Abstract:
:Pseudomonas aeruginosa and Serratia marcescens can cause refractory keratitis resulting in corneal perforation and blindness. These bacteria produce various kinds of proteases. In addition to pseudomonal elastase (LasB) and alkaline protease, LasA protease and protease IV have recently been found to be more important virulence factors of P. aeruginosa . S. marcescens produces a cysteine protease in addition to metalloproteases. These bacterial proteases have a number of biological activities, such as degradation of tissue constituents and host defense-oriented proteins, as well as activation of zymogens (Hageman factor, prekallikrein and pro-matrix metalloproteinases) through limited proteolysis. In this article, the properties of these bacterial proteases are reviewed and the pathogenic roles of these proteases in pseudomonal keratitis are discussed.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Matsumoto Kdoi
10.1515/BC.2004.131keywords:
subject
Has Abstractpub_date
2004-11-01 00:00:00pages
1007-16issue
11eissn
1431-6730issn
1437-4315journal_volume
385pub_type
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