Preparation and in vitro evaluation of α and β-amyrins loaded nanoemulsions.

abstract：:The clinical recognition and adequate treatment of women with hyperglycemia during pregnancy is significant in order to reduce neonatal complications correlated with gestational diabetes mellitus (GDM). The traditional management of pregnant patients with GDM in whom diet restriction is not sufficient enough involves ...

journal_title：Current pharmaceutical biotechnology

authors： Kimber-Trojnar Ż,Marciniak B,Patro-Malysza J,Skorzynska-Dziduszko K,Poniedzialek-Czajkowska E,Mierzynski R,Galczynski K,Trojnar M,Leszczynska-Gorzelak B,Oleszczuk J

更新日期：2014-01-01 00:00:00

abstract：:A novel steroidal oxime (SO) was synthesized using an economic method and then characterized by Fourier transform infrared (FTIR) and 1H nuclear magnetic resonance (NMR). When dispersed in pure water, SO can self-assemble into a nano-scale circular structure which was verified by dynamic light scattering (DLS) and tra...

journal_title：Current pharmaceutical biotechnology

authors： Chou TH,Chen CW

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Alfalfa and red clover are the most widespread and most important perennial legumes, primarily used as a high-quality feed for livestock. Both alfalfa and red clover, as well as some other plant species from Fabaceae family, are a rich natural source of phytoestrogens, nonsteroidal compounds with an estrogen...

journal_title：Current pharmaceutical biotechnology

authors： Tucak M,Horvat D,Cupic T,Krizmanic G,Tomas V,Ravlic M,Popovic S

更新日期：2018-01-01 00:00:00

abstract：:Beyond their originally sole mechanical function, current drug-eluting stents (DES) implement the concept of local drug delivery for the re-opening of stenotic arterial vessels, and for prevention of in-stent restenosis as one of the major limitations of conventional bare metal stents (BMS). Current DES consist of a p...

journal_title：Current pharmaceutical biotechnology

authors： Sternberg K,Grabow N,Petersen S,Weitschies W,Harder C,Ince H,Kroemer HK,Schmitz KP

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Fractalkine (FKN) in its free and membrane bound-forms and its receptor CX3CR1are reported to have an atherosclerotic effect. The relationship of Single Nucleotide Polymorphisms (SNPs) in FKN and CX3CR1genes with the Coronary Artery Disease (CAD) risk showed conflicting results in different populations. The ...

journal_title：Current pharmaceutical biotechnology

authors： Hassan DS,Hashad IM,Abdel Rahman MF,Abdel-Maksoud SM

更新日期：2018-01-01 00:00:00

abstract：:Platelet-rich plasma (PRP) is widely used to promote tissue repair and accelerate osteogenesis, but there is no agreement about its mechanism of action. We characterized the modulatory effect of PRP on the in vitro osteoblast model SaOS-2, by using cell motility/chemoattraction and osteogenesis/mineralization assays, ...

journal_title：Current pharmaceutical biotechnology

authors： Martinotti S,Mazzucco L,Balbo V,Patrone M,Mozzati M,Ranzato E,Burlando B

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Nitrate and nitrite can get into the body through the consumption of contaminated water either directly or indirectly. The accumulation of these compounds in the body, in the long run, leads to health problems, for example, digestive disorders, cancers, and even death threats in children. The aim of this rev...

journal_title：Current pharmaceutical biotechnology

authors： Marhamati M,Afshari A,Kiani B,Jannat B,Hashemi M

更新日期：2020-12-03 00:00:00

abstract：:A review of the developments on the analysis of residues of avermectins and milbemycins (both macrocyclic lactones) is presented. The macrocyclic lactones (MLs) are an important class of chemicals, which are used worldwide as veterinary drugs and as crop protection agents. As a result, residues of MLs are important fr...

journal_title：Current pharmaceutical biotechnology

authors： Danaher M,Radeck W,Kolar L,Keegan J,Cerkvenik-Flajs V

更新日期：2012-05-01 00:00:00

abstract：:With eleven therapeutic antibodies approved worldwide and many more in clinical trials, research on antibody engineering has continued to escalate and expand. This review covers recent progress in generation of antibodies by ex vivo methods, systems for screening these, and the quest for higher affinity, more stable, ...

journal_title：Current pharmaceutical biotechnology

authors： Presta LG

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVE:The aim of the work was to evaluate the effect of moderate physical exercise on the response of circulating phagocytes to the antineoplastic drug NSC 631570. METHODS:Eight healthy adult men aged 23 ± 2 years were recruited to participate in the study; NSC 631570 was administered i.v. in a single therapeutic ...

