CPP mediated insulin delivery: current status and promising future.

Abstract:

:A variety of methods including penetrating enhancers, enzyme inhibitors, as well as cargo mediated drug delivery have been explored to improve the intolerance of parenteral administrated insulin, but little success has been achieved so far. Under this background, cell penetrating peptides (CPPs), with their ability to enhance transport efficiency of macromolecular drugs have been demonstrated to be able to increase insulin bioavailability (BA) in a number of studies, of which a BA up to 50.7% relative to subcutaneously administered insulin could be achieved by nasal route under optimal conditions. Furthermore, CPPs could be conveniently formulated with insulin, or be grafted onto drug-loaded cargoes to facilitate the cargo mediated insulin delivery. Here we reviewed the recent achievements on CPP-mediated insulin transport, and outlined various CPP-based delivery strategies which are expected to show potential in clinical translation in the future.

journal_name

Curr Pharm Biotechnol

authors

Liu E,Sheng J,Ye J,Wang Y,Gong J,Yang VC,Wang J,He H

doi

10.2174/1389201015666140813125840

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

240-55

issue

3

eissn

1389-2010

issn

1873-4316

pii

CPB-61766

journal_volume

15

pub_type

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