4-Dimethylaminopyridine as a catalyst in heroin synthesis.

Abstract:

:In this paper, we describe an acetylating method for fast synthesis of heroin from morphine in the presence of 4-dimethylaminopyridine (4-DMAP) as a catalyst. In the reaction which led to heroin formation, the morphine base was subjected to a solution made up of 4-DMAP (catalyst), methylene chloride (solvent) and acetic anhydride (acetylating agent). We showed that in comparison with classic acetylating procedures, reaction time can be reduced from at least several hours at elevated temperatures to <10 min at room temperature. In general, reaction time is dependent on the molar concentration ratio between morphine and 4-DMAP.

journal_name

Forensic Sci Int

authors

Klemenc S

doi

10.1016/s0379-0738(02)00291-8

keywords:

subject

Has Abstract

pub_date

2002-10-09 00:00:00

pages

194-9

issue

3

eissn

0379-0738

issn

1872-6283

pii

S0379073802002918

journal_volume

129

pub_type

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