Amelioration of myocardial ischemic reperfusion injury with Calendula officinalis.

abstract：BACKGROUND:Recombinant monoclonal antibodies (mAbs) are useful in research, diagnosis, and therapy. The increased demands of recombinant mAbs require efficient production systems. A variety of expression vectors have been developed for stable or transient production of mAbs in mammalian cells. Although a few commercial...

journal_title：Current pharmaceutical biotechnology

authors： Zhang G,Liu J,Fan W,Chen Q,Shi B

更新日期：2017-01-01 00:00:00

abstract：:Fc-based therapeutics including therapeutic full-size monoclonal antibodies (mAbs) and Fcfusion proteins represent fastest-growing market in biopharmaceutical industrial. However, one major challenge during development of Fc-based therapeutics is how to maintain their efficacy in clinic use. Many factors may lead to f...

journal_title：Current pharmaceutical biotechnology

authors： Chen X,Zeng F,Huang T,Cheng L,Liu H,Gong R

更新日期：2016-01-01 00:00:00

abstract：:Clostridium perfringens alpha-toxin is thought to be an important agent in gas gangrene, which is a lifethreatening infection with fever, pain, edema, myonecrosis, and gas production. The toxin (370 residues) is composed of an N-terminal domain (1-250 residues, N-domain) in which the catalytic site is found and a C-te...

journal_title：Current pharmaceutical biotechnology

authors： Nagahama M

更新日期：2013-01-01 00:00:00

abstract：:Platelet concentrates for surgical use are innovative tools of regenerative medicine, and were widely tested in oral and maxillofacial surgery. Unfortunately, the literature on the topic is contradictory and the published data are difficult to sort and interpret. In bone graft, implant and reconstructive surgery, the ...

journal_title：Current pharmaceutical biotechnology

authors： Simonpieri A,Del Corso M,Vervelle A,Jimbo R,Inchingolo F,Sammartino G,Dohan Ehrenfest DM

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:In Saudi Arabia, the incidence and mortality rates of breast cancer are high. Although current treatments are effective, breast cancer cells develop resistance to these treatments. Numerous studies have demonstrated that active compounds in plant extracts, such as the phenolic compound Rosmarinic Acid (RA), ...

journal_title：Current pharmaceutical biotechnology

authors： Albogami S,Darwish H,Abdelmigid HM,Alotaibi S,El-Deen AN,Alnefaie A,Alattas A

更新日期：2020-01-01 00:00:00

abstract：: ...

journal_title：Current pharmaceutical biotechnology

authors： Giaginis C

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Semaphorin 3B (SEMA3B) is characterized as a strong suppressing factor of the proliferation of cancerous cells and also by its anti-angiogenic effect. However, the knowledge on the changes in the expression profile of SEMA3B under the influence of cisplatin in endometrial cancer remains fragmented. The aim o...

journal_title：Current pharmaceutical biotechnology

authors： Peszek W,Kras P,Grabarek BO,Boroń D,Oplawski M

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Connexin (Cx) proteins are the building blocks of gap junctions. Among these, Cx37 and Cx40 are expressed on vascular system and reported to have cardioprotective role. Linking polymorphisms in genes coding for Cx and coronary artery disease (CAD) risk showed conflicting results in different populations. Non...

journal_title：Current pharmaceutical biotechnology

authors： El Tahry FA,Hashad IM,Abdel Rahman MF,Gad MZ

更新日期：2017-11-10 00:00:00

abstract：:Lipid nanocapsules with their unique composition represent a promising biocompatible drug delivery platform in nanometer range with narrow size distribution. They are highly stable in comparison to other nano-vectors and were found to impart very desirable characteristics to the therapeutic molecule being delivered wi...

journal_title：Current pharmaceutical biotechnology

authors： Nasr M,Abdel-Hamid S

更新日期：2015-01-01 00:00:00

abstract：:X-ray is a non-thermal technology that has shown good efficacy in reducing pathogenic and spoilage bacteria, viruses and parasites. X-ray hygiene technology resulted in a high microbial loss in numerous food products, such as dairy products, ready-to-eat shrimp, oysters, fresh products, strawberries, shredded iceberg ...

