Abstract：
:Cocaine was the second most widely used drug in Europe in 2016, with 3.5 million consumers aged 15-64 years old. Adulterants are pharmacologically active substances developed for medical purposes, however, there is little knowledge about their influence in the human body when there is concomitant use with cocaine. The objective of this work was to validate a method that allows the identification, confirmation and quantification of cocaine adulterants in blood samples collected in vivo or post-mortem. The studied substances were atropine, phenacetin, hydroxyzine, ketamine, lidocaine and tetramisole. A retrospective study of the prevalence of these substances, as well as their relative concentrations, was made analysing 97 real blood samples previously tested positive for cocaine and/or its metabolites. The analytes of interest were extracted, using a simple method based on protein precipitation with frozen acetonitrile and further analysis by GC/MS. The method was fully validated in accordance with parameters and criteria implemented in the lab and SWGTOX recommendations (mean recovery: 94-115%; CV: 6.2-13%; BIAS: 2.7-7.8%). 31 samples were positive for adulterants: phenacetin (19%), tetramisole (15%), lidocaine (8%) and hydroxyzine (1%). Concentrations were higher in post-mortem samples for all compounds analysed. Lidocaine was more prevalent in samples collected in vivo whereas tetramisole was present almost exclusively in post-mortem samples. Phenacetin was evenly distributed between post-mortem and in vivo samples. The validated method allows rapid, precise, accurate and economic analysis of selected compounds and requires smaller sample aliquots which can be important in post-mortem cases. The information collected can be important in future studies of correlation between the presence of adulterants and cocaine toxicity.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Gameiro R,Costa S,Barroso M,Franco J,Fonseca Sdoi
10.1016/j.forsciint.2019.03.005subject
Has Abstractpub_date
2019-06-01 00:00:00pages
95-102eissn
0379-0738issn
1872-6283pii
S0379-0738(19)30087-8journal_volume
299pub_type
杂志文章abstract：:One of the major challenges in the near future is the identification of genes that affect the metabolism of different drugs. Large scale association studies that utilise single nucleotide polymorphisms (SNPs) have been considered a valuable tool for this purpose. CYP2D6, CYP2C19, CYP2C9, CYP3A4 and CYP1A2 were found t...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2010.10.004
更新日期：2011-04-15 00:00:00
abstract：:In this study it is demonstrated that human odor collected from items recovered at a post-blast scene can be evaluated using human scent specific canine teams to locate and identify individuals who have been in contact with the improvised explosive device (IED) components and/or the delivery vehicle. The purpose of th...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2010.03.021
更新日期：2010-06-15 00:00:00
abstract：:The mechanical properties of the human brain at high strain rate were investigated to analyse the mechanisms that cause backspatter when a cranial gunshot wound occurs. Different concentrations of gelatine and a new material (M1) developed in this work were tested and compared to bovine brain samples. Kinetic energy a...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2014.03.022
更新日期：2014-06-01 00:00:00
abstract：:A rare case of death of a young man due to airway obstruction in the course of angioedema (Quincke's edema). Type I hereditary angioedema due to C1 esterase inhibitor deficiency had been diagnosed in the man while he was alive. The information concerning the man's health state was given in the Public Prosecutor's deci...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2015.07.025
更新日期：2015-09-01 00:00:00
abstract：INTRODUCTION:Age assessment based on dental development is often requested in order to assess whether an individual is older or younger than 18 years of age. There are several statistical approaches to estimate age based upon third molar development. The aim of this study was to apply the principles of transition analy...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2020.110145
更新日期：2020-03-01 00:00:00
abstract：:Forensic samples are commonly influenced by various environmental factors, including ultraviolet (UV) irradiation; thus, forensic applications of DNA repair (e.g., PreCR™, Restorase®) have been investigated, focusing on short tandem repeat typing. However, current DNA-based examinations are used for both human and bod...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.110077
更新日期：2020-01-01 00:00:00
abstract：:An examination of the organ weights associated with victims of drowning, asphyxiation and trauma was undertaken to determine (a) the effects of asphyxiation compared to a trauma group, and in turn, (b) the effects of drowning compared to an asphyxiation group. Included in the study were 217 drowning deaths, 166 pure a...
