The role of dopamine in eye growth responses to color and luminance flicker in chicks.

Abstract:

:Stroboscopic luminance flicker has been found to prevent the increase in eye growth normally associated with form deprivation through the release of retinal dopamine. In this study, we sought to investigate whether dopamine plays a role in the decreased growth observed with 2 Hz sine-wave luminance flicker and increased growth with color flicker. Starting 5-7 days after hatching, chicks were exposed to 2 Hz sinusoidally modulated illumination (Mean: 680 lux) for 4 days and were otherwise in the dark. Chicks were exposed to color-modulated red and green (RG) light, to luminance modulated RGB components (LUM), or to a no-flicker (NF) control. Chicks received daily 10 μL intravitreal injections of apomorphine, spiperone, or saline. Fellow eyes received no injection. Spiperone injections prevented the decrease in eye growth typically seen with LUM flicker, with a relative increase in eye length, but no other significant effects compared with saline controls. Apomorphine injections prevented the increase in eye growth typically seen with RG flicker, with a relative decrease in eye length compared to saline controls. These results indicate a role for the activation of D2-receptor types in the inhibition of eye growth in response to luminance flicker, and a lack of dopamine receptor activation associated with the increase in eye growth with color flicker.

journal_name

Exp Eye Res

authors

Chuang KK,Rucker FJ

doi

10.1016/j.exer.2019.107822

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

107822

eissn

0014-4835

issn

1096-0007

pii

S0014-4835(19)30300-8

journal_volume

189

pub_type

杂志文章
  • Light elicits the release of docosahexaenoic acid from membrane phospholipids in the rat retina in vitro.

    abstract::Docosahexaenoic acid is the major polyunsaturated fatty acid in photoreceptor membrane phospholipids and is thought to be necessary for photoreceptor function. Docosahexaenoic acid may be metabolized to docosanoids or, by retroconversion, to eicosapentaenoic acid followed by lipoxygenation and synthesis of n-3 metabol...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1006/exer.1996.0116

    authors: Reinboth JJ,Clausen M,Remé CE

    更新日期:1996-09-01 00:00:00

  • Impact of euthanasia, dissection and postmortem delay on metabolic profile in mouse retina and RPE/choroid.

    abstract::Metabolomics studies in the retina and retinal pigment epithelium (RPE) in animal models or postmortem donors are essential to understanding the retinal metabolism and to revealing the underlying mechanisms of retinal degenerative diseases. We have studied how different methods of euthanasia (CO2 or cervical dislocati...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1016/j.exer.2018.05.032

    authors: Zhu S,Yam M,Wang Y,Linton JD,Grenell A,Hurley JB,Du J

    更新日期:2018-09-01 00:00:00

  • In-vitro and ex-situ regional mass spectral analysis of phospholipids and glucose in the vitreous humor from diabetic and non-diabetic human donors.

    abstract::The causes of vitreous humor (VH) liquefaction remain unclear. Diabetes accelerates this process and other ocular diseases. The weakening of the blood-retina barrier observed with diabetes could enhance the rate of transfer of relatively small molecules such as glucose (Glu) and phospholipids (PLs) from the retina to ...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1016/j.exer.2020.108221

    authors: Schnepf A,Yappert MC,Borchman D

    更新日期:2020-11-01 00:00:00

  • Localization of fluorescence-labeled lectin binding sites on photoreceptor cells of the monkey retina.

    abstract::The binding of eight fluorescence-labeled lectins to the photoreceptors of the monkey retina was investigated using a post-embedding staining method. Concanavalin A (specific for mannosyl and glucosyl residues) bound to the outer and inner segments of both rods and cones, while the degree of staining was more intense ...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1016/0014-4835(83)90094-5

    authors: Uehara F,Sameshima M,Muramatsu T,Ohba N

    更新日期:1983-01-01 00:00:00

  • Localization of thrombospondin-1 and myofibroblasts during corneal wound repair.

    abstract::Thrombospondin-1 (TSP-1) is a multifunctional matrix protein that has recently been examined in various wound processes, primarily for its ability to activate the latent complex of transforming growth factor-beta (TGF-β). TGF-β has been shown to play a major role in stimulating mesenchymal cells to synthesize extracel...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1016/j.exer.2011.06.018

    authors: Matsuba M,Hutcheon AE,Zieske JD

    更新日期:2011-10-01 00:00:00

  • Inner retinal preservation in rat models of retinal degeneration implanted with subretinal photovoltaic arrays.

    abstract::Photovoltaic arrays (PVA) implanted into the subretinal space of patients with retinitis pigmentosa (RP) are designed to electrically stimulate the remaining inner retinal circuitry in response to incident light, thereby recreating a visual signal when photoreceptor function declines or is lost. Preservation of inner ...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1016/j.exer.2014.09.004

    authors: Light JG,Fransen JW,Adekunle AN,Adkins A,Pangeni G,Loudin J,Mathieson K,Palanker DV,McCall MA,Pardue MT

