VIP Inhibits Porphyromonas gingivalis LPS-induced immune responses in human monocytes.

Abstract:

:Lipopolysaccharide (LPS) from the Gram-negative pathogen Porphyromonas gingivalis (Pg) stimulates cytokine secretion in immune cells, and thereby initiates the inflammation associated with periodontitis. Modulation of pro-inflammatory cytokine activity is a plausible therapeutic target in periodontal disease. Vasoactive intestinal peptide (VIP) has a role in immunoregulation, and has been identified as a molecule with therapeutically beneficial immunosuppressive effects in inflammatory and autoimmune conditions. We aimed to investigate the effect of VIP on immune responses induced by Pg LPS in vitro. VIP (10(-8) M) significantly (P < 0.05) inhibits TNF-alpha production by human monocytic THP1 cells stimulated with Pg LPS. In parallel, we showed that VIP inhibits nuclear translocation of NFkappaB and c-Jun in a time-dependent manner, but does not decrease the expression of CD14 receptors. This is the first report to show the potential of VIP as an immunomodulator of Pg-stimulated inflammatory pathways in human monocytes.

journal_name

J Dent Res

authors

Foster N,Cheetham J,Taylor JJ,Preshaw PM

doi

10.1177/154405910508401106

keywords:

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

999-1004

issue

11

eissn

0022-0345

issn

1544-0591

pii

84/11/999

journal_volume

84

pub_type

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