Transplacental transfer of immunosuppressants and biologics used for the treatment of inflammatory bowel disease.

abstract：:Carbon nanotubes are nano sized cylindrical chicken wire like structures made of carbon atoms. Carbon nanotubes have applications in electronics, energy storage, electromagnetic devices, environmental remediation and in medicine as well. The biomedical applications of carbon nanotubes can be owed to features like low ...

journal_title：Current pharmaceutical biotechnology

authors： Wani TU,Mohi-Ud-Din R,Wani TA,Hassan R,Itoo AM,Sheikh FA,Khan NA,Pottoo FH

更新日期：2020-11-10 00:00:00

abstract：BACKGROUND:`Herbal mixtures` containing synthetic cannabinoid receptor agonists (SCRAs) are promoted as legal alternative to marihuana and are easily available via the Internet. Keeping analytical methods for the detection of these SCRAs up-to-date is a continuous challenge for clinicians and toxicologists due to the h...

journal_title：Current pharmaceutical biotechnology

authors： Hutter M,Broecker S,Kneisel S,Franz F,Brandt SD,Auwarter V

更新日期：2018-01-01 00:00:00

abstract：:Tumor cells show metabolic features distinctive from normal tissues, with characteristically enhanced aerobic glycolysis, glutaminolysis and lipid synthesis. Peroxisome proliferator activated receptor α (PPAR α) is activated by nutrients (fatty acids and their derivatives) and influences these metabolic pathways actin...

journal_title：Current pharmaceutical biotechnology

authors： Grabacka M,Pierzchalska M,Reiss K

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Large-scale population studies showed that the SNP rs1764391 of Connexin37 gene also known as Cx37 gene may play a pivotal role in the occurrence and development of acute myocardial infarction (AMI). Published results, however, are highly controversial. OBJECTIVE:This study aimed to examine the association ...

journal_title：Current pharmaceutical biotechnology

authors： Li J,Qin R,Wang W,Huang Z,Huang DL,Li T,Wang F,Zeng XT,Sun ZY,Liu XF,Huang F,Guo T

更新日期：2020-01-01 00:00:00

abstract：:The growing prevalence of disorders of lipid and sterol homeostasis such as obesity and atherosclerosis in Western societies has increased demand for the development of therapies for their prevention and treatment. Crucial for this development is an understanding of the underlying cellular mechanisms which are involve...

journal_title：Current pharmaceutical biotechnology

authors： Traini M,Jessup W

更新日期：2012-02-01 00:00:00

abstract：:Control of VEGF signaling is an intense objective of pre-clinical and clinical studies in HCC disease with steadily increasing clinical application. Despite its emerging role, several aspects of anti-VEGF based treatments are poorly investigated, like the impact on tumor cells themselves, such as the effect on intrace...

journal_title：Current pharmaceutical biotechnology

authors： Raskopf E,Vogt A,Decker G,Hirt S,Daskalow K,Cramer T,Standop J,Gonzalez-Carmona MA,Sauerbruch T,Schmitz V

更新日期：2012-09-01 00:00:00

abstract：:The idea of cancer stem cell (CSC) has recently moved to the forefront of cancer research. There is still a lack of a widespread consensus on their description and definition. ,The increasing literature on CSCs has compelled researchers worldwide to rewrite the natural history of cancer including those cells as princi...

journal_title：Current pharmaceutical biotechnology

authors： Albini A,Cesana E,Noonan DM

更新日期：2011-02-01 00:00:00

abstract：:Autonomic neural functions are important to regulate vital functions in the living body. There are different methods to evaluate indirectly and directly autonomic, sympathetic and parasympathetic, neural functions of human body. Among various methods, microneurography is a technique to evaluate directly sympathetic ne...

journal_title：Current pharmaceutical biotechnology

authors： Mano T

更新日期：2005-08-01 00:00:00

abstract：:Hyaluronan (HA) is a highly biocompatible biopolymer that is widely used for a variety of therapeutic purposes including surgical preparations, adhesion prevention, viscosupplementation and drug and cytokine delivery. Delivery can be accomplished effectively when HA-based carriers are synthesized in the form of hydrog...

journal_title：Current pharmaceutical biotechnology

authors： Peattie RA

更新日期：2012-06-01 00:00:00

abstract：:Apolipoprotein M (apoM) has been suggested to play a role in reverse cholesterol transport. Here we studied the influence of liver X-receptor (LXR) agonist on the transcriptional regulation of apoM. Studies were performed in murine liver and intestinal mucosal cells in vivo and in human intestinal Caco-2 cells in vitr...

