Abstract：
:In our study 1-(3,4-methylenedioxyphenyl)-2-propanone (MDP-2-P or PMK) was prepared by two different routes, i.e. by oxidizing isosafrole in an acid medium and by 1-(3,4-methylenedioxyphenyl)-2-nitropropene reduction. The final product-MDP-2-P was subjected to GC/MS analysis. The intermediates and reaction by-products were identified and the 'route specific' impurities were established. The following impurities are the markers of the greatest importance: 1-(3,4-methylenedioxyphenyl)-1-propanone (compound 10, Table 2), 1-methoxy-1-(3,4-methylenedioxyphenyl)-2-propanone (compound 11, Table 2) and 2,2,4-trimethyl-5-(3,4-methylenedioxyphenyl)-[1,3]dioxolane (compound 13, Table 2) (the 'oxidising isosafrole route') and N-cyclohexylacetamide (compound 3, Table 1), 3-methyl-6,7-methylenedioxyisoquinoline-1,4-dione (compound 15, Table 1) (the 'MDP-2-nitropropene reduction route'). Subsequently, MDMA was prepared by reductive amination of MDP-2-P using NaBH4 as reducing agent (so-called 'cool method'). Impurities were extracted with n-heptane under alkaline conditions. The impurity profiles were obtained by means of GC/MS, some reaction by-products were identified by means of the EI mass spectra including low energy EI mass spectra and 'route specific' impurities were established. 4-Methyl-5-(3,4-methylenedioxyphenyl)-[1,3]dioxolan-2-one (compound 22, Table 2), N-methyl-2-methoxy-1-methyl-2-(3,4-methylenedioxyphenyl)-ethaneamine (compound 18, Table 2), 3-methyl-6,7-methylenedioxyisoquinoline-1,4-dione (compound 15, Table 1) and N-cyclohexyloacetamide (compound 3, Table 1) were found to be the synthesis markers of greatest importance.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Swist M,Wilamowski J,Zuba D,Kochana J,Parczewski Adoi
10.1016/j.forsciint.2004.06.016keywords:
subject
Has Abstractpub_date
2005-05-10 00:00:00pages
181-92issue
2-3eissn
0379-0738issn
1872-6283pii
S0379-0738(04)00390-1journal_volume
149pub_type
杂志文章abstract：:The identification of X bodies is an everyday preoccupation in forensic pathology. This retrospective analysis studied all methods of identification and characteristics of unidentified bodies arrived in the Department of Forensic Medicine and Pathology (University Hospital R. Poincaré, Garches, France) during a 6-year...
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pub_type： 杂志文章,评审
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abstract：:Two hundred and sixty UK Caucasian individuals have been typed for the STR locus D12S391. Measurements of absolute band shift, relative to an allelic ladder, allowed fragments differing by one base pair to be consistently distinguished. The intermediate alleles typed from such fragments comprised approximately 5% of t...
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pub_type： 杂志文章
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2013.09.005
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journal_title：Forensic science international
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journal_title：Forensic science international
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2017.09.005
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(89)90088-1
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2009.07.008
更新日期：2009-11-20 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.03.005
更新日期：2019-06-01 00:00:00
abstract：:Forensic science faces many challenges, some high profile and others that are less visible. It is argued that a holistic understanding of the complex matrix of forensic science is critical to robust and transparent forensic reconstruction approaches. This paper explores the value of incorporating the contrasting appro...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2018.08.026
更新日期：2018-11-01 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2003.11.008
更新日期：2004-01-28 00:00:00
abstract：BACKGROUND:Studies testing the Willems method of age estimation with gender-specific scores on different population groups have reported consistently more accurate results over other methods. Not enough is known about the validity of Willems non-gender specific scores. AIM:The present study aimed to compare the accura...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2016.05.012
更新日期：2016-09-01 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(94)90378-6
更新日期：1994-09-06 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章,评审
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更新日期：2004-12-16 00:00:00
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doi：10.1016/j.forsciint.2019.04.019
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2005.05.031
更新日期：2006-05-10 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2009.09.004
更新日期：2010-01-30 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(89)90242-9
更新日期：1989-04-01 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2011.03.011
更新日期：2011-05-20 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2005.11.019
更新日期：2006-11-22 00:00:00
abstract：:A minisatellite probe, MZ 1.3, detecting hypervariable fragment patterns was isolated from a human genomic library. A repetitive sequence of 27 bp length was identified which is contained in the probe approx. 40 times. The MZ 1.3 repeat shows variable homology of 53-73% to the repetitive sequence of the protein III ge...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(90)90252-t
更新日期：1990-02-01 00:00:00
abstract：:The present study was made on an experimental animal model of a death from anaphylaxis, in which postmortem changes in levels of histamine and 1-methylhistamine, in whole blood were measured. Instead of the usual immunological method administering compound 48/80, a degranulating agent of mast cell and the effect close...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(90)90233-o
更新日期：1990-03-01 00:00:00
abstract：:This study determines the development rates of the immature stages of the fly Ophyra albuquerquei Lopes, 1985. In this study, with 70% relative humidity and a 12-h photophase, eggs, larvae, and pupae were kept in a biochemical oxygen demand chamber at temperatures of 10, 15, 17, 20, 22, 25, 27, 30, 33, 35, and 40°C. W...
journal_title：Forensic science international
pub_type： 杂志文章
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更新日期：2015-09-01 00:00:00
