Gallic Acid Protects from Acute Multiorgan Injury Induced by Lipopolysaccharide and D-galactosamine.

abstract：BACKGROUND:In this study, local sustainable enzyme sources involving excised digestive juice of African land snail and yeast were utilized to achieve the simultaneous saccharification (SSF) and fermentation (SSF) of plantain pseudostem (PPS) waste, and afterwards their effects on terpenoids using gas chromatography cou...

journal_title：Current pharmaceutical biotechnology

authors： Uchenna AP,Charity ON,Abbey B

更新日期：2019-01-01 00:00:00

abstract：:Beyond their originally sole mechanical function, current drug-eluting stents (DES) implement the concept of local drug delivery for the re-opening of stenotic arterial vessels, and for prevention of in-stent restenosis as one of the major limitations of conventional bare metal stents (BMS). Current DES consist of a p...

journal_title：Current pharmaceutical biotechnology

authors： Sternberg K,Grabow N,Petersen S,Weitschies W,Harder C,Ince H,Kroemer HK,Schmitz KP

更新日期：2013-01-01 00:00:00

abstract：:This paper reviews the current state-of-the-art development of single-molecule detection (SMD)-based methods for ultrasensitive and specific analysis of genomic sequences. We first discuss several newly devised single fluorescent probe strategies that allow separation-free detection of low-abundance DNA sequences, suc...

journal_title：Current pharmaceutical biotechnology

authors： Yeh HC,Chao SY,Ho YP,Wang TH

更新日期：2005-12-01 00:00:00

abstract：:Immuno-isolation provides a potentially safe and effective method of delivering recombinant therapeutic molecules. Its application as a drug-delivery platform for the treatment of cancer has shown promising developments recently. This review will summarize the principle and current progress of this novel therapy parad...

journal_title：Current pharmaceutical biotechnology

authors： Cirone P,Saller RM,Chang PL

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Burn is still an important global public health challenge. Wound colonization of antibiotic resistant bacteria such as Acinetobacter baumannii can lead to high morbidity and mortality in burn patients. The aim of this study was to evaluate the inhibitory effect of tazobactam on efflux pump, which can cause a...

journal_title：Current pharmaceutical biotechnology

authors： Azimi L,Tahbaz SV,Alaghehbandan R,Alinejad F,Lari AR

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:Advanced gastrointestinal stromal tumours (GISTs) are treated with tyrosine kinase inhibitors, which also have antiangiogenic properties. Dual-energy CT (DECT) allows to acquire semi-quantitative iodine images which might correlate with blood pool and tumor vascularity. In this feasibility-study, we correlated ...

journal_title：Current pharmaceutical biotechnology

authors： Schramm N,Schlemmer M,Englhart E,Hittinger M,Becker C,Reiser M,Berger F

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is a primary liver cancer with high mortality. Paeoniflorin is a pinane monoterpene picroside with anti-tumor effect isolated from Chinese peony root and white peony root. OBJECTIVE:To investigate the underlying mechanism of paeoniflorin (PF) regulating hepatocellular carcinom...

journal_title：Current pharmaceutical biotechnology

authors： Zhou Y,Liu X,Gao Y,Tan R,Wu Z,Zhong Q,Zeng F

更新日期：2020-10-09 00:00:00

abstract：:Toll-like receptor 9 (TLR9) can sense pathogen DNA and CpG ODN or even self-DNA by trafficking assisted by Unc93B1, an endoplasmic reticulum (ER) transmembrane protein, from ER to endolysosomes or cell surface. In previous study, we found that an oligodeoxynucleotide with CCT repeats (SAT05f) could selectively inhibit...

journal_title：Current pharmaceutical biotechnology

authors： Zhang X,Sun W,Wu X,Wang H,Yan Y,Guo S,Song D,Li H,Gao S,Wang L,Yu Y,Wang L

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND & OBJECTIVE:Nutritional culturomics (NCs) is a specific focus area of culturomics epistemology developing digital humanities and computational linguistics approaches to search for macro-patterns of public interest in food, nutrition and diet choice as a major component of cultural evolution. Cultural evoluti...

journal_title：Current pharmaceutical biotechnology

authors： Troumbis AY,Hatziantoniou M,Vasios GK

更新日期：2019-01-01 00:00:00

abstract：:Using gene knockout mice of particular genes is one of the most effective methods in conducting successful study on the mode of action of target gene products in targeted organs. So called the knockout technology is now a powerful tool that can lead us to find clear understanding on difficult questions such as the eff...

journal_title：Current pharmaceutical biotechnology

authors： Miyamoto N,Namiki K,Tokuhara N,Uesugi M,Takahashi E,Kuromitsu J,Kasuya Y

