Release of growth factors, cytokines and therapeutic molecules by hyaluronan-based hydrogels.

abstract：BACKGROUND:Enterotoxigenic Escherichia coli (ETEC) is the main cause of fatal diarrhea in piglets during the first week of life and over the time of weaning. Pathogenesis of ETEC-causing diarrhea involves intestinal colonization mediated by fimbriae. Although, both IgY and egg yolk phosvitin (PV) possess antimicrobial ...

journal_title：Current pharmaceutical biotechnology

authors： Gujral N,Yoo H,Bamdad F,Lee KY,Suh JW,Sunwoo H

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Epithelial-mesenchymal transition (EMT) is a molecular reprogramming that leads to an increased ability to migrate, which can promote invasion and metastasis. EMT can be initiated in response to the activity of signaling pathways such as Wnt as well as miRNAs. OBJECTIVE:The aim of the study was to determine...

journal_title：Current pharmaceutical biotechnology

authors： Zmarzły N,Hermyt E,Kruszniewska-Rajs C,Gola J,Witek A,Mazurek U,Ostenda A,Boroń D

更新日期：2020-12-18 00:00:00

abstract：BACKGROUND:The present limitations related to the ocular administration of antifungal drugs for the treatment of fungal keratitis include poor ocular bioavailability, limited retention time, and low ocular tissues penetration. METHODS:This study aimed to prepare a novel ophthalmic voriconazole-loaded nanosuspension ba...

journal_title：Current pharmaceutical biotechnology

authors： Qin T,Dai Z,Xu X,Zhang Z,You X,Sun H,Liu M,Zhu H

更新日期：2020-08-20 00:00:00

abstract：OBJECTIVE:RA is one of autoimmune diseases, has drawn great attention of the world. Currently, the anti- IL-1β monoclonal antibody Canakinumab (ACZ885) for treatment of RA has entered into clinical trials. However, Full length antibody has large molecular weight, and is difficult to penetrate the tissue or the nidus. I...

journal_title：Current pharmaceutical biotechnology

authors： Li T,Xu L,Ren G,Yin C,Zhou B,Ye X,Li Q,Li N,Li D

更新日期：2013-01-01 00:00:00

abstract：:Conventional biochemical assays are performed via an averaging procedure with the lysate of a large number of target cells; however, the averaged data lose information regarding the heterogeneity of individual cells. For quantitative assay of single cells, it is necessary to isolate single cells, extract cellular comp...

journal_title：Current pharmaceutical biotechnology

authors： Sasaki A,Sakata H,Kinjo M

更新日期：2010-01-01 00:00:00

abstract：:The bioethical and juridical debate on the status of frozen embryos sometimes adds new issues arising from new scientific evidence or by accidental occurrences that bring to the attention of the scientific community the need for new practical solutions. Within this scenario, there have been, in recent years, episodes ...

journal_title：Current pharmaceutical biotechnology

authors： Busardò FP,Vergallo GM,Turillazzi E,Bolino G,Vullo A,Frati P

更新日期：2016-01-01 00:00:00

abstract：AIM OF THE STUDY:To assess tramadol and O-desmethyltramadol (M1) concentrations and their correlations with analgesia in patients with cancer pain. PATIENTS AND METHODS:Thirty opioid-naive patients with nociceptive pain intensity on VAS (visual analogue scale) > 40 received controlled-release tramadol as the first (15...

journal_title：Current pharmaceutical biotechnology

authors： Leppert W,Mikolajczak P

更新日期：2011-02-01 00:00:00

abstract：:Recent research has shown that the endogenous gas hydrogen sulphide (H2S) is a signalling molecule of considerable biological potential and has been suggested to be involved in a vast number of physiological processes. In the vascular system, H2S is synthesized from cysteine by cystathionine-γ-lyase (CSE) in smooth mu...

journal_title：Current pharmaceutical biotechnology

authors： Skovgaard N,Gouliaev A,Aalling M,Simonsen U

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Nanotechnology involves the synthesis of materials that are in nanometre sizes (1 to 100 nm). Nanotechnology has appeared as a new area of fundamental science and is getting worldwide consideration due to its extensive applications. They have exceptional physicochemical properties due to their unique size, s...

journal_title：Current pharmaceutical biotechnology

authors： Roy A

更新日期：2020-10-27 00:00:00

abstract：BACKGROUND:Worldwide, the progress in reducing neonatal mortality has been very slow. The rate of preterm birth has increased over the last 20 years in low-income and middle-income countries. Its association with increased mortality and morbidity is based on experimental studies and neonatal outcomes from countries wit...