journal_title：Current pharmaceutical biotechnology

authors： Calayir E,Becker TM,Kratzer A,Ebner B,Panzenböck U,Stefujl J,Kostner GM

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:Frequent administrations for DPPIV-resistant GLP-1 analogs are necessary to maintain the blood concentrations due to the short half-life of less than 5 minutes. However, most delivery systems that possess the ability of sustainable release of GLP-1 have drawbacks such as low yield, high cost and undesirable s...

journal_title：Current pharmaceutical biotechnology

authors： Fan L,Fan Y,Fan H,Huang K

更新日期：2020-01-01 00:00:00

abstract：:In order to valorize novel biotechnology innovations, there is a need to evaluate ex-ante their market potential. A case in point is biofortification, i.e. the enhancement of the micronutrient content of staple crops through conventional or genetic breeding techniques. In a recent article in Nature Biotechnology, for ...

journal_title：Current pharmaceutical biotechnology

authors： De Steur H,Blancquaert D,Gellynck X,Lambert W,Van Der Straeten D

更新日期：2012-12-01 00:00:00

abstract：:There is a growing trend of herbal medicines in India as well as other parts of the world. The use of herbal medicines alone or alongside prescription drugs for disease management is quite common now. We hereby carry out a review of dominant species of Selinum mainly S. vaginatum C.B. Clarke and S. wallichianum (DC.) ...

journal_title：Current pharmaceutical biotechnology

authors： Srivastava RP,Dixit P,Singh L,Verma PC,Saxena G

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:We sought to evaluate the safety of imipenem and meropenem in the treatment of infections in neurosurgical patients. METHODS:An observational retrospective study was conducted of consecutive cases treated with imipenem from Sept. 2007 to Sept. 2009 and meropenem within 1 year from Sept. 2008 in Beijing Tiant...

journal_title：Current pharmaceutical biotechnology

authors： Wu Y,Chen K,Shi Z,Wang Q

更新日期：2014-01-01 00:00:00

abstract：:A novel steroidal oxime (SO) was synthesized using an economic method and then characterized by Fourier transform infrared (FTIR) and 1H nuclear magnetic resonance (NMR). When dispersed in pure water, SO can self-assemble into a nano-scale circular structure which was verified by dynamic light scattering (DLS) and tra...

journal_title：Current pharmaceutical biotechnology

authors： Chou TH,Chen CW

更新日期：2015-01-01 00:00:00

abstract：:Charged-hydrophobic mixed mode chromatography methods have been applied to antibody purification for decades and have focused more recently on the specific task of aggregate removal. They exploit various combinations of alkyl and aromatic hydrophobic groups with positively and/or negatively charged residues. Charge an...

journal_title：Current pharmaceutical biotechnology

authors： Gagnon P

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Secondary metabolites of plants, the polyphenols, play a vital role in protection from many health problems in human beings. Structurally favored phytochemicals may be studied to protect multiorgan injury. At pharmacological doses, gallic acid is nontoxic to mammals and is generally absorbed in the intestine...

journal_title：Current pharmaceutical biotechnology

authors： Rakshit S,Nirala SK,Bhadauria M

更新日期：2020-01-01 00:00:00

abstract：:Comprehensive analytical technologies are rapidly becoming a cornerstone of modern nutritional sciences. Two of these technologies, mass spectrometry (MS) and nuclear magnetic resonance (NMR), have proven highly informative for the global analysis of metabolites, commonly referred to as metabolomics. Metabolomics prov...

journal_title：Current pharmaceutical biotechnology

authors： Zulyniak MA,Mutch DM

更新日期：2011-07-01 00:00:00

abstract：:Essential oils have increased interest as promising ingredients for novel pharmaceutical dosage forms. These oils are reported to provide synergistic effects of their active ingredients, in parallel with their biodegradable properties. In addition, essential oils may also have therapeutic effects in diabetes, inflamma...

journal_title：Current pharmaceutical biotechnology

authors： Severino P,Andreani T,Chaud MV,Benites CI,Pinho SC,Souto EB

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Bacterial lipases especially Pseudomonas lipases are extensively used for different biotechnological applications. OBJECTIVES:With the better understanding and progressive needs for improving its activity in accordance with the growing market demand, we aimed in this study to improve the recombinant product...

journal_title：Current pharmaceutical biotechnology

authors： El-Aziz AMA,Shaker MA,Shaaban MI

更新日期：2019-01-01 00:00:00

abstract：:Tinospora cordifolia (Giloy) is a medicinal plant used in folk and Ayurvedic medicines throughout India since ancient times. All the parts of the plant are immensely useful due to the presence of different compounds of pharmaceutical importance belonging to various groups as alkaloids, diterpenoid lactones, glycosides...

