomarker for cancer pa...

journal_title：Current pharmaceutical biotechnology

authors： Ellinger J,Muller SC

更新日期：2014-01-01 00:00:00

abstract：:The non-Hodgkin's lymphomas are a diverse groups of lymphoid neoplasms that collectively rank fifth in cancer incidence and mortality. Conventional treatment for patients with newly-diagnosed non-Hodgkin's lymphoma (NHL) includes radiation or chemotherapy. In addition, those with asymptomatic low-grade disease may fol...

journal_title：Current pharmaceutical biotechnology

authors： Multani P,White CA,Grillo-López A

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Oxymatrine is one of the most promising alkaloids from Sophora flavescens for its excellent pharmacological effects. OBJECTIVE:The aim of this research is to assess the biopharmaceutical and pharmacokinetic activities of oxymatrine, and clarify its mechanisms of absorption and metabolism. METHODS:The biolo...

journal_title：Current pharmaceutical biotechnology

authors： Wang HQ,Chen FH,Wang L,Chi LQ,Wang GH

更新日期：2021-01-18 00:00:00

abstract：:Many theoretical models of molecular interactions, biochemical and chemical reactions are described on the single-molecule level, although our knowledge about the biochemical/chemical structure and dynamics primarily originates from the investigation of many-molecule systems. At present, there are four experimental pl...

journal_title：Current pharmaceutical biotechnology

authors： Földes-Papp Z,Baumann G,Demel U,Tilz GP

更新日期：2004-04-01 00:00:00

abstract：:Cross-border reproductive care (CBRC) is a multifaceted phenomenon. It may involve both the movement of patients to undertake assisted reproductive treatment through technologies otherwise denied and the movement of assisted reproduction professionals, egg and sperm donors and surrogates, as well as the importing and ...

journal_title：Current pharmaceutical biotechnology

authors： Neri M,Turillazzi E,Pascale N,Riezzo I,Pomara C

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:L2-based Human Papillomavirus (HPV) prophylactic vaccines, containing epitopes from HPV minor capsid proteins, are under investigation as second-generation HPV vaccines. No such vaccine has passed clinical trials yet, mainly due to the low immunogenicity of peptide vaccines; so efforts are being continued. A...

journal_title：Current pharmaceutical biotechnology

authors： Negahdaripour M,Nezafat N,Heidari R,Erfani N,Hajighahramani N,Ghoshoon MB,Shoolian E,Rahbar MR,Najafipour S,Dehshahri A,Morowvat MH,Ghasemi Y

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:RA is one of autoimmune diseases, has drawn great attention of the world. Currently, the anti- IL-1β monoclonal antibody Canakinumab (ACZ885) for treatment of RA has entered into clinical trials. However, Full length antibody has large molecular weight, and is difficult to penetrate the tissue or the nidus. I...

journal_title：Current pharmaceutical biotechnology

authors： Li T,Xu L,Ren G,Yin C,Zhou B,Ye X,Li Q,Li N,Li D

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:Previous studies in humans concluded that a multigenic model including specific FSHR, ESR1 and ESR2 genotype patterns may partially explain the poor response to FSH. The aim of our study is to analyse three different loci -polymorphisms in ESR1 Pvu II, ESR2 Rsa I and Ser680Asn FSH receptor gene- in a Greek popu...

journal_title：Current pharmaceutical biotechnology

authors： Anagnostou E,Mavrogianni D,Theofanakis C,Drakakis P,Bletsa R,Demirol A,Gurgan T,Antsaklis A,Loutradis D

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus is the most common disease in Egypt. In this context, Beta vulgaris subspecies cicla L. var. flavescens is an edible plant that has been used in traditional medicine as a therapy for treating some diseases. OBJECTIVES:The current study was performed to evaluate the antibacterial and potent...

journal_title：Current pharmaceutical biotechnology

authors： Mohammed HS,Abdel-Aziz MM,Abu-Baker MS,Saad AM,Mohamed MA,Ghareeb MA

更新日期：2019-01-01 00:00:00

abstract：:Polyphenols are a widely distributed group of natural products found in fruits, vegetables, nuts, seeds, stems and flowers. Such compounds, especially dietary flavonoids and tannins, have been shown to exert antioxidant, antiinflammatory, anti-cancer and antibacterial effects and may have beneficial effects on human h...

journal_title：Current pharmaceutical biotechnology

authors： Coppo E,Marchese A

更新日期：2014-01-01 00:00:00

abstract：:Natural compounds represent a significant source for the development of novel medicines. Finding the target proteins for a natural compound is the most important step towards understanding its molecular mechanism for therapeutic usage. In fact, the search for target proteins could be considered the first step of the d...

journal_title：Current pharmaceutical biotechnology

authors： Yao L

更新日期：2012-07-01 00:00:00