Blood Brain Barrier Permeability Prediction Using Machine Learning Techniques: An Update.

Abstract:

:Blood Brain Barrier (BBB) is the collection of vessels of blood with special properties of permeability that allow a limited range of drug and compounds to pass through it. The BBB plays a vital role in maintaining balance between intracellular and extracellular environment for brain. Brain Capillary Endothelial Cells (BECs) act as vehicle for transport and the transport mechanisms across BBB involve active and passive diffusion of compounds. Efficient prediction models of BBB permeability can be vital at the preliminary stages of drug development. There have been persistent efforts in identifying the prediction of BBB permeability of compounds employing multiple machine learning methods in an attempt to minimize the attrition rate of drug candidates taking up preclinical and clinical trials. However, there is an urgent need to review the progress of such machine learning derived prediction models in the prediction of BBB permeability. In the current article, we have analyzed the recently developed prediction model for BBB permeability using machine learning.

journal_name

Curr Pharm Biotechnol

authors

Saxena D,Sharma A,Siddiqui MH,Kumar R

doi

10.2174/1389201020666190821145346

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

1163-1171

issue

14

eissn

1389-2010

issn

1873-4316

pii

CPB-EPUB-100382

journal_volume

20

pub_type

杂志文章,评审
  • Vancomycin Therapeutic Regime Adjustment in Newborns and Infants with Bacterial Infection: Case Series.

    abstract:BACKGROUND:Vancomycin is used mostly to overcome infections caused by methicillinresistant microorganisms. There are no well-established administration protocols for neonates and infants, so the leak of a specific administration regime in that population may lead to serum concentrations beyond the specified range. OBJ...

    journal_title:Current pharmaceutical biotechnology

    pub_type:

    doi:10.2174/1389201020666190319161511

    authors: Bidu NS,Fernandes BJD,Dias EJC,Filho JNC,Bastos REA,Godoy ALPC,Azeredo FJ,Pedreira JNR,Couto RD

    更新日期:2019-01-01 00:00:00

  • The utilization of gene targeting models during in preclinical study of drug discovery process--example of phenotypic and functional analysis of Cacna1beta gene product.

    abstract::Using gene knockout mice of particular genes is one of the most effective methods in conducting successful study on the mode of action of target gene products in targeted organs. So called the knockout technology is now a powerful tool that can lead us to find clear understanding on difficult questions such as the eff...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章

    doi:10.2174/138920109787314999

    authors: Miyamoto N,Namiki K,Tokuhara N,Uesugi M,Takahashi E,Kuromitsu J,Kasuya Y

    更新日期:2009-02-01 00:00:00

  • Small Molecule Inhibitors Limit Endothelial Cell Invasion by Staphylococcus aureus.

    abstract::Staphylococcus aureus is a leading causative agent in sepsis, endocarditis, and pneumonia. An emerging concept is that prognosis worsens when the infecting S. aureus strain has the capacity to not only colonize tissue as an extracellular pathogen, but to invade host cells and establish intracellular bacterial populati...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章

    doi:10.2174/1389201015666140909124310

    authors: Cordero D,Fullenkamp CR,Pelly RR,Reed KM,Caffo LM,Zahrt AN,Newman M,Komanapalli S,Niemeier EM,Bishop DL,Bruns HA,Haynes MK,Sklar LA,Sammelson RE,McDowell SA

    更新日期:2014-01-01 00:00:00

  • Ultrasound: medical imaging and beyond (an invited review).

    abstract::Medical applications of ultrasound were first investigated about seventy years ago. It has rapidly evolved since then, becoming an essential tool in medical imaging. Ultrasound ability to provide real time images with frame rates exceeding several hundred frames per second allows one to view rapid anatomical changes a...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/138920112802502033

    authors: Azhari H

    更新日期:2012-09-01 00:00:00

  • In silico search for drug targets of natural compounds.

    abstract::Natural compounds represent a significant source for the development of novel medicines. Finding the target proteins for a natural compound is the most important step towards understanding its molecular mechanism for therapeutic usage. In fact, the search for target proteins could be considered the first step of the d...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/138920112800958940

    authors: Yao L

    更新日期:2012-07-01 00:00:00

  • Hydrolyzates of silkworm pupae (Bombyx mori) protein is a new source of angiotensin I-converting enzyme inhibitory peptides (ACEIP).