journal_title：Current pharmaceutical biotechnology

authors： Zehi ZB,Afshari A,Noori SMA,Jannat B,Hashemi M

更新日期：2020-01-01 00:00:00

abstract：:Immuno-isolation provides a potentially safe and effective method of delivering recombinant therapeutic molecules. Its application as a drug-delivery platform for the treatment of cancer has shown promising developments recently. This review will summarize the principle and current progress of this novel therapy parad...

journal_title：Current pharmaceutical biotechnology

authors： Cirone P,Saller RM,Chang PL

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Cancer is considered as the main public health problem and the second leading cause of morbidity and mortality worldwide. Numerous environmental-lifestyle related risk factors account for around one-third of cancer deaths. Recently, the key role of lncRNAs has been widely investigated in a variety of disorde...

journal_title：Current pharmaceutical biotechnology

authors： Poursheikhani A,Nokhandani N,Yousefi H,Rad DM,Sahebkar A

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The re-emerging of targeting Dihydroorotate Dehydrogenase (DHODH) in cancer treatment particularly Acute Myelogenous Leukemia (AML) has corroborated the substantial role of DHODH in cancer and received the attention of many pharmaceutical industries. OBJECTIVE:The effects of Brequinar Sodium (BQR) and 4SC-1...

journal_title：Current pharmaceutical biotechnology

authors： Kadir MFA,Othman S,Nellore K

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:`Herbal mixtures` containing synthetic cannabinoid receptor agonists (SCRAs) are promoted as legal alternative to marihuana and are easily available via the Internet. Keeping analytical methods for the detection of these SCRAs up-to-date is a continuous challenge for clinicians and toxicologists due to the h...

journal_title：Current pharmaceutical biotechnology

authors： Hutter M,Broecker S,Kneisel S,Franz F,Brandt SD,Auwarter V

更新日期：2018-01-01 00:00:00

abstract：:With eleven therapeutic antibodies approved worldwide and many more in clinical trials, research on antibody engineering has continued to escalate and expand. This review covers recent progress in generation of antibodies by ex vivo methods, systems for screening these, and the quest for higher affinity, more stable, ...

journal_title：Current pharmaceutical biotechnology

authors： Presta LG

更新日期：2002-09-01 00:00:00

abstract：:Progress in many therapies, in particular in the therapies based on peptides, proteins and nucleic acids used as bioactive compounds, strongly depends on development of appropriate carriers which would be suitable for controlled delivery of the intact abovementioned compounds to required tissues, cells and intracellul...

journal_title：Current pharmaceutical biotechnology

authors： Slomkowski S,Gosecki M

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis (RA) is a common connective tissue disease, characteristic of chronic and invasive synovitis in single or multiple joints and vasculitis. RA is a heterogeneous disease with unclear pathogenesis. Therefore, exploring the etiology and pathogenesis of the disease is essential for identifyin...

journal_title：Current pharmaceutical biotechnology

authors： Liu J,Wang X,Wang S,Liu F

更新日期：2020-10-01 00:00:00

abstract：AIMS:Globally Scientists are working to find more efficient antimicrobial drugs to treat microbial infections and kill drug-resistant bacteria. BACKGROUND:Despite the availability of numerous antimicrobial drugs bacterial infections still poses a serious threat to global health. Due to a constant decline in the effect...

journal_title：Current pharmaceutical biotechnology

authors： Khan K,Qureshi MA,Azam A,Moinuddin,Musarrat J,Javed S

更新日期：2021-01-18 00:00:00

abstract：BACKGROUND:Powdery drugs such as cocaine and heroin are frequently adulterated or diluted predominantly to obtain more doses and to increase the drug dealer's profits, but also to enhance, to modify or to oppose drug effects. The aim of this report is to provide an overview of the recent scientific literature on medici...

journal_title：Current pharmaceutical biotechnology

authors： Solimini R,Rotolo MC,Pellegrini M,Minutillo A,Pacifici R,Busardò FP,Zaami S

更新日期：2017-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) represents the third cause of cancer-related death. Because HCC is multi-centric with time, excluding the few transplanted patients, sooner or later it becomes untreatable with loco-regional therapies and, until some years ago, it was not responsive to systemic therapies. In 2005 a rando...

journal_title：Current pharmaceutical biotechnology

authors： Livraghi T,Ceriani R,Palmisano A,Pedicini V,Pich MG,Tommasini MA,Torzilli G

