Transplantation of corneas reconstructed with cultured adult human corneal endothelial cells in nude rats.

abstract：:The phagocytosis of photoreceptor outer segments (OS) by the retinal pigment epithelium (RPE) is a receptor mediated process. A key component of this process is the receptor tyrosine kinase, Mer. RPE cells from the RCS rat, which lacks a functional mer gene, and do not express Mer protein, are able to bind OS, but are...

journal_title：Experimental eye research

authors： Hall MO,Abrams TA,Burgess BL

更新日期：2003-09-01 00:00:00

abstract：:In a variety of tissues including gastrointestinal mucosa, rebamipide (REB) provides cytoprotection, prevents inflammation, and promotes wound healing. Clinically, REB ophthalmic dispersions are used to treat diabetic keratopathy. In this study, we investigated the optimal particle size of REB to promote corneal wound...

journal_title：Experimental eye research

authors： Nagai N,Ito Y,Okamoto N,Shimomura Y

更新日期：2016-10-01 00:00:00

abstract：:The retinal pigment epithelium (RPE) constitutes a monolayer of cuboidal cells that interact apically with the interphotoreceptor matrix (IPM) and outer segments of the photoreceptor cells and basally with the subjacent Bruch's membrane. This highly polarized structure is maintained by the cytoskeleton of individual c...

journal_title：Experimental eye research

authors： Bonilha VL

更新日期：2014-09-01 00:00:00

abstract：PURPOSE:To investigate the potential protective effect of novel G protein coupled estrogen receptor (GPER1) against the neurotoxicity induced by NMDA in the mouse retina. METHODS:We induce retinal ganglion cells (RGCs) toxic injury through intravitreal injection of NMDA or acute ocular hypertension (AOH) induced by an...

journal_title：Experimental eye research

authors： Jiang M,Ma X,Zhao Q,Li Y,Xing Y,Deng Q,Shen Y

更新日期：2019-12-01 00:00:00

abstract：:Corneal epithelial (CE) cells are exposed to environmental insults (e.g., UV-irradiation), yet they suffer little damage. Our previous studies suggest that chicken CE cells have a novel form of protection involving having ferritin in a nuclear location where it can bind to DNA and sequester free iron. Here we describe...

journal_title：Experimental eye research

authors： Kubilus JK,Beazley KE,Talbot CJ,Linsenmayer TF

更新日期：2016-04-01 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) has been shown to rescue dying photoreceptor cells in the RCS rat, a model with a genetic defect of the RPE that impairs outer segment phagocytosis. The purpose of the present study was to determine whether intravitreal injection of bFGF would have a similar effect on photorecepto...

journal_title：Experimental eye research

authors： Smith SB,Titelman R,Hamasaki DI

更新日期：1996-11-01 00:00:00

abstract：:The carbohydrate epitope Gal alpha 1-3Gal-R (alpha-galactosyl epitope), which is detectable by its binding with Bandeiraea simplicifolia-IB4 lectin, was found in glycosphingolipids (GSLs), both neutral and acidic (gangliosides), from lens tissues of non-primate mammals, but not in those of human senile cataracts and O...

journal_title：Experimental eye research

authors： Ogiso M,Okinaga T,Komoto M,Nishiyama I,Hoshi M

更新日期：1994-12-01 00:00:00

abstract：:The purpose of this study was to correlate potential mechanisms with site(s) of action for TNPA-induced ocular hypotension. In response to R(-)-2, 10, 11-trihydroxy-N-propyl-noraporphine hydrobromide (TNPA, 75 microg), a D2 dopamine receptor agonist, the intraocular pressure decreased by 4.5 and 8 mm Hg at 1 and 2 hr,...

journal_title：Experimental eye research

authors： Chu E,Chu TC,Potter DE

更新日期：1999-12-01 00:00:00

abstract：:Cochlin deposits were observed in the trabecular meshwork (TM) of 8-month-old glaucomatous DBA/2J mice, coincident with the reported onset of increased intraocular pressure and optic nerve damage. An age-dependent increase in cochlin was observed up to 10 months of age and was paralleled by a decrease in type II colla...

journal_title：Experimental eye research

authors： Bhattacharya SK,Annangudi SP,Salomon RG,Kuchtey RW,Peachey NS,Crabb JW

更新日期：2005-05-01 00:00:00

abstract：PURPOSE:This microscopic study was undertaken to compare the melanocytes of peripheral iridectomy specimens from two eyes that had latanoprost-induced iris darkening (LIID) with iridectomies taken from the fellow untreated eyes. METHODS:The two patients in this study were the ones who underwent LIID in the latanoprost...