    abstract::Silkworm pupae protein is a good source of high quality protein. The hydrolyzates of silkworm pupae protein catalyzed by neutrase, pepsin, acidic protease (Asperqiius usamii NO. 537), flavourzyme, alcalase, and trypsin with inhibitory activity on angiotensin I-converting enzyme (ACE) were identified by HPLC. The hydro...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章

    doi:10.2174/138920108785161578

    authors: Wang W,Shen S,Chen Q,Tanga B,He G,Ruan H,Das UN

    更新日期:2008-08-01 00:00:00

  • Identification of a Potential Inhibitor Targeting MurC Ligase of the Drug Resistant Pseudomonas aeruginosa Strain through Structure-Based Virtual Screening Approach and In Vitro Assay.

    abstract:BACKGROUND & OBJECTIVE:Pseudomonas aeruginosa shows resistance to a large number of antibiotics, including carbapenems and third generation cephalosporin. According to the World Health Organization global report published in February 2017, Pseudomonas aeruginosa is on the priority list among resistant bacteria, for whi...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章

    doi:10.2174/1389201020666190719123133

    authors: Messaoudi A,Zoghlami M,Basharat Z,Sadfi-Zouaoui N

    更新日期:2019-01-01 00:00:00

  • Single-molecule detection and probe strategies for rapid and ultrasensitive genomic detection.

    abstract::This paper reviews the current state-of-the-art development of single-molecule detection (SMD)-based methods for ultrasensitive and specific analysis of genomic sequences. We first discuss several newly devised single fluorescent probe strategies that allow separation-free detection of low-abundance DNA sequences, suc...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/138920105775159304

    authors: Yeh HC,Chao SY,Ho YP,Wang TH

    更新日期:2005-12-01 00:00:00

  • Dihydroorotate Dehydrogenase Inhibitors Promote Cell Cycle Arrest and Disrupt Mitochondria Bioenergetics in Ramos Cells.

    abstract:BACKGROUND:The re-emerging of targeting Dihydroorotate Dehydrogenase (DHODH) in cancer treatment particularly Acute Myelogenous Leukemia (AML) has corroborated the substantial role of DHODH in cancer and received the attention of many pharmaceutical industries. OBJECTIVE:The effects of Brequinar Sodium (BQR) and 4SC-1...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章

    doi:10.2174/1389201021666200611113734

    authors: Kadir MFA,Othman S,Nellore K

    更新日期:2020-01-01 00:00:00

  • RNA base damage and repair.

    abstract::Elaborate repair pathways counteract the deleterious effects of DNA damage by mechanisms that are understood in reasonable detail. In contrast, repair of damaged RNA has not been widely explored. This may be because aberrant RNAs are generally assumed to be degraded rather than repaired. The reason for this view is we...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/138920107783018363

    authors: Feyzi E,Sundheim O,Westbye MP,Aas PA,Vågbø CB,Otterlei M,Slupphaug G,Krokan HE

    更新日期:2007-12-01 00:00:00

  • The Role of the Coagulase-negative Staphylococci (CoNS) in Infective Endocarditis; A Narrative Review from 2000 to 2020.

    abstract::Coagulase-negative staphylococci (CoNS) are part of the microbiota of human skin and rarely linked with soft tissue infections. In recent years, CoNS species considered as one of the major nosocomial pathogens and can cause several infections such as catheter-acquired sepsis, skin infection, urinary tract infection, e...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/1389201021666200423110359

    authors: Noshak MA,Rezaee MA,Hasani A,Mirzaii M

    更新日期:2020-01-01 00:00:00

  • Oligonucleotide mediated gene targeting in mammalian cells.

    abstract::Gene targeting can be loosely defined as a process through which a specific chromosomal sequence is recognized and bound by a reagent designed for the purpose. The endpoint may be modulation of events at the target, such as transcription, or a permanent change in sequence at the site. A facile strategy for mammalian c...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/1389201043376625

    authors: Seidman MM

    更新日期:2004-10-01 00:00:00

  • Pattern Recognition Receptors and Control of Innate Immunity: Role of Nucleic Acids.

    abstract::The innate immune system protects against infectious microbes by the recognition of pathogen- associated molecular patterns, which serve to detect pathogens on the host cell surface or in endosomes by pattern recognition receptors such as Toll-like receptors, nucleotide-binding oligomerization domain-containing protei...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/138920112804583087

    authors: Fischer S

    更新日期:2018-01-01 00:00:00

  • Polymorphisms in Gap Junction Proteins and their Role in Predisposition of Acute Myocardial Infarction in Egyptians.

