Mucosal adjuvant properties of mutant LT-IIa and LT-IIb enterotoxins that exhibit altered ganglioside-binding activities.

abstract：:The opacity (Opa) proteins mediate a variety of interactions between the bacterium Neisseria meningitidis and its human host. These interactions are thought to be of central importance in both the asymptomatic colonization of the nasopharynx and the sporadic occurrence of meningococcal disease. The receptor specificit...

journal_title：Infection and immunity

authors： Callaghan MJ,Jolley KA,Maiden MC

更新日期：2006-09-01 00:00:00

abstract：:Human plasma was bactericidal for small numbers of Klebsiella pneumoniae, but larger numbers grew slowly over a period of 24 h. Human polymorphs in a clot of autologous plasma had a bacteriostatic effect on relatively large numbers of bacteria for up to 24 h and were much more effective than plasma alone. The bacteric...

journal_title：Infection and immunity

authors： Ward CG,Hammond JS,Bullen JJ

更新日期：1986-03-01 00:00:00

abstract：:The efficacy of the innate immune system depends on its ability to mount an appropriate response to diverse infections and damaging agents. Key components of this system are pattern recognition receptors that detect pathogen-associated and damage-associated molecular patterns (PAMPs and DAMPs). Nlrp1b is a pattern rec...

journal_title：Infection and immunity

authors： Liao KC,Mogridge J

更新日期：2013-02-01 00:00:00

abstract：:Neutrophil collagenase (matrix metalloproteinase 8 [MMP-8]) is an important mediator of tissue destruction in inflammatory diseases. Studies of anaerobic periodontal infections have shown that active MMP-8 in gingival crevicular fluid is associated with the degradation of periodontal tissues in progressive periodontit...

journal_title：Infection and immunity

authors： Romanelli R,Mancini S,Laschinger C,Overall CM,Sodek J,McCulloch CA

更新日期：1999-05-01 00:00:00

abstract：:Tuberculosis remains a leading killer worldwide, and new approaches for its treatment and prevention are urgently needed. This effort will benefit greatly from a better understanding of gene regulation in Mycobacterium tuberculosis, particularly with respect to this pathogen's response to its host environment. We exam...

journal_title：Infection and immunity

authors： Purkayastha A,McCue LA,McDonough KA

更新日期：2002-03-01 00:00:00

abstract：:Type IV pili (Tfp) of gram-negative species share many characteristics, including a common architecture and conserved biogenesis pathway. Much less is known about the regulation of Tfp expression in response to changing environmental conditions. We investigated the diversity of Tfp regulatory systems by searching for ...

journal_title：Infection and immunity

authors： Boekema BK,Van Putten JP,Stockhofe-Zurwieden N,Smith HE

更新日期：2004-02-01 00:00:00

abstract：:The effect of infection with low-virulence, tissue culture-propagated strains of reticuloendotheliosis virus (REV) on protective vaccinal immunity against Marek's disease (MD) lymphomas was investigated. Vaccinated chickens inoculated at hatching with greater than 10(4) focus-forming units of REV and challenged with M...

journal_title：Infection and immunity

authors： Witter RL,Lee LF,Bacon LD,Smith EJ

更新日期：1979-10-01 00:00:00

abstract：:Deciphering the mechanisms by which Borrelia burgdorferi controls the synthesis of proteins associated with mammalian infection will be an important step toward understanding the pathogenic properties of Lyme disease-causing bacteria. We present results of studies indicating that B. burgdorferi senses a wide variety o...

journal_title：Infection and immunity

authors： Babb K,El-Hage N,Miller JC,Carroll JA,Stevenson B

更新日期：2001-06-01 00:00:00

abstract：:Diffusely adhering Escherichia coli (DAEC) strains expressing F1845 fimbrial adhesin or Dr hemagglutinin belonging to the Afa/Dr family of adhesins infect cultured polarized human intestinal cells through recognition of the brush border-associated decay-accelerating factor (DAF; CD55) as a receptor. The wild-type Afa/...

journal_title：Infection and immunity

authors： Peiffer I,Guignot J,Barbat A,Carnoy C,Moseley SL,Nowicki BJ,Servin AL,Bernet-Camard MF

更新日期：2000-10-01 00:00:00

abstract：:Whole blood and plasma from animals in the acute stage of leptospirosis contained a toxic factor which produced a cytopathic effect on fibroblastic L cell monolayers. Firm adsorption of cytotoxic factor (CTF) to L cells occurred within 1 h. The highest titer of CTF in plasma was reached at 24 h and declined after 48 h...