更新日期：2009-02-01 00:00:00

abstract：PURPOSE:The work was performed to investigate the feasibility of preparing ocular inserts loaded with Poly-ε-Caprolactone (PCL) nanoparticles as a sustained ocular delivery system. METHODS:First, Atorvastatin Calcium-Poly-ε-Caprolactone (ATC-PCL) nanoparticles were prepared and characterized. Then, the optimized nanop...

journal_title：Current pharmaceutical biotechnology

authors： Girgis GNS

更新日期：2020-01-01 00:00:00

abstract：:Active or passive immunotherapy is expected to slow or stop the pathological process of Alzheimer's disease (AD). Immunotherapy for AD has demonstrated that targeting beta-amyloid (Aβ) or tau protein with vaccines or antibodies can reduce AD pathologies. Active anti-Aβ immunization for AD includes using AN1792 and sec...

journal_title：Current pharmaceutical biotechnology

authors： Yang C,Xiao S

更新日期：2015-01-01 00:00:00

abstract：:Better understanding of protein higher order structures (HOS) is of major interest to researchers in the field of biotechnology and biopharmaceutics. Monitoring a protein's HOS is crucial towards understanding the impact of molecular conformation on the biotechnological application. In addition, maintaining the HOS is...

journal_title：Current pharmaceutical biotechnology

authors： Nagarkar RP,Murphy BM,Yu X,Manning MC,Al-Azzam WA

更新日期：2013-01-01 00:00:00

abstract：:Raman spectroscopy has long been used as a powerful tool for chemical composition analyses. Raman scattering light measurement has the advantage of being able to examine biomolecules in a nondestructive and non-labeling manner. However, molecular imaging of cells and tissues by using Raman microscopy had been hampered...

journal_title：Current pharmaceutical biotechnology

authors： Harada Y,Takamatsu T

更新日期：2013-01-01 00:00:00

abstract：:Staphylococcus aureus is a leading causative agent in sepsis, endocarditis, and pneumonia. An emerging concept is that prognosis worsens when the infecting S. aureus strain has the capacity to not only colonize tissue as an extracellular pathogen, but to invade host cells and establish intracellular bacterial populati...

journal_title：Current pharmaceutical biotechnology

authors： Cordero D,Fullenkamp CR,Pelly RR,Reed KM,Caffo LM,Zahrt AN,Newman M,Komanapalli S,Niemeier EM,Bishop DL,Bruns HA,Haynes MK,Sklar LA,Sammelson RE,McDowell SA

更新日期：2014-01-01 00:00:00

abstract：:The prospect of mobilizing the power of the immune system in the fight against cancer has fascinated generations of immunologists. After decades of sporadic successes scattered amongst frequent failures, the field of tumor immunology is now poised to take advantage of a greatly improved understanding of the molecular ...

journal_title：Current pharmaceutical biotechnology

authors： Rabinovich BA,Radu CG

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Herein, we report the biosynthesis procedure to prepare silver nanoparticles as reduction and capping agents with the aqueous plant extract of Perovskia abrotanoides. METHODS:The therapeutic application of silver nanoparticles entirely depends on the size and shape of the nanoparticles therefore, their cont...

journal_title：Current pharmaceutical biotechnology

authors： Mirsadeghi S,Koudehi MF,Rajabi HR,Pourmortazavi SM

更新日期：2020-01-01 00:00:00

abstract：:Lactobacilli are common microorganisms in diverse vegetables and meat products and several of these are also indigenous inhabitants in the gastro-intestinal (GI) tract of humans and animals where they are believed to have health promoting effects on the host. One of the highly appreciated probiotic effects is their ab...

journal_title：Current pharmaceutical biotechnology

authors： Diep DB,Mathiesen G,Eijsink VG,Nes IF

更新日期：2009-01-01 00:00:00

abstract：:Tinospora cordifolia (Giloy) is a medicinal plant used in folk and Ayurvedic medicines throughout India since ancient times. All the parts of the plant are immensely useful due to the presence of different compounds of pharmaceutical importance belonging to various groups as alkaloids, diterpenoid lactones, glycosides...

journal_title：Current pharmaceutical biotechnology

authors： Kumar P,Kamle M,Mahato DK,Bora H,Sharma B,Rasane P,Bajpai VK

更新日期：2020-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs), a form of adult stem cells, are known to have a self-renewing property and the potential to specialize into a multitude of cells and tissues such as adipocytes, cartilage cells, and fibroblasts. MSCs can migrate and home to the desired target zone where inflammation is present. The uniqu...

