Heteroplasmy in hair: differences among hair and blood from the same individuals are still a matter of debate.


:The analysis of mitochondrial DNA (mtDNA) is a useful tool in forensic cases when sample contents too little or degraded nuclear DNA to genotype by autosomal short tandem repeat (STR) loci, but it is especially useful when the only forensic evidence is a hair shaft. Several authors have related differences in mtDNA from different tissues within the same individual, with high frequency of heteroplasmic variants in hair, as also in some other tissues. Is still a matter of debate how the differences influence the interpretation forensic protocols. One difference between two samples supposed to be originated from the same individual are related to an inconclusive result, but depending on the tissue and the position of the difference it should have a different interpretation, based on mutation-rate heterogeneity of mtDNA. In order to investigate it differences in the mtDNA control region from hair shafts and blood in our population, sequences from the hypervariable regions 1 and 2 (HV1 and HV2) from 100 Brazilian unrelated individuals were compared. The frequency of point heteroplasmy observed in hair was 10.5% by sequencing. Our study confirms the results related by other authors that concluded that small differences within tissues should be interpreted with caution especially when analyzing hair samples.


Forensic Sci Int


Paneto GG,Martins JA,Longo LV,Pereira GA,Freschi A,Alvarenga VL,Chen B,Oliveira RN,Hirata MH,Cicarelli RM




Has Abstract


2007-12-20 00:00:00














  • Y-chromosome STR haplotypes in Córdoba (Argentina).

    abstract::Eight Y-chromosome STRs were investigated in a male population sample from Córdoba region (Argentina). Complete Y-chromosomal STRs haplotypes were obtained in 100 individuals, among which 91 different haplotypes were observed. The most common haplotype was shared by 4% of the sample, while 86 haplotypes were unique. T...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Fondevila M,Jaime JC,Salas A,Lareu MV,Carracedo A

    更新日期:2003-11-26 00:00:00

  • A robust and non-invertible fingerprint template for fingerprint matching system.

    abstract::Fingerprint Recognition System is widely deployed in variety of application domain, ranging from forensic to mobile phones. Its widespread deployment in various applications were person authentication are required, has caused concern that a leaked fingerprint template may be used to reconstruct the original fingerprin...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Trivedi AK,Thounaojam DM,Pal S

    更新日期:2018-07-01 00:00:00

  • The color(s) of human hair--forensic hair analysis with SpectraCube.

    abstract::Human hair is among the most common kind of evidence secured at crime scenes. Although DNA analysis through STR-typing is possible in principle, it is not very promising for telogenic hair or single hairs. For the mixed traces frequently found in practice, composed of different hair from an unknown number of individua...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Birngruber C,Ramsthaler F,Verhoff MA

    更新日期:2009-03-10 00:00:00

  • Combination of fatal digoxin poisoning with endocardial fibroelastosis.

    abstract::This is the first report in the forensic literature of a combination of fatal digoxin poisoning with endocardial fibroelastosis (EFE). Typical morphological features of EFE as the cause of clinically diagnosed cardiomyopathy were present in the autopsy of a 3-year-old girl, including cardiac hypertrophy and marked thi...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Grellner W,Käferstein H,Sticht G

    更新日期:1997-10-06 00:00:00

  • DNA and RNA extraction from low amount of blood volume.

    abstract::Clinical and research-based tests in molecular biology require a substantial amount of DNA and RNA, unfortunately, a considerable number of cells is needed for this amount of sample. Blood is one of the best and easiest source of cells, but is not used due to its invasive drawing methods and the needed volume. Another...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Farivar S,Ghazimoradi MH

    更新日期:2019-10-01 00:00:00

  • Longitudinal brainstem laceration associated with complex basilar skull fractures due to a fall: an autopsy case.

    abstract::This report describes an autopsy case of a rare longitudinal brainstem laceration associated with complex basilar skull fractures. The victim was a 40-year-old male who died immediately after falling from a roof (9.2m in height) of a factory onto a concrete floor. The postmortem examination revealed an incomplete ring...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Zhu BL,Quan L,Ishida K,Taniguchi M,Oritani S,Fujita MQ,Maeda H

