Abstract：
:Several commercial PCR multiplex kits incorporate the amelogenin locus for the purpose of human gender identification. Consequently, erroneous results in the electropherogram profile of this locus can carry important forensic implications. In this study, dropout of the amelogenin Y allele was detected in 5 out of 77 phenotypically normal Kathmandu males using the AmpFlSTR Identifiler kit. A battery of male-specific markers including SNPs, STRs, STSs, and a minisatellite were amplified for the five amelogenin null samples in order to delineate the breakpoints of the deletions as well as assess the overall integrity of the Y-chromosome. This study represents the first to examine the haplogroup affiliation of the AMGY deletions. The analyses performed suggest a single origin for the five deletions as indicated by their allocation to a specific Y-haplogroup (J2b2-M241), related Y-STR haplotypes and identical regional localization of breakpoints. The age estimated from the microsatellite variation for the amelogenin deletions (if they are associated by descent) is approximately 6.5+/-3.3 ky, younger than the previously reported related age of the M241 haplogroup representatives (13-14 ky). Our data in combination with previous publications suggest a concentration of afflicted individuals in the Indian subcontinent, possibly as a result of common ancestry. The elevated incidence of the amelogenin dropout in these populations accentuates the need to utilize other loci for gender determination in order to obtain an accurate set of inclusion criteria in forensic casework.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Cadenas AM,Regueiro M,Gayden T,Singh N,Zhivotovsky LA,Underhill PA,Herrera RJdoi
10.1016/j.forsciint.2006.05.002subject
Has Abstractpub_date
2007-03-02 00:00:00pages
155-63issue
2-3eissn
0379-0738issn
1872-6283pii
S0379-0738(06)00287-8journal_volume
166pub_type
杂志文章abstract：:Diphenhydramine is one of the first effective antihistamine agents to have been discovered. The compound is also used for its sedative and antiemetic effects. The first case involving repetitive sedation linked to the use of diphenhydramine as a drug-facilitated crime and subsequent impairment of a 9-year-old female v...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2006.12.006
更新日期：2007-12-20 00:00:00
abstract：:Cocaine abuse is widespread all over the world, and is performed generally by sniffing, injecting or smoking cocaine or crack. The distinction between the recreational use of cocaine from the practice of the so called "coqueo" is still an issue in those countries where this habit is diffused and where it is not consid...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2012.09.005
更新日期：2013-04-10 00:00:00
abstract：:Death in the "microwave oven" has nothing to do with microwaves energy. It is the jargon name given to a criminal form of execution by carbonization that has been adopted by drug dealers in Rio de Janeiro (Brazil). The goal is to torture and intimidate victims, in an attempt of corpse occultation and to make identific...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2015.05.012
更新日期：2015-08-01 00:00:00
abstract：:This study focuses on insects and other arthropods sampled on the exhumation of an infant skeleton belonging to 'Prof. Dr. Rómulo Lambre' skeletal collection. The body was buried in soil inside a wooden coffin in a grave 40cm deep, in autumn, and stored in the cemetery deposit after exhumation. Death records were obta...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2013.12.029
更新日期：2014-04-01 00:00:00
abstract：:The area of the regional unit of Evros in northern Greece is considered the main gateway to the East and marks the end of the European territory and the beginning of the Asian continent. The natural boundary of the Evros River has been the last major obstacle to overcome before entering the Schengen area for hundreds ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.109875
更新日期：2019-09-01 00:00:00
abstract：:Postmortem biochemical indices may provide a useful adjunct to morphological studies in the identification of antemortem brain insult. We studied 34 routine medico-legal cases categorising them into one of four diagnostic groups. There were 11 cases of head trauma, 7 of 'hypoxia' (3 hangings and 4 carbon monoxide or d...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(92)90107-8
更新日期：1992-01-01 00:00:00
abstract：:A series of validation experiments was performed for a Y chromosome specific STR multiplex system following the suggestions made by the Technical Working Group DNA Analysis Methods (TWGDAM). The multiplex PCR products were detected on Perkin-Elmer 373 and 377 automated sequencers using two labeling colors. No problems...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(00)00467-9
