Antifungal Activity, Gas Chromatographic-Mass Spectrometric Analysis And in silico Study of Punica Granatum Peel Extracts Against Fluconazole Resistant Strains of Candida Species.

abstract：:Data obtained through high-throughput technologies have gradually revealed that a unique stratified epithelial architecture of human skin along with the antioxidant-response pathways provided vital defensive mechanisms against UV radiation. However, it is noteworthy that skin is a major target for toxic insult by UV r...

journal_title：Current pharmaceutical biotechnology

authors： Farooqi AA,Li RN,Huang HW,Ismail M,Yuan SS,Wang HM,Liu JR,Tang JY,Chang HW

更新日期：2015-01-01 00:00:00

abstract：:Discovery of disease specific biomarkers in human body fluids has become an important challenge in clinical proteomics. Facing the increasing threat of degenerative and disabling diseases like cancer, cardiovascular, neurological and inflammatory diseases in large parts of the world's population, there is an urgent ne...

journal_title：Current pharmaceutical biotechnology

authors： Berven FS,Flikka K,Berle M,Vedeler C,Ulvik RJ

更新日期：2006-06-01 00:00:00

abstract：:Conventional biochemical assays are performed via an averaging procedure with the lysate of a large number of target cells; however, the averaged data lose information regarding the heterogeneity of individual cells. For quantitative assay of single cells, it is necessary to isolate single cells, extract cellular comp...

journal_title：Current pharmaceutical biotechnology

authors： Sasaki A,Sakata H,Kinjo M

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:The work was performed to investigate the feasibility of preparing ocular inserts loaded with Poly-ε-Caprolactone (PCL) nanoparticles as a sustained ocular delivery system. METHODS:First, Atorvastatin Calcium-Poly-ε-Caprolactone (ATC-PCL) nanoparticles were prepared and characterized. Then, the optimized nanop...

journal_title：Current pharmaceutical biotechnology

authors： Girgis GNS

更新日期：2020-01-01 00:00:00

abstract：:Proliposomes are phospholipid based drug delivery systems that are finding important applications in the field of pharmaceutics. Proliposomes have been extensively studied as a potential carrier for oral delivery of drugs with poor bioavailability, but the mechanism of absorption and cellular uptake pathways has not y...

journal_title：Current pharmaceutical biotechnology

authors： Nekkanti V,Venkatesan N,Betageri GV

更新日期：2015-01-01 00:00:00

abstract：:This paper reviews the current state-of-the-art development of single-molecule detection (SMD)-based methods for ultrasensitive and specific analysis of genomic sequences. We first discuss several newly devised single fluorescent probe strategies that allow separation-free detection of low-abundance DNA sequences, suc...

journal_title：Current pharmaceutical biotechnology

authors： Yeh HC,Chao SY,Ho YP,Wang TH

更新日期：2005-12-01 00:00:00

abstract：:Ribotoxins constitute a family of toxic extracellular fungal RNases that exert a highly specific activity on a conserved region of the larger molecule of rRNA, known as the sarcin-ricin loop. This cleavage of a single phosphodiester bond inactivates the ribosome and leads to protein synthesis inhibition and cell death...

journal_title：Current pharmaceutical biotechnology

authors： Carreras-Sangrà N,Alvarez-García E,Herrero-Galán E,Tomé J,Lacadena J,Alegre-Cebollada J,Oñaderra M,Gavilanes JG,Martínez-Del-Pozo A

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:With the improvements in living standards, height is getting more attention. Malnutrition is one of the main causes of children's short stature, therefore nutritional intervention in adolescence is the key to prevent short stature. The peptides from Antarctic krill (AKPs), the ideal protein model, act in bon...

journal_title：Current pharmaceutical biotechnology

authors： Dai Y,Li Z,Fu M,Li Y,Xue C,Wang J

更新日期：2020-06-12 00:00:00

abstract：BACKGROUND:Fractalkine (FKN) in its free and membrane bound-forms and its receptor CX3CR1are reported to have an atherosclerotic effect. The relationship of Single Nucleotide Polymorphisms (SNPs) in FKN and CX3CR1genes with the Coronary Artery Disease (CAD) risk showed conflicting results in different populations. The ...

journal_title：Current pharmaceutical biotechnology

authors： Hassan DS,Hashad IM,Abdel Rahman MF,Abdel-Maksoud SM

更新日期：2018-01-01 00:00:00

abstract：:Excessive cell proliferation contributes to the pathobiology of human diseases with a high health and socio-economic impact, including cancer and vascular occlusive diseases (e. g., atherosclerosis, in-stent restenosis, transplant vasculopathy, and vessel bypass graft failure). Recent advances in the understanding of ...