    更新日期:2002-03-28 00:00:00

  • Screening of soil evidence by a combination of simple techniques: validity of particle size distribution.

    abstract::The validity of the determination of particle size distribution for forensic soil identification was studied using 73 soil samples collected from a 20 km x 15 km area. Soil particles were first divided into two fractions by wet sieving with a sieve with a 0.05 mm aperture size. Dry sieving was used to analyze the coar...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Sugita R,Marumo Y

    更新日期:2001-11-01 00:00:00

  • Predictive equation for post-mortem interval using spectrophotometric values of post-mortem lividity: A pilot study.

    abstract::The colour of post-mortem lividity and control skin of 86 cadavers was measured spectrophotometrically to obtain L* (value), a* (chroma) and b* (hue) values. In addition, left heart blood (n = 58), right heart blood (n = 57) and blood from the femoral vein (n = 21) were measured. Using these data, we analysed the rela...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Usumoto Y,Kudo K,Tsuji A,Ihama Y,Ikeda N

    更新日期:2019-04-01 00:00:00

  • Identification of forensically important Chrysomya (Diptera: Calliphoridae) species using the second ribosomal internal transcribed spacer (ITS2).

    abstract::The identification of forensically important blowflies of the genus Chrysomya (Diptera: Calliphoridae) may be hampered by their close morphological similarities, especially as immatures. In contrast to most previous studies, the utility of a nuclear rather than mitochondrial genetic marker was investigated to solve th...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Nelson LA,Wallman JF,Dowton M

    更新日期:2008-05-20 00:00:00

  • Driving under the influence of drugs -- evaluation of analytical data of drugs in oral fluid, serum and urine, and correlation with impairment symptoms.

    abstract::A study was performed to acquire urine, serum and oral fluid samples in cases of suspected driving under the influence of drugs of abuse. Oral fluid was collected using a novel sampling/testing device (Dräger DrugTest System). The aim of the study was to evaluate oral fluid and urine as a predictor of blood samples po...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Toennes SW,Kauert GF,Steinmeyer S,Moeller MR

    更新日期:2005-09-10 00:00:00

  • Electrical excitability of skeletal muscle postmortem in casework.

    abstract:UNLABELLED:The paper gives a review of the development of methods of postmortem electrical excitability of skeletal muscle for determining the time since death. For practical application in casework, the following method can be proposed: position of electrodes in the orbicularis oculi muscle, stimulation by rectangular...

    journal_title:Forensic science international

    pub_type: 杂志文章,评审


    authors: Madea B,Henssge C

    更新日期:1990-10-01 00:00:00

  • Psychical and physical symptoms after torture. A prospective controlled study.

    abstract::This is the first controlled study of torture victims published. Ten persons who alleged subjection to torture were examined by two different medical teams during the first months after torture. The testimonies of the probands were found to be credible and the method of examination was found to be reliable. The state ...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Petersen HD,Jacobsen P

    更新日期:1985-11-01 00:00:00

  • Missing, not Forgotten. The German Association for the Recovery of the Fallen in Eastern Europe (VBGO e.V.).

    abstract::For almost three decades, the Association for the Recovery of the Fallen in Eastern Europe (Verein zur Bergung Gefallener in Osteuropa e.V., VBGO) has committed itself to the location, recovery, documentation, and identification of the missing victims of World War II. Through the tireless efforts of the VBGO volunteer...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Indra L,Straub K,Schulz W,Balsam R,Ockert W,Nowack S,Laue A

    更新日期:2020-11-01 00:00:00

  • Distinguishing antemortem from postmortem injuries by LTB4 quantification.

    abstract::Leukotriene B4 (LTB4) in skin samples from seven forensic cases was detected by HPLC to distinguish their antemortem or postmortem origin. In total, there were thirteen antemortem and seven postmortem specimens. The results showed that LTB4 was found in all antemortem wound specimens which were either fresh, or refrig...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: He L,Zhu J