journal_title：Current pharmaceutical biotechnology

authors： Skivka LM,Fedorchuk OG,Susak YM,Susak MY,Malanchuk OM,Rudyk MP,Nowicky YW

更新日期：2015-01-01 00:00:00

abstract：:The accidental or intentional release of plutonium or americium can cause acute and long term adverse health effects if they enter the human body by ingestion, inhalation, or injection. These effects can be prevented by rapid removal of these radionuclides by chelators such as calcium or zinc diethylenetriaminepentaac...

journal_title：Current pharmaceutical biotechnology

authors： Kazzi ZN,Heyl A,Ruprecht J

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:L2-based Human Papillomavirus (HPV) prophylactic vaccines, containing epitopes from HPV minor capsid proteins, are under investigation as second-generation HPV vaccines. No such vaccine has passed clinical trials yet, mainly due to the low immunogenicity of peptide vaccines; so efforts are being continued. A...

journal_title：Current pharmaceutical biotechnology

authors： Negahdaripour M,Nezafat N,Heidari R,Erfani N,Hajighahramani N,Ghoshoon MB,Shoolian E,Rahbar MR,Najafipour S,Dehshahri A,Morowvat MH,Ghasemi Y

更新日期：2020-01-01 00:00:00

abstract：:The prospect of mobilizing the power of the immune system in the fight against cancer has fascinated generations of immunologists. After decades of sporadic successes scattered amongst frequent failures, the field of tumor immunology is now poised to take advantage of a greatly improved understanding of the molecular ...

journal_title：Current pharmaceutical biotechnology

authors： Rabinovich BA,Radu CG

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:In this study, local sustainable enzyme sources involving excised digestive juice of African land snail and yeast were utilized to achieve the simultaneous saccharification (SSF) and fermentation (SSF) of plantain pseudostem (PPS) waste, and afterwards their effects on terpenoids using gas chromatography cou...

journal_title：Current pharmaceutical biotechnology

authors： Uchenna AP,Charity ON,Abbey B

更新日期：2019-01-01 00:00:00

abstract：:Charged-hydrophobic mixed mode chromatography methods have been applied to antibody purification for decades and have focused more recently on the specific task of aggregate removal. They exploit various combinations of alkyl and aromatic hydrophobic groups with positively and/or negatively charged residues. Charge an...

journal_title：Current pharmaceutical biotechnology

authors： Gagnon P

更新日期：2009-06-01 00:00:00

abstract：:Tumor cells show metabolic features distinctive from normal tissues, with characteristically enhanced aerobic glycolysis, glutaminolysis and lipid synthesis. Peroxisome proliferator activated receptor α (PPAR α) is activated by nutrients (fatty acids and their derivatives) and influences these metabolic pathways actin...

journal_title：Current pharmaceutical biotechnology

authors： Grabacka M,Pierzchalska M,Reiss K

更新日期：2013-01-01 00:00:00

abstract：:A variety of technologies can be used in the detection of contagious pathogens. In the early stage of an outbreak of a new infectious disease, rtPCR is advantageous over many other assays. The rtPCR can be developed either using low fidelity DNA polymerase or high fidelity DNA polymerase. The application of high fidel...

journal_title：Current pharmaceutical biotechnology

authors： Li K,Xiao L,Liu C,Zhang J,Sirois P

更新日期：2010-01-01 00:00:00

abstract：:The metastatic cascade and colonization remains a major challenge in clinical therapeutics. The formation of metastasis has many rate limiting steps. The expression of metastases initiation genes in primary tumors is driven by the need for cell motility, invasiveness, handling the shear stress in the vasculature and l...

journal_title：Current pharmaceutical biotechnology

authors： Gueron G,De Siervi A,Vazquez E

更新日期：2011-11-01 00:00:00

abstract：:Carbon nanotubes are nano sized cylindrical chicken wire like structures made of carbon atoms. Carbon nanotubes have applications in electronics, energy storage, electromagnetic devices, environmental remediation and in medicine as well. The biomedical applications of carbon nanotubes can be owed to features like low ...

journal_title：Current pharmaceutical biotechnology

authors： Wani TU,Mohi-Ud-Din R,Wani TA,Hassan R,Itoo AM,Sheikh FA,Khan NA,Pottoo FH

更新日期：2020-11-10 00:00:00

abstract：:In this review, the compartments of the vasculature will be discussed with respect to their potential contribution to the build-up of a differentiated and functionally meaningful vessel system. Chronic ischemia of muscle tissue results in microvessel rarification, which represents a potential therapeutic target, given...