更新日期：2001-09-01 00:00:00
abstract：:The mechanical properties of the human brain at high strain rate were investigated to analyse the mechanisms that cause backspatter when a cranial gunshot wound occurs. Different concentrations of gelatine and a new material (M1) developed in this work were tested and compared to bovine brain samples. Kinetic energy a...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2014.03.022
更新日期：2014-06-01 00:00:00
abstract：:An ingestion of an unknown quantity of U 46 D-Fluid (500 g dichlorophenoxyacetic acid/l) in a suicide is described. Although 2,4-dichlorophenoxyacetic acid (2,4 D) is widely used as a herbicide, intoxications are relatively rare. Quantitation of 2,4-D was performed by diethyl ether extraction from acidified samples (v...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(94)90295-x
更新日期：1994-03-01 00:00:00
abstract：:The technique of isoelectric focusing (IEF) in ultra-thin polyacrylamide gels as a method of phenotyping erythrocyte acid phosphatase (EAP) has been applied to a large number of red cell lysate and dried bloodstains. This paper presents the results of this study and discusses some features of the IEF patterns and prob...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(81)90141-9
更新日期：1981-07-01 00:00:00
abstract：:Cannabis cultivation in order to produce drugs is forbidden in Switzerland. Thus, law enforcement authorities regularly ask forensic laboratories to determinate cannabis plant's chemotype from seized material in order to ascertain that the plantation is legal or not. As required by the EU official analysis protocol th...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2010.03.034
更新日期：2010-07-15 00:00:00
abstract：:Ammunition is typically composed of a lead-based priming mixture which contributes to the characteristics most commonly used for the identification of gunshot residue (GSR). Due to the health risks often associated with lead, the use of lead-free primers in ammunitions is becoming more popular. Thus, the presence of G...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2017.04.015
更新日期：2017-07-01 00:00:00
abstract：:In 2017, 47,600 overdose deaths were reported to be associated with the abuse of opioids, including prescription painkillers (e.g. oxycodone), opiates (e.g. heroin), or synthetic opioids (e.g. fentanyl) within the United States. The recent spike in the presence of synthetic opioids in lots of heroin distributed on the...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.04.019
更新日期：2019-07-01 00:00:00
abstract：AIMS:The aim of this work is to test the stability of mephedrone added to whole blood collected from alive and dead mephedrone free-users and stored at three different temperatures (-20, +4 and +20°C) with and without preservatives up to 6 months, trying to establish the best storage condition in order to reduce possib...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2015.07.021
更新日期：2015-11-01 00:00:00
abstract：:In an investigation of postmortem ethanol diffusion deuterium-labeled ethanol-d6 was instilled by peroral gavage immediately after death by CO into the stomach of rat carcasses which were subsequently kept for 12-72 h at 5 or 30 degrees C. The heart blood, abdominal fluid and several tissues were collected and analyze...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(95)01820-4
更新日期：1995-12-29 00:00:00
abstract：:Luminescent lanthanide ions such as Eu3+ and Tb3+ show emission enhancement, when complexed with Ruhemann's Purples (RPs, reaction products of ninhydrin and ninhydrin analogs with amino acids) via intramolecular energy transfer from the RP ligands (good absorbers) to the ions Eu3+ and Tb+3 (efficient emitters). The au...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(94)90345-x
更新日期：1994-06-10 00:00:00
abstract：:The identification of X bodies is an everyday preoccupation in forensic pathology. This retrospective analysis studied all methods of identification and characteristics of unidentified bodies arrived in the Department of Forensic Medicine and Pathology (University Hospital R. Poincaré, Garches, France) during a 6-year...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2010.05.022
更新日期：2011-01-30 00:00:00
abstract：:The increasing interest in toxicological hair analysis as a marker of human exposure to xenobiotics such as illicit substances or therapeutic drugs, has been made feasible by the extension of mass spectrometry, a highly sensitive method of detection. A newborn exposed to drugs in utero can suffer from a varying degree...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(03)00050-1
更新日期：2003-04-23 00:00:00
