Abstract：
:With the increasing prevalence of obesity, the use of counterfeit drugs for weight loss is widespread owing to their easy and rapid availability. Since counterfeit weight-loss drugs are not prepared under the rigorous standard of Good Manufacturing Practice (GMP), they pose a risk to public health and cause significant side effects. To counteract the risk posed by counterfeit drugs, we investigated counterfeit weight-loss drugs seized by the Incheon Customs Services using UHPLC-PDA. Five of 23 confiscated samples with distinctive pink-coloured coating contained levothyroxine, sennoside A and B, and phenolphthalein in amounts ranging from 0.03-132.40 mg/g. In addition, three unknown compounds in one of the adulterated samples containing phenolphthalein were structurally elucidated by several analytical techniques. Their accurate masses corresponded to molecular formula of C34H22O7, C34H20O6, and C20H12O3, respectively. These compounds were identified as impurities, possibly produced during the synthesis of phenolphthalein or by improper removal during purification. These impurities were detected for the first time in counterfeit drugs.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Lee JH,Park HN,Kim NS,Park S,Bogonda G,Oh K,Kang Hdoi
10.1016/j.forsciint.2019.109932subject
Has Abstractpub_date
2019-10-01 00:00:00pages
109932eissn
0379-0738issn
1872-6283pii
S0379-0738(19)30344-5journal_volume
303pub_type
杂志文章abstract：UNLABELLED:It is frequently difficult to prove the vitality in cases of fatal hanging. Using impulse cytophotometry, Müller et al. (Krim. Forens. Wiss. 44, 1981) reported on possibly vital alterations of the DNA content in five strangulation marks (hypodiploidy). The objective of the present study was to perform a re-e...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(97)00069-8
更新日期：1997-09-19 00:00:00
abstract：:Molecular analyses in a post-mortem setting are becoming increasingly common, particularly in cases of sudden unexplained death, with the aim of identifying genetic mutations which may be responsible for causing death. In retrospective investigations, the access to suitable autopsy biological samples may be limited, a...
journal_title：Forensic science international
pub_type： 杂志文章,评审
doi：10.1016/j.forsciint.2017.09.020
更新日期：2017-11-01 00:00:00
abstract：:In bitemark analysis the extent of distortion of both maxillary and mandibular arches and how one affects the other has not been studied. A single dentition was used to create 49 bites on unembalmed cadavers. Landmarks were placed on digital images of the bitemarks and scanned images of the biting dentition. A sample ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2012.08.044
更新日期：2012-11-30 00:00:00
abstract：:Medicolegal (coroner's) autopsies are an important source of epidemiological data. A large proportion of them comprise sudden natural deaths and an analysis of such cases has never been undertaken at the University Hospital of the West Indies, the only teaching hospital in Jamaica. In a retrospective study, 841 cases ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(02)00268-2
更新日期：2002-09-26 00:00:00
abstract：:Gunshot wounds in suicide cases are self-inflicted wounds. Self-inflicted wounds in suicide cases are usually caused by contact firing and are of great forensic significance. Evaluation of contact wound may be associated with difficulties if the bore gets obstruction prior to firing. This paper investigates the phenom...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(03)00005-7
更新日期：2003-05-05 00:00:00
abstract：:Since it is established that human chorionic gonadotropin (hCG) affects testosterone production and release in the human body, the use of this hormone as a performance enhancing drug has been prohibited by the World Anti-Doping Agency. Nowadays, the only validated biomarker of a hCG doping is its direct quantification...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2011.07.002
更新日期：2011-12-10 00:00:00
abstract：:Allele frequencies and haplotype and haplogroup analysis have been performed for 16 Y-chromosome binary markers and 8 Y-chromosome STRs (DYS19, DYS385I and II, DYS389I and II, DYS390, DYS391, DYS392, DYS393). Data was obtained from a general sample of 93 unrelated individuals living in metropolitan areas from El Salva...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2006.07.005
更新日期：2007-09-13 00:00:00
abstract：:In the case of suicidal drowning forensic examination is difficult, particularly with regard to differentiating between suicide, accident, homicide and natural death. Bondage and weighting with objects, putrescence and attendant lesions aggravate interpretation and investigation of postmortal forensic findings. In thi...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2014.04.022