journal_title：Current pharmaceutical biotechnology

authors： Muñoz-Pérez VM,Ortiz MI,Cariño-Cortés R,Fernández-Martínez E,Rocha-Zavaleta L,Bautista-Ávila M

更新日期：2019-01-01 00:00:00

abstract：:Mammalian cell lines are important host cells for the industrial production of pharmaceutical proteins owing to their capacity for correct folding, assembly and post-translational modification. In particular, Chinese hamster ovary (CHO) cells are the most dependable host cells for the industrial production of therapeu...

journal_title：Current pharmaceutical biotechnology

authors： Omasa T,Onitsuka M,Kim WD

更新日期：2010-04-01 00:00:00

abstract：:The recent developement of platelet concentrate for surgical use is an evolution of the fibrin glue technologies used since many years. The initial concept of these autologous preparations was to concentrate platelets and their growth factors in a plasma solution, and to activate it into a fibrin gel on a surgical sit...

journal_title：Current pharmaceutical biotechnology

authors： Bielecki T,Dohan Ehrenfest DM

更新日期：2012-06-01 00:00:00

abstract：:It is now widely believed that tumors originate from normal cells as a result of accumulated genetic/epigenetic changes. These alterations affect the signaling pathways at transcriptional and post-transcriptional level that drive cells into uncontrolled cell division, growth, and migration. Recent advancement of molec...

journal_title：Current pharmaceutical biotechnology

authors： Yamashita T,Honda M,Kaneko S

更新日期：2008-10-01 00:00:00

abstract：:Biophysical applications ranging from fluorescence microassays to single-molecule microscopy are increasingly dependent on automated nanoscale positional control and stability. A whirlwind of motion-industry innovation has resulted in an array of new motion options offering significant improvements in application perf...

journal_title：Current pharmaceutical biotechnology

authors： Jordan SC,Anthony PC

更新日期：2009-08-01 00:00:00

abstract：:Gene therapy is a potential treatment for severe inherited disorders for which there is little hope of finding a conventional cure. These include lethal diseases like immunodeficiencies and metabolic disorders, and non lethal conditions associated to poor quality of life and life-long symptomatic treatments, like musc...

journal_title：Current pharmaceutical biotechnology

authors： Cavazza A,Mavilio F

更新日期：2012-08-01 00:00:00

abstract：:We have developed a high-pH, pH-shift refolding "Ph-Fold technology", both for academic research and industrial protein drug development applications. Using this technology, we were able to refold some "difficult-to-refold" proteins, some of which are proven important drug targets and protein drug candidates. The tech...

journal_title：Current pharmaceutical biotechnology

authors： Lin X,Umetsu T

更新日期：2010-04-01 00:00:00

abstract：:Many cationic peptides with antimicrobial properties have been isolated from bacteria, fungi, plants, and animals. These peptides vary in molecular size, potency and spectra of activities. This report surveyed the literature to highlight the peptides that have antifungal activity and greatest potential for development...

journal_title：Current pharmaceutical biotechnology

authors： Desbois AP,Tschörner D,Coote PJ

更新日期：2011-08-01 00:00:00

abstract：:Carbon monoxide (CO) has long been considered a purely toxic by-product of incomplete combustion processes. Acute exposure to high concentrations of CO is one of the leading causes of fatal poisoning in industrial countries. However, after two decades of intensive research, there is ample evidence that CO endogenously...

journal_title：Current pharmaceutical biotechnology

authors： Schmidt R,Ryan H,Hoetzel A

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:L2-based Human Papillomavirus (HPV) prophylactic vaccines, containing epitopes from HPV minor capsid proteins, are under investigation as second-generation HPV vaccines. No such vaccine has passed clinical trials yet, mainly due to the low immunogenicity of peptide vaccines; so efforts are being continued. A...

journal_title：Current pharmaceutical biotechnology

authors： Negahdaripour M,Nezafat N,Heidari R,Erfani N,Hajighahramani N,Ghoshoon MB,Shoolian E,Rahbar MR,Najafipour S,Dehshahri A,Morowvat MH,Ghasemi Y

更新日期：2020-01-01 00:00:00

abstract：AIMS:The present study aims to determine the antimicrobial efficacy of Alphonsea madraspatana leaves extract against selected uropathogens. BACKGROUND:The plant Alphonsea madraspatana is an endangered species, reported to exhibit high antimicrobial activity due to the presence of phenolic compounds. Prevalence of high...