journal_title：Infection and immunity

authors： Knight LL,Miller NG,White RJ

更新日期：1973-09-01 00:00:00

abstract：:The innate immune response in human tuberculosis is not completely understood. To improve our knowledge regarding the role of cathelicidin hCAP-18/LL37 in the innate immune response to tuberculosis infection, we used immunohistochemistry, immunoelectron microscopy, and gene expression to study the induction and produc...

journal_title：Infection and immunity

authors： Rivas-Santiago B,Hernandez-Pando R,Carranza C,Juarez E,Contreras JL,Aguilar-Leon D,Torres M,Sada E

更新日期：2008-03-01 00:00:00

abstract：:Previous studies have indicated that the ability to bind to fibronectin is a key feature in successful cell invasion by Campylobacter jejuni. Given the spatial distribution of fibronectin and the architecture of the epithelium, this suggests the possibility that C. jejuni cell invasion might preferentially occur at th...

journal_title：Infection and immunity

authors： Monteville MR,Konkel ME

更新日期：2002-12-01 00:00:00

abstract：:Membrane glycolipids contain the lactose sequence (galactose linked to glucose), and the oligosaccharide is variously extended such that there is a cell-type-specific repertoire. In this study, binding of Pseudomonas aeruginosa M35 to lipid-linked lactose (Gal beta 1-4Glc [structure 1]), lacto-N-neotetraose (Gal beta ...

journal_title：Infection and immunity

authors： Rosenstein IJ,Yuen CT,Stoll MS,Feizi T

更新日期：1992-12-01 00:00:00

abstract：:Immunization with avirulent Salmonella typhimurium strain SL3235, a smooth, aroA- derivative, was shown to induce high levels of resistance to challenge with virulent S. typhimurium in innately hypersusceptible C3H/HeJ mice and inherently resistant C3H/HeNCrlBR mice. Strain SL3235 is one of a class of avirulent aroA- ...

journal_title：Infection and immunity

authors： Killar LM,Eisenstein TK

更新日期：1985-03-01 00:00:00

abstract：:Streptococcus equi and Streptococcus zooepidemicus are major etiological agents of upper and lower airway disease in horses. Despite the considerable animal suffering and economic burden associated with these diseases, the factors that contribute to the virulence of these equine pathogens have not been extensively inv...

journal_title：Infection and immunity

authors： Harrington DJ,Greated JS,Chanter N,Sutcliffe IC

更新日期：2000-10-01 00:00:00

abstract：:Previous studies have reported that human vascular endothelial cells lack the membrane-bound lipopolysaccharide (LPS) receptor, CD14 (mCD14). By optimizing assay conditions, including the selection of anti-CD14 monoclonal antibody, we now demonstrate that human umbilical vein endothelial cells (HUVEC) express CD14 on ...

journal_title：Infection and immunity

authors： Jersmann HP,Hii CS,Hodge GL,Ferrante A

更新日期：2001-01-01 00:00:00

abstract：:Fonsecaea pedrosoi is a fungal pathogen that produces melanin. The functions of melanin and its possible influence in the protective immunological response during infection by F. pedrosoi are not known. In this work, treatment of F. pedrosoi mycelia with proteases and glycosidases followed by a denaturing agent and ho...

journal_title：Infection and immunity

authors： Alviano DS,Franzen AJ,Travassos LR,Holandino C,Rozental S,Ejzemberg R,Alviano CS,Rodrigues ML

更新日期：2004-01-01 00:00:00

abstract：:In this study we investigated the mucosal and systemic responses to two T-cell-independent polysaccharides, a serogroup f polysaccharide (formed of rhamnose glucose polymers [RGPs]) from Streptococcus mutans OMZ 175 and a mannan from Saccharomyces cerevisiae, covalently conjugated either to a linear peptide (peptide 3...

journal_title：Infection and immunity

authors： Lett E,Klopfenstein C,Klein JP,Schöller M,Wachsmann D

更新日期：1995-07-01 00:00:00

abstract：:Since the pH of the gingival crevice increases from below neutrality in health to above pH 8 in disease, we decided to investigate the effect of environmental pH on the growth and enzyme activity of Bacteroides gingivalis W50. Cells were grown in a chemostat under hemin-excess conditions over a range of pH values; sta...

journal_title：Infection and immunity

authors： McDermid AS,McKee AS,Marsh PD

更新日期：1988-05-01 00:00:00

abstract：:Two proteins, HifD and HifE, have been identified as structural components of Haemophilus influenzae pili. Both are localized at the pilus tip, and HifE appears to mediate pilus adherence to host cells. In this study we examined the immunologic and structural diversity of these pilus subunits among type b H. influenza...

