Abstract:
:In this paper, we describe an acetylating method for fast synthesis of heroin from morphine in the presence of 4-dimethylaminopyridine (4-DMAP) as a catalyst. In the reaction which led to heroin formation, the morphine base was subjected to a solution made up of 4-DMAP (catalyst), methylene chloride (solvent) and acetic anhydride (acetylating agent). We showed that in comparison with classic acetylating procedures, reaction time can be reduced from at least several hours at elevated temperatures to <10 min at room temperature. In general, reaction time is dependent on the molar concentration ratio between morphine and 4-DMAP.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Klemenc Sdoi
10.1016/s0379-0738(02)00291-8keywords:
subject
Has Abstractpub_date
2002-10-09 00:00:00pages
194-9issue
3eissn
0379-0738issn
1872-6283pii
S0379073802002918journal_volume
129pub_type
杂志文章abstract::Besides alcohol and drugs of abuse, several popular foods contain potentially toxic substances and cases of intoxication after consumption of these foods attract notice of forensic toxicology. This is also true for the case of a 34-year-old woman who was suspected to have suffered lethal acute intoxication from eating...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2009.12.018
更新日期:2010-04-15 00:00:00
abstract::Generalized arterial calcification in infancy is a rare genetic disorder characterized by abnormal calcification of large and medium sized arteries and marked myointimal proliferation resulting in arterial stenosis. The condition is often fatal secondary to complications of cardiac ischemia, hypertension and cardiac f...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2015.06.017
更新日期:2015-09-01 00:00:00
abstract::Single metal deposition (SMD II) is a fingermark detection technique based on the use of colloidal gold. The technique has been simplified and optimised over the years to become more reliable, sensitive and user-friendly. Physical developer (PD) is a well-established detection method based on silver deposition from a ...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2018.10.032
更新日期:2019-01-01 00:00:00
abstract::Trends in forensic toxicology show the advancement of rapid and sensitive analytical methods for qualitative and quantitative analysis of drugs of abuse. However, forensic toxicologists are continuously faced with the challenges of identifying and quantifying drug blood concentration while simultaneously struggling wi...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2019.03.048
更新日期:2019-07-01 00:00:00
abstract::The discovery in 1934 of the badly burned, pyjama clad body of a young woman protruding from a roadside culvert near Albury, N.S.W., led to one of the largest investigations in the history of Australian crime. Two simple errors, made by a local dentist with no previous experience in forensic odontology called by the p...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/0379-0738(82)90110-4
更新日期:1982-07-01 00:00:00
abstract::A method for identifying human skeletal muscle by detection of human myoglobin using a double-sandwich ELISA was developed. When an extract was prepared from 0.1 g skeletal muscle homogenized with 10 ml PBS, this method was able to detect human myoglobin in extracts diluted 10(4)-fold. There was no difference in the d...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/0379-0738(94)01667-4
更新日期:1995-02-28 00:00:00
abstract::Among 27,000 infants studied prospectively to characterize their sleep-wake behavior, 38 infants died suddenly and unexpectedly under 6 months of age. Of these, 26 died from sudden infant death syndrome (SIDS), 5 from congenital cardiac abnormalities, 2 from infected pulmonary dysplasia, 2 from septic shock with multi...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/s0379-0738(02)00138-x
更新日期:2002-09-14 00:00:00
abstract::The aim of any forensic inquiry concerning accidental or criminal cremations is to identify the victims. This identification depends on an essential approach: a careful collection and ultrasonic cleaning of the fragments and splinters of burned bones, and reconstruction--as far as possible--of bone specimens, which im...