journal_title：Current pharmaceutical biotechnology

authors： Sahu A,Ghosh G,Rath G

更新日期：2020-01-01 00:00:00

abstract：:The clinical recognition and adequate treatment of women with hyperglycemia during pregnancy is significant in order to reduce neonatal complications correlated with gestational diabetes mellitus (GDM). The traditional management of pregnant patients with GDM in whom diet restriction is not sufficient enough involves ...

journal_title：Current pharmaceutical biotechnology

authors： Kimber-Trojnar Ż,Marciniak B,Patro-Malysza J,Skorzynska-Dziduszko K,Poniedzialek-Czajkowska E,Mierzynski R,Galczynski K,Trojnar M,Leszczynska-Gorzelak B,Oleszczuk J

更新日期：2014-01-01 00:00:00

abstract：:Cancer is one of the leading causes of death in the United States and accounts for approximately 8 million deaths per year worldwide. Although there is an increasing number of therapeutic options available for patients with cancer, their efficacy is time-limited and non-curative. Approximately 50-60% cancer patients i...

journal_title：Current pharmaceutical biotechnology

authors： Gutheil WG,Reed G,Ray A,Anant S,Dhar A

更新日期：2012-01-01 00:00:00

abstract：:This paper reviews the current state-of-the-art development of single-molecule detection (SMD)-based methods for ultrasensitive and specific analysis of genomic sequences. We first discuss several newly devised single fluorescent probe strategies that allow separation-free detection of low-abundance DNA sequences, suc...

journal_title：Current pharmaceutical biotechnology

authors： Yeh HC,Chao SY,Ho YP,Wang TH

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Sexual dysfunction and infertility are conditions with high prevalence in the general population. Nutritional factors have been reported to have an impact on sexual and reproductive health. OBJECTIVE:The aim of this review is to summarize the data on nutritional factors that have influence on male and femal...

journal_title：Current pharmaceutical biotechnology

authors： Silva T,Jesus M,Cagigal C,Silva C

更新日期：2019-01-01 00:00:00

abstract：:Until recently, most research efforts aimed at developing anti-cancer tools were focusing on small molecules. Alternative compounds are now being increasingly assessed for their potential anti-cancer properties, including peptides and their derivatives. One earlier limitation to the use of peptides was their limited c...

journal_title：Current pharmaceutical biotechnology

authors： Barras D,Widmann C

更新日期：2011-08-01 00:00:00

abstract：:3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (also known as statins) are drugs active in the blockade of cholesterol synthesis and thus lowering cholesterol serum levels. Since their discovery, experimental evidence showed that statins strongly reduced atherogenesis and the risk of acute ischem...

journal_title：Current pharmaceutical biotechnology

authors： Montecucco F,Quercioli A,Mirabelli-Badenier M,Viviani GL,Mach F

更新日期：2012-01-01 00:00:00

abstract：:There is a growing trend of herbal medicines in India as well as other parts of the world. The use of herbal medicines alone or alongside prescription drugs for disease management is quite common now. We hereby carry out a review of dominant species of Selinum mainly S. vaginatum C.B. Clarke and S. wallichianum (DC.) ...

journal_title：Current pharmaceutical biotechnology

authors： Srivastava RP,Dixit P,Singh L,Verma PC,Saxena G

更新日期：2018-01-01 00:00:00

abstract：:Lactobacilli are common microorganisms in diverse vegetables and meat products and several of these are also indigenous inhabitants in the gastro-intestinal (GI) tract of humans and animals where they are believed to have health promoting effects on the host. One of the highly appreciated probiotic effects is their ab...

journal_title：Current pharmaceutical biotechnology

authors： Diep DB,Mathiesen G,Eijsink VG,Nes IF

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Common variable immunodeficiency (CVID) encompasses a heterogeneous group of primary antibody deficiency disorders characterized by recurrent infections, autoimmunity and malignancies. Gastrointestinal manifestations are frequently associated with CVID. OBJECTIVE:In this cross-sectional study, we evaluated ...

journal_title：Current pharmaceutical biotechnology

authors： Varricchi G,Pecoraro A,Crescenzi L,Marone G,Travaglino A,D'Armiento FP,Genovese A,Spadaro G

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Vulvar Lichen Sclerosus (VLS) is a chronic inflammatory disease with a huge impact on a person's quality of life. A correct therapy is required for relieving symptoms, reversing signs and preventing further anatomical changes. OBJECTIVE:The main objective of the present paper is to provide suggestions for t...

journal_title：Current pharmaceutical biotechnology

authors： Borghi A,Corazza M

更新日期：2021-01-01 00:00:00