journal_title：Current pharmaceutical biotechnology

authors： Kumar P,Kamle M,Mahato DK,Bora H,Sharma B,Rasane P,Bajpai VK

更新日期：2020-01-01 00:00:00

abstract：:Carbon monoxide (CO) has long been considered a purely toxic by-product of incomplete combustion processes. Acute exposure to high concentrations of CO is one of the leading causes of fatal poisoning in industrial countries. However, after two decades of intensive research, there is ample evidence that CO endogenously...

journal_title：Current pharmaceutical biotechnology

authors： Schmidt R,Ryan H,Hoetzel A

更新日期：2012-05-01 00:00:00

abstract：:Staphylococcus aureus is a leading causative agent in sepsis, endocarditis, and pneumonia. An emerging concept is that prognosis worsens when the infecting S. aureus strain has the capacity to not only colonize tissue as an extracellular pathogen, but to invade host cells and establish intracellular bacterial populati...

journal_title：Current pharmaceutical biotechnology

authors： Cordero D,Fullenkamp CR,Pelly RR,Reed KM,Caffo LM,Zahrt AN,Newman M,Komanapalli S,Niemeier EM,Bishop DL,Bruns HA,Haynes MK,Sklar LA,Sammelson RE,McDowell SA

更新日期：2014-01-01 00:00:00

abstract：:Tuberculosis (TB) is a disease of global concern. About one third of the world population is infected with Mycobacterium tuberculosis. Every year, approximately 8 million people get the disease and 2 million die of TB. The currently available vaccine against TB is the attenuated strain of Mycobacterium bovis, Bacillus...

journal_title：Current pharmaceutical biotechnology

authors： Mustafa AS

更新日期：2001-06-01 00:00:00

abstract：:Under normal conditions, most of the central nervous system (CNS) is protected by the blood brain barrier (BBB) from systemic inflammation progression and from the infiltration of immune cells. As a consequence, the CNS developed an original way to provide surveillance, defense and repair, which relies on the complex ...

journal_title：Current pharmaceutical biotechnology

authors： Renaud J,Martinoli MG

更新日期：2014-01-01 00:00:00

abstract：:In recent years, many systems biology approaches have been used with various cancers. The materials described here can be used to build bases to discover novel cancer therapy targets in connection with computer-aided drug design (CADD). A deeper understanding of the mechanisms of cancer will provide more choices and c...

journal_title：Current pharmaceutical biotechnology

authors： Wong YH,Chiu CC,Lin CL,Chen TS,Jheng BR,Lee YC,Chen J,Chen BS

更新日期：2016-01-01 00:00:00

abstract：:The interaction between reactive oxygen species (ROS) and inflammation plays an important role in the pathogenesis of endothelial dysfunction and cardiovascular disease, cancer and other diseases. Thus, antioxidant strategies may be important in immune regulation and in limiting inflammation. Surprisingly, large clini...

journal_title：Current pharmaceutical biotechnology

authors： Spychalowicz A,Wilk G,Śliwa T,Ludew D,Guzik TJ

更新日期：2012-10-01 00:00:00

abstract：:Most cancer patients will experience moderate to severe pain and/or neuropathy during the course of their disease. Recent improvements in the primary treatment of cancer have increased the life span of cancer patients, but not necessarily their quality of life (QoL). The pain and suffering cancer patients experience m...

journal_title：Current pharmaceutical biotechnology

authors： Knopp KL,Nisenbaum ES,Arneric SP

更新日期：2011-10-01 00:00:00

abstract：:The number of diseases found to be associated with defects of the mitochondrial genome has grown significantly over the last decade. Despite major advances in understanding mtDNA defects at the genetic and biochemical level, there is no satisfactory treatment for the vast majority of patients available. This is largel...

journal_title：Current pharmaceutical biotechnology

authors： Weissig V,Torchilin VP

更新日期：2000-12-01 00:00:00

abstract：:Platelet concentrates for surgical use are innovative tools of regenerative medicine, and were widely tested in oral and maxillofacial surgery. Unfortunately, the literature on the topic is contradictory and the published data are difficult to sort and interpret. In bone graft, implant and reconstructive surgery, the ...

journal_title：Current pharmaceutical biotechnology

authors： Simonpieri A,Del Corso M,Vervelle A,Jimbo R,Inchingolo F,Sammartino G,Dohan Ehrenfest DM

更新日期：2012-06-01 00:00:00