journal_title：Experimental eye research

authors： Cracknell KP,Grierson I,Hogg P,Appleton P,Pfeiffer N

更新日期：2003-12-01 00:00:00

abstract：:Stroboscopic luminance flicker has been found to prevent the increase in eye growth normally associated with form deprivation through the release of retinal dopamine. In this study, we sought to investigate whether dopamine plays a role in the decreased growth observed with 2 Hz sine-wave luminance flicker and increas...

journal_title：Experimental eye research

authors： Chuang KK,Rucker FJ

更新日期：2019-12-01 00:00:00

abstract：:Myofibroblasts expressing α-smooth muscle actin (α-SMA) are the key cellular mediator of fibrosis. Fibrovascular epiretinal membranes from patients with proliferative diabetic retinopathy (PDR) are characterized by the accumulation of a large number of myofibroblasts. We explored the hypothesis that proliferating endo...

journal_title：Experimental eye research

authors： Abu El-Asrar AM,De Hertogh G,van den Eynde K,Alam K,Van Raemdonck K,Opdenakker G,Van Damme J,Geboes K,Struyf S

更新日期：2015-03-01 00:00:00

abstract：:Thirty-one trabeculectomy specimens of patients suffering from primary open-angle glaucoma (POAG) who had received no, or only minor, medication prior to surgery were ultrastructurally and quantitatively analysed. Most of the specimens revealed thickened trabeculae, increased amounts of plaque-material deposited withi...

journal_title：Experimental eye research

authors： Rohen JW,Lütjen-Drecoll E,Flügel C,Meyer M,Grierson I

更新日期：1993-06-01 00:00:00

abstract：:Monkey eyes are useful for ophthalmologic research into eye diseases because their histological and functional properties are very similar to those of humans. The monkey laser-induced high intraocular pressure (IOP) model is a common model for ophthalmologic research, especially into glaucoma. Although several studies...

journal_title：Experimental eye research

authors： Sasaoka M,Nakamura K,Shimazawa M,Ito Y,Araie M,Hara H

更新日期：2008-05-01 00:00:00

abstract：:An optimal system for monitoring in vivo corneal wound healing is inexpensive, has utility for wounding and imaging, and is able to provide previews before photography. We outline such an imaging system that takes advantage of a consumer digital camera and an LED-based light source for fluorescein excitation. Using FV...

journal_title：Experimental eye research

authors： Ghoghawala SY,Mannis MJ,Murphy CJ,Rosenblatt MI,Isseroff RR

更新日期：2007-06-01 00:00:00

abstract：:Cultured bovine lens epithelial cells adapt to hypertonic sodium stress via an increase in Na(+)-myo-inositol cotransporter activity and accumulate myo-inositol. At least 12 hr of hypertonic exposure was necessary to enhance myo-inositol accumulation; and thereafter, uptake activity continued to increase throughout th...

journal_title：Experimental eye research

authors： Cammarata PR,Chen HQ,Zhou C,Reeves R

更新日期：1994-07-01 00:00:00

abstract：:Autoradiographic studies showed selective accumulation of [3H]-glycine, [3H]-GABA, and the GABA agonist [3H]-muscimol by neurons of the mudpuppy retina. [3H]-Glycine was taken up by bipolar cells, amacrine cells, and displaced amacrine or ganglion cells. Both [3H]-GABA and [3H]-muscimol were also accumulated by bipola...

journal_title：Experimental eye research

authors： Pourch RG,Goebel DJ,McReynolds JS

更新日期：1984-07-01 00:00:00

abstract：:The mass receptor potential of the excised, superfused retina of the bullfrog was studied. Photoreceptor responses were isolated by addition of sodium aspartate to the Ringer solutions. Responses of the cones were monitored independently from responses of the rods by employing a two-flash method of stimulation which t...

journal_title：Experimental eye research

authors： Sillman AJ,Bolnick DA,Bosettii JB,Haynes LW,Walter AE

更新日期：1984-08-01 00:00:00

abstract：:A number of deep-sea fish have bright yellow lenses whose coloration is attributable to a variety of largely unidentified short-wave absorbing pigments. Here the pigment of the deep-sea fish Stylephorus chordatus has been isolated and identified by NMR and mass spectroscopy as kynurenine; a pigment also found in the h...

journal_title：Experimental eye research

authors： Thorpe A,Truscott RJ,Douglas RH

更新日期：1992-07-01 00:00:00

abstract：:This study was undertaken to develop a feline model of corticosteroid-induced ocular hypertension. In the first experiment, eight cats were selected whose intraocular pressure (17 +/- 0.4 mmHg) was consistently below the mean baseline intraocular pressure of our colony (24 +/- 0.5) during the preceding 2 months. Unila...