    更新日期:1996-07-31 00:00:00

  • Death due to obstruction of the upper airways caused by edema of the laryngeal mucosa in the course of hereditary angioedema.

    abstract::A rare case of death of a young man due to airway obstruction in the course of angioedema (Quincke's edema). Type I hereditary angioedema due to C1 esterase inhibitor deficiency had been diagnosed in the man while he was alive. The information concerning the man's health state was given in the Public Prosecutor's deci...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Arkuszewski P,Meissner E,Szram S

    更新日期:2015-09-01 00:00:00

  • Willems I VS Willems II: A comparative study of accuracy in 5-15 year old Indian children.

    abstract:BACKGROUND:Studies testing the Willems method of age estimation with gender-specific scores on different population groups have reported consistently more accurate results over other methods. Not enough is known about the validity of Willems non-gender specific scores. AIM:The present study aimed to compare the accura...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Hegde S,Patodia A,Dixit U

    更新日期:2016-09-01 00:00:00

  • The forensic analysis of office paper using carbon isotope ratio mass spectrometry--part 2: method development, validation and sample handling.

    abstract::This paper describes the development and validation of a method for the analysis of office papers by measuring carbon isotopes using isotope ratio mass spectrometry (IRMS). The method development phase included testing protocols for storage, sample materials, set-up of the analytical run; and examining the effects of ...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Jones K,Benson S,Roux C

    更新日期:2013-09-10 00:00:00

  • An automatic method for skeletal patterns classification using craniomaxillary variables on a Colombian population.

    abstract:BACKGROUND:The mandibular bone is an important part of the forensic facial reconstruction and it has the possibility of getting lost in skeletonized remains; for this reason, it is necessary to facilitate the identification process simulating the mandibular position only through craniomaxillary measures, for this task,...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Niño-Sandoval TC,Guevara Perez SV,González FA,Jaque RA,Infante-Contreras C

    更新日期:2016-04-01 00:00:00

  • Evaluating the evidentiary value of the analysis of skeletal trauma in forensic research: A review of research and practice.

    abstract::Understanding bone trauma characteristics is a fundamental component of forensic investigations that can assist in understanding the nature of blunt trauma related deaths. The variation of each blunt force trauma (BFT) injury is dependent on a magnitude of factors including, age, sex, health, angle of impact, impact m...

    journal_title:Forensic science international

    pub_type: 杂志文章,评审


    authors: Dempsey N,Blau S

    更新日期:2020-02-01 00:00:00

  • Simultaneous determination of pyrethroids and their metabolites in human plasma using liquid chromatography tandem mass spectrometry.

    abstract::Pyrethroids, organic compounds similar to natural pyrethrums, constitute the majority of insecticides. Pyrethroids are widely used around the world owing to their excellent selective toxicity to certain insects. In addition, they are easily found in daily life, accounting for most household pesticides. Owing to the ea...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Jeong D,Kang JS,Kim KM,Baek SH,Choe S,Pyo J

    更新日期:2019-09-01 00:00:00

  • Tasks of research in forensic medicine - different study types in clinical research and forensic medicine.

    abstract::In the last years the research output of forensic medicine has sometimes been regarded as insufficient and as of poor quality, especially when parameters as impact factors and external funding were taken into account. However, forensic medicine has different tasks compared to clinical medicine. The main difference bet...

    journal_title:Forensic science international

    pub_type: 杂志文章,评审


    authors: Madea B,Saukko P,Musshoff F

    更新日期:2007-01-17 00:00:00

  • Suicide of a cyclist.

    abstract::The rate of suicides in road traffic fatalities is estimated at 1-8% depending on the investigated study material. Especially single-car accidents, for which no technical reason or driving error is apparent, are considered suspicious. The elucidation of suicides in road traffic is difficult if there are no relevant cl...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Schmidt U,Rost T,Jungmann L,Pollak S