journal_title：Forensic science international
pub_type： 更正并重新发布的文章,杂志文章
doi：10.1016/s0379-0738(03)00332-3
更新日期：2003-11-26 00:00:00
abstract：:Evidence of rare disease may be useful in the identification of unknown remains. Osteodystrophy is a condition commonly associated with chronic renal failure. The presence of renal osteodystrophy and medical artifacts associated with the treatment of kidney failure in human remains may provide information about the in...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(94)90263-1
更新日期：1994-03-25 00:00:00
abstract：:Driving while intoxicated (DWI) legislation requires proving the critical breath alcohol concentration (BrAC) at the time of driving. With time delayed analysis, retrograde extrapolation is occasionally employed but has several uncertainties associated with it. The present study attempts to address whether subjects ac...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(92)90013-m
更新日期：1992-12-01 00:00:00
abstract：:Haplotypes and allele frequencies for 12 Y-STR loci were determined in Sichuan Han ethnic population samples of 237 unrelated males living in west China. Only one haplotype was encountered in triple. Twelve of the haplotypes were encountered in duplicate, while 210 haplotypes were unique. The gene diversity was 0.9952...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2007.06.006
更新日期：2008-03-05 00:00:00
abstract：:Considering the high use of inkjet printing in forgery cases, the classification of inkjet printing is particularly important in questioned document examination. In this work, a universal GC-MS method has been developed to analyze various ink components extracted from inkjet printouts. The results indicated that sever...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2020.110562
更新日期：2021-01-01 00:00:00
abstract：OBJECTIVES:To describe the frequency of genital and anal injury and associated demographic and assault characteristics in women alleging sexual assault. DESIGN:Cross-sectional study. SETTING:Sexual Assault Resource Centre (SARC), Western Australia. PARTICIPANTS:Total of 1266 women attending SARC from Jan-2009 to Mar...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2017.03.013
更新日期：2017-06-01 00:00:00
abstract：:The ability to recover trace DNA from fired cartridge cases can help establish important leads regarding the handler of the ammunition. Over recent years, several DNA recovery techniques for fired ammunition have been published. Three techniques of significant interest include tape lifting, direct PCR, and vacuum filt...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2020.110507
更新日期：2020-12-01 00:00:00
abstract：:An accurate and reproducible technique was employed for measurement of water content (RBCH2O) and potassium concentration (RBCK) in rat erythrocytes post mortem. Coefficients of variation for determination of RBCH2O and RBCK, as estimated from the results of duplicate analyses (n = 36), were 1.21% and 1.17%, respectiv...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(88)90014-x
更新日期：1988-07-01 00:00:00
abstract：:In this paper we propose an innovative methodology for automated profiling of illicit tablets by their surface granularity; a feature previously unexamined for this purpose. We make use of the tiny inconsistencies at the tablet surface, referred to as speckles, to generate a quantitative granularity profile of tablets...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2011.03.008
更新日期：2011-07-15 00:00:00
abstract：:Pyrethroids, organic compounds similar to natural pyrethrums, constitute the majority of insecticides. Pyrethroids are widely used around the world owing to their excellent selective toxicity to certain insects. In addition, they are easily found in daily life, accounting for most household pesticides. Owing to the ea...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.06.004
更新日期：2019-09-01 00:00:00
abstract：:This case report describes novel methodology used to identify a 43-year-old post-mortem photo of a drowned male recovered from a London river in the 1970s. Embedded in an array of foils, police super-recognisers (n=25) possessing superior simultaneous face matching ability, and police controls (n=139) provided confide...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.109910
更新日期：2019-09-01 00:00:00
abstract：:The causes of sudden cardiac death are diverse and are function of age. In young people, coronary anomalies, hypertrophic cardiomyopathy are the most common findings at autopsies; in adults, coronary atherosclerosis and acquired forms of cardiomyopathy are frequent findings. In many of non-ischemia related cases autop...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2004.09.011
更新日期：2004-12-02 00:00:00
abstract：:Nyaope is a mixture of low grade heroin, cannabis products, antiretroviral drugs and other materials added as bulking agents. It is a highly physically additive mixture which is smoked by users. As part of the development of a method for the analysis and profiling of nyaope this study evaluates the stability of the ca...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.04.040
更新日期：2019-07-01 00:00:00
abstract：:Over the last decades, the importance of technical and scientific evidence for the criminal justice system has been steadily increasing. Unfortunately, the weight of forensic evidence is not always easy for the trier of fact to assess, as appears from a brief discussion of some recent cases in which the weight of expe...