    abstract:BACKGROUND:Connexin (Cx) proteins are the building blocks of gap junctions. Among these, Cx37 and Cx40 are expressed on vascular system and reported to have cardioprotective role. Linking polymorphisms in genes coding for Cx and coronary artery disease (CAD) risk showed conflicting results in different populations. Non...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章

    doi:10.2174/1389201018666171002125432

    authors: El Tahry FA,Hashad IM,Abdel Rahman MF,Gad MZ

    更新日期:2017-11-10 00:00:00

  • Inhibitory Mechanisms of CME-1, a Novel Polysaccharide from the Mycelia of Cordyceps sinensis, in Platelet Activation.

    abstract::Objective: CME-1 is a polysaccharide purified from the mycelia of medicinal mushroom Cordyceps sinensis, its molecular weight was determined to be 27.6 kDa by using nuclear magnetic resonance and gas chromatography-mass spectrometry. The initiation of arterial thromboses is relevant to various cardiovascular diseases ...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章

    doi:

    authors: Chang YI,Hsu WH,Lu WJ,Jayakumar T,Liao JC,Lin MJ,Wang SH,Geraldine P,Lin KH,Sheu JR

    更新日期:2015-03-03 00:00:00

  • Proliposomes for oral delivery: progress and challenges.

    abstract::Proliposomes are phospholipid based drug delivery systems that are finding important applications in the field of pharmaceutics. Proliposomes have been extensively studied as a potential carrier for oral delivery of drugs with poor bioavailability, but the mechanism of absorption and cellular uptake pathways has not y...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/1389201016666150118134256

    authors: Nekkanti V,Venkatesan N,Betageri GV

    更新日期:2015-01-01 00:00:00

  • By passing microbial resistance: xylitol controls microorganisms growth by means of its anti-adherence property.

    abstract::Xylitol is an important polyalcohol suitable for use in odontological, medical and pharmaceutical products and as an additive in food. The first studies on the efficacy of xylitol in the control and treatment of infections started in the late 1970s and it is still applied for this purpose, with safety and very little ...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/1389201015666141202104347

    authors: Ferreira AS,Silva-Paes-Leme AF,Raposo NR,da Silva SS

    更新日期:2015-01-01 00:00:00

  • Multiwalled Carbon Nanotube-Chitosan Scaffold: Cytotoxic, Apoptoti c, and Necrotic Effects on Chondrocyte Cell Lines.

    abstract:BACKGROUND:Carbon nanotubes (CNTs) have been considered highly successful and proficient in terms of their mechanical, thermal and electrical functionalization and biocompatibility. In regards to their significant extent in bone regeneration, it has been determined that CNTs hold the capability to endure clinical appli...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章

    doi:10.2174/1389201018666170127105555

    authors: Ilbasmis-Tamer S,Ciftci H,Turk M,Degim T,Tamer U

    更新日期:2017-01-01 00:00:00

  • Antibacterial activity of polyphenols.

    abstract::Polyphenols are a widely distributed group of natural products found in fruits, vegetables, nuts, seeds, stems and flowers. Such compounds, especially dietary flavonoids and tannins, have been shown to exert antioxidant, antiinflammatory, anti-cancer and antibacterial effects and may have beneficial effects on human h...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/138920101504140825121142

    authors: Coppo E,Marchese A

    更新日期:2014-01-01 00:00:00

  • Antifungal Activity, Gas Chromatographic-Mass Spectrometric Analysis And in silico Study of Punica Granatum Peel Extracts Against Fluconazole Resistant Strains of Candida Species.

    abstract:AIMS:Candida species is the common cause of opportunistic fungal infections all over the world with increased mortality and morbidity especially in immunosuppressed patients. Fluconazole is the first line therapy for candidiasis. The antifungal resistance pattern in high-risk patients is a major concern. The present st...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章

    doi:10.2174/1389201019666180515104800

    authors: Paul S,Mohanram K,Kannan I

    更新日期:2018-01-01 00:00:00

  • Ex-ante evaluation of biotechnology innovations: the case of folate biofortified rice in China.

    abstract::In order to valorize novel biotechnology innovations, there is a need to evaluate ex-ante their market potential. A case in point is biofortification, i.e. the enhancement of the micronutrient content of staple crops through conventional or genetic breeding techniques. In a recent article in Nature Biotechnology, for ...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章

    doi:10.2174/138920112804724873

    authors: De Steur H,Blancquaert D,Gellynck X,Lambert W,Van Der Straeten D

    更新日期:2012-12-01 00:00:00

  • Current research on protein-protein interactions among auxin-signaling factors in regulation of plant growth and development.