    更新日期:2011-04-15 00:00:00

  • Experimental study of the coupling parameters influencing the terminal effects of thoracic blunt ballistic impacts.

    abstract::The objective of the study is to better understand how blunt projectile ballistic parameters and material properties influence the events leading to injuries. The present work focuses on lateral thoracic impacts and follows an experimental approach. The projectiles are made with a soft foam nose assembled with a rigid...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Pavier J,Langlet A,Eches N,Prat N,Bailly P,Jacquet JF

    更新日期:2015-07-01 00:00:00

  • Whole human blood DNA degradation associated with artificial ultraviolet and solar radiations as a function of exposure time.

    abstract::Laboratory investigations were conducted to evaluate the effect of ultraviolet radiation components and solar radiation exposure as a function of time on the degradation of whole human blood DNA from the standpoint of forensic analysis. Ten μL of whole human male blood samples were exposed to UV-A, UV-B, UV-C, and sol...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Rahi GS,Adams JL,Yuan J,Devone DJ,Lodhi KM

    更新日期:2021-02-01 00:00:00

  • Large-scale in-vivo Caucasian facial soft tissue thickness database for craniofacial reconstruction.

    abstract::A large-scale study of facial soft tissue depths of Caucasian adults was conducted. Over a 2-years period, 967 Caucasian subjects of both sexes, varying age and varying body mass index (BMI) were studied. A user-friendly and mobile ultrasound-based system was used to measure, in about 20min per subject, the soft tissu...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: De Greef S,Claes P,Vandermeulen D,Mollemans W,Suetens P,Willems G

    更新日期:2006-05-15 00:00:00

  • Determination of sex from various hand dimensions of Koreans.

    abstract::In the case of disasters or crime scenes, forensic anthropometric methods have been utilized as a reliable way to quickly confirm the identification of victims using only a few parts of the body. A total of 321 measurement data (from 167 males and 154 females) were analyzed to investigate the suitability of detailed h...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Jee SC,Bahn S,Yun MH

    更新日期:2015-12-01 00:00:00

  • Characterisation of chemical component migration in automotive paint by synchrotron infrared imaging.

    abstract::Synchrotron infrared chemical imaging was employed to examine and assess the extent of interlayer component migration within multilayer automotive paint samples, with a particular emphasis on the cross-linking additive melamine. Two dimensional infrared chemical images revealed that melamine consistently diffuses in s...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Maric M,van Bronswijk W,Lewis SW,Pitts K,Martin DE

    更新日期:2013-05-10 00:00:00

  • Munchausen syndrome by proxy (MSBP): an extreme form of child abuse with a special forensic challenge.

    abstract::Munchausen syndrome by proxy (MSBP) is a special form of child abuse in which an adult repeatedly produces symptoms of illness in a person under his/her care. In most cases the perpetrators are mothers who repeatedly and in different ways produce or feign symptoms of illness in their children in order to obtain medica...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Bartsch C,Risse M,Schütz H,Weigand N,Weiler G

    更新日期:2003-11-26 00:00:00

  • The effectiveness of strong afterglow phosphor powder in the detection of fingermarks.

    abstract::There are numerous types of fluorescent fingermark powders or reagents used with the visualization of latent fingermarks deposited on multicolored substrate surfaces that can present a contrast problem if developed with regular fingermark powders. The developed fingermarks can show bright fluorescence upon exposure to...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Liu L,Zhang Z,Zhang L,Zhai Y

    更新日期:2009-01-10 00:00:00

  • Roadside drug testing: comparison of two legal approaches in Belgium.

    abstract:BACKGROUND:Internationally, urine on-site testing has been used for detecting drivers under the influence of drugs (DUID) but more and more countries, such as Belgium, are switching to oral fluid screening. OBJECTIVE:To compare the previous (published in 1999) and current (published 2009) enforcement procedures of DUI...

    journal_title:Forensic science international

    pub_type: 杂志文章


    authors: Van der Linden T,Wille SM,Ramírez-Fernandez M,Verstraete AG,Samyn N

    更新日期:2015-04-01 00:00:00