journal_title：Current pharmaceutical biotechnology

authors： Ivorra C,Samyn H,Edo MD,Castro C,Sanz-González SM,Déez-Juan A,Andrés V

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Alfalfa and red clover are the most widespread and most important perennial legumes, primarily used as a high-quality feed for livestock. Both alfalfa and red clover, as well as some other plant species from Fabaceae family, are a rich natural source of phytoestrogens, nonsteroidal compounds with an estrogen...

journal_title：Current pharmaceutical biotechnology

authors： Tucak M,Horvat D,Cupic T,Krizmanic G,Tomas V,Ravlic M,Popovic S

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Terminalia arjuna (TA) has been reported and explored traditionally for its cardiotonic properties while the mechanism of antihypertensive effect of TA has not been clearly reported. METHOD:The oxidative stress is a major cause for hypertension, hence different extracts of TA having variable marker yield we...

journal_title：Current pharmaceutical biotechnology

authors： Khatkar S,Nanda A,Ansari SH

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:In Saudi Arabia, the incidence and mortality rates of breast cancer are high. Although current treatments are effective, breast cancer cells develop resistance to these treatments. Numerous studies have demonstrated that active compounds in plant extracts, such as the phenolic compound Rosmarinic Acid (RA), ...

journal_title：Current pharmaceutical biotechnology

authors： Albogami S,Darwish H,Abdelmigid HM,Alotaibi S,El-Deen AN,Alnefaie A,Alattas A

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Nitrate and nitrite can get into the body through the consumption of contaminated water either directly or indirectly. The accumulation of these compounds in the body, in the long run, leads to health problems, for example, digestive disorders, cancers, and even death threats in children. The aim of this rev...

journal_title：Current pharmaceutical biotechnology

authors： Marhamati M,Afshari A,Kiani B,Jannat B,Hashemi M

更新日期：2020-12-03 00:00:00

abstract：BACKGROUND:Common variable immunodeficiency (CVID) encompasses a heterogeneous group of primary antibody deficiency disorders characterized by recurrent infections, autoimmunity and malignancies. Gastrointestinal manifestations are frequently associated with CVID. OBJECTIVE:In this cross-sectional study, we evaluated ...

journal_title：Current pharmaceutical biotechnology

authors： Varricchi G,Pecoraro A,Crescenzi L,Marone G,Travaglino A,D'Armiento FP,Genovese A,Spadaro G

更新日期：2018-01-01 00:00:00

abstract：:The non-Hodgkin's lymphomas are a diverse groups of lymphoid neoplasms that collectively rank fifth in cancer incidence and mortality. Conventional treatment for patients with newly-diagnosed non-Hodgkin's lymphoma (NHL) includes radiation or chemotherapy. In addition, those with asymptomatic low-grade disease may fol...

journal_title：Current pharmaceutical biotechnology

authors： Multani P,White CA,Grillo-López A

更新日期：2001-12-01 00:00:00

abstract：:Autonomic neural functions are important to regulate vital functions in the living body. There are different methods to evaluate indirectly and directly autonomic, sympathetic and parasympathetic, neural functions of human body. Among various methods, microneurography is a technique to evaluate directly sympathetic ne...

journal_title：Current pharmaceutical biotechnology

authors： Mano T

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Large-scale population studies showed that the SNP rs1764391 of Connexin37 gene also known as Cx37 gene may play a pivotal role in the occurrence and development of acute myocardial infarction (AMI). Published results, however, are highly controversial. OBJECTIVE:This study aimed to examine the association ...

journal_title：Current pharmaceutical biotechnology

authors： Li J,Qin R,Wang W,Huang Z,Huang DL,Li T,Wang F,Zeng XT,Sun ZY,Liu XF,Huang F,Guo T

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Powdery drugs such as cocaine and heroin are frequently adulterated or diluted predominantly to obtain more doses and to increase the drug dealer's profits, but also to enhance, to modify or to oppose drug effects. The aim of this report is to provide an overview of the recent scientific literature on medici...

journal_title：Current pharmaceutical biotechnology

authors： Solimini R,Rotolo MC,Pellegrini M,Minutillo A,Pacifici R,Busardò FP,Zaami S

更新日期：2017-01-01 00:00:00

abstract：:Calendula officinalis of family Asteraceae, also known as marigold, has been widely used from time immemorial in Indian and Arabic cultures as an anti-inflammatory agent to treat minor skin wound and infections, burns, bee stings, sunburn and cancer. At a relatively high dose, calendula can lower blood pressure and ch...