更新日期：2014-07-01 00:00:00
abstract：:Preliminary results concerning the use of liquid crystals (LC) in fingerprinting are given. These were based on thin layers of liquid crystals, changing colours (observed in linear polarized light) due to dissolved organic matter, transferred from fingers' surfaces. The possibility is shown of using LC to illustrate n...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(91)90137-8
更新日期：1991-07-01 00:00:00
abstract：:Sex estimation is an integral aspect of biological anthropology. Correctly estimating sex is the first step to many subsequent analyses, such as estimating living stature or age-at-death. Klales et al. (2012) [6] provided a revised version of the Phenice (1969) [3] method that expanded the original three traits (ventr...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2017.05.001
更新日期：2017-08-01 00:00:00
abstract：:Venlafaxine is a phenethylamine antidepressant which inhibits both serotonin and norepinephrine reuptake and is structurally unrelated to the serotonin reuptake inhibitors (SSRIs). Its major metabolite, O-desmethylvenlafaxine (ODV), also inhibits serotonin reuptake. Although metabolized by the cytochrome P-450 (CYP) s...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(01)00455-8
更新日期：2001-09-15 00:00:00
abstract：:This article studies teenage homicide victims in Metro-Dade County, Miami, FL, U.S.A., between the years 1973 through 1982. A total of 263 cases were selected. Cases were then analyzed with respect to age, race, sex, cause of death, scene circumstances, alcohol and drugs detected at autopsy. A discussion follows that ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(84)90190-7
更新日期：1984-07-01 00:00:00
abstract：:This paper focuses on likelihood ratio based evaluations of fibre evidence in cases in which there is uncertainty about whether or not the reference item available for analysis - that is, an item typically taken from the suspect or seized at his home - is the item actually worn at the time of the offence. A likelihood...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2012.02.021
更新日期：2012-07-10 00:00:00
abstract：:The timely identification of vehicles involved in an accident, such as a hit-and-run situation, bears great importance in forensics. To this end, procedures have been defined for analyzing car paint samples that combine techniques such as visual analysis and Fourier transform infrared spectroscopy. This work proposes ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2015.12.040
更新日期：2016-02-01 00:00:00
abstract：:A multicentre retrospective analysis of 4450 autopsies carried out due to suspicion of medical malpractice in 17 German institutes of forensic medicine from 1990 to 2000 was performed for the German Federal Ministry of Health. During the time period analysed an increase of cases could be mentioned. The main results of...
journal_title：Forensic science international
pub_type： 杂志文章,多中心研究
doi：10.1016/j.forsciint.2009.05.013
更新日期：2009-09-10 00:00:00
abstract：:Analysis of cannabis has gained new importance worldwide, mainly for quality control within the legalized recreational and medical cannabis industry, but also for forensic differentiation between drug-type cannabis and legal products such as fiber hemp and CBD-rich/THC-poor cannabis. We herein present an HPLC-DAD meth...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.03.046
更新日期：2019-06-01 00:00:00
abstract：:A 79-year-old woman suffered from acute posttraumatic stress disorder (PTSD) and a loco typico, non-displaced fracture of her right distal radius due to an incident involving the assault of two unleashed owned dogs, which suddenly ran into her and aggressively jumped on her chest and knocked her down to the ground. Re...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2011.02.016
更新日期：2011-05-20 00:00:00
abstract：:Extrahepatic biliary atresia (EHBA) is a rare disease characterized by progressive and obliterative cholangiopathy in infants and is one of the major causes of secondary vitamin K deficiency bleeding (VKDB) due to cholestasis-induced fat malabsorption. Breast feeding increases the tendency of bleeding in EHBA patients...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2012.04.018
更新日期：2012-09-10 00:00:00
abstract：:Y-chromosomal variation at five biallelic markers (Tat, YAP, 12f2, SRY(10831) and 92R7) and nine multiallelic short tandem repeat (STR) loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385I/II and DYS388) in a Norwegian population sample are presented. The material consists of 1766 unrelated males of...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2005.11.009