journal_title:Forensic science international
pub_type: 杂志文章,评审
doi:10.1016/s0379-0738(98)00115-7
更新日期:1998-09-28 00:00:00
abstract::The spectrophotometric method for the determination of carboxyhemoglobin (HbCO) in blood reported by Fretwurst and Meinecke was modified so as to give the same values of percentage HbCO (HbCO%) as those determined by the oxygen electrode method. Values of HbCO% of nine practical samples determined by both the oxygen e...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/0379-0738(81)90157-2
更新日期:1981-09-01 00:00:00
abstract::The increase in the use of photographs on individual identification credentials such as driving licences, credit cards, security passes and passports has led, for the purpose of criminal activities, to the falsification of genuine documents bearing photographs of the perpetrating criminal. These photographs may be use...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/s0379-0738(00)00290-5
更新日期:2000-11-13 00:00:00
abstract::This paper describes a repeatability test, comparing conventional X-ray diffraction (XRD) analyses with the technique of quantitative X-ray diffraction (QXRD) as a determinant of mineral abundance. The conjunctive use of both methods allows specific mineral abundances to be matched between scene of crime (SOC) and sus...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2004.03.017
更新日期:2004-10-04 00:00:00
abstract::Driving under the influence of alcohol (DUIA) and drugs (DUID) is considered an elevated risk for traffic safety. When assessing a driver's fitness to drive, standardized and objective measurement methods are still required, in order to clarify the question whether an individual is under the influence of substances ac...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2020.110559
更新日期:2020-12-01 00:00:00
abstract::In this paper, a novel robust watermarking technique using Imperialistic Competition Algorithm (ICA) in the spatial domain is proposed to protect the intellectual property rights of color images. The proposed method tries to insert the watermark in the blocks which are selected by Modified ICA. In this method, ICA has...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2013.09.005
更新日期:2013-12-10 00:00:00
abstract::We describe two suicide cases in which old paraquat was ingested. In conjunction with lung involvement a pronounced degeneration was observed in skeletal muscle of one who died on the 14th day after the ingestion. The following sarcoplasmic or endoplasmic reticulum Ca2+ ATPase (SERCA) monoclonal antibodies were used f...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/s0379-0738(98)00190-x
更新日期:1999-03-15 00:00:00
abstract::Identification in forensic anthropology and the definition of a biological profile in bioarchaeology are essential to each of those fields and use the same methodologies. Sex, age, stature and ancestry can be conclusive or dispensable, depending on the field. The Fordisc(®) 3.0 computer program was developed to aid in...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2011.03.011
更新日期:2011-05-20 00:00:00
abstract::A challenging step in medical, veterinary and forensic entomology casework is the rapid and accurate identification of insects to estimate the period of insect activity (PIA), which usually approximates the post-mortem interval (PMI). The morphological identification of insect evidence is hampered by species similarit...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2014.07.018
更新日期:2014-09-01 00:00:00
abstract::With the increasing prevalence of obesity, the use of counterfeit drugs for weight loss is widespread owing to their easy and rapid availability. Since counterfeit weight-loss drugs are not prepared under the rigorous standard of Good Manufacturing Practice (GMP), they pose a risk to public health and cause significan...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2019.109932
更新日期:2019-10-01 00:00:00
abstract::Agilent GC-MS MSD Chemstation offers automated library search report for toxicological screening using total ion chromatogram (TIC) and mass spectroscopy in normal mode. Numerous peaks appear in the chromatogram of biological specimen such as blood or urine and often large migrating peaks obscure small target peaks, i...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2010.03.003
更新日期:2010-06-15 00:00:00
abstract:AIM:To validate a method for determining equivalent drug cutoff concentrations for tetrahydrocannabinol and amphetamine in blood and oral fluid, which ensures that the drug prevalence in samples of blood and oral fluid taken simultaneously is equal. METHODS:A method using regression analysis of drug concentrations for...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2011.06.024
