Abstract:
:The ADAMs are a family of integral membrane proteases involved in shedding and fusion events in animal tissues. Here, we report the identification of two ADAMs, ADM-A and ADM-B, in the pathogenic fungus Aspergillus fumigatus. The domain structure of metazoan ADAMs was seen in ADM-A and -B, although with some differences. ADAMs were identified in other filamentous fungi and phylogenetic analysis indicated that the fungal ADAMs were monophyletic and most closely related to metazoan ADAM 10 and 17. Recombinant ADM-B protease specifically cleaved casein and albumin while recombinant propeptide+protease was inactive. A sheddase function is therefore proposed for fungal ADAMs.
journal_name
FEMS Microbiol Lettjournal_title
FEMS microbiology lettersauthors
Lavens SE,Rovira-Graells N,Birch M,Tuckwell Ddoi
10.1016/j.femsle.2005.05.017keywords:
subject
Has Abstractpub_date
2005-07-01 00:00:00pages
23-30issue
1eissn
0378-1097issn
1574-6968pii
S0378-1097(05)00299-5journal_volume
248pub_type
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