Abstract：
:In 2017, 47,600 overdose deaths were reported to be associated with the abuse of opioids, including prescription painkillers (e.g. oxycodone), opiates (e.g. heroin), or synthetic opioids (e.g. fentanyl) within the United States. The recent spike in the presence of synthetic opioids in lots of heroin distributed on the street present specific and significant challenges to law enforcement. Synthetic opioids are extremely toxic substances, which can easily be inhaled. This type of exposure can lead to accidental overdoses by law enforcement and other first responders answering calls involving illicit drugs containing these substances. Due to this extreme toxicity, it is important for these individuals to have tools that can be easily deployed for accurate presumptive field tests. Currently, there are only a limited number of presumptive tests available for fentanyl detection. In this study, we addressed this technology gap by evaluating newly developed lateral flow immunoassays (LFIs) designed for the detection of fentanyl and its derivatives. These LFIs were evaluated for effectiveness in different biofluid matrices, following an in vivo exposure, cross-reactivity with fentanyl analogs, and in case samples. This study demonstrates that LFIs have the potential to be used by law enforcement for the detection of synthetic opioids.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Angelini DJ,Biggs TD,Maughan MN,Feasel MG,Sisco E,Sekowski JWdoi
10.1016/j.forsciint.2019.04.019subject
Has Abstractpub_date
2019-07-01 00:00:00pages
75-81eissn
0379-0738issn
1872-6283pii
S0379-0738(19)30153-7journal_volume
300pub_type
杂志文章abstract：:Since the anthrax mail attacks of 2001, law enforcement agencies have processed thousands of suspicious mail incidents globally, many of which are hoax bioterrorism threats. Bio-insecticide preparations containing Bacillus thuringiensis (Bt) spores have been involved in several such threats in Australia, leading to th...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2011.12.003
更新日期：2012-06-10 00:00:00
abstract：:The increasing interest in toxicological hair analysis as a marker of human exposure to xenobiotics such as illicit substances or therapeutic drugs, has been made feasible by the extension of mass spectrometry, a highly sensitive method of detection. A newborn exposed to drugs in utero can suffer from a varying degree...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(03)00050-1
更新日期：2003-04-23 00:00:00
abstract：:Capillary high performance liquid chromatography (HPLC) was combined with frit fast atom bombardment (FAB) mass spectrometry (MS) and a detailed procedure has been established for on-line analysis of cefaclor in human serum. The capillary column (0.3 mm i.d.) enabled the introduction of entire effluent to the frit int...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(93)90313-y
更新日期：1993-04-01 00:00:00
abstract：:This article describes the first use of an anti-Stokes material, or up-converter, for the development of latent fingermarks on a range of non-porous surfaces. Anti-Stokes materials can absorb long-wavelength light and emit light at a shorter wavelength. This property is unusual in both natural and artificial materials...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2010.09.020
更新日期：2011-04-15 00:00:00
abstract：:In order to evaluate histological features of freezing damages to human tissue after death, we froze samples of liver and heart tissue to temperatures of -12 degrees C, -28 degrees C and -80 degrees C, and stored them for 24 and 72 h, respectively, at those temperatures. After thawing and routine preparation for histo...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(99)00043-2
更新日期：1999-06-28 00:00:00
abstract：:An investigation was made to determine the effects of age and sex on postmortem concentrations (mumol/l) of inosine, hypoxanthine, xanthine, uric acid, uracil and uridine in the vitreous humor of chickens (Gallus domesticus). Five male and 5 female chickens were sampled each week from 0-10 weeks of age. Samples were c...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(90)90206-e
更新日期：1990-09-01 00:00:00
abstract：:This research presents a new software, "Fragmento", for accurate analyses of fragmentary human skeletal remains and facilitation of three-dimensional (3D) fragmentary matching and full bone reconstruction. The framework utilizes the power of statistical bone atlases to create 3D templates for bone matching and to inte...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2017.03.017
更新日期：2017-06-01 00:00:00
abstract：:Based on a method that combines thin layer chromatography and gas chromatography, it proved possible to detect postmortem fatty acid methyl esters (FAMEs) in human tissues (pancreas, liver, heart and adipose tissue). The highest concentrations were found in the pancreas, medium concentrations in the liver and adipose ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(96)02078-6
更新日期：1997-02-07 00:00:00
abstract：:Analysis of cannabis has gained new importance worldwide, mainly for quality control within the legalized recreational and medical cannabis industry, but also for forensic differentiation between drug-type cannabis and legal products such as fiber hemp and CBD-rich/THC-poor cannabis. We herein present an HPLC-DAD meth...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.03.046
更新日期：2019-06-01 00:00:00
abstract：:The procedure used in this laboratory for removing and identifying contamination of hair specimens with drugs is demonstrated by its application to hair contaminated by various experimental models. The models include soaking; coating with drug followed by sweat conditions for 6 h; and soaking in a very high concentrat...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2004.04.024
更新日期：2004-10-29 00:00:00
abstract：:A new series of fingerprint developing membrane were prepared using ninhydrin as the developing agent, and pressure-sensitive emulsifiers as the encapsulated chemicals. The type of emulsifier, plastic film, concentration of the developing agent, modifying ions and thickness of the membrane were studied in order to get...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2014.06.036
更新日期：2014-09-01 00:00:00
abstract：:A cadaver and dead plant organic matter, or litter, are rich energy sources that undergo a complex decomposition process, which impact the surrounding environmental microbiota. Advances in molecular microbiology techniques, with study of the 16S RNA genes, in particular, have highlighted the application of forensic ec...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2017.04.024
更新日期：2017-07-01 00:00:00
abstract：:Two pig (Sus scrofta L.) carcasses were placed in sunlit and shaded plots in September 2003, and again in May 2004. Mean ambient temperatures between sunlit and shaded plots were not significantly different in either September or May, but mean ambient temperatures at sunlit and shaded plots in 2004 were significantly ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2006.01.008
更新日期：2006-12-20 00:00:00