    abstract::In many signaling pathways, various factors have been isolated by molecular genetic studies and wholegenome analysis. Understanding the interactions among these factors is crucial to understanding the signaling process as a whole. Recent studies on auxin signaling in the regulation of plant growth and development have...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/138920101314151120122745

    authors: Muto H,Kinjo M

    更新日期:2012-11-01 00:00:00

  • Green and Simple Synthesis of Silver Nanoparticles by Aqueous Extract of Perovskia abrotanoides: Characterization, Optimization and Antimicrobial Activity.

    abstract:BACKGROUND:Herein, we report the biosynthesis procedure to prepare silver nanoparticles as reduction and capping agents with the aqueous plant extract of Perovskia abrotanoides. METHODS:The therapeutic application of silver nanoparticles entirely depends on the size and shape of the nanoparticles therefore, their cont...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章

    doi:10.2174/1389201020666190618121218

    authors: Mirsadeghi S,Koudehi MF,Rajabi HR,Pourmortazavi SM

    更新日期:2020-01-01 00:00:00

  • Evolving cancer pain treatments: rational approaches to improve the quality of life for cancer patients.

    abstract::Most cancer patients will experience moderate to severe pain and/or neuropathy during the course of their disease. Recent improvements in the primary treatment of cancer have increased the life span of cancer patients, but not necessarily their quality of life (QoL). The pain and suffering cancer patients experience m...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/138920111798357267

    authors: Knopp KL,Nisenbaum ES,Arneric SP

    更新日期:2011-10-01 00:00:00

  • Mechanisms underlying the hepatotoxic effects of ecstasy.

    abstract::3,4-Methylenedioxymethamphetamine (MDMA or ecstasy) is a worldwide illegally used amphetamine-derived designer drug known to be hepatotoxic to humans. Jaundice, hepatomegaly, centrilobular necrosis, hepatitis and fibrosis represent some of the adverse effects caused by MDMA in the liver. Although there is irrefutable ...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/138920110791591535

    authors: Carvalho M,Pontes H,Remião F,Bastos ML,Carvalho F

    更新日期:2010-08-01 00:00:00

  • Carbon monoxide--toxicity of low-dose application.

    abstract::Carbon monoxide (CO) has long been considered a purely toxic by-product of incomplete combustion processes. Acute exposure to high concentrations of CO is one of the leading causes of fatal poisoning in industrial countries. However, after two decades of intensive research, there is ample evidence that CO endogenously...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/138920112800399103

    authors: Schmidt R,Ryan H,Hoetzel A

    更新日期:2012-05-01 00:00:00

  • The current status of novel PET radio-pharmaceuticals in radiotherapy treatment planning of glioma.

    abstract::Malignant glioma is a primary tumor of the central nervous system, representing a major cause of mortality in a young, productive subset of population. The management of this neoplasm requires aggressive treatments, including radiotherapy. Accurate imaging plays a central role in treatment planning process with curati...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/1389201015666140408122318

    authors: Marvaso G,Barone A,Amodio N,Cascini GL,Scotti V,Bianco C

    更新日期:2014-01-01 00:00:00

  • Using photoinduced charge transfer reactions to study conformational dynamics of biopolymers at the single-molecule level.

    abstract::This mini-review describes how single-molecule sensitive fluorescence resonance energy transfer (FRET) and photoinduced electron transfer (PET) reactions can be successfully applied to monitor conformational dynamics in biopolymers. Single-pair FRET experiments are ideally suited to study conformational dynamics occur...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/1389201043376896

    authors: Neuweiler H,Sauer M

    更新日期:2004-06-01 00:00:00

  • Nanosuspension as an Efficient Carrier for Improved Ocular Permeation of Voriconazole.

    abstract:BACKGROUND:The present limitations related to the ocular administration of antifungal drugs for the treatment of fungal keratitis include poor ocular bioavailability, limited retention time, and low ocular tissues penetration. METHODS:This study aimed to prepare a novel ophthalmic voriconazole-loaded nanosuspension ba...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章

    doi:10.2174/1389201021999200820154918

    authors: Qin T,Dai Z,Xu X,Zhang Z,You X,Sun H,Liu M,Zhu H

    更新日期:2020-08-20 00:00:00

  • Novel therapeutic approaches in limiting oxidative stress and inflammation.

    abstract::The interaction between reactive oxygen species (ROS) and inflammation plays an important role in the pathogenesis of endothelial dysfunction and cardiovascular disease, cancer and other diseases. Thus, antioxidant strategies may be important in immune regulation and in limiting inflammation. Surprisingly, large clini...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:

    authors: Spychalowicz A,Wilk G,Śliwa T,Ludew D,Guzik TJ

    更新日期:2012-10-01 00:00:00