abstract：:Most traditional techniques to recover latent fingermarks from metallic surfaces do not consider the metal surface properties and instead focus on the fingermark chemistry. The scanning Kelvin probe (SKP) technique is a non-contact, non-destructive method, used under ambient conditions, which can be utilised to recove...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2018.07.025
更新日期：2018-10-01 00:00:00
abstract：:Allele frequencies for the 19 STRs loci, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D21S11, CSF1PO, F13A01, F13B, FESFPS, FGA, LPL, Penta D, Penta E, TH01, TPOX and VWA were obtained from a sample of 203-1188 unrelated individuals living in the area of south-east Poland. ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2003.10.001
更新日期：2004-01-06 00:00:00
abstract：:Allele frequencies, forensic parameters for the 11 STR loci (TH01, TPOX, CSF1PO, D13S317, D7S820, D16S539, VWA, FESFPS, F13A01, F13B and LPL) were determined in a sample of 140-1262 unrelated adults from the Upper Silesia region (Poland). Comparison of allele frequencies for examined STR loci between the Upper Silesia...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2006.01.011
更新日期：2007-05-03 00:00:00
abstract：:The analysis of mitochondrial DNA (mtDNA) is a useful tool in forensic cases when sample contents too little or degraded nuclear DNA to genotype by autosomal short tandem repeat (STR) loci, but it is especially useful when the only forensic evidence is a hair shaft. Several authors have related differences in mtDNA fr...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2007.02.011
更新日期：2007-12-20 00:00:00
abstract：:Genotype and distribution of allele frequencies at 17 STRs were studied in 526 unrelated Japanese individuals using the PowerPlex 16 system and the AmpFlSTR Identifiler. ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(03)00075-6
更新日期：2003-05-05 00:00:00
abstract：:The analysis of condom traces has recently been added to the standard forensic examination protocol of sexual assault and rape cases. Several recent studies have thus focussed on the detection of condom components and classification of the chemical profiles using statistics, obtaining very promising results. The purpo...
journal_title：Forensic science international
pub_type： 杂志文章,评审
doi：10.1016/j.forsciint.2020.110255
更新日期：2020-05-01 00:00:00
abstract：:A population study on 10 short tandem repeat (STR) loci was performed on 202 unrelated Czech Caucasians. DNA, initially frozen, was thawed and placed FTA paper. The DNA was purified in situ. DNA was amplified by PCR using the AmpFlSTR SGM Plus amplification kit. ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(00)00384-4
更新日期：2001-06-01 00:00:00
abstract：:Pentaerythritol tetranitrate (PETN) and its degradation products are analyzed to discriminate between residues originating from PETN explosions and residues obtained under other circumstances, such as natural degradation on textile, or after handling intact PETN. The degradation products observed in post-explosion sam...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2013.03.042
更新日期：2013-07-10 00:00:00
abstract：:The case of a 13-month-old boy with a diagnosis of unclear unconsciousness is reported on. As the physical examination did not lead to any explanation of his condition, the administration of drugs in the context of Munchausen syndrome by proxy was suspected. Complex forensic-toxicological analyses using HPLC/UV, LC/MS...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2009.04.021
更新日期：2009-08-10 00:00:00
abstract：:CT-scanning as routine examination before medico-legal autopsy was introduced at the Institute of Forensic Medicine in Copenhagen, Denmark, in December 2002. The present series comprises of 525 medico-legal examinations performed in the year 2003. The purpose is to determine the value of CT-scanning prior to the post-...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2006.05.041
更新日期：2007-09-13 00:00:00
abstract：:This report describes the heat-induced alterations in human bone tissue observed using scanning electron microscopy and microradiography. Femoral bone samples were taken from persons varying in age from 1 year to 97 years at the time of their death. The bone was heated at selected temperatures in the range 200-1600 de...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(95)01735-2
更新日期：1995-06-30 00:00:00
abstract：:A total of 201 males from Somalia were typed for the Y-chromosome STRs DYS19, DYS385a/b, DYS389-I, DYS389-II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438 and DYS439 with the PowerPlex Y kit (Promega). A total of 96 different haplotypes were observed and the haplotype diversity was 0.9715. The number of unique haplo...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2005.01.011
更新日期：2005-07-16 00:00:00