更新日期：2006-12-01 00:00:00
abstract：:During a 3-year period (August 1st, 1985 to July 31st, 1988) a systematic investigation of medico-legal autopsy cases with regard to the presence of antibodies for HIV-virus was carried out at the Department of Forensic Medicine in Stockholm, Sweden. Prior to autopsy, blood samples were taken from femoral or subclavia...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(89)90220-x
更新日期：1989-06-01 00:00:00
abstract：:Six metals (copper, magnesium, barium, nickel, chromium and lead) were determined in two separate batches of seized ecstasy tablets by graphite furnace atomic absorption spectroscopy (GFAAS) following digestion with nitric acid and hydrogen peroxide. Large intra-batch variations were found as expected for tablets prod...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2013.04.021
更新日期：2013-09-10 00:00:00
abstract：:Facial profile is an important aspect in physical anthropology, forensic science, and cosmetic research. Thus, facial soft tissue measurement technology plays a significant role in facial restoration. A considerable amount of work has investigated facial soft tissue thickness, which significantly varies according to g...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2016.04.032
更新日期：2016-09-01 00:00:00
abstract：:The analysis of ethyl glucuronide (EtG) in hair is a powerful tool for chronic alcohol abuse control because of the typical wide detection window of the hair matrix and due to the possibility of segmentation, allowing evaluation of alcohol consumption in different periods. Additionally, EtG in hair is often the only d...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2009.07.023
更新日期：2010-03-20 00:00:00
abstract：:A headspace solid-phase microextraction procedure (HS-SPME) was developed for the profiling of traces present in 3,4-methylenedioxymethylampethamine (MDMA). Traces were first extracted using HS-SPME and then analyzed by gas chromatography-mass spectroscopy (GC-MS). The HS-SPME conditions were optimized using varying c...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2009.03.004
更新日期：2009-05-30 00:00:00
abstract：:The effects of absorption time, titer of antiserum or lectin in the absorption stage, and elution temperature on relative antibody or lectin yield in elutes in the absorption-elution procedure were studied in bloodstains and ammoniacal extracts of bloodstains using conventional grouping reagents. In addition, monoclon...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(86)90182-9
更新日期：1986-07-14 00:00:00
abstract：:The article is devoted to the comparative analysis of effectiveness of the most widely used methods for medico-legal examination of the hyoid bone and laryngeal cartilages, i.e. palpation, radiography and complete preparation. A consecutive study of 137 cases of hanging (including 20 cases of roentgenological analysis...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(97)00101-1
更新日期：1997-08-22 00:00:00
abstract：:In order to evaluate histological features of freezing damages to human tissue after death, we froze samples of liver and heart tissue to temperatures of -12 degrees C, -28 degrees C and -80 degrees C, and stored them for 24 and 72 h, respectively, at those temperatures. After thawing and routine preparation for histo...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(99)00043-2
更新日期：1999-06-28 00:00:00
abstract：:The exposition to heavy metal-rich airborne due to fire practicing has forced to the development of heavy metal-free environmental ammunition primers all over the world. Here we characterize the GSR elements present in the Brazilian lead-free ammunition produced by Companhia Brasileira de Cartuchos (CBC) and commercia...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2007.07.005
更新日期：2008-05-02 00:00:00
abstract：:Formalin-fixed and paraffin-embedded tissue (FF-PET) is an invaluable resource for retrospective molecular genetic studies, but the extraction of high-quality genomic DNA from FF-PET is still a problematic issue. Despite the range of DNA extraction methods currently in use, the association of phenol-chloroform extract...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2009.09.004
更新日期：2010-01-30 00:00:00
abstract：:Tire traces can be observed on several crime scenes as vehicles are often used by criminals. The tread abrasion on the road, while braking or skidding, leads to the production of small rubber particles which can be collected for comparison purposes. This research focused on the statistical comparison of Py-GC/MS profi...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2012.10.013
更新日期：2013-07-10 00:00:00
