Therapeutic potential of non-coding RNAs and TLR signalling pathways in Rheumatoid arthritis.

Abstract:

BACKGROUND:Rheumatoid arthritis (RA) is a common connective tissue disease, characteristic of chronic and invasive synovitis in single or multiple joints and vasculitis. RA is a heterogeneous disease with unclear pathogenesis. Therefore, exploring the etiology and pathogenesis of the disease is essential for identifying new promising treatment strategy for RA. Accumulated data have implicated the significant role of non-coding RNA in RA, some of which are demonstrated to regulate inflammation and autoimmunity in RA through toll-like receptor (TLR) signaling pathway. To clarify the mechanism of non-coding RNA regulating the generation of proinflammatory mediators is helpful for understanding the pathogenesis of RA. Moreover, these well established non-coding RNAs can serve as novel biotargets for RA diagnosis and treatment. CONCLUSION:Here, we summarize currently available data on non-coding RNAs, TLRs, and the underlying molecular mechanisms in RA. This review will provide insight into the potential use of non-coding RNA as disease diagnosis and treatment markers for RA.

journal_name

Curr Pharm Biotechnol

authors

Liu J,Wang X,Wang S,Liu F

doi

10.2174/1389201021666201001142829

subject

Has Abstract

pub_date

2020-10-01 00:00:00

eissn

1389-2010

issn

1873-4316

pii

CPB-EPUB-110380

pub_type

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