Abstract：
:Surgery for intractable affective illnesses has generated considerable controversy over the last century. Deep brain stimulation (DBS) has revolutionized neurosurgical practice, especially in the field of advanced Parkinson's disease and, more recently, in selected medical-refractory cases of obsessive-compulsive disorder. In this paper, we propose a discrete area of the rostral cingulate gyrus as a potential target for DBS in medical-resistant depressive patients. Brodmann's area 24a has proved to be a vital link in the integration of neural circuits underlying depression, both through proposed neurobiological models and accurate neuroimaging studies. The full reversibility and adjustability of DBS offer the best chance to treat the multidimensional and life-span profile of depression, so giving hope to a great number of desperate human beings.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Sakas DE,Panourias IGdoi
10.1016/j.mehy.2005.07.036keywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
491-4issue
3eissn
0306-9877issn
1532-2777pii
S0306-9877(05)00528-1journal_volume
66pub_type
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