    更新日期:2014-11-01 00:00:00

  • Impact of a high-fat diet on the fatty acid composition of the retina.

    abstract::Structure and function of the retina mainly rely on its fatty acid (FA) composition. Evidence from epidemiological studies and from animal experiments indicates that FA composition of the retina is influenced by the diet. Mice under chronic high-fat diet (HFD) develop metabolic syndrome, a risk factor for diabetes tha...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1016/j.exer.2020.108059

    authors: Albouery M,Buteau B,Grégoire S,Martine L,Gambert S,Bron AM,Acar N,Chassaing B,Bringer MA

    更新日期:2020-07-01 00:00:00

  • Identification of pathogenic factors potentially involved in Staphylococcus aureus keratitis using proteomics.

    abstract::Staphylococcus is a leading cause of microbial keratitis, characterized by destruction of the cornea by bacterial exoproteins and host-associated factors. The aim of this study was to compare extracellular and cell-associated proteins produced by two different isolates of S. aureus, a virulent clinical isolate (Staph ...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1016/j.exer.2016.08.016

    authors: Khan S,Cole N,Hume EB,Garthwaite LL,Nguyen-Khuong T,Walsh BJ,Willcox MD

    更新日期:2016-10-01 00:00:00

  • Development and degeneration of retina in rds mutant mice: ultraimmunohistochemical localization of opsin.

    abstract::In normal retina the developing photoreceptor cells first show presence of opsin over the distal ends of the ciliary protrusions. In a fully differentiated cell intense activity is seen over the rod outer-segment discs; some activity is also seen over the Golgi zone and near the distal ends of the inner segments but t...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1016/s0014-4835(87)80170-7

    authors: Jansen HG,Sanyal S,De Grip WJ,Schalken JJ

    更新日期:1987-03-01 00:00:00

  • Characterization of adenylate cyclase in human retinal pigment epithelial cells in vitro.

    abstract::Human retinal pigment epithelial cells in culture demonstrate adenylate cyclase activity. It is membrane-bound and modulated by GTP regulatory proteins. It is effectively activated only by beta-adrenergic agonists (L-isoproterenol greater than or equal to L-epinephrine greater than L-norepinephrine) and some prostagla...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1016/s0014-4835(87)80158-6

    authors: Friedman Z,Hackett SF,Campochiaro PA

    更新日期:1987-04-01 00:00:00

  • Influence of molecular shape, conformability, net surface charge, and tissue interaction on transscleral macromolecular diffusion.

    abstract::The purpose of this study was to investigate the influence of molecular shape, conformability, net surface charge and tissue interaction on transscleral diffusion. Unfixed, porcine sclera was clamped in an Ussing chamber. Fluorophore-labelled neutral albumin, neutral dextran, or neutral ficoll were placed in one hemi-...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1016/j.exer.2012.07.007

    authors: Srikantha N,Mourad F,Suhling K,Elsaid N,Levitt J,Chung PH,Somavarapu S,Jackson TL

    更新日期:2012-09-01 00:00:00

  • Modulating the hypoxia-inducible factor signaling pathway as a therapeutic modality to regulate retinal angiogenesis.

    abstract::Hypoxia-inducible factor (HIF) signaling cascade plays a critical role in angiogenesis by activating the transcription of genes encoding angiogenic growth factors. This study evaluated the effects of YC-1, a HIF-1 inhibitor, on the morphological, biochemical and molecular changes in human retinal microvascular endothe...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1016/j.exer.2009.06.013

    authors: DeNiro M,Alsmadi O,Al-Mohanna F

    更新日期:2009-11-01 00:00:00

  • Inflammatory cells proliferate in the choroid and retina without choroidal thickness change in early Type 1 diabetes.

    abstract::Increasing evidence points to inflammation as a key factor in the pathogenesis of diabetic retinopathy (DR). Choroidal inflammatory changes in diabetes have been reported and in vivo choroidal thickness (CT) has been searched as a marker of retinopathy with contradictory results. We aimed to investigate the early stag...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1016/j.exer.2020.108195

    authors: Campos A,Campos EJ,Martins J,Rodrigues FSC,Silva R,Ambrósio AF

    更新日期:2020-10-01 00:00:00

  • Low de novo glutathione synthesis from circulating sulfur amino acids in the lens epithelium.

    abstract::Transport of circulating sulfur amino acids (SAA) into the lens epithelium and de novo glutathione (GSH) synthesis were studied in the perfused guinea-pig eye. Plasma-to-aqueous transfer of SAA was in their intact form (> or = 98%) and comparable with sucrose (an extracellular marker) within 30 min. The unidirectional...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1006/exer.1996.0260

    authors: Mackic JB,Kannan R,Kaplowitz N,Zlokovic BV

    更新日期:1997-04-01 00:00:00

  • Matrix metalloproteinases in keratoconus - Too much of a good thing?