journal_title：Infection and immunity

authors： McCrea KW,Sauver JL,Marrs CF,Clemans D,Gilsdorf JR

更新日期：1998-10-01 00:00:00

abstract：:Fusobacterium nucleatum is closely associated with human periodontal diseases and may also be a causative agent in other infections, such as pericarditis, septic arthritis, and abscesses of tonsils and liver. Initiation and outcome of infective diseases depend critically on the host cell signaling system altered by th...

journal_title：Infection and immunity

authors： Uitto VJ,Baillie D,Wu Q,Gendron R,Grenier D,Putnins EE,Kanervo A,Firth JD

更新日期：2005-02-01 00:00:00

abstract：:Liver-stage antigen 1 (LSA-1) is a potential vaccine candidate against preerythrocytic stages of malaria. We report here the immunogenicity of linear synthetic constructs delineated as T(H)-cell determinants from the nonrepeat regions of Plasmodium falciparum LSA-1 in murine models and human subjects from areas where ...

journal_title：Infection and immunity

authors： Joshi SK,Bharadwaj A,Chatterjee S,Chauhan VS

更新日期：2000-01-01 00:00:00

abstract：:Vitamin D(3) (1,25-dihydroxycholecalciferol) induced the phagocyte oxidative burst and intracellular killing of Salmonella enterica serovar Typhimurium in a phosphatidylinositol 3-kinase-dependent manner. The antimicrobial effect was more pronounced for Salmonella SodCI and SodCII mutants, confirming the role of the p...

journal_title：Infection and immunity

authors： Sly LM,Guiney DG,Reiner NE

更新日期：2002-09-01 00:00:00

abstract：:The interaction of the first component of complement with two serum-sensitive strains of Escherichia coli and Klebsiella pneumoniae was studied. It could be demonstrated that highly purified C1, free of immunoglobulin G and immunoglobulin M, binds to E. coli or K. pneumoniae. C1 binding was also found with specificall...

journal_title：Infection and immunity

authors： Loos M,Wellek B,Thesen R,Opferkuch W

更新日期：1978-10-01 00:00:00

abstract：:A model of invasive Haemophilus influenzae type b disease in rats was used to compare the net in vivo and in vitro multiplication rates of this bacterium. In both the blood of rats and in vitro cultures (fresh rat blood or enriched broth) there was an exponential increase in the number of CFU per milliliter with calcu...

journal_title：Infection and immunity

authors： Rubin LG

更新日期：1986-06-01 00:00:00

abstract：:The orotidine-5'-monophosphate decarboxylase (OMPDC) gene, encoding the final enzyme of the de novo pyrimidine biosynthesis pathway, was deleted using Toxoplasma gondii KU80 knockouts to develop an avirulent nonreverting pyrimidine auxotroph strain. Additionally, to functionally address the role of the pyrimidine salv...

journal_title：Infection and immunity

authors： Fox BA,Bzik DJ

更新日期：2010-09-01 00:00:00

abstract：:It has been proposed that a multivalent malaria vaccine is necessary to mimic the naturally acquired resistance to this disease observed in humans. A major experimental challenge is to identify the optimal components to be used in such a multivalent vaccine. Expression library immunization (ELI) is a method for screen...

journal_title：Infection and immunity

authors： Rainczuk A,Scorza T,Smooker PM,Spithill TW

更新日期：2003-08-01 00:00:00

abstract：:The phenotypic and functional changes of glycolipid presented by CD1d(glycolipid/CD1d) specific Valpha14+ T cells in the liver of mice at early stages of bacterial infection were investigated. After Listeria monocytogenes infection or interleukin-12 (IL-12) treatment, alpha-galactosylceramide/CD1d tetramer-reactive (a...

journal_title：Infection and immunity

authors： Emoto M,Yoshizawa I,Emoto Y,Miamoto M,Hurwitz R,Kaufmann SH

更新日期：2006-10-01 00:00:00

abstract：:Alternate modalities for the treatment of Mycobacterium tuberculosis are needed due to the rise in numbers of immunosuppressed individuals at risk for serious disease and the increasing prevalence of multidrug-resistant isolates. Interleukin-12 (IL-12) has been shown to improve immune responses against M. tuberculosis...

journal_title：Infection and immunity

authors： Nolt D,Flynn JL

更新日期：2004-05-01 00:00:00

abstract：:Burkholderia cenocepacia is an opportunistic pathogen that primarily infects cystic fibrosis (CF) patients. Previously, we reported that ShvR, a LysR regulator, influences colony morphology, virulence, and biofilm formation and regulates the expression of an adjacent 24-kb genomic region encoding 24 genes. In this stu...

journal_title：Infection and immunity

authors： Subramoni S,Nguyen DT,Sokol PA

更新日期：2011-08-01 00:00:00