journal_title：Forensic science international
pub_type： 杂志文章,评审
doi：10.1016/j.forsciint.2004.11.028
更新日期：2006-06-02 00:00:00
abstract：:Extrahepatic biliary atresia (EHBA) is a rare disease characterized by progressive and obliterative cholangiopathy in infants and is one of the major causes of secondary vitamin K deficiency bleeding (VKDB) due to cholestasis-induced fat malabsorption. Breast feeding increases the tendency of bleeding in EHBA patients...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2012.04.018
更新日期：2012-09-10 00:00:00
abstract：:Likelihood ratios are increasingly being adopted to convey expert evaluative opinions to courts. In the absence of appropriate databases, many of these likelihood ratios will include verbal rather than numerical estimates of the support offered by the analysis. However evidence suggests that verbal formulations of unc...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2014.04.005
更新日期：2014-07-01 00:00:00
abstract：:The relationship between extracellular abdominal impedance and postmortem interval (PMI) reflects the combined effects, on impedance, of postmortem cooling of the tissues and of autolysis per se. This study was performed in order to eliminate temperature change as a major factor contributing to the time course of post...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(99)00217-0
更新日期：2000-03-13 00:00:00
abstract：:Little is currently known about the importance of clotting during the drying of blood pools. While this is of little moment for droplets where drying occurs faster than contact-phase-induced clotting, clotting may significantly influence blood pools drying as it transform a liquid into a gel. To investigate this influ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.110008
更新日期：2019-12-01 00:00:00
abstract：:The formation of adipocere slows further decomposition and preserves corpses for decades or even centuries. This resistance to degradation is a serious problem, especially with regard to the reuse of graves after regular resting times. We present results from an exhumation series in modern graveyards where coffins fro...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2015.09.010
更新日期：2015-12-01 00:00:00
abstract：:Four novel alkyl 2-cyanoacrylate monomers (alkyl=1-cyanoethyl, 2-cyanoethyl, trideuteromethyl and pentadeuteroethyl) have been tested for their ability to develop latent fingermarks that can then be visualized using mid-infrared spectral (chemical) imaging. Each of the four monomers was chosen for its potential to pro...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2010.10.012
更新日期：2011-04-15 00:00:00
abstract：:A collaborative exercise was carried out by the European DNA Profiling Group (EDNAP) in order to evaluate the distribution of mitochondrial DNA (mtDNA) heteroplasmy amongst the hairs of an individual who displays point heteroplasmy in blood and buccal cells. A second aim of the exercise was to study reproducibility of...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/S0379-0738(03)00181-6
更新日期：2004-02-10 00:00:00
abstract：:Fluvoxamine is a selective serotonin reuptake inhibitor that has been considered relatively safe in overdose. At therapeutic and supratherapeutic concentrations, fluvoxamine affects cardiac conduction, prolongs QTc interval, causes hypotension, obtundation, and can increase propensity for seizures. A man in his 60s wa...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.02.047
更新日期：2019-07-01 00:00:00
abstract：:Sodium oxybate (Xyrem®), the sodium salt of γ- hydroxybutyric acid (GHB), is a first-line treatment of the symptoms induced by type 1 narcolepsy (NT1) and it is highly effective in improving sleep architecture, decreasing excessive daytime sleepiness and the frequency of cataplexy attacks. Using an ultra-high-performa...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2017.01.015
更新日期：2017-05-01 00:00:00
abstract：:Fifteen autosomal short tandem repeat (STR) markers (D3S1358, HUMTH01, D21S11, D18S51, PENTA E, D5S818, D13S317, D7S820, D16S539, CSF1PO, PENTA D, HUMvWA, D8S1179, HUMTPOX, FGA) were analyzed in 1734 individuals living in urban areas of cities from six different Argentinian provinces (Buenos Aires, Neuquén, Tucumán, L...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2006.02.042
更新日期：2007-01-05 00:00:00