journal_title：Experimental eye research

authors： Zhan GL,Miranda OC,Bito LZ

更新日期：1992-02-01 00:00:00

abstract：:The purpose of the study was to determine histologic findings after successful laser trabeculoplasty in eyes with glaucoma. Previous studies have examined eyes in which laser did not lower intraocular pressure, or examined only the region of the laser burn itself. Nineteen autopsy eyes from 14 donors with either prima...

journal_title：Experimental eye research

authors： Johnson DH

更新日期：2007-10-01 00:00:00

abstract：:Ion channels and ion transporters play essential roles in the function of the retinal pigment epithelium (RPE). The use of cell cultures has been exploited as a key method for successfully identifying and studying ion channels and transporters of the RPE. Cultured RPE cells enable robust and long-lasting patch-clamp r...

journal_title：Experimental eye research

authors： Reichhart N,Strauss O

更新日期：2014-09-01 00:00:00

abstract：:Interphotoreceptor retinoid-binding protein (IRBP) is a vitamin A carrier present only in the extracellular material lying between the neural retina and the retinal pigment epithelium of vertebrate eyes. The amount of retinol bound endogenously by IRBP in this interphotoreceptor space is known to increase upon illumin...

journal_title：Experimental eye research

authors： Adler AJ,Spencer SA

更新日期：1991-09-01 00:00:00

abstract：:Changes in the distribution of keratan sulfate in the anterior segment of developing ocular tissue were investigated histochemically and immunohistochemically using human eyes from 5 weeks gestation to 2 years after birth. Enzyme digestion methods with streptomyces hyaluronidase, chondroitinase and keratanase showed t...

journal_title：Experimental eye research

authors： Azuma N,Hirakata A,Hida T,Kohsaka S

更新日期：1994-03-01 00:00:00

abstract：:Sodium hyaluronates with molecular weights of 18000, 500000 and 4 x 10(6), labelled with either 3H or 14C, were injected into the anterior chamber or into the centre of the vitreous body of rabbits and their rates of disappearance were followed. The out-flow from the anterior chamber in anaesthetized animals was virtu...

journal_title：Experimental eye research

authors： Laurent UB,Fraser JR

更新日期：1983-04-01 00:00:00

abstract：:The response of the poikilothermal lens to various incubation temperatures in vitro was compared with that of the homothermal lens. The rainbow trout lens was used as the poikilothermal lens and the rat lens as the homothermal lens. In contrast to rat lenses, cataract developed at 37 degrees C in rainbow trout lenses,...

journal_title：Experimental eye research

authors： Iwata S,Hikida M

更新日期：1985-08-01 00:00:00

abstract：:Experimental autoimmune uveoretinitis (EAU) in mice provides a useful platform to study the pathogenesis and experimental therapeutics of human uveitis. One often used EAU model employs C57BL/6 (B6) mice sensitized with a peptide residue having 1 to 20 amino acids of human interphotoreceptor retinoid binding protein (...

journal_title：Experimental eye research

authors： Tajiri N,Kato T,Satoh M,Iizuka M,Taniguchi M,Kitaichi N,Iwabuchi K

更新日期：2020-12-19 00:00:00

abstract：:A micropuncture technique involving the use of microcannulas with tip diameters less than 5 microns was used to measure the pressure in Schlemm's canal and in the meshwork at distances approximately 7 and 14 microns from the inner wall of Schlemm's canal. In one set of experiments where the spontaneous intraocular pre...

journal_title：Experimental eye research

authors： Mäepea O,Bill A

更新日期：1992-06-01 00:00:00

abstract：:This study was performed to further characterize expression and function of the Fas/Fas ligand system in the cornea. Specifically, these experiments examined (1) the effect of genetic inactivation of Fas or Fas ligand genes on keratocyte apoptosis in response to corneal epithelial wounding, (2) whether cultured human ...

journal_title：Experimental eye research

authors： Mohan RR,Liang Q,Kim WJ,Helena MC,Baerveldt F,Wilson SE

更新日期：1997-10-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is the major cause of blindness for people over 60. In the "wet" form of AMD compounds targeting growth factor signaling pathways such as VEGF have been a major focus for therapeutic interventions. In a previously developed rat model of CNV, we utilized two receptor tyrosine kina...

journal_title：Experimental eye research

authors： Wang FE,Shi G,Niesman MR,Rewolinski DA,Miller SS

更新日期：2007-05-01 00:00:00