更新日期：2011-02-01 00:00:00

abstract：:The aim of the present article was to review the role of the placenta function in the transfer of immunosuppressants and monoclonal antibodies used for the treatment of inflammatory bowel disease, as well as the available data regarding the safety of these therapies during pregnancy. Methotrexate can cause congenital ...

journal_title：Current pharmaceutical biotechnology

authors： Chaparro M,Gisbert JP

更新日期：2011-05-01 00:00:00

abstract：:Xylitol is an important polyalcohol suitable for use in odontological, medical and pharmaceutical products and as an additive in food. The first studies on the efficacy of xylitol in the control and treatment of infections started in the late 1970s and it is still applied for this purpose, with safety and very little ...

journal_title：Current pharmaceutical biotechnology

authors： Ferreira AS,Silva-Paes-Leme AF,Raposo NR,da Silva SS

更新日期：2015-01-01 00:00:00

abstract：:Spirulina, a filamentous cyanobacterium, possesses diverse biological activities and nutritional significance due to high concentration of natural nutrients, having bio-modulatory and immuno-modulatory functions. Different Spirulina preparations influence immune system viz. increase phagocytic activity of macrophages,...

journal_title：Current pharmaceutical biotechnology

authors： Khan Z,Bhadouria P,Bisen PS

更新日期：2005-10-01 00:00:00

abstract：:Discovery of disease specific biomarkers in human body fluids has become an important challenge in clinical proteomics. Facing the increasing threat of degenerative and disabling diseases like cancer, cardiovascular, neurological and inflammatory diseases in large parts of the world's population, there is an urgent ne...

journal_title：Current pharmaceutical biotechnology

authors： Berven FS,Flikka K,Berle M,Vedeler C,Ulvik RJ

更新日期：2006-06-01 00:00:00

abstract：:In this review, the compartments of the vasculature will be discussed with respect to their potential contribution to the build-up of a differentiated and functionally meaningful vessel system. Chronic ischemia of muscle tissue results in microvessel rarification, which represents a potential therapeutic target, given...

journal_title：Current pharmaceutical biotechnology

authors： Kupatt C

更新日期：2007-02-01 00:00:00

abstract：:Over the last 50 years, evidence for central involvement of glutamatergic neurotransmission in the pathophysiology of schizophrenia has accumulated. Recent advances in neuroimaging technology now allow several components of glutamatergic neurotransmission to be assessed in the living human brain. Positron emission tom...

journal_title：Current pharmaceutical biotechnology

authors： Egerton A,Stone JM

更新日期：2012-06-01 00:00:00

abstract：:Bone grafts are widely used for augmentation procedures in oral and maxillofacial surgery, with autogenous bone being the gold standard. Recently, the focus of research has shifted towards synthetic bone substitutes, as no second surgery is needed and large quantities of graft can easily be provided. Within the broad ...

journal_title：Current pharmaceutical biotechnology

authors： Gotz W,Papageorgiou SN

更新日期：2017-01-01 00:00:00

abstract：:Malignant glioma is a primary tumor of the central nervous system, representing a major cause of mortality in a young, productive subset of population. The management of this neoplasm requires aggressive treatments, including radiotherapy. Accurate imaging plays a central role in treatment planning process with curati...

journal_title：Current pharmaceutical biotechnology

authors： Marvaso G,Barone A,Amodio N,Cascini GL,Scotti V,Bianco C

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The present limitations related to the ocular administration of antifungal drugs for the treatment of fungal keratitis include poor ocular bioavailability, limited retention time, and low ocular tissues penetration. METHODS:This study aimed to prepare a novel ophthalmic voriconazole-loaded nanosuspension ba...

journal_title：Current pharmaceutical biotechnology

authors： Qin T,Dai Z,Xu X,Zhang Z,You X,Sun H,Liu M,Zhu H

更新日期：2020-08-20 00:00:00

abstract：BACKGROUND:Enterotoxigenic Escherichia coli (ETEC) is the main cause of fatal diarrhea in piglets during the first week of life and over the time of weaning. Pathogenesis of ETEC-causing diarrhea involves intestinal colonization mediated by fimbriae. Although, both IgY and egg yolk phosvitin (PV) possess antimicrobial ...

journal_title：Current pharmaceutical biotechnology

authors： Gujral N,Yoo H,Bamdad F,Lee KY,Suh JW,Sunwoo H

更新日期：2017-01-01 00:00:00