journal_title：Current pharmaceutical biotechnology

authors： Saeedi M,Nezhad MS,Mehranfar F,Golpour M,Esakandari MA,Rashmeie Z,Ghorbani M,Nasimi F,Hoseinian SN

更新日期：2020-09-07 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis (RA) is a common connective tissue disease, characteristic of chronic and invasive synovitis in single or multiple joints and vasculitis. RA is a heterogeneous disease with unclear pathogenesis. Therefore, exploring the etiology and pathogenesis of the disease is essential for identifyin...

journal_title：Current pharmaceutical biotechnology

authors： Liu J,Wang X,Wang S,Liu F

更新日期：2020-10-01 00:00:00

abstract：:Coagulase-negative staphylococci (CoNS) are part of the microbiota of human skin and rarely linked with soft tissue infections. In recent years, CoNS species considered as one of the major nosocomial pathogens and can cause several infections such as catheter-acquired sepsis, skin infection, urinary tract infection, e...

journal_title：Current pharmaceutical biotechnology

authors： Noshak MA,Rezaee MA,Hasani A,Mirzaii M

更新日期：2020-01-01 00:00:00

abstract：:The innate immune system protects against infectious microbes by the recognition of pathogen- associated molecular patterns, which serve to detect pathogens on the host cell surface or in endosomes by pattern recognition receptors such as Toll-like receptors, nucleotide-binding oligomerization domain-containing protei...

journal_title：Current pharmaceutical biotechnology

authors： Fischer S

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:RA is one of autoimmune diseases, has drawn great attention of the world. Currently, the anti- IL-1β monoclonal antibody Canakinumab (ACZ885) for treatment of RA has entered into clinical trials. However, Full length antibody has large molecular weight, and is difficult to penetrate the tissue or the nidus. I...

journal_title：Current pharmaceutical biotechnology

authors： Li T,Xu L,Ren G,Yin C,Zhou B,Ye X,Li Q,Li N,Li D

更新日期：2013-01-01 00:00:00

abstract：:Long-term increase of blood pressure represents one of the most important risk factors triggering many cardiovascular diseases, and via counter-regulatory mechanisms it is itself modulated by them. Adequate perfusion of the respective areas with nutrients requires appropriate production of vasodilatory and vasoconstri...

journal_title：Current pharmaceutical biotechnology

authors： Kristek F

更新日期：2011-09-01 00:00:00

abstract：:Bone is among the most common locations of metastasis and therefore represents an important clinical target for diagnostic follow-up in cancer patients. In the pathogenesis of bone metastases, disseminated tumor cells proliferating in bone interact with the local microenvironment stimulating or inhibiting osteoclast a...

journal_title：Current pharmaceutical biotechnology

authors： Bauerle T,Komljenovic D,Semmler W

更新日期：2012-03-01 00:00:00

abstract：:The IMiDs represent a new proprietary class of thalidomide analogues that possess greater potency and less toxicity than the parent compound. As a group, these agents share the pharmacologic property of modulating cellular response to ligand activation, the precise biologic effect of which is cell lineage and stimulan...

journal_title：Current pharmaceutical biotechnology

authors： Kale V,List AF

更新日期：2006-10-01 00:00:00

abstract：:Objective: CME-1 is a polysaccharide purified from the mycelia of medicinal mushroom Cordyceps sinensis, its molecular weight was determined to be 27.6 kDa by using nuclear magnetic resonance and gas chromatography-mass spectrometry. The initiation of arterial thromboses is relevant to various cardiovascular diseases ...

journal_title：Current pharmaceutical biotechnology

authors： Chang YI,Hsu WH,Lu WJ,Jayakumar T,Liao JC,Lin MJ,Wang SH,Geraldine P,Lin KH,Sheu JR

更新日期：2015-03-03 00:00:00

abstract：:TGF-β isoforms (TGF-β1, -β2, and -β3) are secreted signaling ligands that stimulate the expression of protein components of the extracellular matrix, regulate the growth and differentiation of epithelial cells, modulate immune cell function, and play roles in the development of several essential organs, including the ...

journal_title：Current pharmaceutical biotechnology

authors： Hinck AP,O'Connor-McCourt MD

更新日期：2011-12-01 00:00:00

abstract：:Ivermectin is a broad spectrum antiparasitic veterinary drug introduced in human medicine in 1987. It is considered the drug of choice in onchocerciasis and strongyloidiasis infections, and remains as a therapeutic option for mass treatment in lymphatic filariasis, for which it has widely proved its efficacy. While re...

journal_title：Current pharmaceutical biotechnology

authors： González P,González FA,Ueno K

更新日期：2012-05-01 00:00:00