    abstract::Keratoconus (KC) is a progressive, early onset, and often bilateral eye condition, in which the cornea gradually weakens and bulges out, and in advanced cases may eventually become cone-shaped. The available evidence suggests that it is a multifactorial disease with environmental and genetic contributions. Matrix Meta...

    journal_title:Experimental eye research

    pub_type: 杂志文章,评审

    doi:10.1016/j.exer.2019.03.016

    authors: di Martino E,Ali M,Inglehearn CF

    更新日期:2019-05-01 00:00:00

  • The mRNA expression of cytokines and their receptors in cultured iris pigment epithelial cells: a comparison with retinal pigment epithelial cells.

    abstract::It has been suggested that human iris pigment epithelial (IPE) cells isolated from iridectomized tissue could be used as autologous cells for transplantation into the subretinal space in diseases with dysfunctional retinal pigment epithelium (RPE). RPE cells synthesize a number of cytokines and their receptors which a...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1006/exer.1998.0517

    authors: Kociok N,Heppekausen H,Schraermeyer U,Esser P,Thumann G,Grisanti S,Heimann K

    更新日期:1998-08-01 00:00:00

  • Age-dependent changes in the expression of matrix components in the mouse eye.

    abstract::Although the presence of 'cartilage-specific' collagens in the eye has been documented earlier, very little is known about their synthesis rates during ocular development, growth and aging. The purpose of the present study was to follow changes in the mRNA levels and distribution of key components of the extracellular...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1006/exer.2000.0972

    authors: Ihanamäki T,Salminen H,Säämänen AM,Pelliniemi LJ,Hartmann DJ,Sandberg-Lall M,Vuorio E

    更新日期:2001-04-01 00:00:00

  • The glucose transporter in the plasma membrane of the outer segments of bovine retinal rods.

    abstract::The facilitated diffusion glucose transporter in the plasma membrane of intact outer segments isolated from bovine retinal rods (ROS) was characterized by measurements of: (1) 14C-labeled 3-O-methylglucose fluxes; and (2) glucose-sensitive binding of 3H-labeled cytochalasin B to ROS membranes. Inhibition of 3-O-methyl...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1006/exer.1994.1117

    authors: Li XB,Szerencsei RT,Schnetkamp PP

    更新日期:1994-09-01 00:00:00

  • Horizontal cells of the normal and dystrophic rat retina: a wholemount study using immunolabelling for the 28-kDa calcium-binding protein.

    abstract::Immunocytochemistry with a monoclonal antibody against the 28-kDa calcium-binding protein (28-kDa CaBP) was used to study horizontal cells in both congenic control (RCS-rdy+) and dystrophic (RCS) 3-month-old rat retina. We found that horizontal cells in the RCS-rdy+ rat retinas were distributed evenly from the centre ...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1006/exer.1993.1109

    authors: Chu Y,Humphrey MF,Constable IJ

    更新日期:1993-08-01 00:00:00

  • Hypoxic preconditioning protects photoreceptors against light damage independently of hypoxia inducible transcription factors in rods.

    abstract::Hypoxic preconditioning protects photoreceptors against light-induced degeneration preserving retinal morphology and function. Although hypoxia inducible transcription factors 1 and 2 (HIF1, HIF2) are the main regulators of the hypoxic response, photoreceptor protection does not depend on HIF1 in rods. Here we used ro...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1016/j.exer.2015.12.008

    authors: Kast B,Schori C,Grimm C

    更新日期:2016-05-01 00:00:00

  • Effect of diinosine polyphosphates on intraocular pressure in normotensive rabbits.

    abstract::The ability of diinosine polyphosphates, diinosine triphosphate (Ip(3)I), diinosine tetraphosphate (Ip(4)I) and diinosine pentaphosphate (Ip(5)I) to modify intraocular pressure in normotensive New Zealand white rabbits was tested. Ip(5)I produced increase in intraocular pressure, while Ip(3)I and Ip(4)I produced a dec...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1016/j.exer.2012.05.011

    authors: Guzman-Aranguez A,Díez LM,Martín-Gil A,Gualix J,Miras-Portugal MT,Pintor J

    更新日期:2012-08-01 00:00:00

  • Autophagy in granular corneal dystrophy type 2.

    abstract::Autophagy is a lysosomal degradative process that is essential for cellular homeostasis and metabolic stress adaptation. Defective autophagy is involved in the pathogenesis of many diseases including granular corneal dystrophy type 2 (GCD2). GCD2 is an autosomal dominant disorder caused by substitution of histidine fo...