journal_title：Current pharmaceutical biotechnology

authors： Kupatt C

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Large-scale population studies showed that the SNP rs1764391 of Connexin37 gene also known as Cx37 gene may play a pivotal role in the occurrence and development of acute myocardial infarction (AMI). Published results, however, are highly controversial. OBJECTIVE:This study aimed to examine the association ...

journal_title：Current pharmaceutical biotechnology

authors： Li J,Qin R,Wang W,Huang Z,Huang DL,Li T,Wang F,Zeng XT,Sun ZY,Liu XF,Huang F,Guo T

更新日期：2020-01-01 00:00:00

abstract：:Using gene knockout mice of particular genes is one of the most effective methods in conducting successful study on the mode of action of target gene products in targeted organs. So called the knockout technology is now a powerful tool that can lead us to find clear understanding on difficult questions such as the eff...

journal_title：Current pharmaceutical biotechnology

authors： Miyamoto N,Namiki K,Tokuhara N,Uesugi M,Takahashi E,Kuromitsu J,Kasuya Y

更新日期：2009-02-01 00:00:00

abstract：:Calcium-sensing receptor (CaSR), a member of family C of the G protein-coupled receptors, is expressed most abundantly in the parathyroid glands and kidney. It plays key role in these two organs because it senses changes in extracellular calcium and regulates PTH secretion and calcium reabsorption to suit the extracel...

journal_title：Current pharmaceutical biotechnology

authors： Vezzoli G,Soldati L,Gambaro G

更新日期：2009-04-01 00:00:00

abstract：:Schizophrenia is a severe mental disorder, characterized by a complex symptomatology and a chronic relapsing course, leading to a more or less intensive residual syndrome. The disorder has strong consequences on social functioning and on the patients' quality of life and is associated with a huge economical burden for...

journal_title：Current pharmaceutical biotechnology

authors： Moller HJ

更新日期：2012-06-01 00:00:00

abstract：:Mammalian cells are involved in a range of biotechnological applications and more recently have been increasingly exploited in regenerative medicine. Critical to successful applications involving mammalian cells are their long-term storage and transport, for which cryopreservation in liquid nitrogen is the most freque...

journal_title：Current pharmaceutical biotechnology

authors： Chau DY,Dennis AR,Lin H,Zeitler JA,Tunnacliffe A

更新日期：2015-01-01 00:00:00

abstract：:The purpose of this review article is to describe the history of photodynamic therapy (PDT), its current medical applications, the mechanism of action, contraindications of the method, and different types of photosensitizers used. The second part of the article deals with applications for gastrointestinal diseases. Th...

journal_title：Current pharmaceutical biotechnology

authors： Wiedmann MW,Caca K

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:With the improvements in living standards, height is getting more attention. Malnutrition is one of the main causes of children's short stature, therefore nutritional intervention in adolescence is the key to prevent short stature. The peptides from Antarctic krill (AKPs), the ideal protein model, act in bon...

journal_title：Current pharmaceutical biotechnology

authors： Dai Y,Li Z,Fu M,Li Y,Xue C,Wang J

更新日期：2020-06-12 00:00:00

abstract：:Lipid nanocapsules with their unique composition represent a promising biocompatible drug delivery platform in nanometer range with narrow size distribution. They are highly stable in comparison to other nano-vectors and were found to impart very desirable characteristics to the therapeutic molecule being delivered wi...

journal_title：Current pharmaceutical biotechnology

authors： Nasr M,Abdel-Hamid S

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Epithelial-mesenchymal transition (EMT) is a molecular reprogramming that leads to an increased ability to migrate, which can promote invasion and metastasis. EMT can be initiated in response to the activity of signaling pathways such as Wnt as well as miRNAs. OBJECTIVE:The aim of the study was to determine...

journal_title：Current pharmaceutical biotechnology

authors： Zmarzły N,Hermyt E,Kruszniewska-Rajs C,Gola J,Witek A,Mazurek U,Ostenda A,Boroń D

更新日期：2020-12-18 00:00:00

abstract：:Essential oils have increased interest as promising ingredients for novel pharmaceutical dosage forms. These oils are reported to provide synergistic effects of their active ingredients, in parallel with their biodegradable properties. In addition, essential oils may also have therapeutic effects in diabetes, inflamma...

journal_title：Current pharmaceutical biotechnology

authors： Severino P,Andreani T,Chaud MV,Benites CI,Pinho SC,Souto EB

更新日期：2015-01-01 00:00:00