journal_title：Current pharmaceutical biotechnology

authors： Ray D,Mukherjee S,Falchi M,Bertelli A,Das DK

更新日期：2010-12-01 00:00:00

abstract：:The bioethical and juridical debate on the status of frozen embryos sometimes adds new issues arising from new scientific evidence or by accidental occurrences that bring to the attention of the scientific community the need for new practical solutions. Within this scenario, there have been, in recent years, episodes ...

journal_title：Current pharmaceutical biotechnology

authors： Busardò FP,Vergallo GM,Turillazzi E,Bolino G,Vullo A,Frati P

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Active principles from natural sources, in the form of extracts and natural compounds, provide an infinite number of bioactive compounds with consummate disposal of chemical diversity. These compounds and active principles are of utmost importance in the discovery of drugs of biological origin particularly, ...

journal_title：Current pharmaceutical biotechnology

authors： Das G,Patra JK,Kang SS,Shin HS

更新日期：2021-01-22 00:00:00

abstract：:Control of VEGF signaling is an intense objective of pre-clinical and clinical studies in HCC disease with steadily increasing clinical application. Despite its emerging role, several aspects of anti-VEGF based treatments are poorly investigated, like the impact on tumor cells themselves, such as the effect on intrace...

journal_title：Current pharmaceutical biotechnology

authors： Raskopf E,Vogt A,Decker G,Hirt S,Daskalow K,Cramer T,Standop J,Gonzalez-Carmona MA,Sauerbruch T,Schmitz V

更新日期：2012-09-01 00:00:00

abstract：:Polyphenols are a widely distributed group of natural products found in fruits, vegetables, nuts, seeds, stems and flowers. Such compounds, especially dietary flavonoids and tannins, have been shown to exert antioxidant, antiinflammatory, anti-cancer and antibacterial effects and may have beneficial effects on human h...

journal_title：Current pharmaceutical biotechnology

authors： Coppo E,Marchese A

更新日期：2014-01-01 00:00:00

abstract：:A variety of technologies can be used in the detection of contagious pathogens. In the early stage of an outbreak of a new infectious disease, rtPCR is advantageous over many other assays. The rtPCR can be developed either using low fidelity DNA polymerase or high fidelity DNA polymerase. The application of high fidel...

journal_title：Current pharmaceutical biotechnology

authors： Li K,Xiao L,Liu C,Zhang J,Sirois P

更新日期：2010-01-01 00:00:00

abstract：:Coagulase-negative staphylococci (CoNS) are part of the microbiota of human skin and rarely linked with soft tissue infections. In recent years, CoNS species considered as one of the major nosocomial pathogens and can cause several infections such as catheter-acquired sepsis, skin infection, urinary tract infection, e...

journal_title：Current pharmaceutical biotechnology

authors： Noshak MA,Rezaee MA,Hasani A,Mirzaii M

更新日期：2020-01-01 00:00:00

abstract：:3,4-Methylenedioxymethamphetamine (MDMA or ecstasy) is a worldwide illegally used amphetamine-derived designer drug known to be hepatotoxic to humans. Jaundice, hepatomegaly, centrilobular necrosis, hepatitis and fibrosis represent some of the adverse effects caused by MDMA in the liver. Although there is irrefutable ...

journal_title：Current pharmaceutical biotechnology

authors： Carvalho M,Pontes H,Remião F,Bastos ML,Carvalho F

更新日期：2010-08-01 00:00:00

abstract：:Ivermectin is a broad spectrum antiparasitic veterinary drug introduced in human medicine in 1987. It is considered the drug of choice in onchocerciasis and strongyloidiasis infections, and remains as a therapeutic option for mass treatment in lymphatic filariasis, for which it has widely proved its efficacy. While re...

journal_title：Current pharmaceutical biotechnology

authors： González P,González FA,Ueno K

更新日期：2012-05-01 00:00:00

abstract：:Pathophysiological changes are common in critically ill patients, and can alter the time course of drug concentrations following dosing. The latter is termed pharmacokinetics (PK), and describes the relationship between dose administered and drug concentrations in plasma. Thus, modifications in PK necessitate dose adj...

journal_title：Current pharmaceutical biotechnology

authors： Patel K,Kirkpatrick CM

更新日期：2011-12-01 00:00:00

abstract：:Better understanding of protein higher order structures (HOS) is of major interest to researchers in the field of biotechnology and biopharmaceutics. Monitoring a protein's HOS is crucial towards understanding the impact of molecular conformation on the biotechnological application. In addition, maintaining the HOS is...

journal_title：Current pharmaceutical biotechnology

authors： Nagarkar RP,Murphy BM,Yu X,Manning MC,Al-Azzam WA

更新日期：2013-01-01 00:00:00