Abstract:
:Cochlin deposits were observed in the trabecular meshwork (TM) of 8-month-old glaucomatous DBA/2J mice, coincident with the reported onset of increased intraocular pressure and optic nerve damage. An age-dependent increase in cochlin was observed up to 10 months of age and was paralleled by a decrease in type II collagen. Similar expression patterns exist in the TM of humans with primary open-angle glaucoma. Cochlin deposits, absent in non-glaucomatous mouse and human TM, may disrupt the TM extracellular matrix and obstruct aqueous humor circulation. Studies of DBA/2J mice offer promise for understanding the role cochlin may play in glaucoma.
journal_name
Exp Eye Resjournal_title
Experimental eye researchauthors
Bhattacharya SK,Annangudi SP,Salomon RG,Kuchtey RW,Peachey NS,Crabb JWdoi
10.1016/j.exer.2005.01.028keywords:
subject
Has Abstractpub_date
2005-05-01 00:00:00pages
741-4issue
5eissn
0014-4835issn
1096-0007pii
S0014-4835(05)00032-1journal_volume
80pub_type
信件abstract::Previous studies have suggested that a mannose receptor mediates the phagocytic uptake of effete rod outer segments by retinal pigment epithelial cells. In the present study, the effect of adding a soluble ligand for the mannose receptor, horseradish peroxidase, was examined. Cultured retinal pigment epithelial cells ...
journal_title:Experimental eye research
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journal_title:Experimental eye research
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pub_type: 杂志文章,评审
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更新日期:2005-07-01 00:00:00
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journal_title:Experimental eye research
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更新日期:1991-04-01 00:00:00
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journal_title:Experimental eye research
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doi:10.1006/exer.1999.0700
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1006/exer.1997.0444
更新日期:1998-02-01 00:00:00
abstract::Preretinal pH was measured in the avascular region of 19 rabbit retinas during alternating cycles of light and dark, using a miniature, needle-type pH electrode. In 14 experiments with the rabbits breathing room air, cyclic changes in pH, decreasing in the dark and increasing in the light, were observed. The transitio...
journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1016/0014-4835(91)90106-o
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