更新日期:2011-10-10 00:00:00
abstract::Gasoline was added to moldy samples of unused building materials. The unused samples were allowed to sit at room temperature for 2, 4, 7, and 14 days. Each set of samples was extracted using passive headspace concentration and analyzed using gas chromatography-mass spectrometry. Microbial degradation of the gasoline p...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2013.08.006
更新日期:2013-10-10 00:00:00
abstract::Debrisoquine hydroxylase (CYP2D6) is involved in the metabolism of many toxicologically important drugs. The gene encoding for this enzyme displays a polymorphic distribution in all populations examined. We report a study on 46 cases, where analyses of the CYP2D6 gene were conducted on postmortem femoral blood in orde...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/s0379-0738(98)00169-8
更新日期:1999-01-04 00:00:00
abstract:UNLABELLED:Objective Chloroprene, 2-chloro-1,3 butadiene, is a volatile synthetic liquid. The chloroprene monomer is extremely reactive and is used for the production of latexes and synthetic rubber such as Neoprene. Up to now an acute lethal human exposure has been described only once in the literature [19]. The intox...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2011.03.029
更新日期:2012-02-10 00:00:00
abstract::DNA STR profiles have been generated from 1 ng and low copy number (LCN) templates using 28 and 34 cycles of amplification, respectively. Characteristics which facilitate the interpretation of profiles, such as heterozygous balance, allelic dropout and stutter proportions have been quantified. We demonstrate that a re...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/s0379-0738(01)00557-6
更新日期:2001-12-01 00:00:00
abstract::The 4977 bp deletion of mitochondrial DNA (mtDNA) accumulates in postmitotic tissues with advancing age. The purpose of our study was to detect and quantify these deletion even in blood cells with a high turnover activity. Whole venous blood, isolated human platelets and peripheral blood mononuclear cells (PBMCs) were...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/s0379-0738(00)00249-8
更新日期:2000-09-11 00:00:00
abstract::An estimated 500,000 people died from all causes during the Spanish Civil War between 1936 and 1939, with a further 135,000 killed after the war ended. There are currently over 2000 known mass burial locations throughout Spain but many more are unknown. This study details the successful search for an unmarked mass gra...
journal_title:Forensic science international
pub_type: 历史文章,杂志文章
doi:10.1016/j.forsciint.2016.05.040
更新日期:2016-10-01 00:00:00
abstract::(1) The polymerase chain reaction (PCR) was used to amplify Rh-related cDNAs from erythroid cells cultured by the selective two-phase liquid culture system for human erythroid progenitors in peripheral blood. Two Rh polypeptide cDNAs have been isolated from the PCR products and tentatively designated RhPI cDNA and RhP...
journal_title:Forensic science international
pub_type: 杂志文章,评审
doi:10.1016/0379-0738(96)01935-4
更新日期:1996-06-28 00:00:00
abstract::The tongue was examined for the presence of haemorrhages in 264 medicolegal autopsy cases. The tongue was sectioned transversely and examined macroscopically and microscopically. Haemorrhages were found in marginal and/or central parts of the tongue in 104 cases. Among them, 28 cases showed haemorrhages in central par...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/0379-0738(82)90127-x
更新日期:1982-11-01 00:00:00
abstract::Since the anthrax mail attacks of 2001, law enforcement agencies have processed thousands of suspicious mail incidents globally, many of which are hoax bioterrorism threats. Bio-insecticide preparations containing Bacillus thuringiensis (Bt) spores have been involved in several such threats in Australia, leading to th...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2011.12.003
更新日期:2012-06-10 00:00:00
abstract::Two amphetamine-like piperazine-containing compounds, 1-(3,4-methylenedioxyphenyl)-2-piperazinopropane (3,4-MDPPP), its positional isomer 1-(2,3-methylenedioxyphenyl)-2-piperazinopropane (2,3-MDPPP) and three methcathinone-like piperazine-containing regioisomeric ring substituted 1-(methoxyphenyl)-2-piperazinopropanon...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2013.11.015
更新日期:2014-02-01 00:00:00
abstract::Age estimation is a vital aspect in creating a biological profile and aids investigators by narrowing down potentially matching identities from the available pool. In addition to routine casework, in the present global political scenario, age estimation in living individuals is required in cases of refugees, asylum se...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2013.04.004
更新日期:2013-09-10 00:00:00