abstract：:Craniofacial reconstruction (CFR) is used to recreate a likeness of original facial appearance for an unidentified skull; this technique has been applied in both forensics and archeology. Many CFR techniques rely on the average facial soft tissue thickness (FSTT) of anatomical landmarks, related to ethnicity, age, sex...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2016.07.017
更新日期：2016-09-01 00:00:00
abstract：:The identification of body fluids at a crime scene is an important aspect of forensic casework analysis, being a source for investigative leads and contributing to case evidence. Yet, current methods for the forensic identification of body fluids suffer from several limitations, ranging from poor sensitivity and speci...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2018.07.013
更新日期：2018-09-01 00:00:00
abstract：:In this paper, we describe an acetylating method for fast synthesis of heroin from morphine in the presence of 4-dimethylaminopyridine (4-DMAP) as a catalyst. In the reaction which led to heroin formation, the morphine base was subjected to a solution made up of 4-DMAP (catalyst), methylene chloride (solvent) and acet...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(02)00291-8
更新日期：2002-10-09 00:00:00
abstract：:Downstairs falls frequently occur within domestic environments and are mainly associated with elderly and intoxicated individuals, often feature multiple injuries on various parts of the body. In most cases it is not possible to determine the cause of the fall and/or death solely by means of external examination. In t...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2003.12.016
更新日期：2004-05-10 00:00:00
abstract：:The variety of instruments used for crime of violence is wide. Besides the manufactured legal weapons, there are comparable numbers of purchased instruments, which are used as lethal weapons and significant numbers of comprising home-made ones. The instruments used during the commission of a crime shows similarity thr...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(03)00004-5
更新日期：2003-03-27 00:00:00
abstract：:Forensic identification of sudden unexplained death (SUD) has always been a ticklish issue because it used to be defined as sudden death without a conclusive diagnosis after autopsy. However, benefiting from the developments in genome research, a growing body of evidence points to the importance of ion channelopathies...
journal_title：Forensic science international
pub_type： 杂志文章,评审
doi：10.1016/j.forsciint.2017.03.006
更新日期：2017-06-01 00:00:00
abstract：:Forensic odontologists are involved in all phases of disaster victim identification (DVI). The failure of DVI management to embed odontology teams within all phases of the investigation and to include them in management decisions throughout the operation may lead to delays in the reconciliation process and could possi...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2010.08.013
更新日期：2011-02-25 00:00:00
abstract：:The dead body of a 44-year-old woman, previously known for depression and alcoholism, has been discovered at her place of residence by her husband. A forensic autopsy has been carried out. The results indicated unspecific histological lesions (alveolar oedema, liver steatosis and interstitial nephritis) but did not re...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2008.03.003
更新日期：2008-07-04 00:00:00
abstract：:There has recently been an increase in the research and implementation of advanced measurement techniques to ballistic toolmark identification. This has led to a shift from greyscale imaging to the acquisition of dense areal datasets. With the addition of mathematical correlation algorithms, these advanced techniques ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.02.054
更新日期：2019-05-01 00:00:00
abstract：:Human teeth are biological structures that resist extreme conditions thus becoming a useful source of DNA for human forensic identification purposes. When it is possible, forensic prefer only non-damaged teeth whereas those with cavities are usually rejected to avoid both external and internal bacterial contamination....
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2015.08.021
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:The mandibular bone is an important part of the forensic facial reconstruction and it has the possibility of getting lost in skeletonized remains; for this reason, it is necessary to facilitate the identification process simulating the mandibular position only through craniomaxillary measures, for this task,...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2015.12.025
更新日期：2016-04-01 00:00:00
abstract：:A frequent request of a prosecutor referring to forensic autopsy is to determine the mechanism of an injury and to identify the weapons used to cause those injuries. This task could be problematic in many ways, including changes in the primary injury caused by medical intervention and the process of healing. To accomp...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2012.06.012
更新日期：2012-10-10 00:00:00
abstract：:The identification of cadavers (the main activity of forensic odontologists and anthropologists) is a crucial issue in forensic pathology, but the official entity of this problem is still poorly known in most countries, apart from a few American reports. In this article the authors present a descriptive study of unide...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2009.11.008
更新日期：2010-02-25 00:00:00
abstract：:The worldwide spread of illegal sexual enhancement products is posing a threat to public health. The aim of this study was to investigate illegal products claiming to be effective in improving sexual performance through the online or offline markets between 2014 and 2017; these products include foods, dietary suppleme...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.02.014
更新日期：2019-05-01 00:00:00
abstract：:A new discrimination method for the bioapatite materials bone, antler and ivory was developed using X-ray diffractometry and comprises non-invasive measurements in order to take valuable objects into account. Our approach deals with the analysis of peak intensity ratios resulting from several measurements on each obje...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2020.110159
更新日期：2020-03-01 00:00:00
abstract：:A classification system is described for drugs using thin-layer chromatography (TLC), gas-liquid chromatography (GLC) and ultraviolet (UV) spectrophotometry. The TLC classifications are based on division of the plate into zones relative to a set of mixed drug standards. The GLC classification is based on Kovats' reten...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(79)90265-2
更新日期：1979-01-01 00:00:00
abstract：:Several commercial PCR multiplex kits incorporate the amelogenin locus for the purpose of human gender identification. Consequently, erroneous results in the electropherogram profile of this locus can carry important forensic implications. In this study, dropout of the amelogenin Y allele was detected in 5 out of 77 p...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2006.05.002
更新日期：2007-03-02 00:00:00