    journal_title:Experimental eye research

    pub_type: 杂志文章,评审

    doi:10.1016/j.exer.2015.09.008

    authors: Choi SI,Kim EK

    更新日期:2016-03-01 00:00:00

  • Nanoceria inhibit expression of genes associated with inflammation and angiogenesis in the retina of Vldlr null mice.

    abstract::Oxidative stress and inflammation are important pathological mechanisms in many neurodegenerative diseases, including age-related macular degeneration (AMD). The very low-density lipoprotein receptor knockout mouse (Vldlr-/-) has been identified as a model for AMD and in particular for retinal angiomatous proliferatio...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1016/j.exer.2013.08.003

    authors: Kyosseva SV,Chen L,Seal S,McGinnis JF

    更新日期:2013-11-01 00:00:00

  • Transforming growth factor beta2-induced myofibroblastic differentiation of human retinal pigment epithelial cells: regulation by extracellular matrix proteins and hepatocyte growth factor.

    abstract::Retinal pigment epithelial (RPE) cells possess the potential to transdifferentiate into myofibroblasts after stimulation with transforming growth factor beta (TGFbeta) and are implicated in the pathogenesis of proliferative vitreoretinopathy. In this study we evaluated how TGFbeta2 and various extracellular matrix (EC...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1016/j.exer.2005.12.007

    authors: Gamulescu MA,Chen Y,He S,Spee C,Jin M,Ryan SJ,Hinton DR

    更新日期:2006-07-01 00:00:00

  • Hexose transport in microvascular endothelial cells cultured from bovine retina.

    abstract::The nature of glucose transport at the microvascular blood-retinal barrier was studied using primary cultures of microvascular endothelial cells from bovine retina. Uptake of 3-O-methyl-D-glucose (3MG), a non-metabolizable glucose analogue, was rapid and equilibrative. 3MG uptake could be inhibited by traditional gluc...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1016/0014-4835(83)90011-8

    authors: Betz AL,Bowman PD,Goldstein GW

    更新日期:1983-02-01 00:00:00

  • The spectrum of genetic mutations in patients with asymptomatic mild familial exudative vitreoretinopathy.

    abstract::Familial exudative vitreoretinopathy (FEVR) is a disease exhibits a wide range of clinical signs, ranging mild peripheral retinal vascular anomalies to severe retinal detachments. Individuals with mild FEVR are frequently asymptomatic with good visual function and are often undiagnosed. However, little is known about ...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1016/j.exer.2020.107941

    authors: Chen C,Sun L,Li S,Huang L,Zhang T,Wang Z,Yu B,Ding X

    更新日期:2020-03-01 00:00:00

  • Retinal arterial occlusion leads to acidosis in the cat.

    abstract::This study investigated the changes in pH during retinal artery occlusion by means of extracellular H+ concentration ([H+]o) measurements in the retina under both air and 100% O2 ventilation. Occlusion was produced in intact anesthetised cats by pressing with a probe onto a retinal artery. [H+]o profiles were recorded...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1016/j.exer.2004.11.002

    authors: Birol G,Budzynski E,Wangsa-Wirawan ND,Linsenmeier RA

    更新日期:2005-04-01 00:00:00

  • The Von Sallmann Lecture 1996: an ophthalmological explanation of REM sleep.

    abstract::The hypothesis is advanced that the purpose of the eyeball movements during REM sleep is to stir the aqueous humor behind the closed lids and so avoid the risk that its stagnation could cause corneal anoxia. The relevance of the hypothesis to evolutionary biology and intensive care nursing is discussed. ...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1006/exer.1997.0444

    authors: Maurice DM

    更新日期:1998-02-01 00:00:00

  • Proteoglycans in the mouse interphotoreceptor matrix. V. Distribution at the apical surface of the pigment epithelium before and after retinal separation.

    abstract::The distribution of chondroitin sulfate proteoglycans in the mouse interphotoreceptor matrix (IPM) proximal to the retinal pigment epithelium (RPE) was evaluated with EM histochemical techniques using Cupromeronic Blue (CmB) before and after retinal separation. Densely packed, sheet-like processes surrounding vesicle-...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1016/0014-4835(92)90054-v

    authors: Iwasaki M,Rayborn ME,Tawara A,Hollyfield JG

    更新日期:1992-03-01 00:00:00

  • Expression of matrix metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF) in inflammation-associated corneal neovascularization.

    abstract::Matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF) are all implicated in the development of neovascularization. To investigate the possible role of these factors in corneal neovascularization we have analysed the expression of MMP-2, MMP-9 and VEGF in a...

    journal_title:Experimental eye research

    pub_type: 杂志文章

    doi:10.1006/exer.1999.0790

    authors: Kvanta A,Sarman S,Fagerholm P,Seregard S,Steen B

    更新日期:2000-04-01 00:00:00